| Project/Area Number |
20240036
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KAWATA Mitsuhiro Kyoto Prefectural University of Medicine, 医学研究科, 教授 (60112512)
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| Co-Investigator(Kenkyū-buntansha) |
TOKITA Miwako 京都府立医科大学, 医学研究科, 助教 (10420712)
坂本 浩隆 京都府立医科大学, 医学研究科, 助教 (20363971)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2010: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | ステロイドホルモン / 受容体 / エピジェネティック / 性行動 / ヒストン装飾 / 性差 / 脳構造 / ストレス応答 / ヒストン修飾 / FRAP / FRET / 核マトリックス / SAFB1 / 動態 / エストロゲン受容体 / 視床下部 / 神経核 / 雌雄差 / 周期的変動 / GPR30 / 膜受容体 / 神経系 |
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| Research Abstract |
The present project was undertaken to reveal the interaction of genomic and non-genomic actions of steroid hormones in the nervous system. The study demonstrated the genomic actions of steroid hormones through specific nuclear receptors and non-genomic actions through membrane steroid receptors by using molecular imaging technique, immunohistochemistry and transgenic mouse. The effects of genomic and non-genomic action on brain sexual differentiation and stress responses during critical period were also investigated behaviorally.
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