• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Challenge to the creation of sequence polymers with asymmetric multi-centers

Research Project

Project/Area Number 19K22186
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 33:Organic chemistry and related fields
Research InstitutionKyoto University

Principal Investigator

Nagaki Aiichiro  京都大学, 工学研究科, 准教授 (80452275)

Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2021: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2020: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsフローマイクロリアクター / シークエンス高分子 / 連続不斉炭素中心 / マイクロリアクター
Outline of Research at the Start

不斉炭素構築が可能な画期的な手法として、ブリストル大学のAggarwal教授らの研究が挙げられる。キラル有機リチウム中間体からのキラルホウ素アート錯体の形成を鍵とし、立体化学を制御しながらボロン酸エステルのホモロゲーションを行う反応である。しかし、現在、ボロン酸エステルのホモロゲーションに利用されているキラル有機リチウム中間体からのキラルホウ素アート錯体形成は、フラスコを用いて開発されたものである。単一の不斉炭素のキラリティを制御することさえも容易でない中、連続的不斉炭素中心を有するキラルポリマー(オリゴマー)やシークエンスポリマー(オリゴマー)を合成・創生のための手法開発を目指す。

Outline of Final Research Achievements

The purpose of this research is to approach the development of novel polymeric materials having sophisticated functions by using flow microreactors, which imitate the ultimate reaction space, life system. In the life system proteins which have sequential asymmetric carbon centers can be synthesized.
To achieve this purpose, we worked on (1) the generation and reactions of chiral organolithium species having carbamoyl groups, and (2) control of poly-homologetion reactions. After investigation especially for precise control for reaction time and temperatures, we achieved homologation reaction without racemization.

Academic Significance and Societal Importance of the Research Achievements

タンパク質などのシークエンス高分子は、従来の高分子材料では達成不可能な高機能性材料を創出することが可能であるが、これまでその合成は極めて限定的であった。本研究成果は、フローマイクロリアクターによるシークエンス高分子の合成、すなわちこれまで天然でしか達成できないと考えられていた高機能材料の合成が可能であることを示す、極めて意義深いものである。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (95 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (3 results) Journal Article (35 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 35 results,  Open Access: 22 results) Presentation (47 results) (of which Int'l Joint Research: 7 results,  Invited: 47 results) Book (10 results)

  • [Int'l Joint Research] バーリ大学(イタリア)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] バーリ大学(イタリア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] フランス国立科学研究センター/ポワティエ大学(フランス)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Investigation of Parameter Control for Electrocatalytic Semihydrogenation in a Proton-Exchange Membrane Reactor Utilizing Bayesian Optimization2022

    • Author(s)
      Ashikari Yosuke、Tamaki Takashi、Takahashi Yusuke、Yao Yiyue、Atobe Mahito、Nagaki Aiichiro
    • Journal Title

      Frontiers in Chemical Engineering

      Volume: 3 Pages: 819752-819752

    • DOI

      10.3389/fceng.2021.819752

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow grams-per-hour production enabled by hierarchical bimodal porous silica gel supported palladium column reactor having low pressure drop2022

    • Author(s)
      Ashikari Yosuke、Maekawa Kei、Takumi Masahiro、Tomiyasu Noriyuki、Fujita Chiemi、Matsuyama Kiyoshi、Miyamoto Riichi、Bai Hongzhi、Nagaki Aiichiro
    • Journal Title

      Catalysis Today

      Volume: 388-389 Pages: 231-236

    • DOI

      10.1016/j.cattod.2020.07.014

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flash Electrochemical Approach to Carbocations2022

    • Author(s)
      Takumi Masahiro、Sakaue Hodaka、Nagaki Aiichiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 61 Issue: 10

    • DOI

      10.1002/anie.202116177

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flash Synthesis and Continuous Production of C-Arylglycosides in a Flow Electrochemical Reactor2022

    • Author(s)
      Takumi Masahiro、Nagaki Aiichiro
    • Journal Title

      Frontiers in Chemical Engineering

      Volume: 4 Pages: 862766-862766

    • DOI

      10.3389/fceng.2022.862766

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Switchable Chemoselectivity of Reactive Intermediates Formation and Their Direct Use in A Flow Microreactor2021

    • Author(s)
      Ashikari Yosuke、Tamaki Takashi、Kawaguchi Tomoko、Furusawa Mai、Yonekura Yuya、Ishikawa Susumu、Takahashi Yusuke、Aizawa Yoko、Nagaki Aiichiro
    • Journal Title

      Chemistry A European Journal

      Volume: 27 Issue: 65 Pages: 16107-16111

    • DOI

      10.1002/chem.202103183

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stille, Heck, and Sonogashira coupling and hydrogenation catalyzed by porous-silica-gel-supported palladium in batch and flow2021

    • Author(s)
      Ashikari Yosuke、Maekawa Kei、Ishibashi Mai、Fujita Chiemi、Shiosaki Kiyonari、Bai Hongzhi、Matsuyama Kiyoshi、Nagaki Aiichiro
    • Journal Title

      Green Processing and Synthesis

      Volume: 10 Issue: 1 Pages: 722-728

    • DOI

      10.1515/gps-2021-0069

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flash production of organophosphorus compounds in flow2021

    • Author(s)
      Tamaki Takashi、Nagaki Aiichiro
    • Journal Title

      Tetrahedron Letters

      Volume: 81 Pages: 153364-153364

    • DOI

      10.1016/j.tetlet.2021.153364

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flash Chemistry Makes Impossible Organolithium Chemistry Possible2021

    • Author(s)
      Aiichiro Nagaki, Yosuke Ashikari, Masahiro Takumi, Takashi Tamaki
    • Journal Title

      Chemistry Letters

      Volume: 50 Issue: 3 Pages: 485-492

    • DOI

      10.1246/cl.200837

    • NAID

      130007995528

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insight into the Ferrier Rearrangement by Combining Flash Chemistry and Superacids2021

    • Author(s)
      Naresh Bhuma, Ludivine Lebedel, Hiroki Yamashita, Yutaka Shimizu, Zahra Abada, Ana Arda, Jerome Desire, Bastien Michelet, Agnes Martin-Mingot, Ali Abou-Hassan, Masahiro Takumi, Jerome Marrot, Jesus Jimenez-Barbero, Aiichiro Nagaki, Yves Bleriot, Sebastien Thibaudeau
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 4 Pages: 2036-2041

    • DOI

      10.1002/anie.202010175

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Continuous Production Using a T-Shaped Micro/Milli-Reactor for RUCY-Catalyzed Asymmetric Hydrogenation of Acetophenone2020

    • Author(s)
      Yamamoto Tetsuya、Tonomura Osamu、Nagaki Aichiro
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 53 Issue: 2 Pages: 73-77

    • DOI

      10.1252/jcej.19we083

    • NAID

      130007800544

    • ISSN
      0021-9592, 1881-1299
    • Year and Date
      2020-02-20
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Synthetic Approach to Dimetalated Arenes Using Flow Microreactors and the Switchable Application to Chemoselective Cross-Coupling Reactions2020

    • Author(s)
      Yosuke Ashikari, Tomoko Kawaguchi, Kyoko Mandai, Yoko Aizawa, Aiichiro Nagaki
    • Journal Title

      Journal of American Chemical Society

      Volume: 142 Issue: 40 Pages: 17039-17047

    • DOI

      10.1021/jacs.0c06370

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accelerating Heat-Initiated Radical Reactions of Organic Halides with Tin Hydride Using Flow Microreactor Technologies2020

    • Author(s)
      Yiyuan Jiang, Yosuke Ashikari, Kaiteng Guan, Aiichiro Nagaki
    • Journal Title

      Synlett

      Volume: 31 Issue: 19 Pages: 1937-1941

    • DOI

      10.1055/s-0040-1707307

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Trapping of Transient Thienyllithiums Generated by Deprotonation of 2,3- or 2,5-Dibromothiophene in a Flow Microreactor2020

    • Author(s)
      Kentaro Okano, Yoshiki Yamane, Aiichiro Nagaki, Atsunori Mori
    • Journal Title

      Synlett

      Volume: 31 Issue: 19 Pages: 1913-1918

    • DOI

      10.1055/s-0040-1706479

    • NAID

      120006919999

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors2020

    • Author(s)
      Marco Colella, Arianna Tota, Yusuke Takahashi, Ryosuke Higuma, Susumu Ishikawa, Leonardo Degennaro, Renzo Luisi, Aiichiro Nagaki
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 27 Pages: 10924-10928

    • DOI

      10.1002/anie.202003831

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pd catalysts supported on dual-pore monolithic silica beads for chemoselective hydrogenation under batch and flow reaction conditions2020

    • Author(s)
      Yamada Tsuyoshi、Ogawa Aya、Masuda Hayato、Teranishi Wataru、Fujii Akiko、Park Kwihwan、Ashikari Yosuke、Tomiyasu Noriyuki、Ichikawa Tomohiro、Miyamoto Riichi、Bai Hongzhi、Matsuyama Kiyoshi、Nagaki Aiichiro、Sajiki Hironao
    • Journal Title

      Catalysis Science & Technology

      Volume: 10 Issue: 18 Pages: 6359-6367

    • DOI

      10.1039/d0cy01442g

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bromine-Lithium Exchange on a gem-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers2020

    • Author(s)
      Katia Perez, Baptiste Picard, Daniela Vuluga, Fabrice Burel, Rainier Hreiz, Laurent Falk, Jean-Marc Commenge, Aiichiro Nagaki, Jun-ichi Yoshida, Isabelle Chataigner, Jacques Maddaluno, Julien Legros
    • Journal Title

      Organic Process Research & Development

      Volume: 24 Issue: 5 Pages: 787-791

    • DOI

      10.1021/acs.oprd.0c00203

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 時間を空間で制御する高分子合成化学2020

    • Author(s)
      永木愛一郎、高橋裕輔
    • Journal Title

      高分子

      Volume: 69 Pages: 355-358

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki-Miyaura Coupling2020

    • Author(s)
      Takahashi Yusuke、Ashikari Yosuke、Takumi Masahiro、Shimizu Yutaka、Jiang Yiyuan、Higuma Ryosuke、Ishikawa Susumu、Sakaue Hodaka、Shite Ibuki、Maekawa Kei、Aizawa Yoko、Yamashita Hiroki、Yonekura Yuya、Colella Marco、Luisi Renzo、Takegawa Toshihiro、Fujita Chiemi、Nagaki Aiichiro
    • Journal Title

      European Journal of Organic Chemistry

      Volume: 2020 Issue: 5 Pages: 618-622

    • DOI

      10.1002/ejoc.201901729

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tf2O-mediated Reaction of Alkenyl Sulfoxides with Unprotected Anilines in Flow Microreactors2020

    • Author(s)
      Baralle Alexandre、Inukai Tomoaki、Yanagi Tomoyuki、Nogi Keisuke、Osuka Atsuhiro、Nagaki Aiichiro、Yoshida Jun-ichi、Yorimitsu Hideki
    • Journal Title

      Chemistry Letters

      Volume: 49 Issue: 2 Pages: 160-163

    • DOI

      10.1246/cl.190831

    • NAID

      130007795212

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors2020

    • Author(s)
      Ichinari Daisuke、Ashikari Yosuke、Mandai Kyoko、Aizawa Yoko、Yoshida Jun‐ichi、Nagaki Aiichiro
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 59 Issue: 4 Pages: 1567-1571

    • DOI

      10.1002/anie.201912419

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 18O-Labeled chiral compounds enable the facile determination of enantioselectivity by mass spectroscopy2020

    • Author(s)
      Mandai Kyoko、Tsuchihashi Yuta、Ashikari Yosuke、Yoshida Jun-ichi、Nagaki Aiichiro
    • Journal Title

      Tetrahedron Letters

      Volume: 61 Issue: 2 Pages: 151367-151367

    • DOI

      10.1016/j.tetlet.2019.151367

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Flow Technology for the Genesis and Use of (Highly) Reactive Organometallic Reagents2019

    • Author(s)
      Colella Marco、Nagaki Aichiiro、Luisi Renzo
    • Journal Title

      Chemistry A European Journal

      Volume: 26 Issue: 1 Pages: 19-32

    • DOI

      10.1002/chem.201903353

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oxo‐Thiolation of Cationically Polymerizable Alkenes Using Flow Microreactors2019

    • Author(s)
      Ashikari Yosuke、Saito Kodai、Nokami Toshiki、Yoshida Jun‐ichi、Nagaki Aiichiro
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 67 Pages: 15239-15243

    • DOI

      10.1002/chem.201903426

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation and Reaction of Functional Alkyllithiums by Using Microreactors and Their Application to Heterotelechelic Polymer Synthesis2019

    • Author(s)
      Nagaki Aiichiro、Yamashita Hiroki、Tsuchihashi Yuta、Hirose Katsuyuki、Takumi Masahiro、Yoshida Jun‐ichi
    • Journal Title

      Chemistry A European Journal

      Volume: 25 Issue: 60 Pages: 13719-13727

    • DOI

      10.1002/chem.201902867

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent topics of functionalized organolithiums using flow microreactor chemistry2019

    • Author(s)
      Nagaki Aiichiro
    • Journal Title

      Tetrahedron Letters

      Volume: 60 Issue: 32 Pages: 150923-150923

    • DOI

      10.1016/j.tetlet.2019.07.014

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Practical Continuous‐Flow Controlled/Living Anionic Polymerization2019

    • Author(s)
      Nakahara Yuichi、Furusawa Mai、Endo Yuta、Shimazaki Toshiya、Ohtsuka Keita、Takahashi Yusuke、Jiang Yiyuan、Nagaki Aiichiro
    • Journal Title

      Chemical Engineering & Technology

      Volume: 42 Issue: 10 Pages: 2154-2163

    • DOI

      10.1002/ceat.201900160

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anionic Polymerization Using Flow Microreactors2019

    • Author(s)
      Takahashi Yusuke、Nagaki Aiichiro
    • Journal Title

      Molecules

      Volume: 24 Issue: 8 Pages: 1532-1532

    • DOI

      10.3390/molecules24081532

    • NAID

      120006624112

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monolithiation of 5,5′‐Dibromo‐2,2′‐bithiophene Using Flow Microreactors: Mechanistic Implications and Synthetic Applications2019

    • Author(s)
      Nagaki Aiichiro、Jiang Yiyuan、Yamashita Hiroki、Takabayashi Naoshi、Takahashi Yusuke、Yoshida Jun-ichi
    • Journal Title

      Chemical Engineering & Technology

      Volume: 42 Issue: 10 Pages: 2113-2118

    • DOI

      10.1002/ceat.201900057

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Annulative Synthesis of Thiazoles and Oxazoles from Alkenyl Sulfoxides and Nitriles via Additive Pummerer Reaction2019

    • Author(s)
      Hori Mitsuki、Nogi Keisuke、Nagaki Aiichiro、Yorimitsu Hideki
    • Journal Title

      Asian Journal of Organic Chemistry

      Volume: 8 Issue: 7 Pages: 1084-1087

    • DOI

      10.1002/ajoc.201900169

    • NAID

      120006709414

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockage Detection and Diagnosis of Externally Parallelized Monolithic Microreactors2019

    • Author(s)
      Osamu Tonomura, Satoshi Taniguchi, Kazuki Nishi, Aiichiro Nagaki, Jun-ichi Yoshida, Katsuyuki Hirose, Norio Ishizuka and Shinji Hasebe
    • Journal Title

      Catalysts

      Volume: 9 Issue: 4 Pages: 308-319

    • DOI

      10.3390/catal9040308

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suzuki-Miyaura Coupling Using Monolithic Pd Reactors and Scaling-Up by Series Connection of the Reactors2019

    • Author(s)
      Nagaki Aiichiro、Hirose Katsuyuki、Moriwaki Yuya、Takumi Masahiro、Takahashi Yusuke、Mitamura Koji、Matsukawa Kimihiro、Ishizuka Norio、Yoshida Jun-ichi
    • Journal Title

      Catalysts

      Volume: 9 Issue: 3 Pages: 300-300

    • DOI

      10.3390/catal9030300

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 1.Alkyllithiums Bearing Electrophilic Functional Groups: A Flash Chemistry Approach.2019

    • Author(s)
      Nagaki, A.; Yamashita, H.; Hirose, K.; Tsuchihashi, Y.; Yoshida, J.
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 58 Issue: 12 Pages: 40274030-40274030

    • DOI

      10.1002/anie.201814088

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums by Extremely Fast Micromixing2019

    • Author(s)
      Nagaki Aiichiro、Sasatsuki Kengo、Ishiuchi Satoshi、Miuchi Nobuyuki、Takumi Masahiro、Yoshida Jun‐ichi
    • Journal Title

      Chemistry ? A European Journal

      Volume: 25 Issue: 19 Pages: 4946-4950

    • DOI

      10.1002/chem.201900743

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling and Design of a Flow-Microreactor-Based Process for Synthesizing Ionic Liquids2019

    • Author(s)
      Nakahara Yuichi、Metten Bert、Tonomura Osamu、Nagaki Aiichiro、Hasebe Shinji、Yoshida Jun-ichi
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Issue: 4 Pages: 641-647

    • DOI

      10.1021/acs.oprd.8b00436

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Weight Distribution of Polymers Produced by Anionic Polymerization Enables Mixability Evaluation2019

    • Author(s)
      Endo Yuta、Furusawa Mai、Shimazaki Toshiya、Takahashi Yusuke、Nakahara Yuichi、Nagaki Aiichiro
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Issue: 4 Pages: 635-640

    • DOI

      10.1021/acs.oprd.8b00403

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 高速合成化学と有機電解合成への展開について2022

    • Author(s)
      永木愛一郎
    • Organizer
      電気化学会第89大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] マイクロリアクター研究が導く高速合成化学2022

    • Author(s)
      永木愛一郎
    • Organizer
      京都大学SBCセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] バッチ技術では実現できないフローマイクロリアクター反応技術~基本的な考え方から実際の応用例~2022

    • Author(s)
      永木愛一郎
    • Organizer
      TH企画セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] マイクロフロー研究DXが導く合成化学の変革2022

    • Author(s)
      永木愛一郎
    • Organizer
      nanotech2022特別シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Flash synthetic chemistry using flow microreactors2021

    • Author(s)
      永木愛一郎
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロリアクターを用いた水中アミド化による界面活性剤合成2021

    • Author(s)
      永木愛一郎
    • Organizer
      第2回 化粧品開発展大阪アカデミックフォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間を空間で制御する高分子合成化学:アニオン重合制御から生産実証まで2021

    • Author(s)
      永木愛一郎
    • Organizer
      第70回高分子討論会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] バッチ技術では実現できないフローマイクロリアクター反応・生産技術まで~基本的な考え方から実際の応用例~2021

    • Author(s)
      永木愛一郎
    • Organizer
      情報機構オンラインセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 令和2年度のフロー研究の取り組みについて2021

    • Author(s)
      永木愛一郎
    • Organizer
      2020年度マイクロコンソーシアム講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローマイクロ高速合成化学2021

    • Author(s)
      永木愛一郎
    • Organizer
      近畿化学協会合成部会第2回合成フォーラム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] マイクロリアクターの特長を活かした環境調和型の精密高速合成化学2021

    • Author(s)
      永木愛一郎
    • Organizer
      有機合成化学協会2019年度企業冠賞受賞講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローマイクロリアクターを用いた合成化学の基礎と応用2021

    • Author(s)
      永木愛一郎
    • Organizer
      CMCリサーチウェビナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローショッテン・バウマン反応による界面活性剤の高効率合成2021

    • Author(s)
      永木愛一郎
    • Organizer
      第11回化粧品開発展アカデミックフォーラム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 有機合成への応用技術と実用化事例2020

    • Author(s)
      永木愛一郎
    • Organizer
      サイエンス&テクノロジー特別セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 令和2年度までのマイクロ化学研究の活動と取り組みについて2020

    • Author(s)
      永木愛一郎
    • Organizer
      マイクロコンソーシアム講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローマイクロ高速合成化学2020

    • Author(s)
      永木愛一郎
    • Organizer
      第126回創薬科学セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローマイクロ高速合成化学:フッ素化学への展開について2020

    • Author(s)
      永木愛一郎
    • Organizer
      第14回フッ素化学セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フロー合成による精密合成化学の革新2020

    • Author(s)
      永木愛一郎
    • Organizer
      京大テックフォーラム「フロー合成化学とシステム技術」
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローマイクロリアクターを用いた合成化学の基礎と応用2020

    • Author(s)
      永木愛一郎
    • Organizer
      シーエムシーリサーチ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] バッチ技術では実現できないフローマイクロリアクター反応・生産技術まで ~基本的な考え方から実際の応用例~2020

    • Author(s)
      永木愛一郎
    • Organizer
      情報機構セミナーセミナー「バッチ技術では実現できないフローマイクロリアクター反応・生産技術」
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] マイクロ高速合成化学の開拓とその後の展開について2020

    • Author(s)
      永木愛一郎
    • Organizer
      フロー・マイクロ合成研究会第34回公開講演会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローショッテン・バウマン反応による界面活性剤の高効率合成2020

    • Author(s)
      永木愛一郎
    • Organizer
      第1回化粧品開発展アカデミックフォーラム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] マイクロリアクターを用いた超高速反応による精密有機合成化学2020

    • Author(s)
      永木愛一郎
    • Organizer
      フロー精密合成コンソーシアム(FlowST)第13回ワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] マイクロリアクターによるフラスコでは達成不可能な合成化学2020

    • Author(s)
      永木愛一郎
    • Organizer
      京都リサーチパークサイエンスカフェ「ふれデミックカフェ」
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] フローリアクターを用いた合成反応、プロセス設計と応用例2020

    • Author(s)
      永木愛一郎
    • Organizer
      技術情報協会セミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] マイクロフロー合成とプロセスインフォとの融合と展開について2020

    • Author(s)
      永木愛一郎
    • Organizer
      科学技術振興機構(JST)俯瞰ワークショップ
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      International conference and exhibition on Catalysis and Chemical science Madrid
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フロー合成による精密合成化学の革新」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      京大テックフォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「フローマイクロリアクターを用いた精密合成」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      フロー精密合成コンソーシアム(FlowST)ワークショップ
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「令和1年度のマイクロ化学研究の取り組みと今後の展望」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      京都大学マイクロ化学生産研究コンソーシアム、2019 年度マイクロコンソーシアム講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      住友化学特別講演会、住友化学(株)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors and Its Applications to Palladium Catalyzed Crosscoupling」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      5rd International Conference on Catalysis and Chemical Engineering (CCE-2020)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フラスコで不可能なマイクロリアクターを用いた精密合成化学」2020

    • Author(s)
      永木 愛一郎
    • Organizer
      旭化成講演会、旭化成(株)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「"Impossible" Flask Chemistry Based on Flow Microreactor」2020

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      Bari University
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      奈良工業高等専門学校
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「吉田潤一先生とともに築き上げたマイクロ高速合成化学分野とその後の展開について」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      京都大学マイクロ化学生産研究コンソーシアム、2019 年度マイクロコンソーシアム講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「Reaction Selectivity Control by Extremely Fast Micromixing. Synthesis of Functionalized Ketones from Acid Chlorides and Organolithiums」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      3rd International Caparica Christmas Conference on Translational Chemistry (IC3TC2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フローマイクロリアクターを用いた精密合成」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      情報機構
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      環境&資源エネルギー研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「マイクロリアクターを用いた超高速反応による精密有機合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      有機合成化学協会有機合成夏期セミナー
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「Anionic polymerization using flow microreactor systems and its applications to syntheses of structurally well-defined polymers」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      258th ACS National Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「フローリアクターを用いた合成反応、プロセス設計と応用例」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      技術情報協会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「フローマイクロリアクターを用いた超高速反応による精密有機合成」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      第51回構造有機化学若手の会夏の学校
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「Organolithium Chemistry Using Flow Microreactors」2019

    • Author(s)
      Aiichiro Nagaki
    • Organizer
      The 5th Int'l Conference on Organic Chemistry (COC 2019)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「マイクロ合成化学」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      東邦化学講演会、東邦化学工業(株)
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 「有機リチウム反応の高次制御によるクロスカップリング反応プロセスの高度化」2019

    • Author(s)
      永木 愛一郎
    • Organizer
      日本PDA製薬学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] Vol. 1 Flow Chemistry-Fundamentals, 2nd ed.2021

    • Author(s)
      Aiichiro Nagaki, Jun-ichi Yoshida
    • Total Pages
      432
    • Publisher
      Walter de Gruyter & Co.
    • ISBN
      9783110736793
    • Related Report
      2021 Annual Research Report
  • [Book] フローマイクロ合成の最新動向2021

    • Author(s)
      深瀬浩一、永木愛一郎
    • Total Pages
      250
    • Publisher
      シーエムシー出版
    • ISBN
      9784781316154
    • Related Report
      2021 Annual Research Report
  • [Book] マイクロ・ナノ熱工学の進展2021

    • Author(s)
      芦刈洋祐、永木愛一郎
    • Total Pages
      808
    • Publisher
      株式会社エヌ・ティーエス
    • ISBN
      9784860437220
    • Related Report
      2020 Research-status Report
  • [Book] フロー合成、連続生産のプロセス設計、条件設定と応用事例2020

    • Author(s)
      永木愛一郎ほか
    • Total Pages
      599
    • Publisher
      技術情報協会
    • ISBN
      9784861048203
    • Related Report
      2020 Research-status Report
  • [Book] マイクロリアクター/フロー合成による反応条件を最適化した導入と目的に応じた実生産への適用2020

    • Author(s)
      永木愛一郎ほか
    • Total Pages
      270
    • Publisher
      サイエンス&テクノロジー社
    • ISBN
      9784864282116
    • Related Report
      2020 Research-status Report
  • [Book] マイクロチャネル:マイクロ混合・反応「マイクロ・ナノ熱工学の進展」2019

    • Author(s)
      Ashikari, Y.; Nagaki, A.*
    • Total Pages
      696
    • Publisher
      株式会社エヌ・ティー・エス
    • Related Report
      2019 Research-status Report
  • [Book] マイクロリアクターの研究開発状況とその展望 「化学装置」2019

    • Author(s)
      Takumi, M.; Nagaki, A.*
    • Total Pages
      112
    • Publisher
      工業通信
    • Related Report
      2019 Research-status Report
  • [Book] フローマイクロリアクターを用いた有機合成反応の選択性制御 「化学プロセスの設計とスケールアップ、連続化技術」2019

    • Author(s)
      Takahashi, Y.; Nagaki, A.*
    • Total Pages
      696
    • Publisher
      技術情報協会
    • Related Report
      2019 Research-status Report
  • [Book] フローマイクロリアクターを用いた高分子合成反応とその連続運転 「化学プロセスの設計とスケールアップ、連続化技術」2019

    • Author(s)
      Nagaki, A.*; Nakahara, Y.; Endo, Y.
    • Total Pages
      696
    • Publisher
      技術情報協
    • Related Report
      2019 Research-status Report
  • [Book] フローマイクロリアクターを用いた有機合成反応の選択性制御 「フローマイクロ合成の最新動向」2019

    • Author(s)
      Nagaki, A.*; Takumi, M.
    • Total Pages
      111
    • Publisher
      ファインケミカル
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi