| Project/Area Number |
20059029
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
MINAMI Yasufumi Maebashi Institute of Technology, 工学部, 教授 (40181953)
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| Co-Investigator(Kenkyū-buntansha) |
ZENNO Shuuhei 前橋工科大学, 工学部, 教授 (90313204)
MATSUMOTO Ken 独立行政法人理化学研究所, 分子昆虫学研究室, 専任研究員 (60222311)
MINAMI Michiko 国立大学法人東京学芸大学, 教育学部, 教授 (70272432)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 2009: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2008: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | 分子シャペロン / 翻訳 / mRNA |
|---|
| Research Abstract |
We found that treatment with the Hsp90 inhibitor geldanamycin (GA) leads to a substantial reduction in the number of HeLa cells that contain processing bodies. Stress granules were also affected by this treatment and eIF4E and 4E-T specifically dissociated from these granules. Moreover, treatment with GA weakened the physical interaction of eIF4E with eIF4G. We conclude that the chaperone activity of Hsp90 is likely to be required for the activities of eIF4E that are necessary for its physiological function.
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