| Project/Area Number |
20052013
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
MURAKAMI Yota Kyoto University, 大学院・先端生命科学研究院, 教授 (20260622)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山口 雄輝 東京工業大学, 生命理工学部, 助教授 (50345360)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥28,000,000 (Direct Cost: ¥28,000,000)
Fiscal Year 2009: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 2008: ¥14,000,000 (Direct Cost: ¥14,000,000)
|
|---|
| Keywords | 転写 / RNAポリメラーゼII / クロマチン / RNAプロセシング / 転写伸長 / ヘテロクロマチン / RNA / RNAポリメラーゼ |
|---|
| Research Abstract |
mRNA and non-coding RNA, both of which are transcribed by RNA polymerase II, have different fate with different RNA processing processes. We analyzed the mechanism for the fate-determination mechanism and found that transcriptional elongation factors were involved in fate-determination process of heterochromatic ncRNA in fission yeast. We also found that fission yeast heterochromatin ncRNA formed DNA:RNA hybrid to remain on chromatin and plays a role in heterochromatin formation. In addition, we revealed the mechanism to regulate elongation of transcription by transcriptional elongation factors.
|
