Molecular chaperones functionally linked to translational control
| Project/Area Number |
20059029
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
MINAMI Yasufumi Maebashi Institute of Technology, 工学部, 教授 (40181953)
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| Co-Investigator(Kenkyū-buntansha) |
ZENNO Shuuhei 前橋工科大学, 工学部, 教授 (90313204)
MATSUMOTO Ken 独立行政法人理化学研究所, 分子昆虫学研究室, 専任研究員 (60222311)
MINAMI Michiko 国立大学法人東京学芸大学, 教育学部, 教授 (70272432)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 2009: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2008: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | 分子シャペロン / 翻訳 / mRNA |
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| Research Abstract |
We found that treatment with the Hsp90 inhibitor geldanamycin (GA) leads to a substantial reduction in the number of HeLa cells that contain processing bodies. Stress granules were also affected by this treatment and eIF4E and 4E-T specifically dissociated from these granules. Moreover, treatment with GA weakened the physical interaction of eIF4E with eIF4G. We conclude that the chaperone activity of Hsp90 is likely to be required for the activities of eIF4E that are necessary for its physiological function.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and 4E-T into stress granules and association of eIF4E with eIF4G.2009
Author(s)
Suzuki, Y., Minami, M., Suzuki, M., Abe, K., Zenno, S., Tsujimoto, M., Matsumoto, K., Minami, Y.
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Journal Title
J. Biol. Chem. 284
Pages: 35597-35604
Related Report
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[Journal Article] The Hsp90 inhibitor geldanamycin abrogates colocalization of Eif4e and 4E-T into stress granules and association of eIF4E with Eif4g2009
Author(s)
Suzuki, Y., Minami, M., Suzuki, M., Abe, K., Zenno, S., Tsujimoto, M., Matsumoto, K., Minami, Y.
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Journal Title
J. Biol. Chem 284
Pages: 35597-35604
Related Report
Peer Reviewed
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[Journal Article] Reduced base-base interactions between the DNA seed and RNA target are themajor determinants of a significant reduction in the off-target effect due toDNA-seed containing siRNA.2009
Author(s)
Ui-Tei, K., Nishi, K., Naito, Y., Zenno, S., Juni, A., Saigo, K.
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Journal Title
Proceedings of the 2009 Micro-NanoMechatronics and Human Science (MHS2009)
Pages: 298-304
Related Report
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[Journal Article] Bipartite roles of the central region of the siRNA guide strand in RNA interference due to modified siRAN with a DNA seed arm.2009
Author(s)
Ui-Tei, K., Naito, Y., Zenno, S., Nishi, K., Juni, A., Tanaka, A., Saigo, K.
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Journal Title
Res. Adv. In Nucleic Acids Research 3
Pages: 1-17
Related Report
Peer Reviewed
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