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Development of Biodegradable Drug Eluting Beads (DEB) for the novel treatment of Chronic Pulmonary Aspergillosis

Research Project

Project/Area Number 19K17179
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionTokai University

Principal Investigator

YAMAMOTO Shota  東海大学, 医学部, 臨床助手 (20799548)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords呼吸器感染症 / 慢性肺アスペルギルス症 / 喀血 / ドラッグリバリーシステム / 生分解性ポリマー / 血管内治療 / ドラッグデリバリーシステム / 薬剤溶出性ビーズ / 肺アスペルギルス / 肺アスペルギルス症 / 気管支動脈塞栓術
Outline of Research at the Start

肺アスペルギルス症は糸状真菌であるアスペルギルス属によって生じる肺の慢性感染症である.約50-60%で喀血・血痰を呈し,大量喀血時は致死率50%以上と報告されている.喀血の治療として,ゼラチンスポンジ細片や医療用の血管塞栓用球状塞栓物質(ビーズ)を血管内に注入して止血効果を得る気管支動脈塞栓術は短期的な有効性が確立されているが,再喀血率が高く長期的なコントロールは困難である.現行の塞栓物質では長期的な止血効果・抗真菌効果が見込めないため,本研究では抗真菌薬・油性造影剤・生分解性ポリマーを用いた新規の薬剤溶出性塞栓物質(Drug-eluting beads: DEB)を開発する.

Outline of Final Research Achievements

Pulmonary aspergillosis is a chronic infection of the lungs. The pulmonary aspergillosis causes massive hemoptysis, and the fatality rate is reported to be 11-50%. Bronchial artery embolization, in which gelatin sponge strips or embolic beads are injected to achieve hemostasis, has been proven effective in the short term, but more than half of the patients have recurrent hemoptysis after one year. Because current embolization materials do not provide long-term hemostatic and antifungal effects, we developed a new embolization material with new functions. In this study, we generated novel drug-eluting beads (DEBs) using antifungal drugs, oil-based contrast media, and biodegradable polymers, and confirmed their engineering properties and antifungal effects.

Academic Significance and Societal Importance of the Research Achievements

喀血に対する単純な血管塞栓術と経静脈的抗真菌薬の併用は標準的だが難治性である.トリアゾール系抗真菌薬のボリコナゾールは高い血中濃度では肝不全や完全失明に至る例があり,定期的な血中濃度測定が推奨されている.本研究成果によるビーズを用いることで,血管塞栓効果とともに感染局所のみに高い薬物濃度を維持することが出来,有効性と安全性を両立できる可能性がある.肺アスペルギルス症の治療において血管内からのアプローチはかつて存在せず,同分野の治療方針を変革し得る研究である.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (30 results)

All 2022 2021 2020

All Journal Article (16 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 15 results,  Open Access: 11 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] The impact of bronchial artery embolisation on the quality of life of patients with haemoptysis: a prospective observational study2021

    • Author(s)
      Omachi Naoki、Ishikawa Hideo、Hara Masahiko、Nishihara Takashi、Yamaguchi Yu、Yamamoto Yumiko、Youmoto Mihoko、Hattori Tomoaki、Kitaguchi Kazushi、Yamamoto Shota、Kawaguchi Tomoya、Fukuzawa Masahiro
    • Journal Title

      European Radiology

      Volume: 31 Issue: 7 Pages: 5351-5360

    • DOI

      10.1007/s00330-020-07533-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First experience of efficacy and radiation exposure in 320-detector row CT fluoroscopy-guided interventions2021

    • Author(s)
      Yamamoto Shota、Matsumoto Tomohiro、Suda Satoshi、Tomita Kosuke、Kamei Shunsuke、Hashida Kazunobu、Imai Yutaka、Endo Kazuyuki、Murakami Katsuki、Hasebe Terumitsu
    • Journal Title

      The British Journal of Radiology

      Volume: 94 Issue: 1120 Pages: 1-9

    • DOI

      10.1259/bjr.20200754

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel pulmonary perfusion imaging using chest digital dynamic radiography for pulmonary artery sarcoma2021

    • Author(s)
      Yamamoto Shota、Sakamaki Fumio、Takahashi Genki、Yuji Ryotaro、Matsumoto Tomohiro、Hasebe Terumitsu
    • Journal Title

      Respirology Case Reports

      Volume: 9 Issue: 4 Pages: 1-3

    • DOI

      10.1002/rcr2.737

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diaphragmatic hernia during treatment of lung cancer harboring an EGFR mutation2021

    • Author(s)
      Konno-Yamamoto Aya、Narumoto Osamu、Yamamoto Shota、Yamaguchi Miho、Motoyoshi Makoto、Inoue Yuta、Fukami Takeshi、Tamura Atsuhisa、Matsui Hirotoshi
    • Journal Title

      Oxford Medical Case Reports

      Volume: 2021 Issue: 7

    • DOI

      10.1093/omcr/omab054

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CT-guided bone biopsy using electron density maps from dual-energy CT2021

    • Author(s)
      Yamamoto Shota、Kamei Shunsuke、Tomita Kosuke、Fujita Chikara、Endo Kazuyuki、Hiraiwa Shinichiro、Hasebe Terumitsu
    • Journal Title

      Radiology Case Reports

      Volume: 16 Issue: 9 Pages: 2343-2346

    • DOI

      10.1016/j.radcr.2021.06.009

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pre-operative endovascular coil embolisation for chronic pulmonary aspergillosis2021

    • Author(s)
      Takeuchi H.、Matsumoto T.、Morimoto K.、Atsumi J.、Yamamoto S.、Nakagawa T.、Yamada S.、Kurosaki A.、Shiraishi Y.、Hasebe T.
    • Journal Title

      The International Journal of Tuberculosis and Lung Disease

      Volume: 25 Issue: 9 Pages: 725-731

    • DOI

      10.5588/ijtld.21.0028

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Utility of Surgical Lung Biopsy for Patients with Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis2021

    • Author(s)
      Hashimoto Hiroyuki、Yamamoto Shota、Nakagawa Hiroaki、Suido Yoshihiro、Sato Shintaro、Tabata Erina、Okamori Satoshi、Yoshida Takuo、Ando Koichi、Yoshitake Shigenori、Okada Yohei
    • Journal Title

      Respiration

      Volume: 101 Issue: 4 Pages: 422-432

    • DOI

      10.1159/000519675

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Migrated coil expectorated 12 years after embolization of pulmonary arteriovenous malformation, due probably to abscess formation around the coil2020

    • Author(s)
      Konno-Yamamoto Aya、Yamamoto Shota、Suzuki Junko、Fukami Takeshi、Kitani Masashi、Matsui Hirotoshi
    • Journal Title

      Respiratory Medicine Case Reports

      Volume: 31 Pages: 101245-101245

    • DOI

      10.1016/j.rmcr.2020.101245

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-Term Outcomes of Bronchial Artery Embolization for Patients with Non-Mycobacterial Non-Fungal Infection Bronchiectasis2020

    • Author(s)
      Takeda Keita、Kawashima Masahiro、Masuda Kimihiko、Kimura Yuya、Yamamoto Shota、Enomoto Yu、Igei Hiroshi、Ando Takahiro、Narumoto Osamu、Morio Yoshiteru、Matsui Hirotoshi
    • Journal Title

      Respiration

      Volume: 99 Issue: 11 Pages: 961-969

    • DOI

      10.1159/000511132

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of Shunting Into Pulmonary Artery on Multidetector Row Computed Tomography Arteriography Before Bronchial Arterial Embolization: A Preliminary Study2020

    • Author(s)
      Takeuchi Hitoshi、Matsumoto Tomohiro、Morimoto Kozo、Osawa Takeshi、Tanaka Yoshiaki、Yoshimori Kozo、Kamei Shunsuke、Yamamoto Shota、Kurosaki Atsuko、Hasebe Terumitsu
    • Journal Title

      Journal of Computer Assisted Tomography

      Volume: 44 Issue: 6 Pages: 852-856

    • DOI

      10.1097/rct.0000000000001099

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcatheter arterial embolization for unruptured renal angiomyolipoma using a 1.8-Fr tip microballoon catheter with a mixture of ethanol and Lipiodol2020

    • Author(s)
      Tomita Kosuke、Matsumoto Tomohiro、Kamei Shunsuke、Yamamoto Shota、Suda Satoshi、Zakoji Hidenori、Hasebe Terumitsu
    • Journal Title

      CVIR Endovascular

      Volume: 3 Issue: 1 Pages: 3-8

    • DOI

      10.1186/s42155-019-0095-8

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pulmonary perfusion by chest digital dynamic radiography: Comparison between breath‐holding and deep‐breathing acquisition2020

    • Author(s)
      Yamamoto Shota、Hasebe Terumitsu、Tomita Kosuke、Kamei Shunsuke、Matsumoto Tomohiro、Imai Yutaka、Takahashi Genki、Kondo Yusuke、Ito Yoko、Sakamaki Fumio
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 11 Pages: 247-255

    • DOI

      10.1002/acm2.13071

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bronchial artery embolization for haemothorax and haemoptysis caused by primary lung cancer2020

    • Author(s)
      Yamamoto Shota、Kamei Shunsuke、Kondo Yusuke、Hiraiwa Shinichiro、Hasebe Terumitsu、Sakamaki Fumio
    • Journal Title

      Respirology Case Reports

      Volume: 8 Issue: 2

    • DOI

      10.1002/rcr2.529

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visceral Artery Aneurysms: Techniques for Difficult Cases2020

    • Author(s)
      松本 知博、亀井 俊佑、橋田 和靖、富田 康介、須田 慧、山本 章太、夏山 雄揮、長谷部 光泉
    • Journal Title

      The Official Journal of the Japanese Society of Interventional Radiology

      Volume: 34 Issue: 3 Pages: 210-216

    • DOI

      10.11407/ivr.34.210

    • NAID

      130007799398

    • ISSN
      1340-4520, 2185-6451
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic lymphangiography2020

    • Author(s)
      松本 知博、長谷部 光泉、富田 康介、亀井 俊佑、橋田 和靖、須田 慧、山本 章太、吉松 梨香、山上 卓士、今井 裕
    • Journal Title

      The Official Journal of the Japanese Society of Interventional Radiology

      Volume: 34 Issue: 3 Pages: 177-181

    • DOI

      10.11407/ivr.34.177

    • NAID

      130007799391

    • ISSN
      1340-4520, 2185-6451
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 喀血治療の最前線2020

    • Author(s)
      山本 章太、松本 知博、須田 慧、富田 康介、亀井 俊佑、夏山 雄揮、大佛 健介、橋田 和靖、今井 裕、坂巻 文雄、長谷川 直樹、長谷部 光泉
    • Journal Title

      呼吸器内科

      Volume: 38 Pages: 441-448

    • NAID

      40022402237

    • Related Report
      2020 Research-status Report
  • [Presentation] 胸部デジタルX線動態画像解析の肺血流評価に関する有用性2022

    • Author(s)
      坂巻文雄、山本章太、高橋玄樹、近藤祐介、田崎巌、田中淳、亀井俊佑、村上克己、由地良太郎、長谷部光泉
    • Organizer
      第14回呼吸機能イメージング研究会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 胸部デジタルX線動態画像(chest dynamic digital radiography: CDDR)解析の肺血流評価に関する有用性2021

    • Author(s)
      坂巻文雄、山本章太、高橋玄樹、近藤祐介、田崎厳、富田康介、亀井俊佑、村上克己、由地良太郎、長谷部光泉
    • Organizer
      第13回呼吸機能イメージング研究会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 320列CTで行ったCT透視下IVR:有用性と放射線被曝について(Outcomes and patient radiation exposure in 320-detector row CT fluoroscopy-guided interventions)2021

    • Author(s)
      山本章太、松本知博、大佛健介、須田慧、富田康介、亀井俊佑、橋田和靖、今井裕、遠藤和之、山上卓士、長谷部光泉
    • Organizer
      第50回日本IVR学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 胸部デジタル動態撮影において患者体型が相互相関計算処理画像に及ぼす影響(Impact of shape of the patient’s body on cross-correlation coefficients in chest digital dynamic radiography)2021

    • Author(s)
      江刺聖悟、山本章太、由地良太郎、村上克己、坂巻文雄、長谷部光泉
    • Organizer
      第49回日本放射線技術学会秋季学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Fabrication of drug-eluting beads containing hyaluronic acid/Doxorubicin micelles for the transarterial chemoembolization2021

    • Author(s)
      Kai Hiraga、Terumitsu Hasebe、Yuya Oyama、Shunsuke Kamei、Shota Yamamoto、Atsushi Hotta
    • Organizer
      8th Asian Biomaterials Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of hyaluronic acid/Doxorubicin micelles on drug-eluting beads for the transarterial chemoembolization2021

    • Author(s)
      Kai Hiraga、Terumitsu Hasebe、Yuya Oyama、Shunsuke Kamei、Shota Yamamoto、Atsushi Hotta
    • Organizer
      8th Asian Biomaterials Congress
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Noncoronary interventionsにおけるsnuff box radial access実行可能性の検討2020

    • Author(s)
      山本章太、松本知博、今井裕、亀井俊佑、橋田和靖、 富田康介、須田慧、夏山雄揮、長谷部光和泉
    • Organizer
      第49回日本IVR総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 胸部デジタル動態撮影の診断的価値2020

    • Author(s)
      長谷部光泉、山本 章太、坂巻 文継
    • Organizer
      第61回日本肺癌学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 気管支動脈塞栓術の適応と限界 当院でBAE施行するも喀血治療に難渋した4症例の臨床的特徴についての検討2020

    • Author(s)
      鈴木 学、山本 章太、小林 このみ、辻本 佳恵、坂本 慶太、橋本 理生、石井 聡、仲 剛、岡藤 孝史、志多 由孝、飯倉 元保、泉 信有、田嶋 強、竹田 雄一郎、放生 雅章、杉山 温人
    • Organizer
      第43回日本呼吸器内視鏡学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] ウサギ経膝窩リンパ節リンパ造影でのリピオドール投与量の最適化2020

    • Author(s)
      富田 康介、松本 知博、亀井 俊佑、山本 章太、橋田 和靖、須田 慧、夏山 雄揮、長谷部 光泉
    • Organizer
      第49回日本IVR総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 画像診断から見る難治性血痰・喀血に対する治療戦略2020

    • Author(s)
      松本 知博、山本 章太、亀井 俊佑、富田 康介、須田 慧、夏山 雄揮、橋田 和靖、川島 正裕、益田 公彦、竹内 均、黒崎 敦子、坂巻 文雄、長谷部 光泉
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 喀血をきたすNTMと肺アスペルギルス症の病態と治療:up to date 難治性喀血(NTM/肺アスペルギルス症)に対するIVR血管塞栓術2020

    • Author(s)
      長谷部 光泉、松本 知博、富田 康介、須田 慧、夏山 雄揮、亀井 俊佑、山本 章太、橋田 和靖、遠藤 じゅん、今井 裕、川島 正裕、益田 公彦
    • Organizer
      第39回日本画像医学会 学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 医療機器開発における医工連携 医工連携による血管内治療デバイスの開発 from bench to bedside2020

    • Author(s)
      長谷部 光泉、松本 知博、亀井 俊佑、富田 康介、山本 章太、岡本 穣、武田 健太郎、堀田 篤、鈴木 哲也、今井 裕
    • Organizer
      第61回日本脈管学会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] リンパ管造影 診断から治療へ2020

    • Author(s)
      松本 知博、富田 康介、橋田 和靖、亀井 俊佑、須田 慧、山本 章太、夏山 雄揮、今井 裕、山上 卓士、長谷部 光泉
    • Organizer
      第56回日本医学放射線秋季臨床大会
    • Related Report
      2020 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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