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The role of copepods as primary producers of polyunsaturated fatty acids

Research Project

Project/Area Number 19K15908
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 40040:Aquatic life science-related
Research InstitutionTokyo University of Marine Science and Technology

Principal Investigator

Kabeya Naoki  東京海洋大学, 学術研究院, 助教 (90758731)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsカイアシ / 多価不飽和脂肪酸 / EPA / DHA / 生合成 / 安定同位体 / 不飽和化酵素 / 鎖長延長酵素
Outline of Research at the Start

カイアシ類(コペポーダ類)にはEPAやDHAといった様々な動物にとって生理的に重要な成分が豊富に含まれていることが知られている。カイアシが魚類の餌生物として非常に重要であることを考慮すると、これらカイアシ類がなぜEPAやDHAを豊富に含むのかを解明することは生態系を栄養学的な観点から理解する上で非常に重要である。そのため本研究では、カイアシ類のEPAやDHAの生合成能を解明することを目的としている。

Outline of Final Research Achievements

The biosynthetic capabilities of polyunsaturated fatty acids (PUFA) in copepods were elucidated in the present project. The copepods were tiny crustacean species mainly inhabiting in the aquatic environment. Some PUFA such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are physiologically essential nutrients for many animals, although most of EPA and DHA are originated from marine environment. Therefore, understanding PUFA production mechanism in the marine ecosystem is important. In the present project, we have confirmed that particular species within copepods possessed high biosynthetic capabilities of PUFA including EPA and DHA, and hence those species could be primary producers of PUFA in the marine ecosystem.

Academic Significance and Societal Importance of the Research Achievements

EPAやDHAは人にとっても重要な栄養素であることが知られている。現状これら栄養素のほとんどは海洋由来であり、海洋生態系においてどのようにこれら栄養素が作り出されるのかを明らかにすることは、これら栄養素を今後持続的に得るために重要な基礎情報となる。これまで、EPAやDHAは基本的に微細藻類などによって合成され、食物連鎖の過程で高次の消費者に蓄積されていくと考えられてきた。本研究では、小型甲殻類であるカイアシの一種から微細藻類と同等のEPAやDHAの生合成経路を有する種を見出した。このことは、海洋におけるEPAやDHAの生産について大幅な見直しが必要であることを示している。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (43 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (15 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (24 results) (of which Int'l Joint Research: 13 results) Remarks (1 results)

  • [Int'l Joint Research] Instituto de Acuicultura Torre de la Sal(スペイン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Instituto de Acuicultura Torre de la Sal(スペイン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Instituto de Acuicultura Torre de la Sal(スペイン)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Expression of long-chain polyunsaturated fatty acids biosynthesis genes during the early life-cycle stages of the tropical gar Atractosteus tropicus2021

    • Author(s)
      De la Cruz-Alvarado Fanny Janet、Alvarez-Gonzalez Carlos A.、Llera-Herrera Raul、Monroig Oscar、Kabeya Naoki、Rodriguez-Morales Sergio、Concha-Frias Bartolo、Guerrero-Zarate Rocio、Jimenez-Martinez Luis D.、Pena-Marin Emyr Saul
    • Journal Title

      Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

      Volume: 256 Pages: 110628-110628

    • DOI

      10.1016/j.cbpb.2021.110628

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The evolutionary ecology of fatty‐acid variation: Implications for consumer adaptation and diversification2021

    • Author(s)
      Twining Cornelia W.、Bernhardt Joey R.、Derry Alison M.、Hudson Cameron M.、Ishikawa Asano、Kabeya Naoki、Kainz Martin J.、Kitano Jun、Kowarik Carmen、Ladd Sarah Nemiah、Leal Miguel C.、Scharnweber Kristin、Shipley Jeremy R.、Matthews Blake
    • Journal Title

      Ecology Letters

      Volume: 24 Issue: 8 Pages: 1709-1731

    • DOI

      10.1111/ele.13771

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n?3) exists in the marine Harpacticoida copepod Tigriopus californicus2021

    • Author(s)
      Kabeya Naoki、Ogino Masanari、Ushio Hideki、Haga Yutaka、Satoh Shuichi、Navarro Juan C.、Monroig Oscar
    • Journal Title

      Open Biology

      Volume: 11 Issue: 4 Pages: 200402-200402

    • DOI

      10.1098/rsob.200402

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Marine Gammarids: Molecular Cloning and Functional Characterisation of Three Fatty Acyl Elongases2021

    • Author(s)
      Ribes-Navarro Alberto、Navarro Juan C.、Hontoria Francisco、Kabeya Naoki、Standal Inger B.、Evjemo Jan O.、Monroig Oscar
    • Journal Title

      Marine Drugs

      Volume: 19 Issue: 4 Pages: 226-226

    • DOI

      10.3390/md19040226

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Polyunsaturated fatty acid metabolism in three fish species with different trophic level2021

    • Author(s)
      Galindo A.、Garrido D.、Monroig O.、Perez J.A.、Betancor M.B.、Acosta N.G.、Kabeya N.、Marrero M.A.、Bolanos A.、Rodriguez C.
    • Journal Title

      Aquaculture

      Volume: 530 Pages: 735761-735761

    • DOI

      10.1016/j.aquaculture.2020.735761

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interactive effect of dietary fish oil and pyrimidine nucleotide supplementation on the fatty acid composition of juvenile rainbow trout Oncorhynchus mykiss : Enhancement of ARA and DHA contents in the fillet of fish fed‐supplemented diet2021

    • Author(s)
      Ridwanudin Asep、Kasuya Hitaka、Haga Yutaka、Kabeya Naoki、Satoh Shuichi
    • Journal Title

      Aquaculture Research

      Volume: - Issue: 10 Pages: 4934-4945

    • DOI

      10.1111/are.15327

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Taurine synthesis via the cysteic acid pathway: effect of dietary cysteic acid on growth, body taurine content, and gene expression of taurine-synthesizing enzymes, growth hormone, and insulin-like growth factor 1 in Japanese flounder Paralichthys olivaceus2021

    • Author(s)
      Nakamura Kohei、Gonzales-Plasus Marina Mojena、Ushigusa-Ito Tomoko、Masuda Reiji、Kabeya Naoki、Kondo Hidehiro、Hirono Ikuo、Satoh Shuichi、Haga Yutaka
    • Journal Title

      Fisheries Science

      Volume: 87 Issue: 3 Pages: 353-363

    • DOI

      10.1007/s12562-021-01500-1

    • NAID

      40022567910

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Flatfishes colonised freshwater environments by acquisition of various DHA biosynthetic pathways2020

    • Author(s)
      Matsushita Yoshiyuki、Miyoshi Kaho、Kabeya Naoki、Sanada Shuwa、Yazawa Ryosuke、Haga Yutaka、Satoh Shuichi、Yamamoto Yoji、Str?ssmann Carlos Augusto、Luckenbach John Adam、Yoshizaki Goro
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 516-516

    • DOI

      10.1038/s42003-020-01242-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lipid metabolism in Tinca tinca and its n-3 LC-PUFA biosynthesis capacity2020

    • Author(s)
      Garrido D.、Monroig O.、Galindo A.、Betancor M.B.、Perez J.A.、Kabeya N.、Marrero M.、Rodriguez C.
    • Journal Title

      Aquaculture

      Volume: 523 Pages: 735147-735147

    • DOI

      10.1016/j.aquaculture.2020.735147

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Unique fatty acid desaturase capacities uncovered in Hediste diversicolor illustrate the roles of aquatic invertebrates in trophic upgrading2020

    • Author(s)
      Naoki Kabeya, Ibrahim Gur, Angela, Jan Ove Evjemo, Arne M. Malzahn, Francisco Hontoria, Juan C. Navarro, Oscar Monroig
    • Journal Title

      Philosophical Transactions of the Royal Society B

      Volume: 375 Issue: 1804 Pages: 20190654-20190654

    • DOI

      10.1098/rstb.2019.0654

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diversification of enzymes for biosynthesis of long-chain polyunsaturated fatty acids in aquatic animals: Implications for aquaculture2019

    • Author(s)
      KABEYA NAOKI
    • Journal Title

      NIPPON SUISAN GAKKAISHI

      Volume: 85 Issue: 4 Pages: 386-389

    • DOI

      10.2331/suisan.WA2653

    • NAID

      130007685233

    • ISSN
      0021-5392, 1349-998X
    • Year and Date
      2019-07-15
    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] Functional diversification of teleost Fads2 fatty acyl desaturases occurs independently of the trophic level2019

    • Author(s)
      Garrido Diego、Kabeya Naoki、Betancor Monica B.、Perez Jose A.、Acosta N. Guadalupe、Tocher Douglas R.、Rodriguez Covadonga、Monroig Oscar
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11199-11199

    • DOI

      10.1038/s41598-019-47709-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A key metabolic gene for recurrent freshwater colonization and radiation in fishes2019

    • Author(s)
      Ishikawa Asano, Kabeya Naoki, Ikeya Koki, Kakioka Ryo, Cech Jennifer N., Osada Naoki, Leal Miguel C., Inoue Jun, Kume Manabu, Toyoda Atsushi, Tezuka Ayumi, Nagano Atsushi J., Yamasaki Yo Y., Suzuki Yuto, Kokita Tomoyuki, Takahashi Hiroshi et al.
    • Journal Title

      Science

      Volume: 364 Issue: 6443 Pages: 886-889

    • DOI

      10.1126/science.aau5656

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Functional characterisation of two Δ12-desaturases demonstrates targeted production of linoleic acid as pheromone precursor in Nasonia2019

    • Author(s)
      Florian Semmelmann, Naoki Kabeya, Miriama Malcicka, Astrid Bruckmann, Bastian Broschwitz, Kristina Straub, Rainer Merkl, Oscar Monroig, Reinhard Sterner, Joachim Ruther, Jacintha Ellers
    • Journal Title

      The Journal of Experimental Biology

      Volume: 印刷中

    • DOI

      10.1242/jeb.201038

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Methyl-end desaturases with ?12 and ω3 regioselectivities enable the de novo PUFA biosynthesis in the cephalopod Octopus vulgaris2019

    • Author(s)
      Diego Garrido, Naoki Kabeya, Francisco Hontoria, Juan C Navarro, Diana B Reis, M Virginia Martin, Covadonga Rodriguez, Eduardo Almansa, Oscar Monroig
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

      Volume: 1864 Issue: 8 Pages: 1134-1144

    • DOI

      10.1016/j.bbalip.2019.04.012

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Develop non-fish meal and non-fish oil grow-out diet for Asian seabass (Lates calcarifer).2022

    • Author(s)
      Chainark, P., Obtian, J., Yuttayong, D., Kabeya, N., Haga, Y., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Purine nucleotide affects fatty acid profile of rainbow trout (Oncorhynchus mykiss) through regulation of srebp-1 in the liver and its downstream factors such as fatty acid desaturase and elongase.2022

    • Author(s)
      Tansutaphanit, S., Haga, Y., Kabeya, N., Kondo, H., Hirono, I., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Does enzyme complex treatment improve feed performance of rice protein concentrate-based low fishmeal diet for rainbow trout (Oncorhynchus mykiss) ?2022

    • Author(s)
      Yaman, G., Ueda, S., Takino, T., Kabeya, N., Haga, Y., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cysteic acid pathway: Biosynthesis of taurine in Japanese flounder, Paralichthys olivaceus.2022

    • Author(s)
      Nakamura, K., Gonzales-Plasus, M.M., Masuda, R., Kondo, H., Hirono, I., Kabeya, N., Satoh, S., Haga, Y.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Kabeya, N., Haga, Y., Satoh, S. Biosynthesis of long-chain polyunsaturated fatty acids in an amphidromous fish, ayu sweetfish Plecoglossus altivelis: Functional characterisation of fatty acid desaturase and elongase.2022

    • Author(s)
      Kabeya, N., Haga, Y., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Freshwater colonization of three flatfish families is underpinned by functional plasticity of fatty acid desaturase enabling DHA biosynthesis.2022

    • Author(s)
      Matsushita, Y., Kabeya, N., Chiba, M., Yazawa, R., Luckenbach, J.A., Yoshizaki, G.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of yellow mealworm, (Tenebrio molitor) as a partial replacement of plant-based ingredients in the non-fish meal diets for red sea bream (Pagrus major).2022

    • Author(s)
      Seong, T., Feng, S., Kabeya, N., Haga, Y., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Biosynthesis of taurine in fish.2022

    • Author(s)
      Haga, Y., Ushigusa-Itoh, T., Nakamura, K., Watanabe, R., Kabeya, N., Kondo, H., Hirono, I., Satoh, S.
    • Organizer
      International Symposium on Fish Nutrition and Feeding 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Can Artemia produce essential fatty acids? Roles of elongases in the biosynthesis of long-chain polyunsaturated fatty acids2021

    • Author(s)
      Marc Ramos-Llorens, Alberto Ribes-Navarro, Juan Carlos Navarro, Francisco Hontoria, Naoki Kabeya, Oscar Monroig
    • Organizer
      Aquaculture Europe 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigating the biosynthesis of long-chain polyunsaturated fatty acids in marine gammarids2021

    • Author(s)
      Alberto Ribes-Navarro, Juan C. Navarro, Francisco Hontoria, Naoki Kabeya, Inger B. Standal, Jan O. Evjemo, Oscar Monroig
    • Organizer
      Aquaculture Europe 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular cloning and functional characterisation of three fatty acyl elongases from the marine gammarid Echinogammarus marinus.2021

    • Author(s)
      Ribes-Navarro, A., Navarro, J.C., Hontoria, F., Kabeya, N., Standal, I.B., Evjemo, J.O., Monroig O.
    • Organizer
      Lipids in the Ocean, 2nd Edition
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多毛類イシイソゴカイ Perinereis wilsoniより単離した多価不飽和脂肪酸生合成酵素の機能解析2021

    • Author(s)
      末澤道宏, 壁谷尚樹, 一ノ瀬智士, 小南友里, 芳賀穣, 潮秀樹, 佐藤秀一
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 甲殻類ヨコエビの一種 Melita sp.より単離した脂肪酸鎖長延長酵素の機能解析2021

    • Author(s)
      中野陽, 壁谷尚樹, 一ノ瀬智士, 小南友里, 芳賀穣, 潮秀樹, 佐藤秀一
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヨコエビ・ゴカイ類における多価不飽和脂肪酸(PUFA)生合成酵素遺伝子の探索2021

    • Author(s)
      一ノ瀬智士, 小南友里, 潮秀樹, 中野陽, 末澤道宏, 壁谷尚樹, 芳賀穣, 佐藤秀一
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of fishmeal replacement with an enzyme complex-treated rice protein concentrate on growth performance and feed utilization of rainbow trout.2021

    • Author(s)
      Gunes Yaman, Shinya Ueda, Tadashi Takino, Naoki Kabeya, Shuichi Satoh, Yutaka Haga
    • Organizer
      令和3年度日本水産学会秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規EPA・DHA供給源の探索:①ヨコエビ類の利用性検討2021

    • Author(s)
      中野陽, 壁谷尚樹, 一ノ瀬智士, 小南友里, 芳賀穣, 潮秀樹, 佐藤秀一
    • Organizer
      令和3年度日本水産学会秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新規EPA・DHA供給源の探索:②ゴカイ類の利用性検討2021

    • Author(s)
      末澤道宏, 壁谷尚樹, 一ノ瀬智士, 小南友里, 芳賀穣, 潮秀樹, 佐藤秀一
    • Organizer
      令和3年度日本水産学会秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 海産ハルパクチクス目カイアシ Tigriopus californicus におけるDHA生合成経路の解明2021

    • Author(s)
      壁谷尚樹, 荻野将成, 潮秀樹, 芳賀穣, 佐藤秀一, Navarro, J.C., Monroig, O
    • Organizer
      令和3年度日本水産学会春季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Methyl-end desaturases in the common ragworm demonstrate unique activities enabling the production of various omega-3 polyunsaturated fatty acids via multiple pathways2021

    • Author(s)
      Naoki Kabeya, Ibrahim Gur, Angela Oboh, Jan O. Evjemo, Arne M. Malzahn, Francisco Hontoria, Juan C. Navarro, Oscar Monroig
    • Organizer
      ISSFAL 2021 VIRTUAL CONGRESS
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 海産肉食性回遊魚であるサンマは完全なDHA合成経路をもつ2020

    • Author(s)
      松下芳之, 川村亘, 壁谷尚樹, 矢澤良輔, 吉崎悟朗
    • Organizer
      日本水産学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 植物性飼料原料の栄養価改善に及ぼすエクストルージョン温度条件の影響2020

    • Author(s)
      SANTIZO-TAAN R., KABEYA N., HAGA Y., SATOH S.
    • Organizer
      日本水産学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ニジマスOncorhynchus mykiss幼魚の成長と脂肪酸代謝におよぼす低魚粉と魚油を基にした餌料へのプリンおよびヌクレオチド補給の影響2020

    • Author(s)
      RIDWANUDIN Asep, KABEYA Naoki, HAGA Yutaka, SATOH Shuichi
    • Organizer
      日本水産学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Metabolismo lipidico de la tenca (Tinca tinca): Estudio de la capacidad de biosintesis de omega-3 LC-PUFA2019

    • Author(s)
      Garrido D, Monroig O, Betancor MB, Perez JA, Kabeya N, Giraldez I, Marrero M, Rodriguez C
    • Organizer
      XVII Congreso Nacional de Acuicultura
    • Related Report
      2019 Research-status Report
  • [Presentation] Genes for de novo EPA and DHA biosynthesis are present in the harpacticoid copepod Tigriopus californicus2019

    • Author(s)
      Kabeya N, Monroig O, Ushio H
    • Organizer
      Marine Biotechnology Conference 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Remarks] Naoki KABEYA

    • URL

      https://sites.google.com/view/naoki-kabeya/

    • Related Report
      2021 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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