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Development of a novel cone-beam CT system for adaptive radiation therapy based on patient-specific treatment efficacy

Research Project

Project/Area Number 19K17170
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionYamaguchi University

Principal Investigator

Yuasa Yuki  山口大学, 医学部附属病院, 副診療放射・エックス線技師長 (20749840)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsDeep learning / DECT / CBCT / Iodine image / 深層学習 / 仮想CT画像 / Dual energy CT / ヨードマップ / 仮想非造影CT画像 / Cone-beam CT / 放射線治療 / コーンビームCT / デュアルエナジー
Outline of Research at the Start

本研究では,深層学習による画像生成とデュアルエナジー技術を融合させた新たなデュアルエナジーコーンビームCT (DECBCT) システムの開発と臨床応用に向けた治療効果判定手法の確立を行う.本システムは,CBCT画像からコンピュータによる計算のみで撮像条件が異なる新たな画像を生成し,DECBCTを取得することで,被ばく線量を増加させることなく,解剖学的情報および機能画像の取得を行う.本研究は,システムの開発,評価,画像評価と治療計画への応用,臨床への応用について実施する.本システムにより,肝臓および膵臓に対する放射線治療において解剖学的情報と機能情報を考慮した新たな治療効果判定手法が確立される.

Outline of Final Research Achievements

For the radiation therapy, cone-beam CT is used for patient set-up and observation of tumor and normal tissue. However, cone-beam CT has the issue of low soft tissue contrast and decreased image quality compared to diagnostic CT images. Therefore, we aimed to establish a dual-energy cone-beam CT system by integrating deep learning models with dual-energy technology. In this study, we developed a system that converts images obtained at a single tube voltage into CT images obtained at different tube voltages by inputting them into a deep learning model. This development enables the future expansion of dual-energy cone-beam CT system development.

Academic Significance and Societal Importance of the Research Achievements

本研究で開発したシステムは,医用画像処理と深層学習を応用することで,従来の手法では取得が難しかった単一管電圧で撮影されたCT画像から他管電圧で取得したCT画像の生成が可能となった。従来取得するCT画像を使用することで計算のみで追加画像を取得可能で、患者被ばく線量の低減に貢献することが可能である。また、本システムについては、既存の放射線機器に導入可能であり、画質の向上や画像診断制度の向上に寄与する可能性があると考えられる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (6 results)

All 2023 2022 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pseudo dual-energy CT-derived iodine mapping using single-energy CT data based on a convolution neural network2023

    • Author(s)
      Yuasa Yuki、Shiinoki Takehiro、Fujimoto Koya、Tanaka Hidekazu
    • Journal Title

      BJR|Open

      Volume: 5 Issue: 1 Pages: 1-10

    • DOI

      10.1259/bjro.20220059

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-energy CT-based perfusion imaging in thoracic and abdominal region based on the convolution neural network2020

    • Author(s)
      Yuki Yuasa, Takehiro Shiinoki, Koya Fujimoto, Hidekazu Tanaka
    • Journal Title

      Computer Assisted Radiology and Surgery, Proceedings of the 34th International Congress and Exhibition

      Volume: 15(S1) Pages: 1-214

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estimation of effective imaging dose and excess absolute risk of secondary cancer incidence for four‐dimensional cone‐beam computed tomography acquisition2019

    • Author(s)
      Yuasa Yuki、Shiinoki Takehiro、Onizuka Ryota、Fujimoto Koya
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 11 Pages: 57-68

    • DOI

      10.1002/acm2.12741

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the effects of motion mitigation strategies on respiration‐induced motion in each pancreatic region using cine‐magnetic resonance imaging2019

    • Author(s)
      Fujimoto Koya、Shiinoki Takehiro、Yuasa Yuki、Onizuka Ryota、Yamane Masatoshi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 20 Issue: 9 Pages: 42-50

    • DOI

      10.1002/acm2.12693

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 深層学習を利用した仮想Dual energy CTとヨードマップの生成2022

    • Author(s)
      湯淺勇紀, 椎木健裕, 藤本昂也, 田中秀和
    • Organizer
      第50回日本放射線技術学会秋季学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Single-energy CT-based perfusion imaging in thoracic and abdominal region based on the convolution neural network2020

    • Author(s)
      Yuki Yuasa, Takehiro Shiinoki, Koya Fujimoto, Hidekazu Tanaka
    • Organizer
      Computer Assisted Radiology and Surgery 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2025-01-30  

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