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Development of taste rehabilitation method by sensory memory rehearsal focusing on plasticity of insular cortex

Research Project

Project/Area Number 19K22821
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionTohoku University (2022)
Toho University (2019-2021)

Principal Investigator

Ebihara Satoru  東北大学, 医学系研究科, 教授 (90323013)

Project Period (FY) 2019-06-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords味覚障害 / リハビリテーション / 4味 / 味覚 / 4味 / 想起 / 嚥下 / 味覚閾値 / 舌圧 / 口腔乾燥 / リハーサル
Outline of Research at the Start

高齢化とともに急増している味覚障害は、食欲不振による栄養摂取低下からサルコペニア・フレイルをまねき高齢者の生命を脅かす。この多くは原因不明の特発性である。特発性味覚障害に対してこれまで全く試みられることのなかったリハビリテーションの手法(摂食嚥下リハビリテーションと高次脳機能神経心理訓練)を応用し、有効な治療法を開発することが本研究の目的である。これまでの医学ではほとんど捨て置かれてきた原因不明の味覚障害(特発性味覚障害)の治療を、感覚生理学の知識を基盤に神経心理学の手法を使い、リハビリテーション医療という実学のなかで結実させようとする点で新規性が高い。

Outline of Final Research Achievements

The number of patients with symptoms of dysgeusia has increased with aging, but no clear treatment for dysgeusia has been established. Therefore, we developed a taste rehabilitation method as a new treatment for taste disorders. The taste rehabilitation method is a rehabilitation method based on memorizing the taste around the taste threshold of the person by the filter paper disc method. When the effect was verified in healthy subjects, the rehab group showed a dominant increase in taste sensitivity for all four basic tastes of sweet, salty, sour, and bitter. Based on the above, the taste rehabilitation method developed this time can improve taste sensitivity, and is expected to be one of the treatments for taste disorders.

Academic Significance and Societal Importance of the Research Achievements

近年、高齢化とともに味覚障害患者が増加していることに加え、COVID-19感染後に味覚障害が残存する患者が報告され、味覚障害はこれまでにない大きな社会問題になっている。しかし、多くの味覚障害はその発生機序が不明であり、味覚障害に対する明確な治療法は存在していないのが現状である。そのため味覚障害に長的に悩む患者の急激な増加が危惧される。本研究で、私たちが開発した味覚リハビリテーション法が味覚感受性を改善させる可能性があることがわかった。今後、味覚障害患者に対する新たな治療法の一つとして、味覚リハビリテーション法が確立することが期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (26 results)

All 2022 2021 2020 2019 Other

All Journal Article (20 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 20 results,  Open Access: 10 results) Presentation (4 results) (of which Invited: 4 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Noise pareidolia test for predicting delirium in hospitalized older patients with cognitive decline2022

    • Author(s)
      橋本 裕
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 22 Issue: 10 Pages: 883-888

    • DOI

      10.1111/ggi.14477

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improving taste sensitivity in healthy adults using taste recall training: a randomized controlled trial2022

    • Author(s)
      Otsubo Yuta、Miyagi Midori、Sekiya Hideki、Kano Osamu、Ebihara Satoru
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 13849-13849

    • DOI

      10.1038/s41598-022-18255-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] L-menthol administration facilitates breathing comfort during exhaustive endurance running and improves running capacity in well-trained runners: A randomized crossover study2022

    • Author(s)
      Tsutsumi Yoshiko、Momma Haruki、Ebihara Satoru、Nagatomi Ryoichi
    • Journal Title

      European Journal of Sport Science

      Volume: 1 Issue: 9 Pages: 1-9

    • DOI

      10.1080/17461391.2022.2115404

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limitations of a 6-min walk test to assess the efficacy of menthol for breathlessness2022

    • Author(s)
      Kanezaki Masashi、Ebihara Satoru
    • Journal Title

      ERJ Open Research

      Volume: 8 Issue: 2 Pages: 00090-2022

    • DOI

      10.1183/23120541.00090-2022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Similarities, differences and overlaps between frailty and Parkinson's disease2022

    • Author(s)
      Ebina Junya、Ebihara Satoru、Kano Osamu
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 22 Issue: 4 Pages: 259-270

    • DOI

      10.1111/ggi.14362

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Are Oropharyngeal Dysphagia Screening Tests Effective in Preventing Pneumonia?2022

    • Author(s)
      Okuni Ikuko、Ebihara Satoru
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 2 Pages: 370-370

    • DOI

      10.3390/jcm11020370

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intensive olfactory training and emotional memory in patients with dementia2022

    • Author(s)
      Okuni Ikuko、Ebihara Satoru
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 22 Issue: 2 Pages: 185-186

    • DOI

      10.1111/ggi.14344

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aspiration Pneumonia: A Key Concept in Pneumonia Treatment2021

    • Author(s)
      Ebihara Satoru、Miyagi Midori、Otsubo Yuta、Sekiya Hideki、Ebihara Takae
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 9 Pages: 1329-1330

    • DOI

      10.2169/internalmedicine.6576-20

    • NAID

      130008033328

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and Neural Mechanism of Dysphagia Due to Cancer2021

    • Author(s)
      Okuni Ikuko、Otsubo Yuta、Ebihara Satoru
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 13 Pages: 7033-7033

    • DOI

      10.3390/ijms22137033

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of physical therapists and aromatherapy for fall prevention in older people: A narrative review2021

    • Author(s)
      Ebihara Satoru、Otsubo Yuta、Miyagi Midori
    • Journal Title

      Geriatrics and Gerontology International

      Volume: 21 Issue: 6 Pages: 445-450

    • DOI

      10.1111/ggi.14165

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medical aromatherapy in geriatric syndrome2021

    • Author(s)
      Ebihara Takae、Yamasaki Miyako、Kozaki Koichi、Ebihara Satoru
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 21 Issue: 5 Pages: 377-385

    • DOI

      10.1111/ggi.14157

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of preoperative cervical alignment on postoperative dysphagia after occipitocervical fusion2021

    • Author(s)
      Midori Miyagi, Hiroshi Takahashi, Hideki Sekiya, Satoru Ebihara
    • Journal Title

      Surgical Neurology International

      Volume: 12(350) Pages: 1-6

    • DOI

      10.25259/sni_547_2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Appendicular Skeletal Muscle Mass Correlates with Patient-Reported Outcomes and Physical Performance in Patients with Idiopathic Pulmonary Fibrosis2021

    • Author(s)
      Ebihara Kento、Iwanami Yuji、Yamasaki Keiko、Takemura Ayame、Sato Naofumi、Usui Yusuke、Nakamura Yasuhiko、Kishi Kazuma、Homma Sakae、Ebihara Satoru
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 253 Issue: 1 Pages: 61-68

    • DOI

      10.1620/tjem.253.61

    • NAID

      130007971529

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Geriatric nutritional risk index and 100‐m walk achievement predict discharge to home in elderly patients with heart failure2020

    • Author(s)
      Shimoyama Shota、Ono Tsuyoshi、Ebihara Satoru
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 20 Issue: 11 Pages: 1029-1035

    • DOI

      10.1111/ggi.14014

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of Olfactory Stimulation by L-Menthol on Laboratory-Induced Dyspnea in COPD2020

    • Author(s)
      Kanezaki Masashi、Terada Kunihiko、Ebihara Satoru
    • Journal Title

      Chest

      Volume: in press Issue: 6 Pages: 1455-1465

    • DOI

      10.1016/j.chest.2019.12.028

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of O-C2 angle in the development of dysphagia in patients with halo-vest fixation2020

    • Author(s)
      Miyagi Midori、Takahashi Hiroshi、Tsuchiya Kazuaki、Sekiya Hideki、Ebihara Satoru
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 21 Issue: 1 Pages: 131-131

    • DOI

      10.1186/s12891-020-3155-2

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 2.Association between sarcopenia and pneumonia in older people.2020

    • Author(s)
      Okazaki T, Ebihara S, Mori T, Izumi S, Ebihara T.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 20(1) Issue: 1 Pages: 7-13

    • DOI

      10.1111/ggi.13839

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cough reflex sensitivity and urge-to-cough deterioration in dementia with Lewy bodies.2019

    • Author(s)
      Takae Ebihara, Peijung Gui, Chika Ooyama, Koichi Kozaki, Satoru Ebihara
    • Journal Title

      European Respiratory Journal Open Research

      Volume: 6 Issue: 1 Pages: 00108-2019

    • DOI

      10.1183/23120541.00108-2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of facial skin cooling induced by a handheld fan on the cough reflex threshold and urge to cough induced by citric acid2019

    • Author(s)
      Kanezaki Masashi、Ebihara Satoru
    • Journal Title

      ERJ Open Research

      Volume: 5 Issue: 4 Pages: 00089-2019

    • DOI

      10.1183/23120541.00089-2019

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alleviation of Dyspnea Sensation by Phototherapy in Healthy Adults2019

    • Author(s)
      Izukura Hideaki、Kanezaki Masashi、Ebihara Satoru
    • Journal Title

      Respiratory Care

      Volume: 64 Issue: 9 Pages: 1082-1087

    • DOI

      10.4187/respcare.06496

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Presentation] リハビリテーション医療に生かすアロマセラピー2022

    • Author(s)
      海老原覚
    • Organizer
      日本アロマセラピー学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 口腔衛生管理と誤嚥性肺炎2021

    • Author(s)
      海老原 覚
    • Organizer
      第32回日本老年学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 転倒予防の新機軸2021

    • Author(s)
      海老原 覚
    • Organizer
      第80回日本めまい平衡医学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 誤嚥性肺炎に対する リハビリテーション医学・医療2020

    • Author(s)
      海老原覚
    • Organizer
      第57回日本リハビリテーション医学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Remarks] リハビリテーション医学研究室(大森) 医学研究科リハビリテーション医学講座

    • URL

      https://www.toho-u.ac.jp/med/lab/rinsyo/riha1.html

    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] とろみ測定器2019

    • Inventor(s)
      海老原覚,宮城翠,松浪靖夫,森本博
    • Industrial Property Rights Holder
      海老原覚,宮城翠,松浪靖夫,森本博
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Research-status Report

URL: 

Published: 2019-07-04   Modified: 2024-01-30  

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