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Creation of functional materials for healthcare workers using unique metal nanoparticle synthesis method

Research Project

Project/Area Number 19K22787
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 58:Society medicine, nursing, and related fields
Research InstitutionNational Defense Medical College

Principal Investigator

Nakamura Shingo  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 防衛医学研究センター 医療工学研究部門, 教授 (00505323)

Co-Investigator(Kenkyū-buntansha) 佐藤 正宏  国立研究開発法人国立成育医療研究センター, ゲノム医療研究部, 共同研究員 (30287099)
Project Period (FY) 2019-06-28 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords銀ナノ粒子 / 殺菌活性 / 紫外線照射 / ラジカル / 金属ナノ粒子 / 抗菌性 / 光照射 / 殺菌効果 / 化学物質分解効果
Outline of Research at the Start

我々は粒径制御能力に秀でた簡便な銀ナノ粒子合成法を確立している。一般的な銀ナノ粒子には抗菌性等の性質が備わっていることが良く知られている。我々の作り出した銀ナノ粒子についても、その特徴は備わっていることを既に確認出来ている。そして最近になり、この銀ナノ粒子は光照射というきっかけが与えられることで、ラジカルを放出することがわかった。ラジカルはその種類によっては優れた殺菌効果等を生み出す。本研究では我々の得ているこの様な知見を活用しながら、優れた殺菌効果等を有した複合材料を作り出し、これを深化させて医療従事者用の機能性材料の創製を目指す。

Outline of Final Research Achievements

Silver nanoparticle (AgNP) have been shown to have bactericidal action and virus inactivation effect. In this study, we demonstrated that UV irradiation of AgNP is effective at enhancing bactericidal activity. This bactericidal effect is attributable to the UV irradiation-mediated enhanced production of highly reactive hydroxyl radicals generated from AgNP. Hydroxyl radicals, renowned as powerful oxidizing agents, are likely to be effective against viruses, bacteria, and in the degradation of chemicals. Although biosafety issues and environmental safety concerns related to AgNP, which are often been a subject for discussion, need to be carefully addressed, this system is expected to be useful in protecting healthcare workers from infection with pathogens.

Academic Significance and Societal Importance of the Research Achievements

本研究の最大の成果は、銀ナノ粒子(AgNP)への紫外線照射がラジカルを発生させ、殺菌活性が高まることを実証した点に集約される。本研究ではハンディタイプの簡易型紫外線ランプを使用しており、その汎用性も高い。紫外線の波長もUVA帯域であり、一般的な殺菌目的で使用されるUVC帯域と比べて安全性が高い。本研究成果の活用は、例えば、医療従事者が防護服の脱衣時において病原因子へ誤接触してしまっても、その因子は既に不活化されているために感染をしなくてもすむといったような、新たな感染防護システムの構築につながると期待できる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (21 results)

All 2021 2020 2019

All Journal Article (18 results) (of which Peer Reviewed: 16 results,  Open Access: 14 results) Presentation (3 results)

  • [Journal Article] Efficacy of Bioshell Calcium Oxide Water as Disinfectants to Enable Face Mask Reuse2021

    • Author(s)
      HIRUMA SUMIYO、HATA YUUKI、ISHIHARA MASAYUKI、TAKAYAMA TOMOHIRO、NAKAMURA SHINGO、ANDO NAOKO、FUKUDA KOICHI、SATO YOKO、MURAKAMI KAORU、YOKOE HIDETAKA
    • Journal Title

      Biocontrol Science

      Volume: 26 Issue: 1 Pages: 27-35

    • DOI

      10.4265/bio.26.27

    • NAID

      130007997360

    • ISSN
      1342-4815, 1884-0205
    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Progress in the Development of Disinfectants from Scallop Shell-Derived Calcium Oxide for Clinical and Daily Use2021

    • Author(s)
      HATA YUUKI、ISHIHARA MASAYUKI、HIRUMA SUMIYO、TAKAYAMA TOMOHIRO、NAKAMURA SHINGO、ANDO NAOKO
    • Journal Title

      Biocontrol Science

      Volume: 26 Issue: 3 Pages: 129-135

    • DOI

      10.4265/bio.26.129

    • NAID

      130008091315

    • ISSN
      1342-4815, 1884-0205
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 次亜塩素酸水およびエタノールと比較検討した貝殻焼成酸化カルシウム水の多目的な環境表面用洗浄・除菌剤としての有効性2021

    • Author(s)
      石原雅之、比留間寿美代、秦裕樹、中村伸吾、金山敦宏、加來浩器
    • Journal Title

      日本環境感染学会誌

      Volume: 36 Pages: 292-298

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホタテ貝殻焼成酸化カルシウムの殺菌・消毒剤としての有用性と安全性2021

    • Author(s)
      福田孝一、秦裕樹、比留間寿美代、高山智宏、安藤尚子、石原雅之、中村伸吾
    • Journal Title

      日本防菌防黴学会誌

      Volume: 49 Pages: 405-411

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultraviolet irradiation enhances the microbicidal activity of silver nanoparticles by hydroxyl radicals2020

    • Author(s)
      Nakamura S, Ando N, Sato M, Ishihara M
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 9 Pages: 3204-3204

    • DOI

      10.3390/ijms21093204

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioshell Calcium Oxide (BiSCaO) Ointment for the Disinfection and Healing of Pseudomonas aeruginosa-Infected Wounds in Hairless Rats2020

    • Author(s)
      Takayama Tomohiro、Ishihara Masayuki、Nakamura Shingo、Sato Yoko、Hiruma Sumiyo、Fukuda Koichi、Murakami Kaoru、Yokoe Hidetaka
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 11 Pages: 4176-4176

    • DOI

      10.3390/ijms21114176

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioshell calcium oxide (BiSCaO) for cleansing and healing Pseudomonas aeruginosa?infected wounds in hairless rats2020

    • Author(s)
      Takayama Tomohiro、Ishihara Masayuki、Sato Yoko、Nakamura Shingo、Fukuda Koichi、Murakami Kaoru、Yokoe Hidetaka
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 31 Issue: 2 Pages: 95-105

    • DOI

      10.3233/bme-201082

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concentrated Bioshell Calcium Oxide (BiSCaO) Water Kills Pathogenic Microbes: Characterization and Activity2020

    • Author(s)
      Nakamura Shingo、Ishihara Masayuki、Sato Yoko、Takayama Tomohiro、Hiruma Sumiyo、Ando Naoko、Fukuda Koichi、Murakami Kaoru、Yokoe Hidetaka
    • Journal Title

      Molecules

      Volume: 25 Issue: 13 Pages: 3001-3001

    • DOI

      10.3390/molecules25133001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioshell Calcium Oxide-Containing Liquids as a Sanitizer for the Reduction of Histamine Production in Raw Japanese Pilchard, Japanese Horse Mackerel, and Chub Mackerel2020

    • Author(s)
      Hiruma Sumiyo、Ishihara Masayuki、Nakamura Shingo、Sato Yoko、Asahina Haruka、Fukuda Koichi、Takayama Tomohiro、Murakami Kaoru、Yokoe Hidetaka
    • Journal Title

      Foods

      Volume: 9 Issue: 7 Pages: 964-964

    • DOI

      10.3390/foods9070964

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety of Concentrated Bioshell Calcium Oxide Water Application for Surface and Skin Disinfections against Pathogenic Microbes2020

    • Author(s)
      Ishihara Masayuki、Hata Yuuki、Hiruma Sumiyo、Takayama Tomohiro、Nakamura Shingo、Sato Yoko、Ando Naoko、Fukuda Koichi、Murakami Kaoru、Yokoe Hidetaka
    • Journal Title

      Molecules

      Volume: 25 Issue: 19 Pages: 4502-4502

    • DOI

      10.3390/molecules25194502

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioshell Calcium Oxide Water.2020

    • Author(s)
      Nakamura Shingo
    • Journal Title

      Encyclopedia

      Volume: 2290 Pages: 1-3

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Silver Nanoparticles as Anti-Infectious Regents2020

    • Author(s)
      Nakamura Shingo
    • Journal Title

      Encyclopedia

      Volume: 2295 Pages: 1-3

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Skin Cleansing Technique with Disinfectant using Improved High-Velocity Steam-Air Micromist Jet Spray2020

    • Author(s)
      Fukuda K, Sato Y, Ishihara M, Nakamura S, Takayama T, Murakami K, Fujita M, Yokoe H.
    • Journal Title

      Biocontrol Science

      Volume: 25 Issue: 1 Pages: 35-39

    • DOI

      10.4265/bio.25.35

    • NAID

      130007808912

    • ISSN
      1342-4815, 1884-0205
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Healing of Pseudomonas aeruginosa-infected wounds in diabetic db/db mice by weakly acidic hypochlorous acid cleansing and silver nanoparticle/chitin-nanofiber sheet covering.2020

    • Author(s)
      Kuwabara M, Sato Y, Ishihara M, Takayama T, Nakamura S, Fukuda K, Murakami K, Yokoe H, Kiyosawa T.
    • Journal Title

      Wound Medicine

      Volume: 28 Pages: 100183-100183

    • DOI

      10.1016/j.wndm.2020.100183

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and Application of Silver Nanoparticles (Ag NPs) for the Prevention of Infection in Healthcare Workers2019

    • Author(s)
      Nakamura Shingo、Sato Masahiro、Sato Yoko、Ando Naoko、Takayama Tomohiro、Fujita Masanori、Ishihara Masayuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 15 Pages: 3620-3620

    • DOI

      10.3390/ijms20153620

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Various Disinfectants on Bactericidal Activity Under Organic Matter Contaminated Environments2019

    • Author(s)
      Sato Y, Ishihara M, Nakamura S, Fukuda K, Kuwabara M, Takayama T, Hiruma S, Murakami K, Fujita M, Yokoe H.
    • Journal Title

      Biocontrol Science

      Volume: 24 Issue: 2 Pages: 103-108

    • DOI

      10.4265/bio.24.103

    • NAID

      130007664017

    • ISSN
      1342-4815, 1884-0205
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preparation and Application of Bioshell Calcium Oxide (BiSCaO) Nanoparticle-Dispersions with Bactericidal Activity.2019

    • Author(s)
      Sato Y, Ishihara M, Nakamura S, Fukuda K, Takayama T, Hiruma S, Murakami K, Fujita M, Yokoe H.
    • Journal Title

      Molecules

      Volume: 24 Issue: 18 Pages: 3415-3415

    • DOI

      10.3390/molecules24183415

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of Colloidal Dispersions of Bioshell Calcium Oxide (BiSCaO) for Disinfection.2019

    • Author(s)
      Sato Y, Ohata H, Inoue A, Ishihara M, Nakamura S, Fukuda K, Takayama T, Murakami K, Hiruma S, Yokoe H.
    • Journal Title

      Polymers

      Volume: 11 Issue: 12 Pages: 1991-1991

    • DOI

      10.3390/polym11121991

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 貝殻由来酸化カルシウム水溶液によるマスクの除菌と再利用可能性2021

    • Author(s)
      秦裕樹、石原雅之、福田孝一、高山智宏、比留間寿美代、安藤尚子、村上馨、横江秀隆、中村伸吾
    • Organizer
      日本防菌防黴学会 第48回年次大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ホタテ貝殻焼成酸化カルシウム懸濁液の分散化手法の検討および抗菌活性の検討.2019

    • Author(s)
      佐藤洋子, 中村伸吾, 高山智宏, 比留間寿美代, 安藤尚子, 福田孝一, 藤田真敬, 石原雅之.
    • Organizer
      日本防菌防黴学会第46回年次大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 難治性創傷に対するホタテ貝殻焼成酸化カルシウムの効果.2019

    • Author(s)
      高山智宏, 佐藤洋子, 中村伸吾, 比留間寿美代, 安藤尚子, 福田孝一, 藤田真敬, 村上馨, 横江秀隆, 石原雅之.
    • Organizer
      日本防菌防黴学会第46回年次大会
    • Related Report
      2019 Research-status Report

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Published: 2019-07-04   Modified: 2023-01-30  

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