• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a diagnostic method for cardiomyopathy using pathological images reproduced from myocardial MRI delayed contrast images.

Research Project

Project/Area Number 19K17188
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Ohta Yasutoshi  国立研究開発法人国立循環器病研究センター, 病院, 医長 (90388570)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsMRI / 心臓 / 高分解能 / ディープラーニング / スマートフォン / 心筋症 / 遅延造影 / 画像診断 / 心筋
Outline of Research at the Start

本研究は、近年研究が盛んなディープラーニングの技術のうち、入力画像からスタイル変換させ、画像
出力を行うconditional adversarial networks等の手法を用い、心臓MR遅延造影画像とその剖検マ
クロ病理画像を用いて学習を行い、心臓MR遅延造影画像から病理類似画像を作成する方法を構
築する。

Outline of Final Research Achievements

We developed an imaging technique capable of higher-resolution cardiac delayed enhancement imaging to create a dataset resembling pathological images. We confirmed the achievement of high-resolution imaging in phantoms and validated improved resolution in clinical settings.

For accurate determination of inversion time in cardiac delayed enhancement imaging, we created a program using deep learning to correct for precise inversion time. We successfully implemented this program on a smartphone, confirming its clinical applicability for accurate correction using images displayed on a monitor.

Academic Significance and Societal Importance of the Research Achievements

本研究において、心臓MRI撮像になれていない操作者でも正しく心臓MRI撮像が可能で、心筋病変観察もより高分解能にできる。この画像を蓄積した上で、病理画像と対比、更に心筋病理画像類似画像が作成できれば疾患の非侵襲的診断精度の向上が期待出来る。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Optimization of null point in Look-Locker images for myocardial late gadolinium enhancement imaging using deep learning and a smartphone2023

    • Author(s)
      Ohta Yasutoshi、Tateishi Emi、Morita Yoshiaki、Nishii Tatsuya、Kotoku Akiyuki、Horinouchi Hiroki、Fukuyama Midori、Fukuda Tetsuya
    • Journal Title

      European Radiology

      Volume: - Issue: 7 Pages: 4688-4697

    • DOI

      10.1007/s00330-023-09465-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Image Quality of Submillimeter High-Spatial-Resolution 2D Late Gadolinium-enhanced Images in Cardiac MRI: A Feasibility Study2022

    • Author(s)
      Ohta Yasutoshi、Nishii Tatsuya、Nagai Yasuhiro、Ichiba Yoshito、Tateishi Emi、Kotoku Akiyuki、Horinouchi Hiroki、Fukuyama Midori、Morita Yoshiaki、Fukuda Tetsuya
    • Journal Title

      Radiology: Cardiothoracic Imaging

      Volume: 4 Issue: 6

    • DOI

      10.1148/ryct.220111

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Presentation] 心筋症におけるCMR及びAI活用の現状および課題2023

    • Author(s)
      太田靖利
    • Organizer
      第33回日本心血管画像動態学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 2D法での心筋遅延造影MRI高分解能化の試み2022

    • Author(s)
      太田靖利
    • Organizer
      第94回心臓血管放射線研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Diagnosis of cardiomyopathy by cardiac CT2022

    • Author(s)
      Yasutoshi Ohta
    • Organizer
      e 70th Annual Meeting of the French Society of Radiology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 2D法での心筋遅延造影MRI高分解能化の試み2022

    • Author(s)
      太田靖利
    • Organizer
      第94回日本心臓血管放射線研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Optimization of myocardial signal null point on look-locker image for late gadolinium enhancement imaging using deep neural network and smartphone.2021

    • Author(s)
      Yasutoshi Ohta
    • Organizer
      Society for Cardiovascular Magnetic Resonance annual meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The image quality of sub-millimeter high-spatial-resolution 2D Late Gadolinium-Enhancement Images in Cardiac MRI: A Feasibility Study2021

    • Author(s)
      Yasutoshi Ohta
    • Organizer
      107th Radiological Society of North America
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Optimization of TI null point for late gadolinium enhancement imaging using deep neural network and smartphone.2021

    • Author(s)
      Ohta Yasutoshi, Tateishi Emi, Nishii T, Yoahiaki Morita, Horinouchi Hiroki, Fukuda T.
    • Organizer
      Society for Cardiovascular Magentic Resonance Annual Scientific meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi