Elucidation of the role of tumor endothelial cell-tumor cell clusters in metastasis of renal cancer

• Project/Area Number: 19K18549
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 56030:Urology-related
• Research Institution: Hokkaido University
• Principal Investigator: Kikuchi Hiroshi 北海道大学, 医学研究院, 客員研究員 (20828305)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 腎癌転移 / 腫瘍血管内皮細胞 / クラスター / アノイキス / 腎癌 / 転移

Outline of Research at the Start

がんの進展・転移にはがん細胞とがん間質細胞の相互作用が重要である．がんの血管を裏打ちする腫瘍血管内皮細胞も間質細胞の一つであり，様々な異常性を示す．申請者らは腫瘍血管内皮細胞ががん細胞とクラスターを形成する性質をもつこと，様々な接着因子や増殖因子を高く発現すること，薬剤抵抗性があることなどを見出してきた.
本研究では，がん細胞が腫瘍血管内皮細胞とクラスターを形成することで転移先臓器へと移動する血液中において細胞死から逃れ，遠隔臓器に転移巣を形成すること，さらに薬物治療に対する耐性を示すという仮説を立て，がん進展・転移における腫瘍血管内皮細胞の新しい役割を分子基盤とともに解明することを目指す．

Outline of Final Research Achievements

In co-culture of tumor cells with tumor endothelial cells derived from highly metastatic tumors, it was observed that tumor endothelial cells formed clusters surrounding the tumor cells. In addition, when the survival rate and the rate of apoptosis were compared, the survival rate of tumor cells tended to increase and the rate of apoptosis decreased in co-culture with tumor endothelial cells derived from highly metastatic tumors. These findings suggested that tumor endothelial cells derived from highly metastatic tumors may contribute to tumor cell survival in suspension by cluster formation.
Furthermore, immunostaining of human renal cancer tissues with the endothelial marker (CD34) revealed several cases of intravascular cell clusters containing CD34-positive cells.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から，浮遊状態において腫瘍血管内皮細胞と腫瘍細胞がクラスターを形成することで腫瘍細胞の生存率が高まることが証明された．浮遊状態は人体の中では血液の中での状況と想定される．このクラスター形成が血行性転移の重要な役割を果たしているのではないかと想定される．クラスターが形成されるメカニズムを解明することで，クラスター形成を防ぐことができれば，転移の制御につながるのではないかと考えられる．

Research Products

• [Journal Article] Novel antiangiogenic therapy targeting biglycan using tumor endothelial cell‐specific liposomal siRNA delivery system (2022)
  • Author(s): Maishi Nako、Sakurai Yu、Hatakeyama Hiroto、Umeyama Yui、Nakamura Takashi、Endo Rikito、Alam Mohammad Towfik、Li Cong、Annan Dorcas Akuba‐Muhyia、Kikuchi Hiroshi、Morimoto Hirofumi、Morimoto Masahiro、Akiyama Kosuke、Ohga Noritaka、Hida Yasuhiro、Harashima Hideyoshi、Hida Kyoko
  • Journal Title: Cancer Science Volume: online ahead of print Issue: 5 Pages: 1-1
  • DOI: 10.1111/cas.15323
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of nivolumab plus ipilimumab as first-line therapy for primary tumors in patients with renal cell carcinoma. (2022)
  • Author(s): Kikuchi H, Osawa T, Matsumoto R, Abe T, Maruyama S, Harabayashi T, Miyata H, Kashiwagi A, Ikeshiro S, Sazawa A, Fukui R, Morita K, Takeuchi I, Hori K, Yamashita N, Minami K, Mochizuki T, Murai S, Shinohara N.
  • Journal Title: Urol Oncol. Volume: 40 Issue: 1 Pages: 13.e19-13.e27
  • DOI: 10.1016/j.urolonc.2021.09.014
  • Peer Reviewed
• [Journal Article] Comparative study of postoperative complications after radical cystectomy during the past two decades in Japan: Radical cystectomy remains associated with significant postoperative morbidities (2022)
  • Author(s): Yamada Shuhei,Abe Takashige,Sazawa Ataru,Katano Hidenori,Suzuki Hidetaka,Takeuchi Ichiro,Ishizaki Junji,Minami Keita,Morita Ken,Tsuchiya Kunihiko,Takada Norikata,Maru Shintaro,Ishikawa Shuhei,Sato Soshu,Kawazu Takafumi,Yamashita Takanori,Ono Takenori,Mochizuki Tango,Akino
  • Journal Title: Urologic Oncology: Seminars and Original Investigations Volume: 40 Issue: 1 Pages: 11.e17-11.e25
  • DOI: 10.1016/j.urolonc.2021.09.005
  • Peer Reviewed
• [Journal Article] Outcomes of bacillus Calmette?Gu?rin therapy without a maintenance schedule for high‐risk non‐muscle‐invasive bladder cancer in the second transurethral resection era (2021)
  • Author(s): Kikuchi Hiroshi、Abe Takashige、Matsumoto Ryuji、Osawa Takahiro、Maruyama Satoru、Murai Sachiyo、Shinohara Nobuo
  • Journal Title: International Journal of Urology Volume: 29 Issue: 3 Pages: 251-258
  • DOI: 10.1111/iju.14761
  • Peer Reviewed
• [Journal Article] Correlation between endothelial CXCR7 expression and clinicopathological factors in oral squamous cell carcinoma (2021)
  • Author(s): Yanagiya Misa、Dawood Randa I. H.、Maishi Nako、Hida Yasuhiro、Torii Chisaho、Annan Dorcas A.、Kikuchi Hiroshi、Yanagawa Matsuda Aya、Kitamura Tetsuya、Ohiro Yoichi、Shindoh Masanobu、Tanaka Shinya、Kitagawa Yoshimasa、Hida Kyoko
  • Journal Title: Pathology International Volume: - Issue: 6 Pages: 1-9
  • DOI: 10.1111/pin.13094
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of Health-Related Quality of Life Between Japanese and American Patients with Bladder Cancer as Measured by a Newly Developed Japanese Version of the Bladder Cancer Index (2021)
  • Author(s): Osawa T, Wei JT, Abe T, Honda M, Rew, KT, Dunn R, Yamada S, Furumido J, Kikuchi H, Matsumoto R, Sato Y, Harabayashi T, Takada N, Minami K, Morita K, Kashiwagi A, Fukuhara S, Murai S, Ito YM, Ogasawara K, Shinohara N
  • Journal Title: Bladder Cancer Volume: 7 Issue: 1 Pages: 61-69
  • DOI: 10.3233/blc-200359
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Health-related quality of life in Japanese patients with bladder cancer measured by a newly developed Japanese version of the Bladder Cancer Index (2020)
  • Author(s): Osawa T, Wei JT, Abe T, Honda M, Yamada S, Furumido J, Kikuchi H, Matsumoto R, Hirakawa K, Sato Y, Sasaki Y, Harabayashi T, Takada N, Minami K, Tanaka H, Morita K, Kashiwagi A, Miyajima N, Akino T, Murai S, Ito YM, Fukuhara S, Ogasawara K, Shinohara N
  • Journal Title: International Journal of Clinical Oncology Volume: 25 Issue: 12 Pages: 2090-2098
  • DOI: 10.1007/s10147-020-01770-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development and validation of a porcine organ model for training in essential laparoscopic surgical skills (2020)
  • Author(s): Higuchi Madoka、Abe Takashige、Hotta Kiyohiko、Morita Ken、Miyata Haruka、Furumido Jun、Iwahara Naoya、Kon Masafumi、Osawa Takahiro、Matsumoto Ryuji、Kikuchi Hiroshi、Kurashima Yo、Murai Sachiyo、Aydin Abdullatif、Raison Nicholas、Ahmed Kamran、Khan Muhammad Shamim、Dasgupta Prokar、Shinohara Nobuo
  • Journal Title: International Journal of Urology Volume: 27 Issue: 10 Pages: 929-938
  • DOI: 10.1111/iju.14315
  • Peer Reviewed / Open Access
• [Journal Article] Motion analysis for better understanding of psychomotor skills in laparoscopy: objective assessment-based simulation training using animal organs (2020)
  • Author(s): Ebina Koki、Abe Takashige、Higuchi Madoka、Furumido Jun、Iwahara Naoya、Kon Masafumi、Hotta Kiyohiko、Komizunai Shunsuke、Kurashima Yo、Kikuchi Hiroshi、Matsumoto Ryuji、Osawa Takahiro、Murai Sachiyo、Tsujita Teppei、Sase Kazuya、Chen Xiaoshuai、Konno Atsushi、Shinohara Nobuo
  • Journal Title: Surgical Endoscopy Volume: - Issue: 8 Pages: 4399-4416
  • DOI: 10.1007/s00464-020-07940-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Chemotherapy-induced IL-8 upregulates MDR1/ABCB1 in tumor blood vessels and results in unfavorable outcome (2020)
  • Author(s): Kikuchi Hiroshi、Maishi Nako、Annan Dorcas A.、Towfik Alam Mohammad、Sato Masumi、Morimoto Masahiro、Takeda Ryo、Ishizuka Keita、Matsumoto Ryuji、Akino Tomoshige、Matsuno Yoshihiro、Hida Yasuhiro、Shinohara Nobu、Hida Kyoko
  • Journal Title: Cancer Research Volume: 80 Issue: 14 Pages: 2996-3008
  • DOI: 10.1158/0008-5472.can-19-3791
  • Peer Reviewed
• [Journal Article] Oncologic outcomes of laparoscopic radical nephroureterectomy in conjunction with template-based lymph node dissection: An extended follow-up study (2020)
  • Author(s): Matsumoto Ryuji、Abe Takashige、Takada Norikata、Minami Keita、Harabayashi Toru、Nagamori Satoshi、Hatanaka Kanako C.、Yamashiro Katsushige、Kikuchi Hiroshi、Osawa Takahiro、Maruyama Satoru、Shinohara Nobuo
  • Journal Title: Urologic Oncology: Seminars and Original Investigations Volume: 38 Issue: 12 Pages: 933.e13-933.e18
  • DOI: 10.1016/j.urolonc.2020.05.013
  • Peer Reviewed
• [Journal Article] The updated outcomes of bladder-preserving trimodal therapy using a real-time tumor-tracking radiotherapy system for patients with muscle-invasive bladder cancer (2020)
  • Author(s): Miyata Haruka、Osawa Takahiro、Abe Takashige、Kikuchi Hiroshi、Matsumoto Ryuji、Maruyama Satoru、Nishioka Kentaro、Shimizu Shinichi、Hashimoto Takayuki、Shirato Hiroki、Shinohara Nobuo
  • Journal Title: Japanese Journal of Clinical Oncology Volume: - Issue: 5 Pages: 609-616
  • DOI: 10.1093/jjco/hyz211
  • Peer Reviewed / Open Access
• [Journal Article] Tumor Endothelial Cell-A Biological Tool for Translational Cancer Research (2020)
  • Author(s): Annan Dorcas Akuba-Muhyia、Kikuchi Hiroshi、Maishi Nako、Hida Yasuhiro、Hida Kyoko
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 9 Pages: 3238-3238
  • DOI: 10.3390/ijms21093238
  • Peer Reviewed / Open Access
• [Journal Article] Tumor endothelial heterogeneity in cancer progression (2019)
  • Author(s): Nako Maishi, Dorcas A. Annan, Hiroshi Kikuchi, Yasuhiro Hida and Kyoko Hida
  • Journal Title: Cancers Volume: 11 Issue: 10 Pages: 1511-1511
  • DOI: 10.3390/cancers11101511
  • Peer Reviewed / Open Access
• [Journal Article] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment (2019)
  • Author(s): Dorcas Akuba Muhyia Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
  • Journal Title: Cell Communication and Signaling Volume: 17 Issue: 1 Pages: 169-169
  • DOI: 10.1186/s12964-019-0478-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of immortalized human tumor endothelial cells from renal cancer (2019)
  • Author(s): Nako Maishi, Hiroshi Kikuchi, Masumi Sato, Hiroko Nagao-Kitamoto, Dorcas A. Annan, Shogo Baba, Takayuki Hojo, Misa Yanagiya, Yusuke Ohba, Genichiro Ishii, Kenkichi Masutomi, Nobuo Shinohara, Yasuhiro Hida, Kyoko Hida
  • Journal Title: Int J Mol Sci Volume: 20 Issue: 18 Pages: 4595-4595
  • DOI: 10.3390/ijms20184595
  • Peer Reviewed / Open Access
• [Presentation] Low-dose metronomic cisplatin suppress inflammatory change of tumor microenvironment． (2022)
  • Author(s): 菊地央, 間石奈湖, 佐藤 峰嘉, 武田遼, 樋田泰浩, 樋田京子
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] 泌尿器癌における腫瘍血管内皮細胞の役割 (2021)
  • Author(s): 菊地央, 山田修平, 古御堂純, 宮田遥, 松本隆児, 大澤崇宏, 秋野文臣, 土屋邦彦, 安部崇重, 間石奈湖, 樋田京子, 篠原信雄
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] Promotion of tumor metastasis by forming tumor cell clusters with tumor endothelial cells, Poster (2021)
  • Author(s): Maishi N, Umeyama Y, Kikuchi H, Furumido J, Sato M, Takeda R, Shinohara N, Hida Y, Hida K
  • Organizer: 第80回日本癌学会
• [Presentation] 筋層非浸潤性膀胱癌の治療成績と手術の質の向上に向けて (2021)
  • Author(s): 菊地央, 松本隆児, 大澤崇宏 , 安部崇重, 篠原信雄
  • Organizer: 第86回日本泌尿器科学会 東部総会
• [Presentation] 低用量維持投与のシスプラチンは腫瘍微小環境における骨髄由来免疫抑制細胞の動員と炎症性変化を抑制する (2021)
  • Author(s): 菊地央, 間石奈湖, Li Cong, 武田遼, 樋田泰浩, 樋田京子
  • Organizer: 第30回日本がん転移学会学術集会・総会
• [Presentation] 進行性腎癌に対するニボルマブ＋イピリムマブ療法の原発巣縮小効果 (2021)
  • Author(s): 菊地央, 大澤崇宏, 松本隆児, 安部崇重, 丸山覚, 原林透, 宮田遥, 柏木明, 佐澤陽, 福井理予, 森田研, 竹内一郎, 山下登, 三浪圭太, 篠原信雄
  • Organizer: 第412回北海道地方会
• [Presentation] Efficacy of nivolumab plus ipilimumab in primary tumor as first-line therapy in the patients with advanced renal cell carcinoma (2021)
  • Author(s): Hiroshi Kikuchi, Takahiro Osawa, Ryuji Matsumoto, Takashige Abe, Satoru Maruyama, Toru Harabayashi, Haruka Miyata, Akira Kashiwagi, Ataru Sazawa, Riyo Fukui, Ken Morita, Ichiro Takeuchi, Noboru Yamashita, Keita Minami, Tango Mochizuki, Nobuo Shinohara
  • Organizer: AUA2021 Annual Meeting
  • Int'l Joint Research
• [Presentation] Crosstalk of tumor cells and tumor endothelial cells by forming cell clusters promotes tumor metastasis (2021)
  • Author(s): 間石 奈湖，梅山 悠伊，菊地 央，古御堂 純，佐藤 峰嘉，武田 遼，Dorcas A. Annan, 篠原 信雄，樋田 泰浩，樋田 京子
  • Organizer: 第28回日本血管生物医学会学術集会
• [Presentation] Novel Antiangiogenic Therapy Targeting Biglycan in Tumor Endothelial Cell Using Liposomal-siRNA Delivery System, E-poster, The 21st International Vascular Biology Meeting (2020)
  • Author(s): Maishi N, Sakurai Y, Hatakeyama H, Li C, Alam MT, Kikuchi H, Morimoto H, Morimoto M, Akiyama K, Ohga N, Hida Y, Harashima H, Hida K
  • Organizer: 国際血管生物医学会議
  • Int'l Joint Research
• [Presentation] Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment E-poster (2020)
  • Author(s): Annan DA, Maishi N, Soga T, Dawood RIH, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T, Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y, Hida K
  • Organizer: 国際血管生物医学会議
  • Int'l Joint Research
• [Presentation] Increased ABCB1 expression in tumor blood vessels of urothelial carcinoma after chemotherapy and chemoresistance, E-poster (2020)
  • Author(s): Kikuchi H, Nako Maishi, Dorcas A. Annan, Alam TM, Matsumoto R, Osawa T, Abe T, Hida Y, Harabayashi T, Ameda K, Kashiwagi A, Matsuno Y, Shinohara N, Hida K
  • Organizer: 国際血管生物医学会議
  • Int'l Joint Research
• [Presentation] 泌尿器癌における腫瘍血管内皮細胞の役割 (2020)
  • Author(s): 菊地 央，山田修平，古御堂純，宮田 遥，松本隆児，大澤崇宏，秋野文臣，土屋邦彦，安部祟重，間石奈湖，樋田京子，篠原信雄
  • Organizer: 第108回日本泌尿器科学会総会
• [Presentation] リポソーム siRNA デリバリーシステムを用いた腫瘍血管 biglycan を標的とした新規血管新生阻害療法 (2020)
  • Author(s): 間石奈湖, 櫻井 遊, 畠山浩人, Li C, Alam MT, 菊地 央, 森本浩史, 森本真弘, 樋田泰浩, 原島秀吉, 樋田京子
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] MOTION ANALYSIS TO PROMOTE UNDERSTANDING OF LAPAROSCOPIC SURGERY-DEXTERITY AND OBJECTIVE ASSESSMENT-BASED SIMULATION TRAINING (2020)
  • Author(s): Takashige Abe, Koki Ebina, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Atsushi Konno, Nobuo Shinohara
  • Organizer: American Urological Association(AUA2020)
  • Int'l Joint Research
• [Presentation] LATE RECURRENCE OF NON-MUSCLE-INVASIVE BLADDER CANCER AFTER A 5-YEAR CANCER-FREE PERIOD (2020)
  • Author(s): Yurie Hirata, Takahiro Osawa, Madoka Higuchi, Shiro Hinotsu, Toru Harabayashi, Tango Mochizuki, Nobuyasu Enami, Osamu Nounaka, Yuichiro Shinno, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Sachiyo Murai, Nobuo Shinohara
  • Organizer: American Urological Association(AUA2020)
  • Int'l Joint Research
• [Presentation] THE EFFECTIVENESS OF TEMPLATE-BASED REGIONAL LYMPH NODE DISSECTION IN REDUCING LOCOREGIONAL RECURRENCE IN PATIENTS WITH CLINICALLY NODE-NEGATIVE UPPER URINARY TRACT UROTHELIAL CARCINOMA (2020)
  • Author(s): Ryuji Matsumoto, Takashige Abe, Noritaka Takada, Keita Minami, Toru Harabayashi, Satoru Maruyama, Hiroshi Kikuchi, Takahiro Osawa, Nobuo Shinohara
  • Organizer: American Urological Association(AUA2020)
  • Int'l Joint Research
• [Presentation] URINARY EXTRACELLULAR VESICLE RNA BIOMARKERS FOR HIGH-RISK NON-MUSCLE INVASIVE BLADDER CANCER (2020)
  • Author(s): Keita Minami, Takahiro Osawa, Taku Murakami, Hiroshi Harada, Toru Harabayashi, Norikata Takada, Akira Kashiwagi, Kazushi Hirakawa, Yasuyuki Sato, Ryuji Matsumoto, Hiroshi Kikuchi, Takashige Abe, Sachiyo Murai, Nobuo Shinohara
  • Organizer: American Urological Association(AUA2020)
  • Int'l Joint Research
• [Presentation] HEALTH-RELATED QUALITY OF LIFE IN JAPANESE PATIENTS WITH BLADDER CANCER ACCORDING TO A NEWLY DEVELOPED JAPANESE VERSION OF THE BLADDER CANCER INDEX (2020)
  • Author(s): Takahiro Osawa, John T. Wei, Takashige Abe, Shuhei Yamada, Jun Furumido, Hiroshi Kikuchi, Ryuji Matsumoto, Yoshihiro Sasaki, Kazushi Hirakawa, Akira Kashiwagi, Ken Morita, Hiroshi Tanaka, Keita Minami, Norikata Takada, Toru Harabayashi, Sachiyo Murai, Nobuo Shinohara
  • Organizer: American Urological Association(AUA2020)
  • Int'l Joint Research
• [Presentation] 尿路変向術の基本と注意点 (2020)
  • Author(s): 安部崇重、千葉博基、菊地 央、篠原信雄
  • Organizer: 第85回日本泌尿器科学会東部総会
• [Presentation] 腹腔鏡下腎尿管全摘除術におけるリンパ節郭清術 (2020)
  • Author(s): 安部崇重、菊地 央、松本隆児、大澤崇宏、篠原信雄
  • Organizer: 第34回日本泌尿器内視鏡学会総会
• [Presentation] 症例から考える化学療法、合併症発症例や併存疾患を有する症例 (2020)
  • Author(s): 安部崇重、菊地 央、松本隆児、大澤崇宏
  • Organizer: 第34回日本泌尿器内視鏡学会総会
• [Presentation] 症例から考える化学療法、合併症発症例や併存疾患を有する症例 (2020)
  • Author(s): 安部崇重、菊地 央、松本隆児、大澤崇宏、篠原信雄
  • Organizer: 日本泌尿器腫瘍学会 第6回学術集会
• [Presentation] 鏡視下腎部分切除における阻血法の違いによる術後腎機能の比較検討 (2020)
  • Author(s): 松本隆児、山田修平、古御堂 純、森口卓哉、菊地 央、大澤崇宏、安部崇重、篠原信雄
  • Organizer: 第34回日本泌尿器内視鏡学会総会
• [Presentation] 尿路上皮癌における抗癌剤治療後の腫瘍血管ABCB１発現亢進と薬剤耐性 (2020)
  • Author(s): 菊地 央, 間石奈湖, Dorcas A.Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, 森本真弘, 松本隆児, 大澤崇宏, 安部崇重, 樋田泰浩, 原林 透, 松野吉弘, 篠原信雄, 樋田京子
  • Organizer: 第１回日本癌学会若手の会
• [Presentation] 抗癌剤治療がもたらす腫瘍血管ABCB1発現亢進とその機序，細胞社会ダイバーシティーの統合的解明と制御 (2020)
  • Author(s): 間石奈湖, 菊地 央, 樋田京子
  • Organizer: 第5回公開シンポジウム「多面的1細胞解析技術が解き明かす細胞社会ダイバーシティー」
• [Presentation] Increased ABCB1 expression in tumor blood vessels of urothelial carcinoma after chemotherapy (2019)
  • Author(s): Maishi N., Kikuchi H., Abe T., Matsuno Y., Hida Y., Shinohara N., Hida K
  • Organizer: The 38th Sapporo International Cancer Symposium
  • Int'l Joint Research
• [Presentation] RENAL NEPHROMETRY SCORE CORRELATED WITH TUMOR PROLIFERATIVE ACTIVITY OF T1 CLEAR CELL RENAL CELL CARCINOMA (2019)
  • Author(s): Hiroshi Kikuchi., Takashige Abe., Ryuji Matsumoto., Jun Furumido., Haruka Miyata., Takahiro Osawa., Sachiyo Murai., and Nobuo Shinohara
  • Organizer: American Urological Association (AUA2019)
  • Int'l Joint Research
• [Presentation] Increased ABCB1 expression in tumor blood vessels of urothelial carcinoma after chemotherapy (2019)
  • Author(s): Kikuchi Hiroshi, Nako Maishi, Hirofumi Morimoto, Kunihiko Tsuchiya, Satoshi Maruyama, Takashige Abe, Yasuhiro Hida, Toru Harabayashi, Ryuji Matsumoto, Akira Kashiwagi, Yoshihiro Matsuno, Nobuo Shinohara, Kyoko Hida
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 尿路上皮癌における抗癌剤治療後の腫瘍血管ABCB１発現亢進と薬剤耐性 (2019)
  • Author(s): 菊地 央, 間石奈湖, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, 松本隆児, 大澤崇宏, 安部崇重, 樋田泰浩, 原林 透, 松野吉弘, 篠原信雄, 樋田京子
  • Organizer: 第28回日本癌がん転移学会学術集会・総会