The relation between hypertension-related cognitive decline and neural insulin signaling
| Project/Area Number |
19K21507
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| Project/Area Number (Other) |
18H06432 (2018)
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund (2019)
Single-year Grants (2018) |
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| Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
Fukui Yusuke 国立研究開発法人国立長寿医療研究センター, 統合加齢神経科学研究部, 研究員 (60824802)
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| Project Period (FY) |
2018-08-24 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 認知機能障害 / 糖尿病 / 高血圧 / 糖代謝 / 認知症 / 糖脂質代謝 / インスリンシグナル / 記憶学習能 / 老化 / インスリン受容体基質 / 代謝 |
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| Outline of Research at the Start |
本研究では、高血圧を伴う糖尿病モデルマウスを用いて、代謝、脳・末梢組織のインスリンシグナルと認知機能の変化について解析する。また、神経変性改善作用を持つ脳IRS2シグナルの欠損が、高血圧および糖尿病により誘導される代謝標的組織のインスリンシグナルおよび認知機能の変化に与える影響について精査し、脳IRS2シグナル、糖脂質代謝、末梢組織のインスリンシグナル、認知機能の関連性について明らかにする。
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| Outline of Final Research Achievements |
Middle-aged type2 diabetes (T2DM) model mice showed increased blood lipid level, cognitive impairment, and changes of glucose metabolism-related signaling factors without Aβ alteration. On the other hand, STZ-induced -type1 diabetes (T1DM) mice also showed cognitive impairment, however, no change of glucose metabolism-related signaling factors and Aβ level was observed. Moreover, middle-aged APPKI mice with increased Aβ level showed change of glucose metabolism-related signaling together with cognitive decline.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、栄養代謝異常を持つ認知機能障害モデルマウスを用いて、脳の糖代謝調節経路および代謝の変化と認知機能の関係について解析したもので学術的・社会的意義が深い。
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] A Unique Case with Oral Dyskinesia, Chorea, Ataxia, and Mild Cognitive Impairment with Caudate Atrophy and Characteristic Brain Calcifications2018
Author(s)
Hishikawa N, Fukui Y, Sato K, Takemoto M, Yamashita T, Ohta Y, Abe K.
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Journal Title
Internal Medicine
Volume: 57
Issue: 16
Pages: 2399-2402
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2018-08-15
Related Report
Peer Reviewed
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[Journal Article] Therapeutic Effects of Pretreatment with Tocovid on Oxidative Stress in Postischemic Mice Brain.2018
Author(s)
Shang J, Yan H, Jiao Y, Ohta Y, Liu X, Li X, Morihara R, Nakano Y, Fukui Y, Shi X, Huang Y, Feng T, Takemoto M, Sato K, Hishikawa N, Yamashita T, Abe K.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 27(8)
Issue: 8
Pages: 2096-2105
DOI
Related Report
Peer Reviewed
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