Rapid chemical screening by using ascidian embryo for advancement of "Chemical Developmental Biology"

• Project/Area Number: 20200034
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
• Allocation Type: Single-year Grants
• Research Field: Living organism molecular science; Developmental biology
• Research Institution: Keio University
• Principal Investigator: HOTTA Kohji Keio University, 理工学部, 講師 (80407147)
• Co-Investigator(Kenkyū-buntansha): TASHIRO Etsu 慶應義塾大学, 理工学部, 講師 (00365446)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥31,460,000 (Direct Cost: ¥24,200,000、Indirect Cost: ¥7,260,000); Fiscal Year 2010: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2009: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000); Fiscal Year 2008: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
• Keywords: ホヤ / ケミカルゲノミクス / 小分子化合物 / 創薬 / スクリーニング / 3D / データベース / 神経管閉鎖 / FGFR / 小分子へ化合物 / RT-PCR / 化学発生生物学 / イメージング / 3次元 / whole-animal screening / ハイスループット / 放線菌 / 3次元表現型データベース

Research Abstract

Pharmacological approach such as treatment of chemical inhibitor is useful to know a function of its target protein. Although ascidian is considered as an ideal animal for chemical genomics on the point of high-throughput and high-resolution, there is no established whole-animal experimental system. As a first step, we established a whole-animal drug screening system by using ascidian embryo and constructed a database for ascidian chemicals biology.

Research Products

• [Journal Article] CIPRO 2.5 : Ciona intestinalis Protein Database, a unique integrated repository of large-scale omics data (2011)
  • Author(s): Endo, Toshinori, Ueno, Keisuke, Yonezawa, Kouki, Mineta, Katsuhiko, Hotta, Kohji, Satou, Yutaka, Yamada, Lixy, Ogasawara, Michio, Takahashi, Hiroki., Nakajima, Ayako, Nakachi, Mia, Nomura, Mamoru, Yaguchi, Junko, Sasakura Yasunori, Yamasaki, Chisato, Sera, Miho, Yoshizawa, Akiyasu, Imanishi, Tadashi, Taniguchi, Hisaaki, Inaba, Kazuo.
  • Journal Title: bioinformatic analyses, and curated annotation, with user rating and reviewing functionality Nucleic Acid Research. 39 (Database issue): Epub 39(1)
  • Peer Reviewed
• [Journal Article] Honoo Satake Peptidomic analysis of the central nervous system of the protochordate (2011)
  • Author(s): Tsuyoshi Kawada, Michio Ogasawara, Toshio Sekiguchi, Masato Aoyama, Kohji Hotta, Kotaro Oka
  • Journal Title: Ciona intestinalis : homologs and prototypes of vertebrate peptides and novel peptides Endocrinology epub ahead of print
  • Peer Reviewed
• [Journal Article] Quinotrierixin inhibited ER stress-induced XBP1 mRNA splicing through inhibition of protein synthesis (2011)
  • Author(s): K.Yamamoto, E.Tashiro, M.Imoto
  • Journal Title: Biosci Biotechnol Biochem 75 Pages: 284-288
  • NAID: 10027897707
  • Peer Reviewed
• [Journal Article] A new, convenient cell-based screening method for small-molecule glycolytic inhibitors (2011)
  • Author(s): M.Kitagawa, M.Misawa, S.Ogawa, E.Tashiro, M.Imoto
  • Journal Title: Biosci Biotechnol Biochem 75 Pages: 367-369
  • NAID: 10027898136
  • Peer Reviewed
• [Journal Article] Synthesis and anti-migrative evaluation of moverastin derivatives (2011)
  • Author(s): M.Sawada, S.Kubo, K.Matsumura, Y.Takemoto, H.Kobayashi, E.Tashiro, T.Kitahara, H.Watanabe, M.Imoto
  • Journal Title: Bioorg Med Chem Lett 21 Pages: 1385-1389
  • Peer Reviewed
• [Journal Article] CIPRO 2.5 : Cionaintestinalis Protein Database, a unique integrated repository of large-scale omics data, bioinformatic analyses, and curated annotation, with user rating and reviewing functionality (2011)
  • Author(s): Endo, Toshinori, Ueno, Keisuke, Yonezawa, Kouki, Mineta, Katsuhiko, Hotta, Kohji, Satou, Yutaka, Yamada, Lixy, Ogasawara, Michio, Takahashi, Hiroki., Nakajima, Ayako, Nakachi, Mia, Nomura, Mamoru, Yaguchi, Junko, Sasakura, Yasunori, Yamasaki, Chisato, Sera, Miho, Yoshizawa, Akiyasu, Imanishi, Tadashi, Taniguchi, Hisaaki, Inaba, Kazuo
  • Journal Title: Nucleic Acid Research Volume: 39
  • NAID: 120002834765
  • Peer Reviewed
• [Journal Article] Peptidomic analysis of the central nervous system of the protochordate, Cionaintestinalis : homologs and prototypes of vertebrate peptides and novel peptides (2011)
  • Author(s): Tsuyoshi Kawada, Michio Ogasawara, Toshio Sekiguchi, Masato Aoyama, KohjiHotta, Kotaro Oka, HonooSatake, Peptidomic analysis of the central nervous system of the protochordate, Cionaintestinalis : homologs and prototypes of vertebrate peptides and novel peptides
  • Journal Title: Endocrinology Volume: (accepted)
  • Peer Reviewed
• [Journal Article] ACBD : Database for Ascidian Chemical Genomics. (2010)
  • Author(s): Hira, Yuichiro, Terai, Jun, Imoto, Masaya, Tashiro, Etsu, Hotta, Kohji
  • Journal Title: Available from Nature Precedings
  • URL: http://dx.doi.org/10.1038/npre.2010.5087.1
• [Journal Article] Eiichi Shoguchi Regulation of notochord-specific expression of Ci-Bra downstream genes in Ciona intestinalis embryosZoological (2010)
  • Author(s): Hiroki Takahashil, Kohji Hotta, Chiyo Takagi, Naoto Ueno, Nori Satoh
  • Journal Title: Sci. 27(2) Pages: 110-118
  • Peer Reviewed
• [Journal Article] OkaNetwork structure of projections extending from peripheral neurons in tunic of ascidian larva Developmental Dynamics. (2010)
  • Author(s): Hiroshi Q.Terakubo, Yoko Nakajima, Yasunori Sasakura, Takeo Horie, Alu Konno, Hiroki Takahashi, Kazuo Inaba, Kohji Hotta, Kotaro Oka
  • Journal Title: DD ArtPix Developmental Dynamics. 239(8),239(9) Pages: 2278-2287
  • Peer Reviewed
• [Journal Article] The ANISEED database : digital representation, formalisation and elucidation of a chordate developmental program (2010)
  • Author(s): O.Tassy, D.Dauga, F.Daian, D.Sobral, F.Robin, P.Khoueiry, D.Salgado, V.Fox, D.Caillo, M.Contensin, Renaud Schiappa, Anne Rios, Guillaume Luxardi, M.Gilchrist, K.Makabe, K.Hotta, Fujiwara, T.Kusakabe, N.Satoh, Y.Satou, P.Lemaire
  • Journal Title: Genome Research. 20(10) Pages: 1459-1468
  • Peer Reviewed
• [Journal Article] Metabolomic identification of the target of the filopodia protrusion inhibitor glucopiericidin (2010)
  • Author(s): AM.Kitagawa, S.Ikeda, E.Tashiro, T.Soga, M.Imoto
  • Journal Title: Chemistry and Biology 17 Pages: 989-998
  • Peer Reviewed
• [Journal Article] Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp.MK756-CF1 (2010)
  • Author(s): T.Kawamura, T.Fujimaki, N.Hamanaka, K.Torii, H.Kobayashi, Y.Takahashi, M.Igarashi, N.Kinoshita, Y.Nishimura, E.Tashiro, M.Imoto
  • Journal Title: J.Antibiot (Tokyo) 63 Pages: 601-605
  • Peer Reviewed
• [Journal Article] Distribution and structural diversity of cilia in the tadpole larvae of the ascidian Ciona intestinalis (2010)
  • Author(s): Alu Konno, Maiko Kaizu, Kohji Hotta, Takeo Horie, Yasunori Sasakura, Kazuho Ikeo, Kazuo Inaba
  • Journal Title: Developmental Biology. 337(1) Pages: 42-62
  • Peer Reviewed
• [Journal Article] Network structure of projections extending from peripheral neurons in tunic of ascidian larva (2010)
  • Author(s): Hiroshi Q.Terakubo, Yoko Nakajima, YasunoriSasakura, Takeo Horie, Alu Konno, Hiroki Takahashi, Kazuo Inaba, Kohji Hotta, Kotaro Oka
  • Journal Title: Developmental Dynamics. Volume: 239 Pages: 2278-87
  • Peer Reviewed
• [Journal Article] Blue Fluorescent cGMP Sensor for Multiparameter Fluorescence Imaging (2010)
  • Author(s): Yusuke Niino, Kohji Hotta, Kotaro Oka
  • Journal Title: PLoS One 5(2) Pages: 1-5
  • Peer Reviewed
• [Journal Article] Oligomycin induced the proteasomal degradation of cyclin D1 (2009)
  • Author(s): M.Kanai, S.Iba, R.Okada, E.Tashiro, M.Imoto
  • Journal Title: J.Antibiot (Tokyo) 62 Pages: 425-429
  • Peer Reviewed
• [Journal Article] V-ATPase Inhibitors Overcome Bcl-xL-mediated Chemoresistance through Restoration of a Caspase-independent Apoptotic Pathway. (2009)
  • Author(s): Y.Sasazawa, Y.Futamura, E.Tashiro, M.Imoto
  • Journal Title: Cancr Science 100 Pages: 1460-1467
  • Peer Reviewed
• [Journal Article] Nori Satoh and Hiroki Takahashi Interaction of notochord-derived fibrinogen-like protein with Notch regulates the patterning of the central nervous system of Ciona intestinalis embryos (2009)
  • Author(s): Shigehiro Yamada, Kohji Hotta, Takamasa S.Yamamoto, Naoto Ueno
  • Journal Title: Developmental Biology 328(1) Pages: 1-12
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of human fibroblast growth factor receptor 1 by E2F-1. (2009)
  • Author(s): M.Kanai, E.Tashiro, H.Maruki, Y.Minato, M.Imoto
  • Journal Title: Gene 438 Pages: 49-56
  • Peer Reviewed
• [Journal Article] Simultaneous live cell imaging using dual FRET sensors with a single excitation light. (2009)
  • Author(s): Niino Y, Hotta K, Oka K.
  • Journal Title: PLoS One 4(6) Pages: 1-9
  • Peer Reviewed
• [Journal Article] A novel biological role of tachykinins as an upregulator of oocyte growth : evolutionary origin of tachykinergic functions in the ovary. (2008)
  • Author(s): M.Aoyama, T.Kawada, M.Fujie, K.Hotta, T.Sakai, T.Sekiguchi, K.Oka, N.Satoh, H.Satake
  • Journal Title: Endocrinology 149(9) Pages: 4346-4356
  • Peer Reviewed
• [Journal Article] SAR study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation. II. Structure Elucidation (2008)
  • Author(s): T.Kawamura, E.Tashiro, K.Shindo, M.Imoto
  • Journal Title: J.Antibiot (Tokyo) 61 Pages: 312-317
  • NAID: 10021927823
  • Peer Reviewed
• [Journal Article] Identification and characterization of mouse type II platelet-derived growth factor receptor a transcript. (2008)
  • Author(s): Y.Minato, Y.Nihei, Y.Kodama, E.Tashiro, M.Kanai, M.Imoto
  • Journal Title: Biosci. Biotechnol. Biochem. 72 Pages: 759-766
  • Peer Reviewed
• [Journal Article] Discovery of Incednine as a Potent Modulator of the Anti-apoptotic Function of Bcl-xL from Microbial Origin. (2008)
  • Author(s): Y.Futamura, R.Sawa, Y.Umezawa, M.Igarashi, H.Nakamura, K.Hasegawa, M.Yamasaki, E.Tashiro, Y.Takahashi, Y.Akamatsu, M.Imoto
  • Journal Title: The Journal of American Chemical Society 130 Pages: 1822-1823
  • Peer Reviewed
• [Presentation] FGFR阻害剤添加によって引き起こされたホヤ胚の形態変異の定量的解析 (2010)
  • Author(s): 寺井淳・中村允・鈴木麻友・井本正哉・岡浩太郎・田代悦・堀田耕司
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-09
• [Presentation] Identification of Trierixin as a novel inhibitor for ER stress-oinduced XBP1 activation from Streptomyces sp. (2010)
  • Author(s): Etu Tashiro, Masaya Imoto
  • Organizer: アジアコアプログラム第2回合同セミナー
  • Place of Presentation: タイ・コンケン
  • Year and Date: 2010-11-21
• [Presentation] Current status of tunicate databases, FABA (2010)
  • Author(s): Kohji Hotta
  • Organizer: 1st Tunicate Information System Meeting
  • Place of Presentation: Nice, France
  • Year and Date: 2010-11-12
• [Presentation] (2010)
  • Author(s): Yuichiro Hira, Jun Terai, Mitsuru Nakamura, Etsu Tashiro, Masaya Imoto, Kotaro Oka, Kohji Hotta
  • Organizer: ACBD : Database for Ascidian Chemical Genomics Bio Curation Meeting
  • Place of Presentation: ポスター東京国際交流館
  • Year and Date: 2010-10-12
• [Presentation] ACBD : Database for Ascidian Chemical Genomics (2010)
  • Author(s): YuichiroHira, Jun Terai, Mitsuru Nakamura, Etsu Tashiro, Masaya Imoto, Kotaro Oka, Kohji Hotta
  • Organizer: BioCurationMeeting
  • Place of Presentation: 東京国際交流館
  • Year and Date: 2010-10-11
• [Presentation] FGFR阻害剤添加により引き起こされるホヤ胚形態変異の解析 (2010)
  • Author(s): 寺井淳・中村充・鈴木麻友・井本正哉・岡浩太郎・田代悦・堀田耕司
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学教養学部
  • Year and Date: 2010-09-25
• [Presentation] ホヤ幼生末梢神経から被嚢内へ伸びた突起が形成するネットワーク構造の解析 (2010)
  • Author(s): 堀田耕司, 寺久保洋, 中島陽子, 紺野在, 堀江健夫, 高橋弘樹, 笹倉靖徳, 稲葉一男, 岡浩太郎
  • Organizer: 日本動物学会第81回大会
  • Place of Presentation: 東京大学教養学部
  • Year and Date: 2010-09-24
• [Presentation] 共焦点顕微鏡を用いた化合物添加による形態異常胚の高解像度スクリーニング (2010)
  • Author(s): 寺井淳、中村允、鈴木麻友、井本正哉、岡浩太郎, 田代悦、堀田耕司
  • Organizer: 第19回日本バイオイメージング学会学術集会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2010-09-10
• [Presentation] Actin-based network structure in the tunic of ascidian larvaSociety for Developmental Biology 69th Annual Meeting-Jointly with Japanese Society of Developmental Biologists (2010)
  • Author(s): Kohji HOTTA, Hiroshi Q TERAKUBO, Mitsuru Nakamura, Yoko NAKAJIMA, Yasunori SASAKURA, Takeo HORIE, Alu KONNO, Hiroki TAKAHASHI, Kazuo INABA, Kotaro OKAASNET
  • Organizer: ポスター発表Albuquerque
  • Place of Presentation: New Mexico, USA
  • Year and Date: 2010-08-08
• [Presentation] Quantitative analysis of ascidian tailbud stage embryo at single cell level by constructing 3D Virtual EmbryoSociety for Developmental Biology 69th Annual Meeting-Jointly with Japanese Society of Developmental Biologists (2010)
  • Author(s): Mitsuru Nakamura, Jun Terai, Kohji Hotta, Kotaro Oka
  • Organizer: ポスター発表Albuquerque
  • Place of Presentation: New Mexico, USA
  • Year and Date: 2010-08-07
• [Presentation] FGFR inhibitor affect proliferation of tail epidermal cells and cause neural tube closure defect in ascidian Ciona intestinalis Society for Developmental Biology 69th Annual Meeting-Jointly with Japanese Society of Developmental Biologists (2010)
  • Author(s): Jun Terai, Mayu Suzuki, Masaya Imoto, Etsu Tashiro, Kotaro Oka, Kohji Hotta
  • Organizer: ポスター発表Albuquerque
  • Place of Presentation: New Mexico, USA
  • Year and Date: 2010-08-07
• [Presentation] ACDB : Database for Ascidian Chemical Genomics (2010)
  • Author(s): Kohji Hotta, Yuichiro Hira, Etsu Tashiro, Masaya Imoto, Kotaro Oka
  • Organizer: Society for Developmental Biology 69th Annual Meeting
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2010-08-07
• [Presentation] ACDB : Database for Ascidian Chemical Genomics Society for Developmental Biology 69th Annual Meeting-Jointly with Japanese Society of Developmental Biologists (2010)
  • Author(s): Kohji Hotta, Yuichiro Hira, Etsu Tashiro, Masaya Imoto, Kotaro Oka
  • Organizer: ポスター発表Albuquerque
  • Place of Presentation: New Mexico, USA
  • Year and Date: 2010-08-06
• [Presentation] ASNET : Actin-based network structure in the tunic of ascidian larva (2010)
  • Author(s): Kohji HOTTA, Hiroshi Q TERAKUBO, Mitsuru Nakamura, Yoko NAKAJIMA, Yasunori SASAKURA, Takeo HORIE, Alu KONNO, Hiroki TAKAHASHI, Kazuo INABA, Kotaro OKA
  • Organizer: Society for Developmental Biology 69th Annual Meeting
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2010-08-06
• [Presentation] FGFR inhibitor affect proliferation of tail epidermal cells and cause neural tube closure defect in ascidian Cionaintestinalis (2010)
  • Author(s): Jun Terai, Mayu Suzuki, Masaya Imoto, Etsu Tashiro, Kotaro Oka, Kohji Hotta
  • Organizer: Society for Developmental Biology 69th Annual Meeting -Jointly with Japanese Society of Developmental Biologists
  • Place of Presentation: Albuquerque, New Mexico, USA
  • Year and Date: 2010-08-05
• [Presentation] Actin-based network structure in the tunic of ascidian larva revealed by confocal laser scanning and transmission electron microscopes. (2010)
  • Author(s): KOHJI HOTTA, Hiroshi Terakubo, Yoko Nakajima, Yasunori Sasakura, Takeo Horie, Alu Konno, Hiroki Takahashi, Kazuo Inaba, Kotaro Oka
  • Organizer: 43rd Annual Meeting for the Japanese Society of Developmental Biologists Jointly Sponsored by the Asia-Pacific Developmental Biology Network口頭発表
  • Place of Presentation: International Conference Center
  • Year and Date: 2010-06-22
• [Presentation] Actin-based network structure in the tunic of ascidian larva revealed by confocal laser scanning andtransmission electron microscopes (2010)
  • Author(s): KOHJI HOTTA, Hiroshi Terakubo, Yoko Nakajima, YasunoriSasakura, Takeo Horie, Alu Konno, Hiroki, Takahashi, Kazuo Inaba, Kotaro Oka
  • Organizer: 43rd Annual Meeting for the Japanese Society of Developmental Biologists Jointly Sponsored by the Asia-Pacific Developmental Biology Network
  • Place of Presentation: Kyoto, International Conference Center
  • Year and Date: 2010-06-21
• [Presentation] Ascidian dendritic network in tunic (2010)
  • Author(s): Kohji HOTTA, Hiroshi Q TERAKUBO, Yoko NAKAJIMA, Alu KONNO, Takeo HORIE, Hiroki TAKAHASHI, Yasunori SASAKURA, Kazuo INABA, Kotaro OKA
  • Organizer: 2ND JOINT MEETING OF THE SFBD AND JSDB 2010-From Cells to OrgansInstitut Pasteur
  • Place of Presentation: Paris, France
  • Year and Date: 2010-05-27
• [Presentation] Ascidian dendritic network in tunic (2010)
  • Author(s): Kohji HOTTA, Hiroshi Q TERAKUBO, Yoko NAKAJIMA, Alu KONNO, Takeo HORIE, Hiroki TAKAHASHI, Yasunori SASAKURA, Kazuo INABA, Kotaro OKA
  • Organizer: 2ND JOINT MEETING OF THE SFBD
  • Place of Presentation: Institut Pasteur, Paris, France
  • Year and Date: 2010-05-26
• [Presentation] ケミカルゲノミクスによるホヤ胚形態形成に関わる分子の探索と機能解析 (2010)
  • Author(s): 寺井淳、鈴木麻友、日良裕一郎、井本正哉、岡浩太郎、田代悦、堀田耕司
  • Organizer: 日本ケミカルバイオロジー学会
  • Place of Presentation: 慶應義塾大学
  • Year and Date: 2010-05-18
• [Presentation] FABA2 : A web-based interactive developmental table for the ascidian from hatching larva to juvenile International (2009)
  • Author(s): Kohji Hotta, Akitsu Fukuzawa, Kazuho Ikeo, Takashi Gojobori, Kazuo Inaba, Kotaro Oka
  • Organizer: Symposium Marine Genomics口頭発表
  • Place of Presentation: Okinawa, Hotel Sourthern Plaza Kaiho
  • Year and Date: 2009-12-16
• [Presentation] FABA2 : A web-based interactive developmental table for the ascidian from hatching larva to juvenile (2009)
  • Author(s): Kohji Hotta, Akitsu Fukuzawa, Kazuho Ikeo, Takashi Gojobori, Kazuo Inaba, Kotaro Oka
  • Organizer: International Symposium Marine Genomics
  • Place of Presentation: Okinawa, Hotel Sourthern Plaza Kaiho
  • Year and Date: 2009-12-16
• [Presentation] Toyocamycin inhibits ER stress-induced XBP1 mRNA splicing through IRE1a inhibition (2009)
  • Author(s): Etsu Tashiro, Yumi Yokouchi, Kohta Yamamoto, Masaya Imoto
  • Organizer: AACR-NCI-EORTC合同国際カンファレンス
  • Place of Presentation: ボストン
  • Year and Date: 2009-11-16
• [Presentation] FABA2 : Three dimensional real-image embryo reconstructions for standardizing developmental stages from hatching larva to juvenile (2009)
  • Author(s): K.Hotta, A.Fukuzawa, K.Mitsuhara, K.Ikeo, T.Gojobori, K.Inaba, K.Oka
  • Organizer: 5th International Tunicate Meeting口頭発表
  • Place of Presentation: 沖縄、小禄、沖縄産業支援センター
  • Year and Date: 2009-06-24
• [Presentation] FABA2 : Three dimensional real-image embryo reconstructions for standardizing developmental stages from hatching larva to juvenile (2009)
  • Author(s): K.Hotta, A.Fukuzawa, K.Mitsuhara, K.Ikeo, T.Gojobori, K.Inaba, K.Oka
  • Organizer: 5th International Tunicate Meeting
  • Place of Presentation: 沖縄、小禄、沖縄産業支援センター
  • Year and Date: 2009-06-24
• [Presentation] The structure and evolution of caudal epidermal neurons in ascidian larva (2009)
  • Author(s): Hiroshi Q.Terakubo, Hiroki Takahashi, Yoko Nakajima, Yasunori Sasakura, Takeo Horie, Kohji Hotta, Kotaro Oka
  • Organizer: 5th International Tunicate Meeting口頭発表
  • Place of Presentation: 沖縄、小禄、沖縄産業支援センター
  • Year and Date: 2009-06-23
• [Presentation] Ascidians : An Emerging Model in Chemical-Developmental Biology and High-throughput Whole-Animal Chemical Screening (2009)
  • Author(s): Yuichiro Hira, Jun Terai, Masaya Imoto, Kotaro Oka, Etsu Tashiro, Kohji Hotta
  • Organizer: 5th International Tunicate Meeting、口頭発表
  • Place of Presentation: 小禄、沖縄産業支援センター
  • Year and Date: 2009-06-23
• [Presentation] The structure and evolution of caudal epidermal neurons in ascidian larva (2009)
  • Author(s): Hiroshi Q.Terakubo, Hiroki Takahashi, Yoko Nakajima, Yasunori Sasakura, Takeo Horie, Kohii Hotta, Kotaro Oka
  • Organizer: 5th International Tunicate Meeting
  • Place of Presentation: 沖縄、小禄、沖縄産業支援センター
  • Year and Date: 2009-06-23
• [Presentation] Ascidians : An Emerging Model in Chemical-Developmental Biology and High-throughput Whole-Animal Chemical Screening (2009)
  • Author(s): Yuichiro Hira, Jun Terai, Masaya Imoto, Kotaro Oka, Etsu Tashiro, Kohii Hotta
  • Organizer: 5th Intemational Tunicate Meeting
  • Place of Presentation: 沖縄、小禄、沖縄産業支援センター
  • Year and Date: 2009-06-22
• [Presentation] 新規XBP1阻害剤キノトリエリキシンは不良タンパク質の蓄積を阻害することで小胞体ストレスを抑制する (2009)
  • Author(s): 山本浩太、田代悦、井本正哉
  • Organizer: ケミカルバイオロジー学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-05-18
• [Presentation] 放線菌由来新規テルペン化合物NT17Aによる細胞死誘導機構の解析 (2009)
  • Author(s): 小田一成、田代悦、本橋慶一郎、瀬戸治男、井本正哉
  • Organizer: 日本農芸化学会
  • Place of Presentation: 東京
  • Year and Date: 2009-03-29
• [Presentation] BrefeldinAが誘導する小胞体ストレス応答の制御機構解析 (2009)
  • Author(s): 新荘聡子、田代悦、井本正哉
  • Organizer: 日本農芸化学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-03-27
• [Presentation] 新規XBP1活性化阻害剤トリエリキシンの発見 (2008)
  • Author(s): 田代悦、二村友史、井本正哉
  • Organizer: 日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2008-10-28
• [Presentation] 小胞体ストレスが誘導する転写因子XBP1の活性化を抑制する新規化合物トリエリキシンとキノトリエリキシンの発見・構造解析・生物活性・構造活性相関 (2008)
  • Author(s): 河村達郎、田代悦、二村友史、新藤一敏、井本正哉
  • Organizer: 天然有機化合物討論会
  • Place of Presentation: 福岡
  • Year and Date: 2008-09-30
• [Presentation] トリエリキシンおよびその類縁体のXBP1阻害活性および抗腫瘍活性の評価 (2008)
  • Author(s): 河村達郎、田代悦、井本正哉
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] トヨカマイシンによるXBP1活性化阻害機構の解析 (2008)
  • Author(s): 田代悦、井本正哉
  • Organizer: がん分子標的治療研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] 小分子化合物と統計処理を用いた小胞体ストレス応答機構の解析 (2008)
  • Author(s): 新庄聡子、田代悦、井本正哉
  • Organizer: 日本ケミカルバイオロジー研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-19
• [Presentation] トヨカマイシンによるXBP1活性化阻害機構の解析 (2008)
  • Author(s): 田代悦、井本正哉
  • Organizer: 日本ケミカルバイオロジー研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-05-19
• [Remarks] ホームページ等
• [Remarks] 三次元個体表現型データベース(3DPL)
  • URL: http://chordate.bpni.bio.keio.ac.jp/3dpl/top.html
• [Remarks] ホヤ化学発生生物学データベースACBD ver.1
  • URL: http://chordate.bpni.bio.keio.ac.jp/acbd/top.html
• [Remarks] ホヤ化学発生生物学データベースACBD ver.1
  • URL: http://chordate.bpni.bio.keio.ac.jp/acbd/top.html
• [Remarks] 三次元個体表現型データベース(3DPL)作成
  • URL: http://chordate.bpni.bio.keio.ac.jp/3dpl/top.html
• [Remarks] 小分子化合物を用いたホヤに関する論文データベース(ACBD)のプロトタイプ作成
  • URL: http://chordate.bpni.bio.keio.ac.jp/acbd/top.html
• [Remarks] 三次元個体表現型データベースのプロトタイプ作成
  • URL: http://chordate.bpni.bio.keio.ac.jp/20090315/3dpl/top.html