Identification of immune environment cells in the central nervous system which support the development of primary CNS lymphoma
Project/Area Number |
19K17820
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 54010:Hematology and medical oncology-related
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 中枢神経原発悪性リンパ腫 |
Outline of Research at the Start |
中枢神経系原発悪性リンパ腫(Primary central nervous system lymphoma: PCNSL)は脳内に原発する悪性リンパ腫で、殆どの症例はびまん性大細胞性B細胞リンパ腫 (Diffuse large B cell lymphoma; DLBCL)の病理形態を示す。PCNSLのゲノム解析において特に免疫制御に関係する遺伝子の異常を高頻度に認めたことなどから、全身性DLBCLとの遺伝子型と表現型の違いの原因として、脳内の特殊な免疫環境が影響しているという仮説を立てた。本研究では、腫瘍細胞と周囲の免疫細胞との関連について明らかにすることでPCNSLの病態を解明したい。
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Outline of Final Research Achievements |
By RNA sequencing analysis using the nCounter system, we have already performed quantitative RNA analysis of 770 genes related to neuroinflammation in 30 patients with CNS primary malignant lymphoma and compared the results between the poor and good prognosis groups using volcano plots. We found that 48 genes were significantly up-regulated in the poor prognosis group. Furthermore, multivariate analysis revealed that three genes, TUBB4A, S100B, and SLC6A1, had a significant effect on prognosis.
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Academic Significance and Societal Importance of the Research Achievements |
前述の3つの遺伝子は、オリゴデンドロサイトなどの中枢神経の免疫環境に関連していたことから、PCNSLの免疫環境細胞が臨床予後に関係している可能性があることが示唆される。シングルセルシークエンス解析を通じて更に詳細な解析を行うことで、予後予測のためのバイオマーカーの同定につながり、将来的に創薬につながっていくことが期待される。
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Report
(5 results)
Research Products
(37 results)
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[Journal Article] A single-cell atlas of non-haematopoietic cells in human lymph nodes and lymphoma reveals a landscape of stromal remodelling.2021
Author(s)
Abe Y, Sakata-Yanagimoto M, Fujisawa M, Miyoshi H, Suehara Y, Hattori K, Kusakabe M, Sakamoto T, Nishikii H, Nguyen TB, Owada Y, Enomoto T, Sawa A, Bando H, Yoshida C, Tabata R, Terao T, Nakayama M, Ohshima K, Usuki K, Oda T, Matsue K, Chiba S
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Journal Title
Nature cell biology
Volume: 24
Issue: 4
Pages: 565-578
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tet2-deficency in immune cells exacerbates tumor progression by increasing angiogenesis in a lung cancer model.2021
Author(s)
Nguyen YTM, Fujisawa M, Nguyen TB, Suehara Y, Tatsuhiro S, Matsuoka R, Abe Y, Fukumoto K, Hattori K, Noguchi M, Matsubara D, Chiba S, Sakata-Yanagimoto M.
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Journal Title
Cancer science
Volume: 112
Issue: 12
Pages: 4931-4943
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 血管免疫芽球性 T 細胞リンパ腫の遺伝子異常に基づく亜分類は予後と関連する2022
Author(s)
Yasuhito Suehara, Manabu Fujisawa,Yoshiaki Abe, Keiichiro Hattori,Yasuhisa Yokoyama, Hidekazu Nishikii, Naoshi Obara, Takeshi Sugio, Koji Kato, Koichi Akashi, Kosei Matsue,Kengo Takeuchi, Naoya Nakamura, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, Shigeru Chiba, Mamiko Sakata-Yanagimoto
Organizer
第84回日本血液学会学術集会
Related Report
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