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The effect of low-level laser therapy (LLLT) on bone metabolism in diabetic condition

Research Project

Project/Area Number 19K21392
Project/Area Number (Other) 18H06304 (2018)
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund (2019)
Single-year Grants (2018)
Review Section 0907:Oral science and related fields
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Mikami Risako  東京医科歯科大学, 歯学部附属病院, 特任助教 (30822548)

Project Period (FY) 2018-08-24 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords歯周病 / 糖尿病 / レーザー / low-level laser therapy / LLLT / 骨芽細胞 / 骨代謝
Outline of Research at the Start

近年歯周病と糖尿病の相互関係が数多く報告されており、糖尿病患者に対するより安全な歯周病治療が求められている。我々は低出力レーザー照射(low-level laser therapy: LLLT)が創傷治癒や骨形成を促進することに着目し、LLLTを糖尿病患者の外科的処置へ応用することを着想した。
本研究では、まずin vitroにて高血糖状態における骨芽細胞へLLLTが与える効果を検討した後、糖尿病モデルラットの抜歯窩へLLLTを行い、高血糖下でのLLLTが骨代謝に与える効果を解明する。
本研究により、糖尿病患者における歯科治療の新たな補助療法の開発への寄与を目指す。

Outline of Final Research Achievements

The purpose of this study is to apply low-level laser therapy (LLLT) to dental treatment in patients with diabetes. In this study, we performed in vitro and in vivo experiments to show the effects of diabetes on periodontal tissue was investigated. Experiments using periodontal tissue cells have shown that hyperglycemic conditions significantly suppressed cell proliferation and differentiation. In vivo study have revealed that diabetes delayed wound healing of oral mucosa and inhibits osseointegration of dental implant. In addition, a systematic review and meta-analysis was performed to investigate the effects of LLLT on periodontal treatment, which showed that LLLT suppressed the pain associated with periodontal therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究から、糖尿病による高血糖状態により誘導された酸化ストレスがインプラント治療時の歯槽骨への結合を阻害する可能性が示唆された。このことは糖尿病患者におけるインプラント治療の予後の改善策の開発へつながる可能性がある。その改善策の一つとして、今後LLLTの可能性を検討していく予定である。また、過去の研究のシステマティックレビューを行い、歯周外科治療の際にLLLTを併用することで疼痛を軽減させることが示された。このことはLLLTが歯周外科治療における患者のストレス軽減に大きく寄与することを示唆する内容であり、さらなる臨床応用の広がりが待たれる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Annual Research Report
  • Research Products

    (12 results)

All 2021 2020 2019 2018

All Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association between circulating tumor necrosis factor receptors and oral bacterium in patients receiving hemodialysis: a cross-sectional study2021

    • Author(s)
      Mikami R, Mizutani K, Gohda T, Gotoh H, Matsuyama Y, Aoyama N, Matsuura T, Kido D, Takeda K, Izumi Y, Fujiwara T, Iwata T
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 25 Issue: 1 Pages: 58-65

    • DOI

      10.1007/s10157-020-01952-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel minimally‐invasive approach for metal tattoo removal with Er:YAG laser laser2021

    • Author(s)
      Mikami Risako、Mizutani Koji、Nagai Shigeyuki、Pavlic Verica、Iwata Takanori、Aoki Akira
    • Journal Title

      Journal of Esthetic and Restorative Dentistry

      Volume: - Issue: 4 Pages: 550-559

    • DOI

      10.1111/jerd.12721

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3‐year observation: A prospective cohort study2021

    • Author(s)
      Mizutani Koji、Shioyama Hidehiro、Matsuura Takanori、Mikami Risako、Takeda Kohei、Izumi Yuichi、Aoki Akira、Iwata Takanori
    • Journal Title

      Journal of Periodontology

      Volume: online ahead Issue: 9 Pages: 1262-1273

    • DOI

      10.1002/jper.20-0590

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Patient-reported outcomes of laser-assisted pain control following non-surgical and surgical periodontal therapy: A systematic review and meta-analysis2020

    • Author(s)
      Mikami Risako、Mizutani Koji、Sasaki Yoshiyuki、Iwata Takanori、Aoki Akira
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 9 Pages: e0238659-e0238659

    • DOI

      10.1371/journal.pone.0238659

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 低侵襲の歯周外科治療にEr:YAGレーザーを応用した症例の長期経過2020

    • Author(s)
      水谷 幸嗣, 三上 理沙子, 松浦 孝典, 和泉 雄一, 岩田 隆紀, 青木 章
    • Journal Title

      日本歯科保存学雑誌

      Volume: 63 Pages: 96-104

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低侵襲の歯周外科治療にEr : YAGレーザーを応用した症例の長期経過2020

    • Author(s)
      水谷 幸嗣、三上 理沙子、松浦 孝典、和泉 雄一、岩田 隆紀、青木 章
    • Journal Title

      日本歯科保存学雑誌

      Volume: 63 Pages: 96-104

    • NAID

      130007804979

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Promotion of Tissue Healing and Regeneration with Low-Reactive Level Laser Therapy Using Diode Lasers in Dental Field: Review of Basic and Clinical Research2019

    • Author(s)
      Mikami Risako、Mizutani Koji、Aoki Akira、Noda Masahiro、Ejiri Kenichiro、Izumi Yuichi
    • Journal Title

      Nippon Laser Igakkaishi

      Volume: 40 Issue: 1 Pages: 15-29

    • DOI

      10.2530/jslsm.jslsm-40_0012

    • NAID

      130007636813

    • ISSN
      0288-6200, 1881-1639
    • Year and Date
      2019-04-15
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Periodontal regenerative effect of enamel matrix derivative in diabetes2018

    • Author(s)
      Takeda Kohei、Mizutani Koji、Matsuura Takanori、Kido Daisuke、Mikami Risako、Noda Masahiro、Buranasin Prima、Sasaki Yoshiyuki、Izumi Yuichi
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 11 Pages: e0207201-e0207201

    • DOI

      10.1371/journal.pone.0207201

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 2型糖尿病が歯肉毛細血管に及ぼす影響2020

    • Author(s)
      藤野愛子,武田浩平,水谷幸嗣,三上理沙子,石角 篤,木平成子,竹内俊介,伊藤裕理,岩田隆紀
    • Organizer
      第63回秋季日本歯周病学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 三上理沙子,水谷幸嗣,武田浩平,宮安杏奈,岩田隆紀2020

    • Author(s)
      前歯部の審美不良を伴う広汎型重度慢性歯周炎患者に対して歯周組織再生療法と歯周形成手術を 含む治療を行った一症例
    • Organizer
      第63回秋季日本歯周病学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The impact of diabetes on periodontal parameters in Japanese hemodialysis patients: A cross-sectional study2019

    • Author(s)
      Risako Mikami, Koji Mizutani, Tomohito Gohda, Norio Aoyama, Takanori Matsuura, Daisuke Kido, Hiromichi Gotoh, Yuichi Izumi, Yoshiyuki Sasaki, and Takanori Iwata
    • Organizer
      105th Annual Meeting of the American Academy of Periodontology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 東京医科歯科大学歯学部第5・第6学年の歯周治療臨床実習の現状2018

    • Author(s)
      青木 章,竹内 康雄,秋月 達也,水谷 幸嗣,片桐 さやか,池田 裕一, 前川 祥吾,渡辺 数基,松浦 孝典,大津 杏理,柿﨑 翔,駒崎 利奈, 三上 理沙子,秀島 雅之,二階堂 徹,荒木 孝二,和泉 雄一
    • Organizer
      第61回春季日本歯周病学会
    • Related Report
      2018 Annual Research Report

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Published: 2018-08-27   Modified: 2024-03-26  

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