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Building Medical Diagnosis Systems with Multiple Medical Examination Data Using Unsupervised and Semi-Supervised Learning

Research Project

Project/Area Number 19K12120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 61030:Intelligent informatics-related
Research InstitutionYamaguchi University

Principal Investigator

Mabu Shingo  山口大学, 大学院創成科学研究科, 教授 (70434321)

Co-Investigator(Kenkyū-buntansha) 呉本 尭  日本工業大学, 先進工学部, 教授 (40294657)
平野 綱彦  山口大学, 医学部附属病院, 准教授 (00382333)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords深層学習 / ニューラルネットワーク / 医用画像 / 教師なし学習 / 半教師あり学習 / 異常検知 / 音声認識 / 機械学習 / 医用データ
Outline of Research at the Start

一般に,深層学習には大量の教師データが必要であるが,医療分野では臓器ごと,疾患ごとに十分な量の教師データを得ることは難しく,既存の深層学習手法の単なる医用データへの適用では十分な診断精度を達成できない.したがって,教師データの少なさをカバーできる方式の実現を目的とする.具体的には,胸部CT画像を主とした教師なし疾患検知システムと,経験を積むごとに賢くなる半教師あり疾患検知システムを研究する.さらに,肺聴診音など複数の検査情報を統合した診断システムへ展開し,放射線科医の評価も取り入れながら臨床展開の可能性を探る.

Outline of Final Research Achievements

We conducted research on improving the performance of machine learning even with a small amount of supervised data from various aspects, applied it to various medical data, and studied prediction models by integrating information from multiple examinations. Specifically, we studied the following and obtained better diagnostic performance. 1) Classification of chest X-ray images based on transfer learning, 2) classification of auscultatory sounds using pre-learning of convolutional long short-term memory and anomaly detection method, 4) transformation of image features between different hospitals and its application to the classification of chest CT and thyroid tissue images, 5) pseudo-labeling for chest X-ray classification, and 6) prediction of physical activity using multiple medical examination data.

Academic Significance and Societal Importance of the Research Achievements

AIは一般に大量の教師データを必要とするが,これはAIを広く社会に普及させる上で大きな問題になる.特に,医療分野は大量の教師データが得にくい分野である.したがって,本研究では,教師データが得にくい様々な状況に対応できる方式の研究を行った.本研究の成果は,汎用的なものであるため医療に限らずAIの応用が見込まれるすべての分野に対して有用である.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (25 results)

All 2022 2021 2020 2019

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (17 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results)

  • [Journal Article] SAUNet++: an automatic segmentation model of COVID-19 lesion from CT slices2022

    • Author(s)
      Hanguang Xiao, Zhiqiang Ran, Shingo Mabu, Yuewei Li, Li Li
    • Journal Title

      The Visual Computer

      Volume: - Issue: 6 Pages: 2291-2304

    • DOI

      10.1007/s00371-022-02414-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Segmentation of Lung Nodules on CT Images Using a Nested Three-Dimensional Fully Connected Convolutional Network2022

    • Author(s)
      Shoji Kido, Shunske Kidera, Yasushi Hirano, Shingo Mabu, Tohru Kamiya, Nobuyuki Tanaka, Yuki Suzuki, Masahiro Yanagawa, Noriyuki Tomiyama
    • Journal Title

      Frontiers in Artificial Intelligence

      Volume: 5 Pages: 782225-782225

    • DOI

      10.3389/frai.2022.782225

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Segmentation of Diffuse Lung Abnormality Patterns on Computed Tomography Images using Partially Supervised Learning2022

    • Author(s)
      Yuki Suzuki, Shoji Kido, Shingo Mabu, Masahiro Yanagawa, Noriyuki Tomiyama, Yoshinobu Sato
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 11 Issue: 0 Pages: 25-36

    • DOI

      10.14326/abe.11.25

    • NAID

      130008154494

    • ISSN
      2187-5219
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semi-supervised CycleGAN for domain transformation of chest CT images and its application to opacity classification of diffuse lung diseases2021

    • Author(s)
      Shingo Mabu, Masashi Miyake, Takashi Kuremoto, Shoji Kido
    • Journal Title

      International Journal of Computer Assisted Radiology and Surgery

      Volume: 16 Issue: 11 Pages: 1925-1935

    • DOI

      10.1007/s11548-021-02490-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lung Sound Classification Using Deep Neural Networks with Pre-training2020

    • Author(s)
      若本亮佑, 間普真吾, 木戸尚治, 呉本尭
    • Journal Title

      IEEJ Transactions on Electronics, Information and Systems

      Volume: 140 Issue: 12 Pages: 1402-1409

    • DOI

      10.1541/ieejeiss.140.1402

    • NAID

      130007948685

    • ISSN
      0385-4221, 1348-8155
    • Year and Date
      2020-12-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Automatic Classification of Respiratory Sounds Based on Time-Frequency Analysis and Convolutional Neural Network2020

    • Author(s)
      南弘毅,陸慧敏,金亨燮,平野靖,間普真吾,木戸尚治
    • Journal Title

      Medical Imaging Technology

      Volume: 38 Issue: 1 Pages: 40-47

    • DOI

      10.11409/mit.38.40

    • NAID

      130007796400

    • ISSN
      0288-450X, 2185-3193
    • Year and Date
      2020-01-25
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SemiSupervised Learning for Class Association Rule Mining Using Genetic Network Programming2020

    • Author(s)
      Shingo Mabu, Takuro Higuchi, Takashi KUremoto
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 15 Issue: 5 Pages: 733-740

    • DOI

      10.1002/tee.23109

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Investigating the Effects of Transfer Learning on ROI-based Classification of Chest CT Images: A Case Study on Diffuse Lung Diseases2020

    • Author(s)
      Shingo Mabu, Ami Atsumo, Shoji Kido, Takashi Kuremoto and Yasushi Hirano
    • Journal Title

      Journal of Signal Processing Systems

      Volume: 92 Issue: 3 Pages: 307-313

    • DOI

      10.1007/s11265-019-01499-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] ニューラルネットワークを用いた慢性閉塞性肺疾患における身体活動性の予測と検査項目の重要度評価2022

    • Author(s)
      中原祥喜, 間普真吾, 平野綱彦, 村田順之, 土居恵子, 松永和人
    • Organizer
      第13回呼吸機能イメージング研究会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 自己符号化器を用いた慢性閉塞性肺疾患における身体活動性の予測に関する研究2021

    • Author(s)
      中原祥喜, 間普真吾, 平野綱彦, 村田順之, 土居恵子, 松永和人
    • Organizer
      第40回日本医用画像工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CycleGAN を用いた甲状腺組織画像のドメイン変換と識別システムへの応用2021

    • Author(s)
      一氏 良仁, 間普 真吾, 八田 聡美, 稲井 邦博, 木戸 尚治
    • Organizer
      第40回日本医用画像工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 畳み込み自己符号化器つき Deep Autoencoding Gaussian Mixture Model を用いた胸部 CT 画像における異常検知2021

    • Author(s)
      栗林 雅刀, 間普 真吾, 若本 亮佑, 呉本 尭, 木戸 尚治
    • Organizer
      第40回日本医用画像工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Object Detection for Chest X-ray Image Diagnosis Using Deep Learning with Pseudo Labeling2021

    • Author(s)
      Thanawit Gerdprasert, Shingo Mabu
    • Organizer
      2021 IEEE 12th International Workshop on Computational Intelligence and Applications
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Domain Transformation of Chest CT Images Using Semi-Supervised Cycle GAN for Opacity Classification of Diffuse Lung Diseases2021

    • Author(s)
      Masashi Miyake, Shingo Mabu, Shoji Kido, Takashi Kuremoto
    • Organizer
      2021 International Conference on Artificial Life and Robotics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anomaly Detection of lung sounds using DAGMM2021

    • Author(s)
      Ryosuke Wakamoto, Shingo Mabu, Shoji Kido, Takashi Kuremoto
    • Organizer
      2021 International Conference on Artificial Life and Robotics
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Automatic Classification of Respiratory Sounds Based on Convolutional Neural Network with Multi Images2020

    • Author(s)
      Koki Minami, Huimin Lu, Tohru Kamiya, Shingo Mabu, Shoji Kido
    • Organizer
      International Conference on Biomedical Imaging, Signal Processing
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Automatic Classification of Respiratory Sounds Considering Time Series Information Based on VGG16 with LSTM2020

    • Author(s)
      Naoki Asatani, Tohru Kamiya, Shingo Mabu, Shoji Kido
    • Organizer
      20th International Conference on Control, Automation and Systems
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 2つの解像度スペクトログラムとTF-CRNNによる呼吸音の分類2020

    • Author(s)
      浅谷尚希,神谷亨,間普真吾,木戸尚治
    • Organizer
      第33回バイオメディカル・ファジイ・システム学会年次大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 畳み込み敵対的自己符号化器を用いた胸部CT画像における教師なし陰影分類システム2020

    • Author(s)
      満河祐治,間普真吾,呉本尭,木戸尚治
    • Organizer
      計測自動制御学会システム・情報部門学術講演会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Study on Data Augmentation in Thoracic CT Images Using Adversarial Generative Networks (GANs) for Opacity Classification of Diffuse Lung Diseases2020

    • Author(s)
      Kaito Akagi, Shingo Mabu, Takashi Kuremoto,
    • Organizer
      Innovative Application Research and Education (ICIARE2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Introduction to Deep Learning and Its Application to Medical Image Diagnosis2020

    • Author(s)
      Shingo Mabu
    • Organizer
      International Conference on Innovative Application Research and Education (ICIARE2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Automatic Classification of Large-Scale Respiratory Sound Dataset Based on Convolutional Neural Network2019

    • Author(s)
      Koki Minami, Huimin Lu, Hyoungseop Kim, Shingo Mabu, Yasushi Hirano and Shoji Kido
    • Organizer
      2019 19th International Conference on Control, Automation and Systems
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Detection Method for Liver Cancer Region Based on Faster R-CNN2019

    • Author(s)
      Muki Furuzuki, Huimin Lu, Hyoungseop Kim, Yasushi Hirano, Shingo Mabu, Masahiro Tanabe and Shoji Kido
    • Organizer
      2019 19th International Conference on Control, Automation and Systems
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cycle GANを用いた胸部CT画像のドメイン変換とその識別システムへの応用2019

    • Author(s)
      三宅将司,間普真吾,木戸尚治,呉本尭,平野靖
    • Organizer
      第38回日本医用画像工学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 時間-周波数解析とCNNを用いた呼吸音の自動分類2019

    • Author(s)
      南弘毅,陸慧敏,金亨燮,平野靖,間普真吾,木戸尚治
    • Organizer
      第38回日本医用画像工学会大会
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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