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Establishment of diagnostic and therapeutic methods for cardiogenic cerebral infarction by multiple approaches

Research Project

Project/Area Number 19K17566
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionYamaguchi University

Principal Investigator

Omuro Takuya  山口大学, 大学院医学系研究科, 助教 (00760787)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords心房細動 / 血栓 / 血流解析 / 左房心内膜障害 / 左房壁ずり応力 / Wall share stress / 心原性脳塞栓症
Outline of Research at the Start

心房細動の最も深刻な合併症である心原性脳梗塞の原因である左房内血栓の形成機序解明ならびに予防のため、MRIや心臓超音波検査などを使用した左房内の血流解析、また、血液凝固因子と血流の関連など、複合的なアプローチによる診断および治療法を構築することを目的とする。

Outline of Final Research Achievements

We investigated the relationship between left atrial blood flow and left atrial wall shear stress (WSS) in atrial fibrillation and left atrial endocardial injury. The left atrial blood flow vector in patients with a history of AF was observed to be smaller than that in non-AF patients, and left atrial circulation measured by 4D-flow MRI showed a significant positive correlation with the CHA2DS2-VASc score. Left atrial WSS was significantly lower in the paroxysmal AF group than in the non-paroxysmal AF group.
Left atrial low-voltage areas (LVAs), which electrophysiologically represent left atrial endocardial injury, were determinants of thrombosis risk (spontaneous echocardiographic contrast and decreased left atrial appendage flow velocity) on transesophageal echocardiography. Furthermore, left atrial WSS tended to decrease as LVAs became widespread.

Academic Significance and Societal Importance of the Research Achievements

心房細動における左房内血栓形成と左房内血流および左房心内膜障害の直接的な関連性は不明である。本研究では、心房細動既往の有無により洞調律下においても左房内血流が変化し、左房内渦流や左房壁ずり応力の低下を認め、左房心内膜障害の程度も左房内血栓形成リスクおよび左房壁ずり応力と関連していた。今後、さらに研究を要するが、左房内血栓形成リスク診断には、CHA2DS2-Vasc Scoreのような臨床的背景に加え、左房心内膜障害や左房内血流の流体力学的評価を加えることで、より個別的な予防および治療が行える可能性がある。そして心原生脳塞栓症予防に寄与できれば健康維持および医療費削減にも期待できる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Presentation (10 results)

  • [Presentation] Relationship between left atrial vortex assessed by 4D flow cardiac magnetic resonance and stroke risk in patients with paroxysmal atrial fibrillation2023

    • Author(s)
      Takuya Omuro, Yasuhiro Yoshiga, Masakazu Fukuda, Hironori Ishiguchi, Shohei Fujii, Masahiro Hisaoka, Tomoyuki Uchida, Akihiko Shimizu, Masafumi Yano
    • Organizer
      第69回日本不整脈心電学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 発作性心房細動における左房壁ずり応力の検討2023

    • Author(s)
      廣中泰貴, 早田拓海, 小室拓也, 中元麻友, 國光健太, 豊田紋子, 田中智子, 有吉亨, 和田靖明, 田中伸明
    • Organizer
      第47回日本超音波検査学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 発作性心房細動におけるVFMを用いた左房内血流解析および壁ずり応力の計測2023

    • Author(s)
      廣中泰貴, 小室拓也, 中元麻友, 國光健太, 豊田紋子, 田中智子, 有吉亨, 小室あゆみ, 和田靖明, 田中伸明
    • Organizer
      日本超音波医学会第96回学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Left atrial low-voltage areas associate thromboembolic risk in patients with persistent atrial fibrillation who preserved left atrial appendage flow velocity2022

    • Author(s)
      Takuya Omuro, Yasuhiro Yoshiga, Masakazu Fukuda, Hironori Ishiguchi, Syohei Fujii, Masahiro Hisaoka, Tomoyuki Uchida, Takeshi Ueyama, Akihiko Shimizu, Masafumi Yano
    • Organizer
      第68回日本不整脈心電学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] VFM法による左房内血流解析および壁ずり応力計測の試み2022

    • Author(s)
      廣中泰貴, 早田拓海, 小室拓也, 中元麻友, 國光健太, 豊田紋子, 田中智子, 有吉亨, 和田靖明, 田中伸明
    • Organizer
      第47回日本超音波検査学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Relationship between Left Atrial Low Voltage Areas and Wall Shear Stress Measured by 4D Flow Magnetic Resonance Imaging2022

    • Author(s)
      Takuya Omuro, Yasuhiro Yoshiga, Masakazu Fukuda, Hironori Ishiguchi, Syohei Fujii, Masahiro Hisaoka, Masafumi Yano
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Relationship between left atrial low voltage areas and wall shear stress measured by 4D flow Magnetic Resonance Imaging2022

    • Author(s)
      Takuya Omuro, Yasuhiro Yoshiga, Masakazu Fukuda, Hironori Ishiguchi, Syohei Fujii, Masahiro Hisaoka, Masafumi Yano
    • Organizer
      第86回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Left atrial low-voltage areas associate thromboembolic risk in patients with persistent atrial fibrillation who preserved left atrial appendage flow velocity2022

    • Author(s)
      Takuya Omuro, Yasuhiro Yoshiga, Masakazu Fukuda, Hironori Ishiguchi, Syohei Fujii, Masahiro Hisaoka, Masafumi Yano
    • Organizer
      第68回日本不整脈心電学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Vector flow mapping法による左房内血流解析および壁ずり応力計測の試み2022

    • Author(s)
      廣中泰貴, 早田拓海, 小室拓也, 中元麻友, 國光健太, 豊田紋子, 田中智子, 有吉亨, 和田靖明, 田中伸明
    • Organizer
      第47回日本超音波検査学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 持続性心房細動における左心耳血栓およびもやもやエコーと左房低電位領域の関連2021

    • Author(s)
      小室拓也、吉賀康裕、福田昌和、石口博智、藤井翔平、久岡雅弘、安木康太、古谷一貴、丸山昂汰、矢野雅文
    • Organizer
      第1回日本不整脈心電学会中国・四国支部地方会
    • Related Report
      2021 Research-status Report

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Published: 2019-04-18   Modified: 2024-01-30  

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