| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Although it has been shown that serum copper concentrations are elevated in obese and diabetic patients, the effect of copper intervention on the prevention and treatment of obesity and diabetes and its mechanisms remain unresolved. In this study, we evaluated the effects of a copper chelator on obesity and lipid metabolism in high-fat diet-induced obese mice. The findings of this study demonstrate that a copper chelator contributes to the prevention of the development of obesity and diabetes through changes in lipid metabolism in the liver, and the findings of this study suggest that copper might be the possible target for the prevention and treatment of obesity and diabetes.
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