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Genetic basis underlying latitudinal adaptation of seasonal reproduction in sticklebacks

Research Project

Project/Area Number 19KK0187
Research Category

Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 45:Biology at organismal to population levels and anthropology, and related fields
Research InstitutionThe University of Tokyo (2021-2022)
National Institute of Genetics (2019-2020)

Principal Investigator

Ishikawa Asano  東京大学, 大学院新領域創成科学研究科, 准教授 (20722101)

Co-Investigator(Kenkyū-buntansha) 北野 潤  国立遺伝学研究所, ゲノム・進化研究系, 教授 (80346105)
山崎 曜  国立遺伝学研究所, ゲノム・進化研究系, 助教 (40816021)
Project Period (FY) 2019-10-07 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Keywords緯度適応 / 季節性繁殖 / 日長応答性
Outline of Research at the Start

本研究では、イトヨが広緯度に連続的に分布するヨーロッパ大陸をフィールドに(1)北極圏と南欧の繁殖「期間」と「時期」の違いを生み出す遺伝的変異をQTL解析と全ゲノム解析によって同定する。また(2)ヨーロッパ大西洋側に連続的に分布するイトヨ集団で緯度勾配ゲノムスキャンを行い、(1)の中で緯度勾配に応じてアリル頻度が変化する遺伝的変異を得る。これが、ヨーロッパ全土の広い緯度で繁殖期の多様性をもたらす有力な候補遺伝的変異である。この変異の起源や進化的動態、各地域で受けた自然選択も検証する。更に(3)同定した変異をイトヨに導入し、異なる日長や温度条件下での生理的機能や適応度に対する効果を解析する。

Outline of Final Research Achievements

The length and timing of the breeding season vary widely across latitudinal gradients. However, little is known about the genetic basis underlying the latitudinal adaptation of seasonal reproduction. In this project, we analyzed the three-spined stickleback in European in Continental Europe, which inhabits a wide range of latitudes. We revealed that the evolution of the breeding season due to latitudinal adaptation occurs by a different mechanism than the evolution of the breeding season associated with freshwater colonization.

Academic Significance and Societal Importance of the Research Achievements

生物の形質は、しばしば緯度と相関する。これは緯度の違いが、日長や温度などの非生物的環境、あるいはそれによって生まれる生物的環境の勾配を作り、異なる選択圧をもたらすからである。特に繁殖期の変化は、種分化の引き金となり、集団の更なる多様化を引き起こす。このため、繁殖期の緯度勾配は、種分化速度を介して、地球上の種多様性の緯度勾配を作り出す重要な要素になりうる。本研究の今後の解析により、繁殖期の長さや時期を決定する新たな遺伝子を見出すことで、種多様性を生む機構を理解することができる。また、これらを他種に応用することで、水産・畜産利用価値の高い生物の効率的な育種システムを確立できる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (31 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (6 results) Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 9 results)

  • [Int'l Joint Research] ノルウェー生命科学大学(ノルウェー)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ヴィーゴ大学(スペイン)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ノルウェー生命科学大学(ノルウェー)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ヴィーゴ大学(スペイン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ヴィーゴ大学(スペイン)

    • Related Report
      2019 Research-status Report
  • [Int'l Joint Research] ノルウェー生命科学大学(ノルウェー)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Convergent copy number increase of genes associated with freshwater colonization in fishes2022

    • Author(s)
      Ishikawa Asano、Yamanouchi Shun、Iwasaki Wataru、Kitano Jun
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: 377 Issue: 1855 Pages: 1855-1855

    • DOI

      10.1098/rstb.2020.0509

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of a chromosome-level Japanese stickleback species genome using ultra-dense linkage analysis with single-cell sperm sequencing2022

    • Author(s)
      Yoshitake Kazutoshi、Ishikawa Asano、Yonezawa Ryo、Kinoshita Shigeharu、Kitano Jun、Asakawa Shuichi
    • Journal Title

      NAR Genomics and Bioinformatics

      Volume: 4 Issue: 2

    • DOI

      10.1093/nargab/lqac026

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Construction of a chromosome-level Japanese stickleback species genome using ultra-dense linkage analysis with single-cell sperm sequencing.2022

    • Author(s)
      Yoshitake K, Ishikawa A, Yonezawa R, Kinoshita S, Kitano J, and Asakawa S.
    • Journal Title

      NAR Genomics and Bioinformatics

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergent copy number increase of genes associated with freshwater colonisation in fishes2022

    • Author(s)
      Ishikawa A, Yamanouchi S, Iwasaki W, and Kitano J.
    • Journal Title

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Volume: -

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic basis for variation in the number of cephalic pores in a hybrid zone between closely related species of goby, Gymnogobius breunigii and Gymnogobius castaneus2021

    • Author(s)
      Kakioka Ryo、Kume Manabu、Ishikawa Asano、Ansai Satoshi、Hosoki Takuya K、Yamasaki Yo Y、Nagano Atsushi J、Toyoda Atsushi、Kitano Jun
    • Journal Title

      Biological Journal of the Linnean Society

      Volume: - Issue: 1 Pages: 143-154

    • DOI

      10.1093/biolinnean/blab033

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The evolutionary ecology of fatty‐acid variation: Implications for consumer adaptation and diversification2021

    • Author(s)
      Twining Cornelia W.、Bernhardt Joey R.、Derry Alison M.、Hudson Cameron M.、Ishikawa Asano、Kabeya Naoki、Kainz Martin J.、Kitano Jun、Kowarik Carmen、Ladd Sarah Nemiah、Leal Miguel C.、Scharnweber Kristin、Shipley Jeremy R.、Matthews Blake
    • Journal Title

      Ecology Letters

      Volume: 24 Issue: 8 Pages: 1709-1731

    • DOI

      10.1111/ele.13771

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Copy number variation of a fatty acid desaturase gene <i>Fads2</i> associated with ecological divergence in freshwater stickleback populations2021

    • Author(s)
      Ishikawa Asano、Stuart Yoel E.、Bolnick Daniel I.、Kitano Jun
    • Journal Title

      Biology Letters

      Volume: 17 Issue: 8 Pages: 20210204-20210204

    • DOI

      10.1098/rsbl.2021.0204

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Patterns of genomic divergence and introgression between Japanese stickleback species with overlapping breeding habitats2020

    • Author(s)
      Ravinet Mark、Kume Manabu、Ishikawa Asano、Kitano Jun
    • Journal Title

      Journal of Evolutionary Biology

      Volume: 34 Issue: 1 Pages: 114-127

    • DOI

      10.1111/jeb.13664

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multiple waves of freshwater colonization of the three-spined stickleback in the Japanese Archipelago2020

    • Author(s)
      Kakioka Ryo、Mori Seiichi、Kokita Tomoyuki、Hosoki Takuya K.、Nagano Atsushi J.、Ishikawa Asano、Kume Manabu、Toyoda Atsushi、Kitano Jun
    • Journal Title

      BMC Evolutionary Biology

      Volume: 20 Issue: 1 Pages: 143-143

    • DOI

      10.1186/s12862-020-01713-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in the contributions of sex linkage and androgen regulation to sex-biased gene expression in juvenile and adult sticklebacks.2020

    • Author(s)
      Kitano J, Kakioka R, Ishikawa A, Toyoda A Kusakabe M.
    • Journal Title

      Journal of Evolutionary Biology

      Volume: 33 Issue: 8 Pages: 1129-1138

    • DOI

      10.1111/jeb.13662

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diversity in reproductive seasonality in the three-spined stickleback, Gasterosteus aculeatus2020

    • Author(s)
      Ishikawa Asano、Kitano Jun
    • Journal Title

      Journal of Experimental Biology

      Volume: 223 Issue: Suppl_1

    • DOI

      10.1242/jeb.208975

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Presentation] ゲノム編集から多機能性遺伝子が持つ間接効果を検証する2023

    • Author(s)
      石川 麻乃
    • Organizer
      第70回日本生態学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Single cell Multiome reveals genetic mechanism of reproductive seasonality in sticklebacks.2023

    • Author(s)
      Liu L, Ishikawa A.
    • Organizer
      第70回日本生態学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Genome editing reveals a role of a pleiotropic gene on prey preference and its effect on ecosystems(イトヨの餌生物の嗜好性におけるハブ遺伝子の役割と生態系への影響)2023

    • Author(s)
      Sutrisno A, Ishikawa A.
    • Organizer
      第70回日本生態学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] イトヨ近縁種における環境ストレス耐性の違いとその分子機構2023

    • Author(s)
      原田 慧、石川 麻乃
    • Organizer
      第70回日本生態学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 網羅的発現解析とゲノム編集から見えた季節性繁殖の収斂進化を担う鍵遺伝子とその進化2022

    • Author(s)
      石川 麻乃
    • Organizer
      2022年度日本魚類学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] A key gene important for freshwater colonization and radiation2022

    • Author(s)
      Ishikawa A
    • Organizer
      日本生態学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] A key metabolic gene important for freshwater colonization and adaptation2021

    • Author(s)
      Ishikawa A
    • Organizer
      ICZ Virtual Conference 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Genetic molecular mechanisms underlying life-history evolution in sticklebacks2021

    • Author(s)
      Ishikawa A
    • Organizer
      NIBB-Academia Sinica International Webinar of Aquatic Model Organisms for Basic Biology to Human Disease Models
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒトと魚をつなぐ脂肪酸代謝の進化機構2021

    • Author(s)
      石川 麻乃
    • Organizer
      第75回日本人類学会大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] トゲウオから探る季節性生活史の収斂進化の分子遺伝基盤2021

    • Author(s)
      石川 麻乃
    • Organizer
      日本遺伝学会第93回大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] トゲウオから探る生活史の収斂進化の分子遺伝機構2021

    • Author(s)
      石川 麻乃
    • Organizer
      第66回日本生態学会
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Invited
  • [Presentation] トゲウオから探る生活史の収斂進化の鍵遺伝子2020

    • Author(s)
      石川 麻乃
    • Organizer
      第52回種生物学会シンポジウム
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Molecular genetic mechanisms underlying convergent evolution of life-history traits in sticklebacks2020

    • Author(s)
      Ishikawa A
    • Organizer
      第43回日本分子生物学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 生活史の適応進化を生む分子遺伝機構 ー変異/遺伝子、生理、適応度を繋ぐー2020

    • Author(s)
      石川 麻乃
    • Organizer
      第67回日本生態学会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2019-10-10   Modified: 2024-01-30  

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