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The mechanism of enhanced OXPHOS after the EMT

Research Project

Project/Area Number 19K23877
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0901:Oncology and related fields
Research InstitutionHokkaido University

Principal Investigator

Handa Haruka  北海道大学, 医学研究院, 特任助教 (00844721)

Project Period (FY) 2019-08-30 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords上皮間葉転換 / ミトコンドリア / OXPHOS
Outline of Research at the Start

現在までに①正常細胞のEMT誘導ではOXPHOS活性が亢進すること,②EMTによりmitoNEET(mNT)の発現が減少し,これがOXPHOS活性の亢進に必須であることを見出している。本研究によりミトコンドリアの機能や動態がEMTで制御されるメカニズムを解明することで,EMTに関連した細胞生物学に有力な知見を与えうる。

Outline of Final Research Achievements

Epithelial-mesenchymal transition (EMT) is well-known to be involved in cancer malignant progression that confers tumour cells resistance against various types of cancer treatments.
This study showed that the OXPHOS level was changed after normal EMT. A certain protein whose expression level was changed after EMT might be involved in the enhancement of OXPHOS.

Academic Significance and Societal Importance of the Research Achievements

癌の悪性度進展に上皮間葉転換が深くかかわることが知られている。本研究では,正常細胞における上皮間葉転換を利用し,ミトコンドリア内代謝における変化を見出し,さらにその分子メカニズムを明らかにする手がかりとしてミトコンドリア外膜タンパク質を同定した。今後,この分子の癌細胞EMTにおける意義を明らかにすることで,国民病といわれる癌に新たな治療法を提案しうる。

Report

(3 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • Research Products

    (1 results)

All 2021

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure2021

    • Author(s)
      Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S.
    • Journal Title

      Commun Biol.

      Volume: 4 Issue: 1 Pages: 138-138

    • DOI

      10.1038/s42003-021-01675-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2019-09-03   Modified: 2022-01-27  

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