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MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

Research Project

Project/Area Number 20227006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionNagoya University

Principal Investigator

KAIBUCHI Kozo  名古屋大学, 医学系研究科, 教授 (00169377)

Co-Investigator(Kenkyū-buntansha) AMANO Mutsuki  名古屋大学, 大学院・医学系研究科, 准教授 (90304170)
WATANABE Takashi  名古屋大学, 大学院・医学系研究科, 特任講師 (10402562)
MORI Daisuke  名古屋大学, 大学院・医学系研究科, 特任講師 (00381997)
NISHIOKA Tomoki  名古屋大学, 大学院・医学系研究科, 助教 (70435105)
TSUBOI Daisuke  名古屋大学, 大学院・医学系研究科, 助教 (80584672)
ARIMURA Nariko  名古屋大学, 大学院・医学系研究科, 助教 (20420375)
Project Period (FY) 2008 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000)
Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000)
Fiscal Year 2010: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2009: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2008: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
Keywordsシグナル伝達 / 遊走 / 細胞骨格 / 極性 / プロテオーム / 微小管 / 脳・神経 / 小胞輸送
Research Abstract

In response to extracellular and intracellular signals, cell exhibits a polarized morphology with adhering neighboring cells and extracellular matrix. Cell polarization is a fundamental process that makes cells enable to exert specific physiological roles in tissues. The understanding for the molecular mechanisms by which cell polarization isregulated had remained largely unknown. Our researches revealed signaling networks for cellular polarization and its maintenance in migrating cells and neurons.

Assessment Rating
Verification Result (Rating)

A

Report

(8 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report   Self-evaluation Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (116 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (63 results) (of which Peer Reviewed: 63 results) Presentation (45 results) (of which Invited: 4 results) Book (2 results) Remarks (6 results)

  • [Journal Article] Spatial regulation of VEGF receptor endocytosis in angiogenesis2013

    • Author(s)
      Nakayama, M.
    • Journal Title

      Nat Cell Biol

      Volume: 15 Issue: 3 Pages: 249-60

    • DOI

      10.1038/ncb2679

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice2013

    • Author(s)
      D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
    • Journal Title

      Glia

      Volume: 61 Issue: 5 Pages: 679-693

    • DOI

      10.1002/glia.22461

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IQGAP1 suppresses TbetaRII-mediated myofibroblastic activation and metastatic growth in liver2013

    • Author(s)
      Liu, C.
    • Journal Title

      J Clin Invest

      Volume: 123 Issue: 3 Pages: 1138-56

    • DOI

      10.1172/jci63836

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.2012

    • Author(s)
      Wang S., Watanabe T., Matsuzawa K., Katsumi A., Kakeno M., Matsui T., Ye F., Sato K., Murase K., Sugiyama I., Kimura K., Mizoguchi A., Ginsberg M. H., Collard J. G. & Kaibuchi K.
    • Journal Title

      J Cell Biol

      Volume: 199 Pages: 331-345

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3zeta Affinity Chromatography.2012

    • Author(s)
      Nishioka T., Nakayama M., Amano M. & Kaibuchi K.
    • Journal Title

      Cell Struct Funct

      Volume: 37 Pages: 39-48

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.2012

    • Author(s)
      Kato K., Yazawa T., Taki K., Mori K., Wang S., Nishioka T., Hamaguchi T., Itoh T., Takenawa T., Kataoka C., Matsuura Y., Amano M., Murohara T. & Kaibuchi K.
    • Journal Title

      Mol Biol Cell

      Volume: 23 Pages: 2593-2604

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.2012

    • Author(s)
      Wang, Shujie, et al.
    • Journal Title

      Journal of Cell Biology

      Volume: 199 Issue: 2 Pages: 331-345

    • DOI

      10.1083/jcb.201202041

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration2012

    • Author(s)
      Kato, K.
    • Journal Title

      Mol Biol Cell

      Volume: 23 Issue: 13 Pages: 2593-604

    • DOI

      10.1091/mbc.e11-11-0958

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3ζ Affinity Chromatography2012

    • Author(s)
      Nishioka T., et al
    • Journal Title

      Cell Structure and Function

      Volume: 37 Issue: 1 Pages: 39-48

    • DOI

      10.1247/csf.11044

    • NAID

      130004137575

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Latent process genes for cell differentiation are common decoders of neurite extension length2012

    • Author(s)
      Watanabe, K.
    • Journal Title

      J Cell Sci

      Volume: 125 Pages: 2198-211

    • DOI

      10.1242/jcs.097709

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin2012

    • Author(s)
      Li, W.
    • Journal Title

      J Cell Biol

      Volume: 199 Issue: 5 Pages: 849-62

    • DOI

      10.1083/jcb.201206101

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012

    • Author(s)
      Chiyoda, T.
    • Journal Title

      J Cell Biol

      Volume: 197 Issue: 5 Pages: 625-41

    • DOI

      10.1083/jcb.201110110

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility2012

    • Author(s)
      Ishida-Takagishi M, Enomoto A, et al.
    • Journal Title

      Nat Commun

      Volume: 3 Issue: 1 Pages: 859-859

    • DOI

      10.1038/ncomms1861

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Girdin in the determination of cell polarity during cell migration2012

    • Author(s)
      Ohara K, Enomoto A, et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 5 Pages: e36681-e36681

    • DOI

      10.1371/journal.pone.0036681

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct Distribution and Localization of Rho-kinase in Mouse Epithelial, Muscle and Neural Tissues2012

    • Author(s)
      Iizuka, M.
    • Journal Title

      Cell Structure and Function

      Volume: 37 Issue: 2 Pages: 155-175

    • DOI

      10.1247/csf.12018

    • NAID

      130004137587

    • ISSN
      0386-7196, 1347-3700
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DGKzeta is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway2012

    • Author(s)
      Okada, M.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 420 Issue: 2 Pages: 479-84

    • DOI

      10.1016/j.bbrc.2012.03.057

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flexible search for single-axon morphology during neuronal spontaneous polarization.2011

    • Author(s)
      Naoki H., Nakamuta S., Kaibuchi K. & Ishii S.
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of selective transport in neuronal polarization.2011

    • Author(s)
      Namba T., Nakamuta S., Funahashi Y. & Kaibuchi K.
    • Journal Title

      Dev Neurobiol

      Volume: 71 Pages: 445-457

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca^/calmodulin-dependent protein kinases.2011

    • Author(s)
      Nakamuta S., Funahashi Y., Namba T., Arimura N., Picciotto M. R., Tokumitsu H., Soderling T. R., Sakakibara A., Miyata T., Kamiguchi H. & Kaibuchi K.
    • Journal Title

      Sci Signal

      Volume: 4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca^,<2+>/Calmodulin-Dependent Protein Kinases2011

    • Author(s)
      Nakamuta S., et al
    • Journal Title

      Science Signaling

      Volume: 4 Issue: 199

    • DOI

      10.1126/scisignal.2002011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Numb controls E-cadherin endocytosis through p120 catenin with aPKC2011

    • Author(s)
      Sato K., et al
    • Journal Title

      Molecular Biology of the Cell

      Volume: 22 Issue: 17 Pages: 3103-3119

    • DOI

      10.1091/mbc.e11-03-0274

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells2011

    • Author(s)
      Li W., et al
    • Journal Title

      Journal of Cell Biology

      Volume: 193 Issue: 6 Pages: 973-983

    • DOI

      10.1083/jcb.201101108

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiexible search for single-axon morphology during neuronal spontaneous polarization2011

    • Author(s)
      Naoki H., et al
    • Journal Title

      PloS One

      Volume: 6 Issue: 4 Pages: e19034-e19034

    • DOI

      10.1371/journal.pone.0019034

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex2011

    • Author(s)
      Takeda S., et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 410 Issue: 1 Pages: 29-33

    • DOI

      10.1016/j.bbrc.2011.05.099

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal polarity in 20112011

    • Author(s)
      Doe CQ, Kaibuchi K
    • Journal Title

      Developmental Neurobiology

      Volume: 71 Issue: 6 Pages: 401-402

    • DOI

      10.1002/dneu.20863

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse2011

    • Author(s)
      Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H
    • Journal Title

      Science Signaling

      Volume: 4(179) Issue: 170

    • DOI

      10.1126/scisignal.2001127

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein kinase G signaling disrupts Racl-dependent focal adhesion assembly in liver specific pericytes2011

    • Author(s)
      Routray C., et al
    • Journal Title

      American Journal of Physiology Cell Physiology

      Volume: 301 Issue: 1 Pages: C66-C74

    • DOI

      10.1152/ajpcell.00038.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of selective transport in neuronal polarization2011

    • Author(s)
      Namba T., et al
    • Journal Title

      Developmental Neurobiology

      Volume: 71 Issue: 6 Pages: 445-457

    • DOI

      10.1002/dneu.20876

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C.elegans2011

    • Author(s)
      Qadota H., et al
    • Journal Title

      Journal of Molecular Biology

      Volume: 407 Issue: 2 Pages: 222-231

    • DOI

      10.1016/j.jmb.2011.01.039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of selective transport in neuronal polarization2011

    • Author(s)
      Namba T., et al
    • Journal Title

      Dev Neurobiol

      Volume: in press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010

    • Author(s)
      Nakano A., Kato H., Watanabe T., Min K. D., Yamazaki S., Asano Y., Seguchi O., Higo S., Shintani Y., Asanuma H., Asakura M., Minamino T., Kaibuchi K., Mochizuki N., Kitakaze M. & Takashima S
    • Journal Title

      Nat Cell Biol

      Volume: 12 Pages: 583-590

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis.2010

    • Author(s)
      Itoh N., Nakayama M., Nishimura T., Fujisue S., Nishioka T., Watanabe T. & Kaibuchi K.
    • Journal Title

      Cytoskeleton (Hoboken)

      Volume: 67 Pages: 297-308

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.2010

    • Author(s)
      Amano M., Tsumura Y., Taki K., Harada H., Mori K., Nishioka T., Kato K., Suzuki T., Nishioka Y., Iwamatsu A. & Kaibuchi K.
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.2010

    • Author(s)
      Amano M., Nakayama M. & Kaibuchi K.
    • Journal Title

      Cytoskeleton (Hoboken)

      Volume: 67 Pages: 545-554

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners.2010

    • Author(s)
      Namba, T., Kaibuchi, K.
    • Journal Title

      Dev Cell 19

      Pages: 7-8

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.2010

    • Author(s)
      Amano, M., Tsumura, Y., Taki, K., Harada, H., Mori, K., Nishioka, T., Kato, K., Suzuki, T., Nishioka, Y., Iwamatsu, A., Kaibuchi, K.
    • Journal Title

      PLoS ONE 5

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Switching DISC1 function in neurogenesis : Dixdcl selects DISC1 binding partners2010

    • Author(s)
      Namba T., Kaibuchi K.
    • Journal Title

      Dev Cell

      Volume: 19 Pages: 7-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation2010

    • Author(s)
      Nakano A., et al
    • Journal Title

      Nat Cell Biol

      Volume: 12 Pages: 583-590

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells2010

    • Author(s)
      Matsumoto S., et al
    • Journal Title

      EMBO J

      Volume: 29 Pages: 1192-1204

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis2010

    • Author(s)
      Itoh N., et al
    • Journal Title

      Cytoskeleton

      Volume: 67 Pages: 297-308

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase/ROCK : A key regulator of the cytoskeleton and cell polarity2010

    • Author(s)
      Amano M., et al
    • Journal Title

      Cytoskeleton

      Volume: 67 Pages: 545-554

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis2010

    • Author(s)
      Itoh, N., et al.
    • Journal Title

      Cytoskeleton (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase2010

    • Author(s)
      Amano, M., et al.
    • Journal Title

      PLoS One 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module2010

    • Author(s)
      Terawaki, S., et al.
    • Journal Title

      EMBO J 29

      Pages: 236-250

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009

    • Author(s)
      Watanabe T., Noritake J., Kakeno M., Matsui T., Harada T., Wang S., Itoh N., Sato K., Matsuzawa K., Iwamatsu A., Galjart N. & Kaibuchi K.
    • Journal Title

      J Cell Sci

      Volume: 122 Pages: 2969-2979

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP2009

    • Author(s)
      Mori K., Amano M., Takefuji M., Kato K., Morita Y., Nishioka T., Matsuura Y., Murohara T. & Kaibuchi K.
    • Journal Title

      J Biol Chem

      Volume: 284 Pages: 5067-5076

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab272009

    • Author(s)
      Arimura N., Kimura T., Nakamuta S., Taya S., Funahashi Y., Hattori A., Shimada A., Menager C., Kawabata S., Fujii K., Iwamatsu A., Segal R. A., Fukuda M. & Kaibuchi K.
    • Journal Title

      Dev Cell

      Volume: 16 Pages: 675-686

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity.2009

    • Author(s)
      Arimura N., Hattori A., Kimura T., Nakamuta S., Funahashi Y., Hirotsune S., Furuta K., Urano T., Toyoshima Y. Y. & Kaibuchi K.
    • Journal Title

      J Neurochem

      Volume: 111 Pages: 380-390

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009

    • Author(s)
      Watanabe, T., Noritake, J., Kakeno, M., Matsui, T., Harada, T., Wang, S., Itoh, N., Sato, K., Matsuzawa, K., Iwamatsu, A., Galjart, N., Kaibuchi, K.
    • Journal Title

      Journal of Cell Science 122

      Pages: 2969-2979

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP.2009

    • Author(s)
      Mori, K., Amano, M., Takefuji, M., Kato, K., Morita, Y., Nishioka, T., Matsuura, Y., Murohara, T., Kaibuchi, K.
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 5067-5076

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009

    • Author(s)
      Enomoto, A., Asai, N., Namba, T., Wang, Y., Kato, T., Tanaka, M., Tatsumi, H., Taya, S., Tsuboi, D., Kuroda, K., Kaneko, N., Sawamoto, K., Miyamoto, R., Jijiwa, M., Murakumo, Y., Sokabe, M., Seki, T., Kaibuchi, K., Takahashi, M.
    • Journal Title

      Neuron 63

      Pages: 774-787

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.2009

    • Author(s)
      Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R.A., Fukuda, M., Kaibuchi, K.
    • Journal Title

      Dev Cell 16

      Pages: 675-686

    • Related Report
      2010 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus2009

    • Author(s)
      Enomoto, A., et al.
    • Journal Title

      Neuron 63

      Pages: 774-787

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity2009

    • Author(s)
      Arimura, N., et al.
    • Journal Title

      J Neurochem 11

      Pages: 380-390

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity2009

    • Author(s)
      Hou, S.T., et al.
    • Journal Title

      J Neurochem 11

      Pages: 870-881

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules2009

    • Author(s)
      Watanabe, T., et al.
    • Journal Title

      J Cell Sci 122

      Pages: 2969-2979

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct interaction of Dysbindin with the AP-3 complex via its mu subunit2009

    • Author(s)
      Taneichi-Kuroda, S., et al.
    • Journal Title

      Neurochem Int 54

      Pages: 431-438

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases2009

    • Author(s)
      Iguchi, Y., et al.
    • Journal Title

      J Biol Chem 284

      Pages: 22059-22066

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab272009

    • Author(s)
      Arimura, N., et al.
    • Journal Title

      Dev Cell 16

      Pages: 675-686

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP.2009

    • Author(s)
      Mori, K, et al.
    • Journal Title

      J Biol Chem 284

      Pages: 5067-5076

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab27.2009

    • Author(s)
      Arimura, N, et al.
    • Journal Title

      Dev Cell (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural study of Racl and its effectors beneath the substratum-facing membrane2008

    • Author(s)
      Watanabe, T, et al.
    • Journal Title

      Cell Struct Funct 33

      Pages: 101-107

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia2008

    • Author(s)
      Ikeda, M, et al.
    • Journal Title

      Hum Mol Genet 17

      Pages: 3212-3222

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Neuronal Polarity in vitro and in vivo2013

    • Author(s)
      Kaibuchi K
    • Organizer
      Keystone Symposium
    • Place of Presentation
      Tahoe City, USA
    • Year and Date
      2013-03-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuronal Polarity in vitro and in vivo2013

    • Author(s)
      Kaibuchi, K.
    • Organizer
      Keystone symposium Growing to Extremes: Cell Biology and Pathology of Axons
    • Place of Presentation
      Tahoe City, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Neuronal polarity in vitro and in vivo2013

    • Author(s)
      Kaibuchi, K.
    • Organizer
      Symposium on Sensory Systems & Neural Circuits
    • Place of Presentation
      東京大学伊藤国際学術研究センター、東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Protein phosphorylation remains a black box in signal transduction: Developing a new method to search for substrates of protein kinases2012

    • Author(s)
      Kaibuchi, K.
    • Organizer
      14th Internatioal Congress of Histochemistry and Cytochemistry
    • Place of Presentation
      京都国際会館、京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Key Regulators in Neuronal Polarization2012

    • Author(s)
      Kaibuchi, K.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Signaling for neuronal polarization2011

    • Author(s)
      Kaibuchi K
    • Organizer
      2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
    • Place of Presentation
      Tainan, Taiwan
    • Year and Date
      2011-11-19
    • Related Report
      2012 Final Research Report
  • [Presentation] Signaling for neuronal polarization2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
    • Place of Presentation
      Tainan, Taiwan(招待)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Tiam1 acts with the PAR complex to control talin-mediated Rac1 activation2011

    • Author(s)
      Kaibuchi K
    • Organizer
      5th Mechanobiology Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 統合失調症の発症脆弱性因子DISC1の病態生理機能2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      第54回日本神経化学会
    • Place of Presentation
      瑠璃光、加賀市、石川県(招待)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synapse Alteration and Schizophrenia2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      The Synapse
    • Place of Presentation
      The Grand Hotel Bristol, Stresa, Italy(招待)
    • Year and Date
      2011-09-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] DISC1 acts as a cargo adapter for neuronal transport of specific proteins and messenger RNAs2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      ISN-ESN 2011
    • Place of Presentation
      Megaron Athens International Conference Centre, Athens, Greece(招待)
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 神経研究とプロテオミクス:質量分析計に何ができるのか2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      包括型脳科学研究推進支援ネットワーク夏のワークショップ
    • Place of Presentation
      神戸国際会議場、神戸市、兵庫県(招待)
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] How internal and external signals regulate neuronal polarity2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      Developmental Neurobiology Course
    • Place of Presentation
      沖縄科学技術大学院大学、国頭郡、沖縄(招待)
    • Year and Date
      2011-07-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neurotrophins regulate neuronal polarity acting through Ca^ and CaMKK. EMBO Cell Biology of the Neuron: Polarity2011

    • Author(s)
      Kaibuchi K
    • Organizer
      Plasticity and Regeneration
    • Place of Presentation
      Creta, Greece
    • Year and Date
      2011-05-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurotrophins regulate neuronal polarity acting through Ga2+ and CaMKK2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      EMBO Cell Biology of the Neuron : Polarity, Plasticity and Regeneration
    • Place of Presentation
      Fodele Beach & Water Park Holiday Resort, Herakli on, Creta, Greece(招待)
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^2011

    • Author(s)
      Kaibuchi K
    • Organizer
      Emerging Concepts on Neuronal Cytoskelton
    • Place of Presentation
      Santa Cruz, Chile
    • Year and Date
      2011-04-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^<2+>2011

    • Author(s)
      Kaibuchi K.
    • Organizer
      Emerging Concepts on Neuronal Cytoskelton
    • Place of Presentation
      Hotel Santa Cruz, Santa Cruz, Chile(招待)
    • Year and Date
      2011-04-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rho-kinase/ROCK : a key regulator of cytoskeleton and cell polarity2010

    • Author(s)
      Kaibuchi K.
    • Organizer
      MEXT Priority Research Project "Cell Proliferation Control" International Svmnosium
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] DISC1 serves as a cargo adapter2010

    • Author(s)
      Kaibuchi K.
    • Organizer
      OzBio2010/IUBMB
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms. Cold Spring Harbor Asia Conference2010

    • Author(s)
      Kaibuchi K
    • Organizer
      1st Francis Crick Neuroscience Symposium
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms.2010

    • Author(s)
      Kaibuchi K.
    • Organizer
      Cold Spring Harbor Asia Conference, 1st Francis Crick Neuroscience Symposium
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-04-13
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms2010

    • Author(s)
      Kaibuchi K.
    • Organizer
      Cold Spring Harbor Asia Conference, 1st Francis Crick Neuroscience Symposium
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-04-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kaibuchi K
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸国際会議場 神戸
    • Year and Date
      2009-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Par and Tiam1 complex in polarized cell migration2009

    • Author(s)
      貝淵弘三
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Spain
    • Year and Date
      2009-10-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Par and Tiam1 complex in polarized cell migration2009

    • Author(s)
      Kaibuchi K
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2009-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Role of Par and Tiam1 complex in polarized cell migration.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2009-10-22
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Neuronal polarity: From extracellular signals to intracellular mechanisms2009

    • Author(s)
      Kaibuchi K
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋国際会議場 名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Neuronal polarity : From extracellular signals to intracellular mechanisms2009

    • Author(s)
      貝淵弘三
    • Organizer
      第32回日本神経科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] DISC1 serves a cargo receptor delivering signaling molecules and mRNAs2009

    • Author(s)
      貝淵弘三
    • Organizer
      From Gene Discovery to Cell Biology in Psychiatry
    • Place of Presentation
      USA
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration2009

    • Author(s)
      Kaibuchi K
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-08-24
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration2009

    • Author(s)
      貝淵弘三
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      UK
    • Year and Date
      2009-08-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Role of Rho and Rho-kinase in vascular smooth muscle contraction2009

    • Author(s)
      貝淵弘三
    • Organizer
      Satellite Symposium of the IUPS 2009、ISSM2009
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Axon formation and polarized transport.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      渋川
    • Year and Date
      2009-06-22
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Axon formation and polarized transport2009

    • Author(s)
      貝淵弘三
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      伊香保
    • Year and Date
      2009-06-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      Kaibuchi K
    • Organizer
      ESF-EMBO Symposium
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2009-05-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Axon formation and polarized vesicle transport.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      ESF-EMBO Symposium
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2009-05-23
    • Related Report
      2010 Self-evaluation Report
  • [Presentation] Axon formation and polarized vesicle transport2009

    • Author(s)
      貝淵弘三
    • Organizer
      ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
    • Place of Presentation
      Spain
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Rho Proteins and Neuronal Polarity2008

    • Author(s)
      Kaibuchi K
    • Organizer
      FASEB Summer Research Conferences
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2008-07-16
    • Related Report
      2012 Final Research Report 2008 Annual Research Report
  • [Presentation] 細胞遊走における Rho ファミリーと Par 複合体の役割2008

    • Author(s)
      貝淵弘三
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      パシフィコ横浜 横浜
    • Year and Date
      2008-06-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 細胞遊走におけるRhoファミリーとPar複合体の役割2008

    • Author(s)
      貝淵弘三
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-30
    • Related Report
      2010 Self-evaluation Report 2008 Annual Research Report
  • [Presentation] Neuronal development and cargo transport2008

    • Author(s)
      Kaibuchi K
    • Organizer
      Gordon Research Conference on Molecular & Cellular Neurobiology
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      2008-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Rho-kinase and Rho family GTPase signaling2008

    • Author(s)
      Mutsuki Amano
    • Organizer
      FASEB Suramer Research Conferences
    • Place of Presentation
      Vermont, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Rho-kinase contributes to sustained Rho activation through the phosphorylation of p190A RhoGAP in vascular smooth muscle cells2008

    • Author(s)
      森和孝
    • Organizer
      第12回Molecular Cardiovascular Conference
    • Place of Presentation
      キロロ
    • Related Report
      2008 Annual Research Report
  • [Presentation] Axon formation and polarized vesicle trnasport2008

    • Author(s)
      貝淵弘三
    • Organizer
      BMB 2008
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report
  • [Book] Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases2009

    • Author(s)
      Watanabe T., Sato K., and Kaibuchi K.
    • Publisher
      Cold Spring Harb Perspect Biol.
    • Related Report
      2012 Final Research Report
  • [Book] Cold Spring Harbor perspectives in biology 1(Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases.)2009

    • Author(s)
      Watanabe, T., Sato, K., Kaibuchi, K.
    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/index.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 名古屋大学大学院医学系研究科神経情報薬理学講座ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/index.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2011 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2010 Self-evaluation Report
  • [Remarks]

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2010 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 神経情報薬理学講座ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2019-07-29  

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