Elucidating the physiology of nesfatin-1-expressing neurons in feeding suppression in rats
Project/Area Number |
19K21248
|
Project/Area Number (Other) |
18H06133 (2018)
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Multi-year Fund (2019) Single-year Grants (2018) |
Review Section |
0802:Biomedical structure and function and related fields
|
Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
SAITO Reiko 産業医科大学, 医学部, 助教 (80525353)
|
Project Period (FY) |
2018-08-24 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Nesfatin-1 / 摂食行動 / nesfatin-1 / kisspeptin |
Outline of Research at the Start |
nesfatin-1は摂食抑制作用をもつペプチドである。このペプチドと他の摂食抑制効果のある物質との関連性を検討した。キスぺプチンにも摂食を抑制する効果があるが、キスぺプチンの摂食抑制の脳内の経路の一部にnesfatin-1が関連することを確認した。その他の物質とnesfatin-1の関連を今後検討することにより、nesfatin-1が新たな抗肥満治療につながることが期待される。
|
Outline of Final Research Achievements |
The anorectic neuropeptide nesfatin-1 directly activates oxytocin neurons in the hypothalamus, a feeding control center in the brain. This discovery has revealed a potential pathway involved in feeding suppression. Nesfatin-1-expressing neurons are widely distributed in the central nervous system, but their physiological properties are currently unknown. In this study, we found that nesfatin-1-expressing neurons in the rat hypothalamus were activated by the administration of anorectic peptide. This feeding suppressant effect was significantly attenuated by nesfatin-1 antisense. These results suggest that nesfatin-1 may be involved in the regulation of feeding suppression in rats.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究において、摂食抑制効果のある物質の抑制経路に、Nesfatin-1が関連していることが明らかとなった。Nesfatin-1はレプチン抵抗性を示す肥満患者においてもその摂食抑制作用を発揮するため、Nesfatin-1の摂食調節における役割を明らかにすることにより、新たな肥満治療につながる可能性があり、今後の摂食経路および肥満治療の開発のために意義深い結果であると考える。
|
Report
(3 results)
Research Products
(2 results)
-
[Journal Article] Expression of hypothalamic feeding-related peptide genes and neuroendocrine responses in an experimental allergic encephalomyelitis rat model.2020
Author(s)
Tanaka K, Saito R, Sanada K, Nishimura H, Nishimura K, Sonoda S, Ueno H, Motojima Y, Matsuura T, Yoshimura M, Maruyama T, Onaka T, Yamamoto Y, Kusuhara K, Ueta Y.
-
Journal Title
Peptides
Volume: -
Pages: 170313-170313
DOI
Related Report
Peer Reviewed / Open Access
-