• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of novel therapy with small molecule targeting CD200 against pancreatic cancer

Research Project

Project/Area Number 19K22668
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Research InstitutionNara Medical University

Principal Investigator

SHO MASAYUKI  奈良県立医科大学, 医学部, 教授 (50364063)

Co-Investigator(Kenkyū-buntansha) 赤堀 宇広  奈良県立医科大学, 医学部, 学内講師 (10423922)
長井 美奈子  奈良県立医科大学, 医学部, 助教 (80646092)
Project Period (FY) 2019-06-28 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords難治性消化器癌 / 免疫治療 / 治療抵抗性 / 膵癌 / 小分子化合物
Outline of Research at the Start

本研究では,まずCD200を阻害し得る小分子化合物を新たにスクリーニング探索する.当該小分子化合物が見い出すことができれば,様々なin vitroおよびin vivoでの検証からその有用性を検討し,さらにPD-1抗体治療および化学放射線治療との併用によって,既存治療に対する治療抵抗性および抗体治療の限界を克服し,根治を目指した新たな膵癌集学的治療戦略の開発を行う.未だ人類にとっての最難治癌である膵癌に対する治療成績を革新的に進歩させることを目標とする.

Outline of Final Research Achievements

Pancreatic cancer remains to be one of the most intractable cancers. In this study, we aimed to develop novel multidisciplinary treatment to overcome the limitations of current conventional therapy. We have recently found that CD200 may be involved in not only tumor immunity but also treatment resistance. Based on our findings, we tried to explore the small molecule compounds that could block the function of CD200 in tumor environment. Although it is still under investigation, we will continue our research to fully meet the purpose of this research.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的が達成できれば,今日の癌治療における既成概念を転換できる可能性はある.さらに,低コストでの化合物の大量生産が実現すれば,免疫チェックポイント抗体治療において大きな社会問題となっている莫大な医療費問題を解決し得る可能性もあり,医療経済的観点からも研究の意義は大きい.また,人類にとって最難治癌である膵癌での効果が証明できれば,膵癌に留まらず,幅広く,癌治療全体にパラダイムシフトを起こせる可能性もあると考える.

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (5 results)

All 2021 2020

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results)

  • [Journal Article] Clinical Importance of CD200 Expression in Colorectal Liver Metastasis2021

    • Author(s)
      Matsuo Yasuko、Sho Masayuki、Nomi Takeo、Hokuto Daisuke、Yoshikawa Takahiro、Kamitani Naoki、Nakamura Kota、Iwasa Yosuke
    • Journal Title

      Annals of Surgical Oncology

      Volume: XX Issue: 9 Pages: 5362-5372

    • DOI

      10.1245/s10434-020-09471-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of laminin γ2 as a prognostic and predictive biomarker for determining response to gemcitabine-based therapy in pancreatic ductal adenocarcinoma2021

    • Author(s)
      Okada Yasuyuki、Nishiwada Satoshi、Yamamura Kensuke、Sho Masayuki、Baba Hideo、Takayama Tetsuji、Goel Ajay
    • Journal Title

      European Journal of Cancer

      Volume: 146 Pages: 125-134

    • DOI

      10.1016/j.ejca.2020.12.031

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential2021

    • Author(s)
      Nakamura Kota、Sho Masayuki、Akahori Takahiro、Nishiwada Satoshi、Kunishige Tomohiro、Nakagawa Kenji、Nagai Minako、Takagi Tadataka、Terai Taichi、Ikeda Naoya
    • Journal Title

      Pancreatology

      Volume: 21 Issue: 3 Pages: 573-580

    • DOI

      10.1016/j.pan.2021.01.013

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A MicroRNA Signature Identifies Pancreatic Ductal Adenocarcinoma Patients at Risk for Lymph Node Metastases2020

    • Author(s)
      Nishiwada Satoshi、Sho Masayuki、Banwait Jasjit K.、Yamamura Kensuke、Akahori Takahiro、Nakamura Kota、Baba Hideo、Goel Ajay
    • Journal Title

      Gastroenterology

      Volume: 159 Issue: 2 Pages: 562-574

    • DOI

      10.1053/j.gastro.2020.04.057

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of liquid biopsy for surgical management of pancreatic cancer2020

    • Author(s)
      Nagai Minako、Sho Masayuki、Akahori Takahiro、Nakagawa Kenji、Nakamura Kota
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 4 Issue: 3 Pages: 216-223

    • DOI

      10.1002/ags3.12317

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2019-07-04   Modified: 2022-01-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi