Connectome Project X: X-ray microscopy revealing neuronal wiring diagram
| Project/Area Number |
20200001
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MIZUTANI Haruo 東京大学, 総括プロジェクト機構, 特任 (40444103)
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| Co-Investigator(Kenkyū-buntansha) |
MAKINO Takaki 東京大学, 総括プロジェクト機構, 特任助教 (20418651)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Fiscal Year 2010: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2009: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2008: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Keywords | 神経回路網 / ニューロインフォマティクス / コネクトーム / X線顕微鏡 / シナプス分解能 / 神経ネットワーク / シナプス |
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| Research Abstract |
Our purpose is to develop an atlas of neuronal circuits in the brain using high resolution X-ray microscopy by laser and synchrotron radiation. In this study, a full-field soft X-ray microscope revealed synapses in the mouse cerebral cortex with 25 nm resolution. Moreover, phase contrast hard X-ray nano-tomography unveiled 3D structure of the mouse brain tissue with isometric nano-meter voxel sizes of 60 nm resolution. In the near future, X-ray microscopy is expected to contribute "Connectome Project" to begin deciphering the wiring diagram of the whole brain by applying the nano-resolution X-ray 3D imaging.
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Report
(4 results)
Research Products
(50 results)
