Comprehensive lipidomics of skin lipid profiles in the development of dermatitis
Project/Area Number |
19K17816
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 53050:Dermatology-related
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Research Institution | Keio University |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | リピドミクス / 脂質 / 皮膚炎 / LC-MS/MS / 皮膚 / アトピー性皮膚炎 / セラミド / 質量分析 |
Outline of Research at the Start |
皮膚には多種多様な脂質分子が存在し,皮膚の健康を維持する上で不可欠である。本研究では,アトピー性皮膚炎の病態が進行するにつれてどのような症状が生じて,その時どのような脂質分子に異常を生じているのかを網羅的に捉えることで,皮膚疾患の原因となる脂質代謝異常を見出す。また,皮膚の機能を制御する新たな脂質代謝系を探索し,アトピー性皮膚炎をはじめとする様々な皮膚疾患の治療基盤構築,治療標的の発見を目指す。
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Outline of Final Research Achievements |
Various lipids are indispensable for the maintenance of skin homeostasis, and disregulated lipid metabolism can cause disease onset of dermatitis such as atopic dermatitis. To clarify the disease pathogenesis of dermatitis, it’s important to capture the comprehensive lipidome profile in the course of disease onset and progression. We performed LC-MS/MS based comprehensive lipidomics in mouse model of atopic dermatitis. As a results, we found unique alterations of lipid metabolism involved in disease onset and progression and underlying mechanisms for the disuregulation of lipid balances.
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Academic Significance and Societal Importance of the Research Achievements |
これまでに様々な皮膚疾患において脂質組成異常が認められていたが,疾患発症後の解析であったため多くの脂質分子に異常が生じており,病態を引き起こす正体は明らかではなかった。本研究では,症状が出る前の段階で生じる脂質代謝異常を特定し,皮膚疾患の発症および悪化に関わる脂質代謝異常の一つを見出すことに成功した。また,脂質組成異常を生じる原因となる酵素反応を示唆し,皮膚炎の治療に有効な新規標的候補を見出したと言える。
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Homeostatic Function of Dermokine in the Skin Barrier and Inflammation.2020
Author(s)
Akira Utsunomiya, Takenao Chino, Natsuko Utsunomiya, Vu Huy Luong, Atsushi Tokuriki, Tatsuro Naganuma, Makoto Arita, Kiyoshi Higashi, Koichi Saito, Noriyuki Suzuki, Ayako Ohara, Manabu Sugai, Koji Sugawara, Daisuke Tsuruta, Noritaka Oyama, Minoru Hasegawa
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Journal Title
Journal of Investigative Dermatology
Volume: 140
Issue: 4
Pages: 838-849
DOI
Related Report
Peer Reviewed
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[Presentation] Aberrant sebaceous lipid metabolism in the early stage of spontaneous dermatitis in Tmem79-deficient mice2020
Author(s)
Ari Morimoto, Yoshihiro Ito, Takashi Sasaki, Aiko Shiohama, Hiroshi Kawasaki, Ai Hirabayashi, Mayuko Sato, Kiminori Toyooka, Eiryo Kawakami, Tatsuro Naganuma, Makoto Arita, Haruhiko Koseki, Takeshi Matsui, Masayuki Amagai
Organizer
日本研究皮膚科学会 第45年次学術大会総会
Related Report
Int'l Joint Research
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