Regulation of fate-determination of RNA and role of transcriptional machinery in heterochromatin formatin
| Project/Area Number |
20052013
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
MURAKAMI Yota Kyoto University, 大学院・先端生命科学研究院, 教授 (20260622)
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| Co-Investigator(Kenkyū-buntansha) |
山口 雄輝 東京工業大学, 生命理工学部, 助教授 (50345360)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥28,000,000 (Direct Cost: ¥28,000,000)
Fiscal Year 2009: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2008: ¥14,000,000 (Direct Cost: ¥14,000,000)
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| Keywords | 転写 / RNAポリメラーゼII / クロマチン / RNAプロセシング / 転写伸長 / ヘテロクロマチン / RNA / RNAポリメラーゼ |
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| Research Abstract |
mRNA and non-coding RNA, both of which are transcribed by RNA polymerase II, have different fate with different RNA processing processes. We analyzed the mechanism for the fate-determination mechanism and found that transcriptional elongation factors were involved in fate-determination process of heterochromatic ncRNA in fission yeast. We also found that fission yeast heterochromatin ncRNA formed DNA:RNA hybrid to remain on chromatin and plays a role in heterochromatin formation. In addition, we revealed the mechanism to regulate elongation of transcription by transcriptional elongation factors.
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Report
(3 results)
Research Products
(48 results)
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[Journal Article] Phosphorylation of Swi6/HP1 regulates transcriptional gene silencing at heterochromatin.2009
Author(s)
Shimada A., Dohke K., Sadaie M., Shinmyozu, K., Nakayama, J-I., Urano, T., Murakami, Y.
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Journal Title
Genes & Dev. 23
Pages: 18-23
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Peer Reviewed
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[Journal Article] Schizosaccharomyces pombe Orc5 plays multiple roles in the maintenance of genome stability throughout the cell cycle.2008
Author(s)
Kato H., Matsunaga, F., Miyazaki S., Yin, L., D'Urso, G, Tanaka, K., Murakami, Y.
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Journal Title
Cell Cycle 7
Pages: 1083-1094
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Peer Reviewed
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[Presentation] DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation2008
Author(s)
Yamaguchi, Y., Chen, Y., Tsugeno, Y., Handa, H
Organizer
The 8th EMBL Transcription Meeting
Place of Presentation
Heidelberg, Germany
Related Report
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[Presentation] DSIF, the Pafl complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation2008
Author(s)
Yamaguchi, Y., Chen, Y. Tsugeno, Y., and Handa, H.
Organizer
The 8th EMBL Transcription Meeting
Place of Presentation
Heidelberg, Germany
Related Report
