MOLECULAR MECHANISMS UNDERLYING CELL POLARIZATION IN MIGRATING CELLS AND NEURONS

• Project/Area Number: 20227006
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Cell biology
• Research Institution: Nagoya University
• Principal Investigator: KAIBUCHI Kozo 名古屋大学, 医学系研究科, 教授 (00169377)
• Co-Investigator(Kenkyū-buntansha): AMANO Mutsuki 名古屋大学, 大学院・医学系研究科, 准教授 (90304170) ; WATANABE Takashi 名古屋大学, 大学院・医学系研究科, 特任講師 (10402562) ; MORI Daisuke 名古屋大学, 大学院・医学系研究科, 特任講師 (00381997) ; NISHIOKA Tomoki 名古屋大学, 大学院・医学系研究科, 助教 (70435105) ; TSUBOI Daisuke 名古屋大学, 大学院・医学系研究科, 助教 (80584672) ; ARIMURA Nariko 名古屋大学, 大学院・医学系研究科, 助教 (20420375)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥195,000,000 (Direct Cost: ¥150,000,000、Indirect Cost: ¥45,000,000); Fiscal Year 2012: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000); Fiscal Year 2011: ¥31,200,000 (Direct Cost: ¥24,000,000、Indirect Cost: ¥7,200,000); Fiscal Year 2010: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000); Fiscal Year 2009: ¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000); Fiscal Year 2008: ¥39,000,000 (Direct Cost: ¥30,000,000、Indirect Cost: ¥9,000,000)
• Keywords: シグナル伝達 / 遊走 / 細胞骨格 / 極性 / プロテオーム / 微小管 / 脳・神経 / 小胞輸送

Research Abstract

In response to extracellular and intracellular signals, cell exhibits a polarized morphology with adhering neighboring cells and extracellular matrix. Cell polarization is a fundamental process that makes cells enable to exert specific physiological roles in tissues. The understanding for the molecular mechanisms by which cell polarization isregulated had remained largely unknown. Our researches revealed signaling networks for cellular polarization and its maintenance in migrating cells and neurons.

Assessment Rating

Verification Result (Rating)

A

Research Products

• [Journal Article] Spatial regulation of VEGF receptor endocytosis in angiogenesis (2013)
  • Author(s): Nakayama, M.
  • Journal Title: Nat Cell Biol Volume: 15 Issue: 3 Pages: 249-60
  • DOI: 10.1038/ncb2679
  • Peer Reviewed
• [Journal Article] Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice (2013)
  • Author(s): D Ibi, I Nagai, A Nakajima, H Mizoguchi, T Kawase, D Tsuboi, S Kano, Y Sato, M Hayakawa, U. C. Lange, D. J. Adams, M. Azim Surani, T Satoh, A Sawa, K Kaibuchi, T Nabeshima and K Yamada
  • Journal Title: Glia Volume: 61 Issue: 5 Pages: 679-693
  • DOI: 10.1002/glia.22461
  • Peer Reviewed
• [Journal Article] IQGAP1 suppresses TbetaRII-mediated myofibroblastic activation and metastatic growth in liver (2013)
  • Author(s): Liu, C.
  • Journal Title: J Clin Invest Volume: 123 Issue: 3 Pages: 1138-56
  • DOI: 10.1172/jci63836
  • Peer Reviewed
• [Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. (2012)
  • Author(s): Wang S., Watanabe T., Matsuzawa K., Katsumi A., Kakeno M., Matsui T., Ye F., Sato K., Murase K., Sugiyama I., Kimura K., Mizoguchi A., Ginsberg M. H., Collard J. G. & Kaibuchi K.
  • Journal Title: J Cell Biol Volume: 199 Pages: 331-345
  • Peer Reviewed
• [Journal Article] Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3zeta Affinity Chromatography. (2012)
  • Author(s): Nishioka T., Nakayama M., Amano M. & Kaibuchi K.
  • Journal Title: Cell Struct Funct Volume: 37 Pages: 39-48
  • Peer Reviewed
• [Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration. (2012)
  • Author(s): Kato K., Yazawa T., Taki K., Mori K., Wang S., Nishioka T., Hamaguchi T., Itoh T., Takenawa T., Kataoka C., Matsuura Y., Amano M., Murohara T. & Kaibuchi K.
  • Journal Title: Mol Biol Cell Volume: 23 Pages: 2593-2604
  • Peer Reviewed
• [Journal Article] Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. (2012)
  • Author(s): Wang, Shujie, et al.
  • Journal Title: Journal of Cell Biology Volume: 199 Issue: 2 Pages: 331-345
  • DOI: 10.1083/jcb.201202041
  • Peer Reviewed
• [Journal Article] The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration (2012)
  • Author(s): Kato, K.
  • Journal Title: Mol Biol Cell Volume: 23 Issue: 13 Pages: 2593-604
  • DOI: 10.1091/mbc.e11-11-0958
  • Peer Reviewed
• [Journal Article] Proteomic Screening for Rho-kinase Substrates by Combining Kinase and Phosphatase Inhibitors with 14-3-3ζ Affinity Chromatography (2012)
  • Author(s): Nishioka T., et al
  • Journal Title: Cell Structure and Function Volume: 37 Issue: 1 Pages: 39-48
  • DOI: 10.1247/csf.11044
  • NAID: 130004137575
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed
• [Journal Article] Latent process genes for cell differentiation are common decoders of neurite extension length (2012)
  • Author(s): Watanabe, K.
  • Journal Title: J Cell Sci Volume: 125 Pages: 2198-211
  • DOI: 10.1242/jcs.097709
  • Peer Reviewed
• [Journal Article] Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin (2012)
  • Author(s): Li, W.
  • Journal Title: J Cell Biol Volume: 199 Issue: 5 Pages: 849-62
  • DOI: 10.1083/jcb.201206101
  • Peer Reviewed
• [Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression (2012)
  • Author(s): Chiyoda, T.
  • Journal Title: J Cell Biol Volume: 197 Issue: 5 Pages: 625-41
  • DOI: 10.1083/jcb.201110110
  • Peer Reviewed
• [Journal Article] The Dishevelled-associating protein Daple controls the non-canonical Wnt/Rac pathway and cell motility (2012)
  • Author(s): Ishida-Takagishi M, Enomoto A, et al.
  • Journal Title: Nat Commun Volume: 3 Issue: 1 Pages: 859-859
  • DOI: 10.1038/ncomms1861
  • Peer Reviewed
• [Journal Article] Involvement of Girdin in the determination of cell polarity during cell migration (2012)
  • Author(s): Ohara K, Enomoto A, et al.
  • Journal Title: PLoS One Volume: 7 Issue: 5 Pages: e36681-e36681
  • DOI: 10.1371/journal.pone.0036681
  • Peer Reviewed
• [Journal Article] Distinct Distribution and Localization of Rho-kinase in Mouse Epithelial, Muscle and Neural Tissues (2012)
  • Author(s): Iizuka, M.
  • Journal Title: Cell Structure and Function Volume: 37 Issue: 2 Pages: 155-175
  • DOI: 10.1247/csf.12018
  • NAID: 130004137587
  • ISSN: 0386-7196, 1347-3700
  • Peer Reviewed
• [Journal Article] DGKzeta is involved in LPS-activated phagocytosis through IQGAP1/Rac1 pathway (2012)
  • Author(s): Okada, M.
  • Journal Title: Biochem Biophys Res Commun Volume: 420 Issue: 2 Pages: 479-84
  • DOI: 10.1016/j.bbrc.2012.03.057
  • Peer Reviewed
• [Journal Article] Flexible search for single-axon morphology during neuronal spontaneous polarization. (2011)
  • Author(s): Naoki H., Nakamuta S., Kaibuchi K. & Ishii S.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] The role of selective transport in neuronal polarization. (2011)
  • Author(s): Namba T., Nakamuta S., Funahashi Y. & Kaibuchi K.
  • Journal Title: Dev Neurobiol Volume: 71 Pages: 445-457
  • Peer Reviewed
• [Journal Article] Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca^/calmodulin-dependent protein kinases. (2011)
  • Author(s): Nakamuta S., Funahashi Y., Namba T., Arimura N., Picciotto M. R., Tokumitsu H., Soderling T. R., Sakakibara A., Miyata T., Kamiguchi H. & Kaibuchi K.
  • Journal Title: Sci Signal Volume: 4
  • Peer Reviewed
• [Journal Article] Local Application of Neurotrophins Specifies Axons Through Inositol 1,4,5-Trisphosphate, Calcium, and Ca^,<2+>/Calmodulin-Dependent Protein Kinases (2011)
  • Author(s): Nakamuta S., et al
  • Journal Title: Science Signaling Volume: 4 Issue: 199
  • DOI: 10.1126/scisignal.2002011
  • Peer Reviewed
• [Journal Article] Numb controls E-cadherin endocytosis through p120 catenin with aPKC (2011)
  • Author(s): Sato K., et al
  • Journal Title: Molecular Biology of the Cell Volume: 22 Issue: 17 Pages: 3103-3119
  • DOI: 10.1091/mbc.e11-03-0274
  • Peer Reviewed
• [Journal Article] EB1 promotes microtubule dynamics by recruiting Sentin in Drosophila cells (2011)
  • Author(s): Li W., et al
  • Journal Title: Journal of Cell Biology Volume: 193 Issue: 6 Pages: 973-983
  • DOI: 10.1083/jcb.201101108
  • Peer Reviewed
• [Journal Article] Fiexible search for single-axon morphology during neuronal spontaneous polarization (2011)
  • Author(s): Naoki H., et al
  • Journal Title: PloS One Volume: 6 Issue: 4 Pages: e19034-e19034
  • DOI: 10.1371/journal.pone.0019034
  • Peer Reviewed
• [Journal Article] Role of a tyrosine phosphorylation of SMG-9 in binding of SMG-9 to IQGAP and the NMD complex (2011)
  • Author(s): Takeda S., et al
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 410 Issue: 1 Pages: 29-33
  • DOI: 10.1016/j.bbrc.2011.05.099
  • Peer Reviewed
• [Journal Article] Neuronal polarity in 2011 (2011)
  • Author(s): Doe CQ, Kaibuchi K
  • Journal Title: Developmental Neurobiology Volume: 71 Issue: 6 Pages: 401-402
  • DOI: 10.1002/dneu.20863
  • Peer Reviewed
• [Journal Article] Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse (2011)
  • Author(s): Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H
  • Journal Title: Science Signaling Volume: 4(179) Issue: 170
  • DOI: 10.1126/scisignal.2001127
  • Peer Reviewed
• [Journal Article] Protein kinase G signaling disrupts Racl-dependent focal adhesion assembly in liver specific pericytes (2011)
  • Author(s): Routray C., et al
  • Journal Title: American Journal of Physiology Cell Physiology Volume: 301 Issue: 1 Pages: C66-C74
  • DOI: 10.1152/ajpcell.00038.2011
  • Peer Reviewed
• [Journal Article] The role of selective transport in neuronal polarization (2011)
  • Author(s): Namba T., et al
  • Journal Title: Developmental Neurobiology Volume: 71 Issue: 6 Pages: 445-457
  • DOI: 10.1002/dneu.20876
  • Peer Reviewed
• [Journal Article] PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C.elegans (2011)
  • Author(s): Qadota H., et al
  • Journal Title: Journal of Molecular Biology Volume: 407 Issue: 2 Pages: 222-231
  • DOI: 10.1016/j.jmb.2011.01.039
  • Peer Reviewed
• [Journal Article] The role of selective transport in neuronal polarization (2011)
  • Author(s): Namba T., et al
  • Journal Title: Dev Neurobiol Volume: in press
  • Peer Reviewed
• [Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. (2010)
  • Author(s): Nakano A., Kato H., Watanabe T., Min K. D., Yamazaki S., Asano Y., Seguchi O., Higo S., Shintani Y., Asanuma H., Asakura M., Minamino T., Kaibuchi K., Mochizuki N., Kitakaze M. & Takashima S
  • Journal Title: Nat Cell Biol Volume: 12 Pages: 583-590
  • Peer Reviewed
• [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis. (2010)
  • Author(s): Itoh N., Nakayama M., Nishimura T., Fujisue S., Nishioka T., Watanabe T. & Kaibuchi K.
  • Journal Title: Cytoskeleton (Hoboken) Volume: 67 Pages: 297-308
  • Peer Reviewed
• [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase. (2010)
  • Author(s): Amano M., Tsumura Y., Taki K., Harada H., Mori K., Nishioka T., Kato K., Suzuki T., Nishioka Y., Iwamatsu A. & Kaibuchi K.
  • Journal Title: PLoS One Volume: 5
  • Peer Reviewed
• [Journal Article] Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. (2010)
  • Author(s): Amano M., Nakayama M. & Kaibuchi K.
  • Journal Title: Cytoskeleton (Hoboken) Volume: 67 Pages: 545-554
  • Peer Reviewed
• [Journal Article] Switching DISC1 function in neurogenesis : Dixdc1 selects DISC1 binding partners. (2010)
  • Author(s): Namba, T., Kaibuchi, K.
  • Journal Title: Dev Cell 19 Pages: 7-8
  • Peer Reviewed
• [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase. (2010)
  • Author(s): Amano, M., Tsumura, Y., Taki, K., Harada, H., Mori, K., Nishioka, T., Kato, K., Suzuki, T., Nishioka, Y., Iwamatsu, A., Kaibuchi, K.
  • Journal Title: PLoS ONE 5
  • Peer Reviewed
• [Journal Article] Switching DISC1 function in neurogenesis : Dixdcl selects DISC1 binding partners (2010)
  • Author(s): Namba T., Kaibuchi K.
  • Journal Title: Dev Cell Volume: 19 Pages: 7-8
  • Peer Reviewed
• [Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation (2010)
  • Author(s): Nakano A., et al
  • Journal Title: Nat Cell Biol Volume: 12 Pages: 583-590
  • Peer Reviewed
• [Journal Article] Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells (2010)
  • Author(s): Matsumoto S., et al
  • Journal Title: EMBO J Volume: 29 Pages: 1192-1204
  • Peer Reviewed
• [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis (2010)
  • Author(s): Itoh N., et al
  • Journal Title: Cytoskeleton Volume: 67 Pages: 297-308
  • Peer Reviewed
• [Journal Article] Rho-kinase/ROCK : A key regulator of the cytoskeleton and cell polarity (2010)
  • Author(s): Amano M., et al
  • Journal Title: Cytoskeleton Volume: 67 Pages: 545-554
  • Peer Reviewed
• [Journal Article] Identification of focal adhesion kinase (FAK) and phosphatidylinositol 3-kinase (PI3-kinase) as Par3 partners by proteomic analysis (2010)
  • Author(s): Itoh, N., et al.
  • Journal Title: Cytoskeleton (in press)
  • Peer Reviewed
• [Journal Article] A proteomic approach for comprehensively screening substrates of protein kinases such as Rho-kinase (2010)
  • Author(s): Amano, M., et al.
  • Journal Title: PLoS One 5
  • Peer Reviewed
• [Journal Article] The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module (2010)
  • Author(s): Terawaki, S., et al.
  • Journal Title: EMBO J 29 Pages: 236-250
  • Peer Reviewed
• [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. (2009)
  • Author(s): Watanabe T., Noritake J., Kakeno M., Matsui T., Harada T., Wang S., Itoh N., Sato K., Matsuzawa K., Iwamatsu A., Galjart N. & Kaibuchi K.
  • Journal Title: J Cell Sci Volume: 122 Pages: 2969-2979
  • Peer Reviewed
• [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP (2009)
  • Author(s): Mori K., Amano M., Takefuji M., Kato K., Morita Y., Nishioka T., Matsuura Y., Murohara T. & Kaibuchi K.
  • Journal Title: J Biol Chem Volume: 284 Pages: 5067-5076
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27 (2009)
  • Author(s): Arimura N., Kimura T., Nakamuta S., Taya S., Funahashi Y., Hattori A., Shimada A., Menager C., Kawabata S., Fujii K., Iwamatsu A., Segal R. A., Fukuda M. & Kaibuchi K.
  • Journal Title: Dev Cell Volume: 16 Pages: 675-686
  • Peer Reviewed
• [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity. (2009)
  • Author(s): Arimura N., Hattori A., Kimura T., Nakamuta S., Funahashi Y., Hirotsune S., Furuta K., Urano T., Toyoshima Y. Y. & Kaibuchi K.
  • Journal Title: J Neurochem Volume: 111 Pages: 380-390
  • Peer Reviewed
• [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules. (2009)
  • Author(s): Watanabe, T., Noritake, J., Kakeno, M., Matsui, T., Harada, T., Wang, S., Itoh, N., Sato, K., Matsuzawa, K., Iwamatsu, A., Galjart, N., Kaibuchi, K.
  • Journal Title: Journal of Cell Science 122 Pages: 2969-2979
  • Peer Reviewed
• [Journal Article] Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP. (2009)
  • Author(s): Mori, K., Amano, M., Takefuji, M., Kato, K., Morita, Y., Nishioka, T., Matsuura, Y., Murohara, T., Kaibuchi, K.
  • Journal Title: The Journal of Biological Chemistry 284 Pages: 5067-5076
  • Peer Reviewed
• [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus. (2009)
  • Author(s): Enomoto, A., Asai, N., Namba, T., Wang, Y., Kato, T., Tanaka, M., Tatsumi, H., Taya, S., Tsuboi, D., Kuroda, K., Kaneko, N., Sawamoto, K., Miyamoto, R., Jijiwa, M., Murakumo, Y., Sokabe, M., Seki, T., Kaibuchi, K., Takahashi, M.
  • Journal Title: Neuron 63 Pages: 774-787
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27. (2009)
  • Author(s): Arimura, N., Kimura, T., Nakamuta, S., Taya, S., Funahashi, Y., Hattori, A., Shimada, A., Menager, C., Kawabata, S., Fujii, K., Iwamatsu, A., Segal, R.A., Fukuda, M., Kaibuchi, K.
  • Journal Title: Dev Cell 16 Pages: 675-686
  • Peer Reviewed
• [Journal Article] Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus (2009)
  • Author(s): Enomoto, A., et al.
  • Journal Title: Neuron 63 Pages: 774-787
  • Peer Reviewed
• [Journal Article] CRMP-2 directly binds to cytoplasmic dynein and interferes with its activity (2009)
  • Author(s): Arimura, N., et al.
  • Journal Title: J Neurochem 11 Pages: 380-390
  • Peer Reviewed
• [Journal Article] CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity (2009)
  • Author(s): Hou, S.T., et al.
  • Journal Title: J Neurochem 11 Pages: 870-881
  • Peer Reviewed
• [Journal Article] Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules (2009)
  • Author(s): Watanabe, T., et al.
  • Journal Title: J Cell Sci 122 Pages: 2969-2979
  • Peer Reviewed
• [Journal Article] Direct interaction of Dysbindin with the AP-3 complex via its mu subunit (2009)
  • Author(s): Taneichi-Kuroda, S., et al.
  • Journal Title: Neurochem Int 54 Pages: 431-438
  • Peer Reviewed
• [Journal Article] TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases (2009)
  • Author(s): Iguchi, Y., et al.
  • Journal Title: J Biol Chem 284 Pages: 22059-22066
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27 (2009)
  • Author(s): Arimura, N., et al.
  • Journal Title: Dev Cell 16 Pages: 675-686
  • Peer Reviewed
• [Journal Article] Rho-kinase contributes to sustained RhoA activation through phosphorylation of p190A RhoGAP. (2009)
  • Author(s): Mori, K, et al.
  • Journal Title: J Biol Chem 284 Pages: 5067-5076
  • Peer Reviewed
• [Journal Article] Anterograde transport of TrkB in axons is mediated by direct interaction with Slpl and Rab27. (2009)
  • Author(s): Arimura, N, et al.
  • Journal Title: Dev Cell (in press)
  • Peer Reviewed
• [Journal Article] Ultrastructural study of Racl and its effectors beneath the substratum-facing membrane (2008)
  • Author(s): Watanabe, T, et al.
  • Journal Title: Cell Struct Funct 33 Pages: 101-107
  • Peer Reviewed
• [Journal Article] Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia (2008)
  • Author(s): Ikeda, M, et al.
  • Journal Title: Hum Mol Genet 17 Pages: 3212-3222
  • Peer Reviewed
• [Presentation] Neuronal Polarity in vitro and in vivo (2013)
  • Author(s): Kaibuchi K
  • Organizer: Keystone Symposium
  • Place of Presentation: Tahoe City, USA
  • Year and Date: 2013-03-11
• [Presentation] Neuronal Polarity in vitro and in vivo (2013)
  • Author(s): Kaibuchi, K.
  • Organizer: Keystone symposium Growing to Extremes: Cell Biology and Pathology of Axons
  • Place of Presentation: Tahoe City, USA
  • Invited
• [Presentation] Neuronal polarity in vitro and in vivo (2013)
  • Author(s): Kaibuchi, K.
  • Organizer: Symposium on Sensory Systems & Neural Circuits
  • Place of Presentation: 東京大学伊藤国際学術研究センター、東京
  • Invited
• [Presentation] Protein phosphorylation remains a black box in signal transduction: Developing a new method to search for substrates of protein kinases (2012)
  • Author(s): Kaibuchi, K.
  • Organizer: 14th Internatioal Congress of Histochemistry and Cytochemistry
  • Place of Presentation: 京都国際会館、京都
  • Invited
• [Presentation] Key Regulators in Neuronal Polarization (2012)
  • Author(s): Kaibuchi, K.
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場、福岡
  • Invited
• [Presentation] Signaling for neuronal polarization (2011)
  • Author(s): Kaibuchi K
  • Organizer: 2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
  • Place of Presentation: Tainan, Taiwan
  • Year and Date: 2011-11-19
• [Presentation] Signaling for neuronal polarization (2011)
  • Author(s): Kaibuchi K.
  • Organizer: 2011 Taiwan-Japan Joint Symposium on Cell Signaling and Gene Regulation
  • Place of Presentation: Tainan, Taiwan(招待)
  • Year and Date: 2011-11-19
• [Presentation] Tiam1 acts with the PAR complex to control talin-mediated Rac1 activation (2011)
  • Author(s): Kaibuchi K
  • Organizer: 5th Mechanobiology Conference
  • Place of Presentation: Singapore
  • Year and Date: 2011-11-10
• [Presentation] 統合失調症の発症脆弱性因子DISC1の病態生理機能 (2011)
  • Author(s): Kaibuchi K.
  • Organizer: 第54回日本神経化学会
  • Place of Presentation: 瑠璃光、加賀市、石川県(招待)
  • Year and Date: 2011-09-26
• [Presentation] Synapse Alteration and Schizophrenia (2011)
  • Author(s): Kaibuchi K.
  • Organizer: The Synapse
  • Place of Presentation: The Grand Hotel Bristol, Stresa, Italy(招待)
  • Year and Date: 2011-09-05
• [Presentation] DISC1 acts as a cargo adapter for neuronal transport of specific proteins and messenger RNAs (2011)
  • Author(s): Kaibuchi K.
  • Organizer: ISN-ESN 2011
  • Place of Presentation: Megaron Athens International Conference Centre, Athens, Greece(招待)
  • Year and Date: 2011-08-31
• [Presentation] 神経研究とプロテオミクス:質量分析計に何ができるのか (2011)
  • Author(s): Kaibuchi K.
  • Organizer: 包括型脳科学研究推進支援ネットワーク夏のワークショップ
  • Place of Presentation: 神戸国際会議場、神戸市、兵庫県(招待)
  • Year and Date: 2011-08-23
• [Presentation] How internal and external signals regulate neuronal polarity (2011)
  • Author(s): Kaibuchi K.
  • Organizer: Developmental Neurobiology Course
  • Place of Presentation: 沖縄科学技術大学院大学、国頭郡、沖縄(招待)
  • Year and Date: 2011-07-20
• [Presentation] Neurotrophins regulate neuronal polarity acting through Ca^ and CaMKK. EMBO Cell Biology of the Neuron: Polarity (2011)
  • Author(s): Kaibuchi K
  • Organizer: Plasticity and Regeneration
  • Place of Presentation: Creta, Greece
  • Year and Date: 2011-05-09
• [Presentation] Neurotrophins regulate neuronal polarity acting through Ga2+ and CaMKK (2011)
  • Author(s): Kaibuchi K.
  • Organizer: EMBO Cell Biology of the Neuron : Polarity, Plasticity and Regeneration
  • Place of Presentation: Fodele Beach & Water Park Holiday Resort, Herakli on, Creta, Greece(招待)
  • Year and Date: 2011-05-08
• [Presentation] Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^ (2011)
  • Author(s): Kaibuchi K
  • Organizer: Emerging Concepts on Neuronal Cytoskelton
  • Place of Presentation: Santa Cruz, Chile
  • Year and Date: 2011-04-25
• [Presentation] Neurotrophins specify axonal fate of hippocampal neurons acting through inositol 1, 4, 5-triphosphate and Ca^<2+> (2011)
  • Author(s): Kaibuchi K.
  • Organizer: Emerging Concepts on Neuronal Cytoskelton
  • Place of Presentation: Hotel Santa Cruz, Santa Cruz, Chile(招待)
  • Year and Date: 2011-04-25
• [Presentation] Rho-kinase/ROCK : a key regulator of cytoskeleton and cell polarity (2010)
  • Author(s): Kaibuchi K.
  • Organizer: MEXT Priority Research Project "Cell Proliferation Control" International Svmnosium
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 2010-11-06
• [Presentation] DISC1 serves as a cargo adapter (2010)
  • Author(s): Kaibuchi K.
  • Organizer: OzBio2010/IUBMB
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2010-09-30
• [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms. Cold Spring Harbor Asia Conference (2010)
  • Author(s): Kaibuchi K
  • Organizer: 1st Francis Crick Neuroscience Symposium
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-04-13
• [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms. (2010)
  • Author(s): Kaibuchi K.
  • Organizer: Cold Spring Harbor Asia Conference, 1st Francis Crick Neuroscience Symposium
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-04-13
• [Presentation] Neuronal polarity-From extracellular signals to intracellular mechanisms (2010)
  • Author(s): Kaibuchi K.
  • Organizer: Cold Spring Harbor Asia Conference, 1st Francis Crick Neuroscience Symposium
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-04-13
• [Presentation] Axon formation and polarized vesicle transport (2009)
  • Author(s): Kaibuchi K
  • Organizer: BMB 2008
  • Place of Presentation: 神戸国際会議場 神戸
  • Year and Date: 2009-12-11
• [Presentation] Role of Par and Tiam1 complex in polarized cell migration (2009)
  • Author(s): 貝淵弘三
  • Organizer: RAMIC, National Network on Cell Adhesion and Migration
  • Place of Presentation: Spain
  • Year and Date: 2009-10-23
• [Presentation] Role of Par and Tiam1 complex in polarized cell migration (2009)
  • Author(s): Kaibuchi K
  • Organizer: RAMIC, National Network on Cell Adhesion and Migration
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2009-10-22
• [Presentation] Role of Par and Tiam1 complex in polarized cell migration. (2009)
  • Author(s): Kaibuchi K.
  • Organizer: RAMIC, National Network on Cell Adhesion and Migration
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2009-10-22
• [Presentation] Neuronal polarity: From extracellular signals to intracellular mechanisms (2009)
  • Author(s): Kaibuchi K
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋国際会議場 名古屋
  • Year and Date: 2009-09-18
• [Presentation] Neuronal polarity : From extracellular signals to intracellular mechanisms (2009)
  • Author(s): 貝淵弘三
  • Organizer: 第32回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-18
• [Presentation] DISC1 serves a cargo receptor delivering signaling molecules and mRNAs (2009)
  • Author(s): 貝淵弘三
  • Organizer: From Gene Discovery to Cell Biology in Psychiatry
  • Place of Presentation: USA
  • Year and Date: 2009-09-15
• [Presentation] Roles of Rho family GTPases and Par proteins in directional migration (2009)
  • Author(s): Kaibuchi K
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-24
• [Presentation] Roles of Rho family GTPases and Par proteins in directional migration. (2009)
  • Author(s): Kaibuchi K.
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Oxford, UK
  • Year and Date: 2009-08-24
• [Presentation] Roles of Rho family GTPases and Par proteins in directional migration (2009)
  • Author(s): 貝淵弘三
  • Organizer: Gordon Research Conferences
  • Place of Presentation: UK
  • Year and Date: 2009-08-24
• [Presentation] Role of Rho and Rho-kinase in vascular smooth muscle contraction (2009)
  • Author(s): 貝淵弘三
  • Organizer: Satellite Symposium of the IUPS 2009、ISSM2009
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-24
• [Presentation] Axon formation and polarized transport. (2009)
  • Author(s): Kaibuchi K.
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 渋川
  • Year and Date: 2009-06-22
• [Presentation] Axon formation and polarized transport (2009)
  • Author(s): 貝淵弘三
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保
  • Year and Date: 2009-06-22
• [Presentation] Axon formation and polarized vesicle transport (2009)
  • Author(s): Kaibuchi K
  • Organizer: ESF-EMBO Symposium
  • Place of Presentation: Sant Feliu de Guixols, Spain
  • Year and Date: 2009-05-23
• [Presentation] Axon formation and polarized vesicle transport. (2009)
  • Author(s): Kaibuchi K.
  • Organizer: ESF-EMBO Symposium
  • Place of Presentation: Sant Feliu de Guixols, Spain
  • Year and Date: 2009-05-23
• [Presentation] Axon formation and polarized vesicle transport (2009)
  • Author(s): 貝淵弘三
  • Organizer: ESF-EMBO Symposium CELL POLARITY AND MEMBRANE TRAFFIC
  • Place of Presentation: Spain
  • Year and Date: 2009-05-23
• [Presentation] Rho Proteins and Neuronal Polarity (2008)
  • Author(s): Kaibuchi K
  • Organizer: FASEB Summer Research Conferences
  • Place of Presentation: Vermont, USA
  • Year and Date: 2008-07-16
• [Presentation] 細胞遊走における Rho ファミリーと Par 複合体の役割 (2008)
  • Author(s): 貝淵弘三
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: パシフィコ横浜 横浜
  • Year and Date: 2008-06-30
• [Presentation] 細胞遊走におけるRhoファミリーとPar複合体の役割 (2008)
  • Author(s): 貝淵弘三
  • Organizer: 第60回日本細胞生物学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-06-30
• [Presentation] Neuronal development and cargo transport (2008)
  • Author(s): Kaibuchi K
  • Organizer: Gordon Research Conference on Molecular & Cellular Neurobiology
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2008-06-10
• [Presentation] Rho-kinase and Rho family GTPase signaling (2008)
  • Author(s): Mutsuki Amano
  • Organizer: FASEB Suramer Research Conferences
  • Place of Presentation: Vermont, USA
• [Presentation] Rho-kinase contributes to sustained Rho activation through the phosphorylation of p190A RhoGAP in vascular smooth muscle cells (2008)
  • Author(s): 森和孝
  • Organizer: 第12回Molecular Cardiovascular Conference
  • Place of Presentation: キロロ
• [Presentation] Axon formation and polarized vesicle trnasport (2008)
  • Author(s): 貝淵弘三
  • Organizer: BMB 2008
  • Place of Presentation: 神戸
• [Book] Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases (2009)
  • Author(s): Watanabe T., Sato K., and Kaibuchi K.
  • Publisher: Cold Spring Harb Perspect Biol.
• [Book] Cold Spring Harbor perspectives in biology 1(Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases.) (2009)
  • Author(s): Watanabe, T., Sato, K., Kaibuchi, K.
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/index.htm
• [Remarks] 名古屋大学大学院医学系研究科神経情報薬理学講座ホームページ
  • URL: http://www.med.nagoya-u.ac.jp/Yakuri/index.htm
• [Remarks]
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• [Remarks] ホームページ
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• [Remarks]
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• [Remarks] 名古屋大学大学院医学系研究科 神経情報薬理学講座ホームページ
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