The effects of in-uterine environment on infant health other than birth weight
| Project/Area Number |
19K11735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | National Center for Child Health and Development |
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Principal Investigator |
Kawai Tomoko 国立研究開発法人国立成育医療研究センター, 周産期病態研究部, 室長 (40423404)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 周産期環境 / 栄養 / DNAメチル化 / 臍帯血 / 胎児期環境 / 臍帯血DNAメチル化 / 胎児発育 / 臍帯血エピゲノム / 妊娠期体重増加量 / 胎盤エピゲノム / 子宮内環境 / 胎児エピゲノム / 栄養摂取 / 出生体重 |
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| Outline of Research at the Start |
早産児あるいは低出生体重児は、そうでない児に比べ高確率に将来疾病を発症する事実が疫学的に証明されている。一方で我々はこれまでに、正期産で正常範囲の体重で出生した児であっても、子宮内栄養環境が不適切であった事実はエピゲノムを介して記憶されていることを認め、報告した(Kawai et al. 2015)。我々は、一見正常な児であっても、母親の妊娠中の体重増加が少ないことに関連して認められるエピゲノム異常が早産児のそれと類似していることを認めた。つまり栄養不足は細胞レベルで発達スピードを遅らせている可能性が示唆される。本研究では、この分子メカニズムに関連する栄養素を具体的に追及することを目的とする。
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| Outline of Final Research Achievements |
The purpose of this study was to elucidate the possibility that maternal nutritional status during the perinatal period may play a role in the future development of disease in the child from an epigenomic perspective. Epigenetics has attracted attention as a mechanism for intracellular memory of environmental influences. Among them, DNA methylation, a chemical modification of nucleic acid that is passed on to daughter cells during cell division, has attracted attention as a molecular mechanism involved in memory. We detected DNA methylation changes associated with maternal factors prior to pregnancy in cord blood from approximately 300 Japanese subjects. This change has been also reported by other research groups, suggesting involvement of effects on the child's future glucose metabolism.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果から、次世代の健康に影響を及ぼす可能性のある周産期の因子を同定し、次世代の疾病発症予防に繋げられることが期待される。
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] DNA methylation analysis of cord blood samples in neonates born to gestational diabetes mothers diagnosed before 24 gestational weeks.2022
Author(s)
Kasuga Y, Kawai T, Miyakoshi K, Hori A, Tamagawa M, Hasegawa K, Ikenoue S, Ochiai D, Saisho Y, Hida M, Tanaka M, Hata K
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Journal Title
BMJ Open Diabetes Res Care.
Volume: 10
Issue: 1
Pages: e002539-e002539
DOI
Related Report
Peer Reviewed / Open Access
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