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Construction of a three-dimensional snoring generation model for sleep apnea prediction and acoustic analysis

Research Project

Project/Area Number 19K12227
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionTomakomai National College of Technology

Principal Investigator

Mikami Tsuyoshi  苫小牧工業高等専門学校, 創造工学科, 教授 (40321369)

Co-Investigator(Kenkyū-buntansha) 高橋 弘毅  東京都市大学, その他部局等, 教授 (40419693)
中村 嘉彦  苫小牧工業高等専門学校, 創造工学科, 准教授 (60402476)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords睡眠時無呼吸症候群 / いびき / 3Dプリンタ / 生体信号 / 睡眠時無呼吸
Outline of Research at the Start

本研究では,睡眠時無呼吸症候群(SAS)の代表的な症状である「いびき」に着目し,いびきの音響特性から無呼吸の前兆を予測する工学的手法の構築を目的とする.いびきは同一人物であっても一晩の間でいびきは多様に変化し,無呼吸の前兆を示すようないびきの音響特性は未だ十分に明らかになっていない.本研究では,上気道の立体模型を3次元プリンタにより構築し,いびきを発生させる音響実験を様々な生理条件を模擬した環境下で行い,無呼吸の前兆を示す上気道の狭小化といびきの音響特徴との関連性を明らかにする.

Outline of Final Research Achievements

In this study, we focus on "snoring", which is a typical symptom of sleep apnea syndrome (SAS), and aim to construct an engineering method to predict apnea precursors from the acoustic characteristics of snoring. Therefore, we constructed a three-dimensional model of the upper airway using a three-dimensional printer, and performed experiments to generate snoring and apnea (obstruction of the airway) on the three-dimensional model in an environment simulating various physiological conditions to show signs of apnea. We will clarify the relationship between the narrowing and obstruction of the upper airway and the acoustic characteristics of snoring.
As a research result, we were able to reproduce the phenomenon that causes SAS by experiments using a three-dimensional model, but we could not generate the snoring sound associated with the phenomenon.

Academic Significance and Societal Importance of the Research Achievements

睡眠時無呼吸症候群(SAS)は自覚することが難しいため, 早期発見に繋がる技術開発が緊急の課題と言える.SASの患者によく見られる症状として「いびき」があり,いびき音にSAS固有の特徴が内在している可能性がこれまで指摘されてきた.もしこの特徴が明らかになれば,SASの早期発見のための新たな技術開発に繋がる.

本研究は上気道の立体モデルに基づき,SASおよびいびきの発声を模擬的に実現することで,いびき発生の機序とSASとの関連性について明らかにし,SASの前兆予測を可能とすることを目的としている.これにより,SASの早期発見に繋がると考えられる.

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2022 2020

All Presentation (5 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Presentation] Development of an automated segmentation method for tongue region from head MRI using U-Net2022

    • Author(s)
      Kenta Tezuka, Yoshihiko Nakamura, Tsuyoshi Mikami, Kazuya Yonezawa
    • Organizer
      Chitose International Forum on Science and Technology (CIF) 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Study on Automatic Tongue Contour Extraction from Head MRI using Convolutional Neural Network2022

    • Author(s)
      Yuya Kato, Yoshihiko Nakamura, Tsuyoshi Mikami, Kazuya Yonezawa
    • Organizer
      Chitose International Forum on Science and Technology (CIF) 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 畳込みニューラルネットワークを用いた重症睡眠時無呼吸症の画像認識2022

    • Author(s)
      三上 剛, 中村嘉彦, 米澤一也
    • Organizer
      生体医工学シンポジウム2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] 畳み込みニューラルネットワークを用いた頭部 MRI からの舌の自動輪郭抽出に関する研究2022

    • Author(s)
      加藤優弥, 中村嘉彦, 三上剛, 米澤一也
    • Organizer
      第41回日本医用画像工学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] U-Net を用いた頭部 MRI からの舌領域自動抽出に関する研究2022

    • Author(s)
      手塚健太, 中村嘉彦, 三上剛, 米澤
    • Organizer
      第41回日本医用画像工学会大会
    • Related Report
      2022 Annual Research Report
  • [Book] New Research on Sleep and Sleep Disorders2020

    • Author(s)
      Olivier Ratt(編集),Tsuyoshi Mikami, Hirotaka Takahashi, Kazuya Yonezawa(第6章執筆)
    • Total Pages
      224
    • Publisher
      Nova Science Publisher
    • ISBN
      9781536168822
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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