• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive lipidomics of skin lipid profiles in the development of dermatitis

Research Project

Project/Area Number 19K17816
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53050:Dermatology-related
Research InstitutionKeio University

Principal Investigator

Naganuma Tatsuro  慶應義塾大学, 薬学部(芝共立), 助教 (60779619)

Project Period (FY) 2019-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsリピドミクス / 脂質 / 皮膚炎 / LC-MS/MS / 皮膚 / アトピー性皮膚炎 / セラミド / 質量分析
Outline of Research at the Start

皮膚には多種多様な脂質分子が存在し,皮膚の健康を維持する上で不可欠である。本研究では,アトピー性皮膚炎の病態が進行するにつれてどのような症状が生じて,その時どのような脂質分子に異常を生じているのかを網羅的に捉えることで,皮膚疾患の原因となる脂質代謝異常を見出す。また,皮膚の機能を制御する新たな脂質代謝系を探索し,アトピー性皮膚炎をはじめとする様々な皮膚疾患の治療基盤構築,治療標的の発見を目指す。

Outline of Final Research Achievements

Various lipids are indispensable for the maintenance of skin homeostasis, and disregulated lipid metabolism can cause disease onset of dermatitis such as atopic dermatitis. To clarify the disease pathogenesis of dermatitis, it’s important to capture the comprehensive lipidome profile in the course of disease onset and progression. We performed LC-MS/MS based comprehensive lipidomics in mouse model of atopic dermatitis. As a results, we found unique alterations of lipid metabolism involved in disease onset and progression and underlying mechanisms for the disuregulation of lipid balances.

Academic Significance and Societal Importance of the Research Achievements

これまでに様々な皮膚疾患において脂質組成異常が認められていたが,疾患発症後の解析であったため多くの脂質分子に異常が生じており,病態を引き起こす正体は明らかではなかった。本研究では,症状が出る前の段階で生じる脂質代謝異常を特定し,皮膚疾患の発症および悪化に関わる脂質代謝異常の一つを見出すことに成功した。また,脂質組成異常を生じる原因となる酵素反応を示唆し,皮膚炎の治療に有効な新規標的候補を見出したと言える。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (8 results)

All 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast2020

    • Author(s)
      Mori Keisuke, Obara Takashi, Seki Naoya, Miyamoto Masatoshi, Naganuma Tatsuro, Kitamura Takuya, Kihara Akio
    • Journal Title

      Journal of Lipid Research

      Volume: 61 Issue: 7 Pages: 1104-1114

    • DOI

      10.1194/jlr.ra120000803

    • NAID

      120007126048

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.2020

    • Author(s)
      Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, Ayako Ohara, Manabu Sugai, Koji Sugawara, Daisuke Tsuruta, Noritaka Oyama, Minoru Hasegawa
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 140 Issue: 4 Pages: 838-849

    • DOI

      10.1016/j.jid.2019.09.011

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] Aberrant sebaceous lipid metabolism in the early stage of spontaneous dermatitis in Tmem79-deficient mice2020

    • Author(s)
      Ari Morimoto, Yoshihiro Ito, Takashi Sasaki, Aiko Shiohama, Hiroshi Kawasaki, Ai Hirabayashi, Mayuko Sato, Kiminori Toyooka, Eiryo Kawakami, Tatsuro Naganuma, Makoto Arita, Haruhiko Koseki, Takeshi Matsui, Masayuki Amagai
    • Organizer
      日本研究皮膚科学会 第45年次学術大会総会
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 炎症性皮膚疾患の病態形成過程における脂質代謝変動の包括的メタボローム解析2020

    • Author(s)
      永沼達郎,飯野雄大,平野愛美,岡村真宜,有田誠
    • Organizer
      第62回 日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト培養ケラチノサイトにおける脂肪酸代謝系の包括的解析2019

    • Author(s)
      中野裕介,永沼達郎,有田誠
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Research-status Report
  • [Presentation] アレルギー性接触皮膚炎の病態形成過程における脂肪酸代謝系の包括的解析2019

    • Author(s)
      平野愛美,永沼達郎,有田誠
    • Organizer
      第18回次世代を担う若手ファーマ・バイオフォーラム2019
    • Related Report
      2019 Research-status Report
  • [Presentation] アレルギー性接触性皮膚炎の病態制御に関わる脂肪酸代謝系の包括的解析2019

    • Author(s)
      平野愛美,永沼達郎,有田誠
    • Organizer
      第61回脂質生化学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Untargeted lipidomics revealed dysregulated ceramide metabolism in the initiation phase of atopic dermatitis2019

    • Author(s)
      Yudai Iino, Tatsuro Naganuma, Makoto Arita
    • Organizer
      60th International Conference on the Bioscience of Lipids
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi