Reduction of death from colorectal cancer with help of artificial intelligence
| Project/Area Number |
19KK0421
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Showa University |
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Principal Investigator |
Mori Yuichi 昭和大学, 医学部, 兼任講師 (20459209)
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| Project Period (FY) |
2019 – 2022
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
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| Keywords | 人工知能 / 内視鏡 / 大腸癌 / 大腸ポリープ |
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| Outline of Research at the Start |
本国際研究では、人工知能(AI)を利用した大腸内視鏡検査により、「命を救える」ことを証明する。申請者ら（森悠一・工藤進英・三澤将史）は、4期にわたる科研費支援および名大（森健策教授）との医工連携研究により大腸内視鏡診断支援システムを開発したが、これにより、将来の癌死が抑制できるか立証するのは本邦では困難だった。
本研究では、内視鏡疫学研究の先駆者であるオスロ大学の協力の下、ノルウェー独自の「死亡データが自動リンクする公的検診レジストリー」を研究利用することで、超低コストの大規模ランダム化試験を実施する。AIによる死亡率抑制効果をプライマリーエンドポイントとし、内視鏡AIの真の有効性を検証する。
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| Outline of Final Research Achievements |
Artificial intelligence (AI) for colonoscopy is expected to automatically detect colorectal polyps during colonoscopy and prevent doctors from overlooking them. The aim of this study project is to verify/infer whether future cancer deaths can actually be reduced by the use of AI. In order to achieve this objective, microsimulation studies and meta-analyses were conducted on the effect of AI on cancer incidence and mortality. Results of these studies were used to develop a randomised controlled trial design sufficient to verify the effectiveness of AI. These have enabled the establishment of a research infrastructure that will form the basis for large-scale clinical trials.
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| Academic Significance and Societal Importance of the Research Achievements |
人工知能（AI)の臨床応用においては、その有用性について十分な証拠が欠如している。本研究は、AIを大腸内視鏡に併用することで、将来の大腸がん罹患率を約５パーセント減らすことができることを高精度のシミュレーション研究で示した点において、学術的意義がある。今後は、実際の患者様への導入をすることでリアルワールドの有効性を検証する必要があるため、その意味で、研究インフラを確立させた本研究の社会的意義は大きい。
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Proceedings from the First Global Artificial Intelligence in Gastroenterology and Endoscopy Summit.2020
Author(s)
Parasa S, Wallace M, Bagci U, Antonino M, Berzin T, Byrne M, Celik H, Farahani K, Golding M, Gross S, Jamali V, Mendonca P, Mori Y, Ninh A, Repici A, Rex D, Skrinak K, Thakkar SJ, van Hooft JE, Vargo J, Yu H, Xu Z, Sharma P.
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Journal Title
Gastrointest Endosc.
Volume: in press
Issue: 4
Pages: 938-945.e1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Cost savings in colonoscopy with artificial intelligence-aided polyp diagnosis: an add-on analysis of a clinical trial (with video).2020
Author(s)
Mori Y, Kudo SE, East JE, Rastogi A, Bretthauer M, Misawa M, Sekiguchi M, Matsuda T, Saito Y, Ikematsu H, Hotta K, Ohtsuka K, Kudo T, Mori K.
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Journal Title
Gastrointest Endosc.
Volume: in press
Issue: 4
Pages: 905-911.e1
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Treatment policy for colonic laterally spreading tumors based on each clinicopathological feature of 4 subtypes: actual status of pseudo-depressed type.2020
Author(s)
Ishigaki T, Kudo SE, Miyachi H, Hayashi T, Minegishi Y, Toyoshima N, Misawa M, Mori Y, Kudo T, Wakamura K, Baba T, Sawada N, Ishida F, Hamatani S.
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Journal Title
Gastrointest Endosc
Volume: in press
Issue: 5
Pages: 1083-1094.e6
DOI
Related Report
Peer Reviewed
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[Journal Article] Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI.2020
Author(s)
Kataoka S, Kudo SE, Misawa M, Nakamura H, Takeda K, Toyoshima N, Mori Y, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Baba T, Ishida F.
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Journal Title
Endosc Int Open
Volume: 3
Issue: 03
Pages: E360-E367
DOI
Related Report
Peer Reviewed
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[Journal Article] Endocytoscopic intramucosal capillary network changes and crypt architecture abnormalities can predict relapse in patients with an ulcerative colitis Mayo endoscopic score of 1.2020
Author(s)
Maeda Y, Kudo SE, Ogata N, Mori Y, Misawa M, Homma M, Nemoto T, Ogawa M, Sasanuma S, Sato Y, Kataoka S, Kouyama Y, Sakurai T, Igarashi K, Ogawa Y, Kato K, Ichimasa K, Nakamura H, Kudo T, Hayashi T, Wakamura K, Baba T, Inoue H, Ohtsuka K.
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Journal Title
Dig Endosc
Volume: in press
Issue: 7
Pages: 1082-1091
DOI
Related Report
Peer Reviewed
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[Journal Article] Endocytoscopy for the differential diagnosis of colorectal low-grade adenoma: a novel possibility for the "resect and discard" strategy.2020
Author(s)
Kudo T, Suzuki K, Mori Y, Misawa M, Ichimasa K, Takeda K, Nakamura H, Maeda Y, Ogawa Y, Hayashi T, Wakamura K, Ishida F, Inoue H, Kudo SE.
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Journal Title
Gastrointest Endosc
Volume: 3
Issue: 3
Pages: 676-683
DOI
Related Report
Peer Reviewed
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[Journal Article] Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms.2019
Author(s)
Kudo SE, Misawa M, Mori Y, Hotta K, Ohtsuka K, Ikematsu H, Saito Y, Takeda K, Nakamura H, Ichimasa K, Ishigaki T, Toyoshima N, Kudo T, Hayashi T, Wakamura K, Baba T, Fumio I, Inoue H, Itoh H, Oda M, Mori K.
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Journal Title
Clin Gastroenterol Hepatol.
Volume: in press
Issue: 8
Pages: 1874-1881.e2
DOI
Related Report
Peer Reviewed
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[Journal Article] Correction: Advanced imaging for detection and differentiation of colorectal neoplasia: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2019.2019
Author(s)
Bisschops R, East JE, Hassan C, Hazewinkel Y, Kaminski MF, Neumann H, Pellis M, Antonelli G, Bustamante Balen M, Coron E, Cortas G, Iacucci M, Yuichi M, Longcroft-Wheaton G, Mouzyka S, Pilonis N, Puig I, van Hooft JE, Dekker E.
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Journal Title
Endoscopy
Volume: in press
Issue: 12
Pages: C6-C6
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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