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A preliminary prospective study to explore blood biomarkers associated with social isolation in middle aged and elderly people

Research Project

Project/Area Number 19K21591
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Studies on the Super-Aging Society
Research InstitutionKyushu University

Principal Investigator

kato takahiro  九州大学, 大学病院, 講師 (70546465)

Co-Investigator(Kenkyū-buntansha) 瀬戸山 大樹  九州大学, 大学病院, 助教 (30550850)
Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords社会的孤立 / ひきこもり / 血液バイオマーカー / 信頼ゲーム / アセチルコリン / ニコチン酸 / 孤独 / 社会的ひきこもり / 孤独死 / 炎症
Outline of Research at the Start

本研究では、中高齢の健常者および中高齢うつ病患者を対象に、前向きパイロット研究として、精神医学的構造化面接、社会的孤立・孤独に関連した心理検査、各種血液検査(炎症系・代謝物など)、PC版「信頼ゲーム」など多軸的データを取得し、相関解析等により、中高齢者における社会的孤立・孤独の病態基盤、特に生物学的基盤を萌芽的に見出し、孤独対策のための将来の国家プロジェクト立案のために必要な基礎データを取得する。

Outline of Final Research Achievements

In this study, we conducted a prospective pilot study to find out the factors related to social isolation in middle-aged and elderly volunteers (mainly healthy people) and middle-aged and elderly depressed patients by obtaining multiaxial data such as psychiatric evaluation, questionnaires related to social isolation and loneliness, blood tests, and PC version of "trust game" and conducting correlation analysis. Due to the COVID-19 pandemic, we had to change some of our protocols to online surveys. We succeeded in preliminary identification of factors related to social isolation, by considering the impact of the COVID-19 pandemic. We hope that our results obtained in this study will shed new lights on planning future national projects to combat social isolation and loneliness.

Academic Significance and Societal Importance of the Research Achievements

社会的孤立は孤独死や社会的ひきこもりなどの社会問題に直結し、喫緊の課題であるが、打開策は見出されていない。本研究では中高齢ボランティア(健常者)および中高齢のうつ病患者を対象に、精神医学的評価、社会的孤立・孤独に関連した検査、血液検査、PC版「信頼ゲーム」など多軸的データを取得し、相関解析等を実施し、中高齢の社会的孤立に関連する因子を探る前向きパイロット研究を実施した。コロナ禍により一部オンライン調査へ変更したが、社会的孤立に関連する因子に関してコロナ禍の影響にも鑑みて予備的同定に成功した。今回の結果が、社会的孤立対策のための将来の国家プロジェクト立案の礎になることが期待される。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (3 results) (of which Invited: 1 results) Book (5 results) Funded Workshop (1 results)

  • [Journal Article] Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation2021

    • Author(s)
      Setoyama Daiki、Yoshino Atsuo、Takamura Masahiro、Okada Go、Iwata Masaaki、Tsunetomi Kyohei、Ohgidani Masahiro、Kuwano Nobuki、Yoshimoto Junichiro、Okamoto Yasumasa、Yamawaki Shigeto、Kanba Shigenobu、Kang Dongchon、Kato Takahiro A.
    • Journal Title

      Journal of Affective Disorders

      Volume: 279 Pages: 20-30

    • DOI

      10.1016/j.jad.2020.09.118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study2021

    • Author(s)
      Kubo Hiroaki、Setoyama Daiki、Watabe Motoki、Ohgidani Masahiro、Hayakawa Kohei、Kuwano Nobuki、Sato-Kasai Mina、Katsuki Ryoko、Kanba Shigenobu、Kang Dongchon、Kato Takahiro A.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 2199-2199

    • DOI

      10.1038/s41598-020-75115-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder2021

    • Author(s)
      Enomoto Shingo、Kato Takahiro A.
    • Journal Title

      Neurochemistry International

      Volume: 142 Pages: 104921-104921

    • DOI

      10.1016/j.neuint.2020.104921

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Internet society, internet addiction, and pathological social withdrawal2020

    • Author(s)
      Kato Takahiro A.、Shinfuku Naotaka、Tateno Masaru
    • Journal Title

      Current Opinion in Psychiatry

      Volume: 33 Issue: 3 Pages: 264-270

    • DOI

      10.1097/yco.0000000000000601

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social withdrawal in major depressive disorder: a case-control study of hikikomori in japan2020

    • Author(s)
      Teo Alan R.、Nelson Sarah、Strange Wynn、Kubo Hiroaki、Katsuki Ryoko、Kurahara Keita、Kanba Shigenobu、Kato Takahiro A.
    • Journal Title

      Journal of Affective Disorders

      Volume: 274 Pages: 1142-1146

    • DOI

      10.1016/j.jad.2020.06.011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autism spectrum conditions in hikikomori : A pilot case?control study2020

    • Author(s)
      Katsuki Ryoko、Tateno Masaru、Kubo Hiroaki、Kurahara Keita、Hayakawa Kohei、Kuwano Nobuki、Kanba Shigenobu、Kato Takahiro A.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 12 Pages: 652-658

    • DOI

      10.1111/pcn.13154

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精神疾患におけるミクログリア活性化制御をターゲットとした創薬への期待2020

    • Author(s)
      加藤隆弘
    • Journal Title

      老年精神医学雑誌

      Volume: 31 Pages: 700-710

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 精神疾患ミクログリア仮説からみた双極性障害とその橋渡し研究2020

    • Author(s)
      加藤隆弘, 扇谷昌宏, 神庭重信
    • Journal Title

      日本臨牀

      Volume: 78 Pages: 1654-1661

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Defining pathological social withdrawal: proposed diagnostic criteria for hikikomori2020

    • Author(s)
      Kato Takahiro A.、Kanba Shigenobu、Teo Alan R.
    • Journal Title

      World Psychiatry

      Volume: 19 Issue: 1 Pages: 116-117

    • DOI

      10.1002/wps.20705

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 連載「精神分析と脳科学が出会ったら?」第2回】現代の多層化・複雑化した脳科学研究と精神分析の居場所2020

    • Author(s)
      加藤隆弘
    • Journal Title

      こころの科学

      Volume: 209 Pages: 128-131

    • Related Report
      2019 Research-status Report
  • [Journal Article] 【精神医学における平成時代の変化と新時代への展望】現代社会における抑うつ症候群としての新型/現代型うつ2020

    • Author(s)
      加藤 隆弘, 香月 亮子
    • Journal Title

      臨床精神医学

      Volume: 49(2) Pages: 219-230

    • Related Report
      2019 Research-status Report
  • [Journal Article] Hikikomori: Multidimensional understanding, assessment and future international perspectives2019

    • Author(s)
      Kato Takahiro A.、Kanba Shigenobu、Teo Alan R.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 73(8) Issue: 8 Pages: 427-440

    • DOI

      10.1111/pcn.12895

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ひきこもり治療にロボットをどう活かすか?ドラえもんがのび太を救う2019

    • Author(s)
      加藤隆弘
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 国際調査で見えてきた「ひきこもり」の課題-なぜひきこもりは日本に多いのか?2019

    • Author(s)
      加藤隆弘
    • Organizer
      熊本学園大学水俣学研究センター 第16期公開講座「『ひきこもり』を知る・考える-『個人の問題』で片づけてしまわないために」
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 発達障害とひきこもり-大学病院ひきこもり外来での取り組み2019

    • Author(s)
      加藤隆弘
    • Organizer
      第7回成人発達障害支援学会
    • Related Report
      2019 Research-status Report
  • [Book] みんなのひきこもり:つながり時代の処世術2020

    • Author(s)
      加藤隆弘
    • Total Pages
      204
    • Publisher
      木立の文庫
    • Related Report
      2020 Annual Research Report
  • [Book] 書評「青年のひきこもり・その後―包括的アセスメントと支援の方法論」(近藤 直司 著2019

    • Author(s)
      加藤隆弘
    • Total Pages
      181
    • Publisher
      岩崎学術出版社
    • Related Report
      2019 Research-status Report
  • [Book] 訳『精神力動的精神医学 第5版』第12章2019

    • Author(s)
      加藤隆弘
    • Total Pages
      544
    • Publisher
      岩崎学術出版社
    • Related Report
      2019 Research-status Report
  • [Book] 訳『精神力動的精神医学 第5版』第13章2019

    • Author(s)
      加藤隆弘
    • Total Pages
      544
    • Publisher
      岩崎学術出版社
    • Related Report
      2019 Research-status Report
  • [Book] ひきこもり 文化横断的討論 引きこもりへの多元的アプローチ2019

    • Author(s)
      加藤隆弘
    • Total Pages
      76
    • Publisher
      岩崎学術出版社
    • Related Report
      2019 Research-status Report
  • [Funded Workshop] Online Symposium of The International Hikikomori Research Consortium2021

    • Related Report
      2020 Annual Research Report

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Published: 2019-07-04   Modified: 2022-01-27  

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