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Development of method to detect thermal denaturation induced by ultrasound using acoustic cavitation signals

Research Project

Project/Area Number 19K20725
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Takagi Ryo  国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (20771885)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords超音波治療 / 超音波診断 / 音響キャビテーション / 圧電 / 生体ファントム / 強力集束超音波治療 / キャビテーション
Outline of Research at the Start

本研究では,キャビテーション気泡からの超音波反射信号の情報を積極的に解析し,組織変性検出に活用する.組織の弾性や粘性の違いによって,音響キャビテーション気泡の挙動・振動が変化し,その結果,超音波照射時に,そこから反射される超音波信号がどのように変化するか,ということを数値計算や実験で調べるために,新たな数値計算コードや実験系も創造する必要がある.本技術を確立することで,キャビテーション気泡が生じて,かつ,治療領域が生じている領域や,キャビテーション気泡は生じているが,加熱凝固には至ってない領域を検出できる可能性があり,超音波治療時の治療情報の分解能を向上させることができると考えられる.

Outline of Final Research Achievements

This research was conducted to improve the accuracy of an ultrasound diagnosis technique to support the ultrasound treatment, which is not widely used in Japan. It is generally difficult to detect the ultrasound-treated region where there are cavitation (boiling at room temperature) bubbles using the diagnostic ultrasound. In this study, the new ultrasound diagnosis technique was developed to noninvasively detect the ultrasound-treated area even if there are cavitation bubbles in the tissue during ultrasound treatment. The accuracy of an ultrasound diagnosis could be better than a conventional method by using our technique which is focused on the reflected ultrasound signals from the cavitation bubbles.

Academic Significance and Societal Importance of the Research Achievements

本研究は、これまで解明されていなかった、超音波治療部位に生じた、たんぱく変性、キャビテーション気泡生成と診断用超音波信号変化の関係を明らかにした点で、学術的意義がある。その関係から、超音波治療における、超音波診断技術の精度を向上させることができた点で、超音波診断における新しい技術の創生と現状の超音波治療機器の普及拡大の観点から社会的意義があると考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Products Report
  • Research Products

    (19 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Patent(Industrial Property Rights) (7 results) (of which Overseas: 2 results)

  • [Journal Article] Investigation of feasibility of noise suppression method for cavitation-enhanced high-intensity focused ultrasound treatment2021

    • Author(s)
      Takagi Ryo、Koseki Yoshihiko、Yoshizawa Shin、Umemura Shin-ichiro
    • Journal Title

      Ultrasonics

      Volume: 114 Pages: 106394-106394

    • DOI

      10.1016/j.ultras.2021.106394

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The feasibility of a noise elimination method using continuous wave response of therapeutic ultrasound signals for ultrasonic monitoring of high-intensity focused ultrasound treatment2021

    • Author(s)
      Takagi Ryo、Washio Toshikatsu、Koseki Yoshihiko
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 48 Issue: 2 Pages: 123-135

    • DOI

      10.1007/s10396-021-01083-5

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A visualization method for a wide range of rising temperature induced by high-intensity focused ultrasound using a tissue-mimicking phantom2021

    • Author(s)
      Takagi Ryo、Yoshinaka Kiyoshi、Washio Toshikatsu、Koseki Yoshihiko
    • Journal Title

      International Journal of Hyperthermia

      Volume: 39 Issue: 1 Pages: 22-33

    • DOI

      10.1080/02656736.2021.2012603

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a High-intensity Focused Ultrasound Exposure Device for Reducing Skin Burn Risk2020

    • Author(s)
      NISHII Shogo、SEO Kohei、IZDEBSKI Aleksander Tatsuya、KUSHIMA Miki、TAKAGI Ryo、YOSHIZAWA Shin、UMEMURA Shin-ichiro、ICHIZUKA Kiyotake、SEKIZAWA Akihiko
    • Journal Title

      The Showa University Journal of Medical Sciences

      Volume: 32 Issue: 1 Pages: 1-9

    • DOI

      10.15369/sujms.32.1

    • NAID

      130007837745

    • ISSN
      0915-6380, 2185-0968
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Visualization Method for Wide Range of Temperature Rise Induced by High Intensity Focused Ultrasound Using Tissue-mimicking Phantom2019

    • Author(s)
      Yushi Nakamura, Kiyoshi Yoshinaka, and Ryo Takagi
    • Journal Title

      Proc. of The 40th Symposium on Ultrasonic Electronics

      Volume: 40

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 深層学習を用いた 強力集束超音波治療時における 超音波診断画像のノイズ抑制技術2022

    • Author(s)
      高木亮, 小関義彦
    • Organizer
      日本音響学会2022年春季研究発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Visualization method for wide range of temperature distribution to evaluate therapeutic ultrasound devices2021

    • Author(s)
      高木亮, 葭仲潔, 中村裕志
    • Organizer
      The 20th annual international symposium for therapeutic ultrasound (ISTU2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 治療デバイス評価のための広帯域温度可視化用生体模擬ファントムの開発2021

    • Author(s)
      高木亮, 葭仲 潔, 小関義彦
    • Organizer
      日本ハイパーサーミア学会第38回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Noise Suppression Technique Using Deep Learning for Ultrasound Images During Ultrasound-guided High Intensity Focused Ultrasound Treatment2021

    • Author(s)
      高木亮, 小関義彦
    • Organizer
      The 42nd Symposium on UltraSonic Electronics(USE2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波治療デバイス評価のための広範囲温度分布可視化範囲拡大手法の開発2020

    • Author(s)
      高木亮, 葭仲潔, 中村裕志
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 強力集束超音波治療デバイス評価のための生体模擬ファントムを用いた温度上昇可視化範囲拡大手法の開発2019

    • Author(s)
      高木亮 葭仲潔 中村裕志
    • Organizer
      第18回日本超音波治療研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] Development of Visualization Method for Wide Range of Temperature Rise Induced by High Intensity Focused Ultrasound Using Tissue-mimicking Phantom2019

    • Author(s)
      中村裕志 葭仲潔 高木亮
    • Organizer
      The 40th Symposium on UltraSonic Electronics(USE2019)
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] 超音波評価装置及び超音波評価方法2024

    • Inventor(s)
      高木 亮
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2024
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 感温ファントム及びこれを用いた超音波評価装置2023

    • Inventor(s)
      高木 亮、葭 仲潔
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2023
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 感温ファントム及びこれを用いた超音波評価装置2022

    • Inventor(s)
      高木 亮、葭 仲潔
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-551253
    • Filing Date
      2022
    • Related Report
      Products Report
  • [Patent(Industrial Property Rights)] 温度上昇評価装置2021

    • Inventor(s)
      高木亮、乾康二
    • Industrial Property Rights Holder
      産業技術総合研究所、大塚メディカルデバイス
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-077837
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 超音波評価装置及び超音波評価方法2020

    • Inventor(s)
      高木亮
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-132362
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 感温ファントム及びこれを用いた超音波評価装置2020

    • Inventor(s)
      高木亮、葭仲潔
    • Industrial Property Rights Holder
      国立研究開発法人産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 感温ファントム及びこれを用いた超音波評価装置2019

    • Inventor(s)
      高木亮
    • Industrial Property Rights Holder
      国立研究開発法人 産業技術総合研究所
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-183644
    • Filing Date
      2019
    • Acquisition Date
      2019
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-03-27  

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