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2010 Fiscal Year Self-evaluation Report

Molecular mechanisms underlying cell polarization in migrating cells and neurons

Research Project

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Project/Area Number 20227006
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Cell biology
Research InstitutionNagoya University

Principal Investigator

KAIBUCHI Kozo  Nagoya University, 医学系研究科, 教授 (00169377)

Project Period (FY) 2008 – 2012
Keywordsシグナル伝達 / 遊走 / 細胞骨格 / 極性 / プロテオーム / 微小管 / 脳・神経 / 小胞輸送
Research Abstract

生体を構成する種々の細胞は特徴的な極性を獲得し固有の生理機能を担っている。遊走する細胞、神経細胞や上皮細胞がその顕著な例である。細胞極性の獲得と維持は生体機能に必須であるものの、その分子基盤には不明の点も多い。本研究では、(1)遊走細胞と(2)神経細胞をモデルシステムとし、細胞極性の獲得・維持機構を制御するシグナル伝達機構の解明を行う。また、細胞極性の形成に関与する細胞骨格と選択的蛋白質・小胞輸送の制御機構の解明を目指す。さらには、(3)両システムに関連したプロテオミクス解析やシミュレーションモデルの作成により包括的な理解を目指す。

  • Research Products

    (14 results)

All 2010 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners.2010

    • Author(s)
      Namba, T., Kaibuchi, K.
    • Journal Title

      Dev Cell 19

      Pages: 7-8

    • Peer Reviewed
  • [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase.2010

    • Author(s)
      Amano, M., Tsumura, Y., Taki, K., Harada, H., Mori, K., Nishioka, T., Kato, K., Suzuki, T., Nishioka, Y., Iwamatsu, A., Kaibuchi, K.
    • Journal Title

      PLoS ONE 5

      Pages: e8704

    • Peer Reviewed
  • [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.2009

    • Author(s)
      Watanabe, T., Noritake, J., Kakeno, M., Matsui, T., Harada, T., Wang, S., Itoh, N., Sato, K., Matsuzawa, K., Iwamatsu, A., Galjart, N., Kaibuchi, K.
    • Journal Title

      Journal of Cell Science 122

      Pages: 2969-2979

    • Peer Reviewed
  • [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP.2009

    • Author(s)
      Mori, K., Amano, M., Takefuji, M., Kato, K., Morita, Y., Nishioka, T., Matsuura, Y., Murohara, T., Kaibuchi, K.
    • Journal Title

      The Journal of Biological Chemistry 284

      Pages: 5067-5076

    • Peer Reviewed
  • [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.2009

    • Author(s)
      Enomoto, A., Asai, N., Namba, T., Wang, Y., Kato, T., Tanaka, M., Tatsumi, H., Taya, S., Tsuboi, D., Kuroda, K., Kaneko, N., Sawamoto, K., Miyamoto, R., Jijiwa, M., Murakumo, Y., Sokabe, M., Seki, T., Kaibuchi, K., Takahashi, M.
    • Journal Title

      Neuron 63

      Pages: 774-787

    • Peer Reviewed
  • [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.2009

    • Author(s)
      Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R.A., Fukuda, M., Kaibuchi, K.
    • Journal Title

      Dev Cell 16

      Pages: 675-686

    • Peer Reviewed
  • [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms.2010

    • Author(s)
      Kaibuchi K.
    • Organizer
      Cold Spring Harbor Asia Conference, 1st Francis Crick Neuroscience Symposium
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2010-04-13
  • [Presentation] Role of Par and Tiam1 complex in polarized cell migration.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      RAMIC, National Network on Cell Adhesion and Migration
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2009-10-22
  • [Presentation] Roles of Rho family GTPases and Par proteins in directional migration.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      Gordon Research Conferences
    • Place of Presentation
      Oxford, UK
    • Year and Date
      2009-08-24
  • [Presentation] Axon formation and polarized transport.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      渋川
    • Year and Date
      2009-06-22
  • [Presentation] Axon formation and polarized vesicle transport.2009

    • Author(s)
      Kaibuchi K.
    • Organizer
      ESF-EMBO Symposium
    • Place of Presentation
      Sant Feliu de Guixols, Spain
    • Year and Date
      2009-05-23
  • [Presentation] 細胞遊走におけるRhoファミリーとPar複合体の役割2008

    • Author(s)
      貝淵弘三
    • Organizer
      第60回日本細胞生物学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-06-30
  • [Book] Cold Spring Harbor perspectives in biology 1(Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases.)2009

    • Author(s)
      Watanabe, T., Sato, K., Kaibuchi, K.
    • Total Pages
      a003020
  • [Remarks] ホームページ

    • URL

      http://www.med.nagoya-u.ac.jp/Yakuri/

URL: 

Published: 2012-02-13   Modified: 2016-04-21  

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