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Development of a completely non-invasive real-time imaging blood flow measuring device capable of various measurements

Research Project

Project/Area Number 19K12855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institute of Technology, Toyama College

Principal Investigator

Akiguchi Shunsuke  富山高等専門学校, その他部局等, 准教授 (50462130)

Co-Investigator(Kenkyū-buntansha) 田尻 智紀  富山高等専門学校, その他部局等, 講師 (10735525)
安東 嗣修  金城学院大学, 薬学部, 教授 (50333498)
経田 僚昭  富山高等専門学校, その他部局等, 准教授 (50579729)
八賀 正司  公立小松大学, 保健医療学部, 教授 (80123305)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords非侵襲計測装置 / 血流計測装置 / 音響光学素子 / 深層学習 / レーザードップラー流速分布測定装置
Outline of Research at the Start

血管内血栓や微細領域の血流分布など、目視による主観的な判定方法に頼っていたり、そもそも目視自体が難しい状況が数多く見受けられる。このような中で、可能な限り多くの情報を患者の負担を限りなく少なくした状態で高精度に計測することが可能な装置の開発に取り組む。本研究で目指す、流れ方向を含んだ血流情報を非侵襲的にリアルタイムイメージング計測できる装置はこれまでに例がなく、本装置の特性を生かせば、血管新生と関連が深い癌の早期発見、日焼けなどによる炎症の血流計測、血管内の血栓観察、微細領域の血流分布観測など、多様な計測への応用が期待できる。

Outline of Final Research Achievements

This research project is to develop a completely non-invasive real-time imaging blood flow measuring device capable of various measurements using laser beams. The three themes of "real-time imaging," "in vivo blood flow velocity direction information," and "measurement area expansion" were established and addressed. For "real-time imaging," we confirmed that processing is possible in less than 10 ms for 64 channels, which is the current projected maximum measurement range. For "in vivo blood flow direction information," we constructed an optical system that includes an AOM and confirmed it could successfully perform measurements using flow paths and blood in which the flow direction has been changed. In the "measurement area expansion" section, we constructed a system in which the measurement area was expanded from a point to a plane.

Academic Significance and Societal Importance of the Research Achievements

本装置で取得できる血流情報は血液検査のように抜き出した静的な情報ではなく、実際に生体内を今まさに流れている血流を動的に計測するため、血液検査とは異なる情報を獲得できる。この計測結果を瞬時に、さらにイメージング画像などのわかりやすい形で出力できれば応用範囲が劇的に広がる。さらに従来装置では不可能であった血流の流れ方向も新たな情報として取得できれば動脈静脈の判断も可能となる。この装置の特性を生かせば、血管新生と関連が深い癌の早期発見、日焼けなどによる炎症の血流計測、血管内の血栓観察、微細領域の血流分布観測など、多様な計測への応用が期待できる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (15 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (10 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Deep Learning Method for Melanoma Discrimination Using Blood Flow Distribution Images2021

    • Author(s)
      Akiguchi S, Kyoden T, Tajiri T, Andoh T, Hachiga T
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering (First published)

      Volume: 16-5 Issue: 5 Pages: 813-815

    • DOI

      10.1002/tee.23363

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical visualization of blood shear stress using laser Doppler velocimetry combined with acousto-optic module2021

    • Author(s)
      Tajiri Tomoki、Kyoden Tomoaki、Akiguchi Shunsuke、Andoh Tsugunobu、Hachiga Tadashi
    • Journal Title

      Optics Communications

      Volume: 483 Pages: 126607-126607

    • DOI

      10.1016/j.optcom.2020.126607

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血流異常を診断するための非侵襲光技術2020

    • Author(s)
      経田僚昭, 秋口俊輔, 田尻智紀, 安東嗣修, 八賀正司
    • Journal Title

      エレクトロニクス実装学会誌

      Volume: 23 Pages: 1-6

    • NAID

      130007883766

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessing the infinitely expanding intersection region for the development of large-scale multipoint laser Doppler velocimetry2019

    • Author(s)
      T. Kyoden, S. Akiguchi, T. Tajiri, T. Andoh, N. Furuichi, R. Doihara, T. Hachiga
    • Journal Title

      Flow Measurement and Instrumentation 101660

      Volume: 70 Pages: 101660-101660

    • DOI

      10.1016/j.flowmeasinst.2019.101660

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 細胞培養における深層学習を用いたコロニー領域の抽出2021

    • Author(s)
      寺林大樹, 秋口俊輔, 経田僚昭, 百生登, 安東嗣修, 八賀正司
    • Organizer
      日本伝熱学会北陸信越支部秋季セミナー
    • Related Report
      2021 Annual Research Report
  • [Presentation] Deep Learning Method for Extracting Areas of Cancer Cells Using Microscope Images2021

    • Author(s)
      Taiki Terabayashi, Shunsuke Akiguchi, Tomoaki Kyouden, Tomoki Tajiri, Tsugunobu Andoh, Tadasi Hachiga
    • Organizer
      The 6th International Conference on "Science of Technology Innovation"
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 近赤外光による皮膚癌血流画像を用いた深層学習診断2021

    • Author(s)
      寺林 大樹, 秋口 俊輔, 経田 僚昭, 百生 登, 安東 嗣修, 八賀 正司
    • Organizer
      日本伝熱学会北陸信越支部春季セミナー
    • Related Report
      2021 Annual Research Report
  • [Presentation] レーザードップラー血流速計におけるメラノーマ判別システムの開発2020

    • Author(s)
      寺林大樹,秋口俊輔,経田僚昭
    • Organizer
      日本福祉工学会九州支部大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 血流イメージング機能を用いた血流関連疾患判別機能の検討2020

    • Author(s)
      寺林大樹,秋口俊輔,経田僚昭,田尻智紀,安東嗣修,八賀正司
    • Organizer
      JapanATフォーラム2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 血流速度とその方向成分を考慮した微細流路内の血流イメージング2020

    • Author(s)
      荒木桃子,秋口俊輔,経田僚昭,田尻智紀,安藤嗣修,八賀正司
    • Organizer
      JapanATフォーラム2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 癌細胞の経日観察を行うための計測環境及び計測位置同定システムの構築2020

    • Author(s)
      嶋﨑凌,秋口俊輔,経田僚昭
    • Organizer
      JapanATフォーラム2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Development of multi-point Laser Doppler Velocimeter for measuring simultaneous blood velocity distribution2020

    • Author(s)
      Momoko Araki, Shunshuke Akiguchi, Tomoaki Kyouden, Tomoki Tajiri, Tsugunobu Andoh, Tadashi Hachiga
    • Organizer
      The 5th International Conference on “Science of Technology Innovation” 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血流の方向判別機能を有する流速分布計測装置2019

    • Author(s)
      荒木桃子、秋口俊輔、経田僚昭、田尻智紀、安東嗣修、八賀正司
    • Organizer
      2019年度電気・情報関係学会北陸支部連合大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 血流の一方向成分判別機能を有する計測視野拡大LDV2019

    • Author(s)
      荒木桃子、秋口俊輔、経田僚昭、百正登、田尻智紀、安東嗣修、八賀正司
    • Organizer
      2019 年度日本伝熱学北陸信越支部・春季セミナー
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 悪性黒色腫診断装置2020

    • Inventor(s)
      安東嗣修、経田僚昭、秋口俊輔、田尻智紀、八賀正司
    • Industrial Property Rights Holder
      安東嗣修、経田僚昭、秋口俊輔、田尻智紀、八賀正司
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-000977
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2023-01-30  

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