| Project/Area Number |
19K21316
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| Project/Area Number (Other) |
18H06213 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0902:General internal medicine and related fields
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | microRNA / 細胞老化 / 認知機能障害 / 老化 / 血液脳関門 / 脳血管内皮細胞 / アストロサイト |
|---|
| Outline of Research at the Start |
mRNAの翻訳抑制や分解を引き起こすmicroRNAに着目して、細胞の老化・劣化のメカニズムを探索し、細胞にその劣化因子を導入して逆に加齢させることで、均質な加齢性細胞を作成し、血液脳関門を模倣したin vitroモデル等を構築することにより、認知症等におけるドラッグスクリーニングや創薬化につながる研究計画である。
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| Outline of Final Research Achievements |
We identified microRNAs which are associated with cellular senescence in the brain. Over-/under-expressing these microRNAs in a specific combination, cells are aged quickly. This result leads to the future applications for the basic in vitro research of aging, which is a major key factor of dementia. Since hearing impairment has been paid attention as one of the mid-life risk factors for dementia, we also focused on the research of hearing impairment. We newly identified that low platelets are a novel risk factor for hearing loss development. Suppressing the onset of hearing loss by interventions to low platelets may contribute to the risk reduction of dementia development. This is a new achievement which can lead to the establishment of new anti-dementia therapy.
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| Academic Significance and Societal Importance of the Research Achievements |
高齢化社会に伴う認知症患者の急増が先進各国を含めて世界的な問題となっている。我が国でも例外ではないが、認知症に対する薬剤開発は思うように進んでおらず、新たな視点での治療法の研究開発に応用可能な技術の基礎的知見を得た。
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