| Budget Amount *help |
¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2010: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
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| Research Abstract |
Exposure of environmental electrophiles to cultured cells and experimental animals caused a covalent or oxidative modification of the reactive thiols of sensor proteins such as PTP1B and Keap1, thereby activating EGFR and Nrf2, respectively. Our findings suggest that environmental electrophiles invade into cells, and then can modulate cellular signal transduction pathways (e.g., initial response, cell proliferation and apoptotic cell death) in a concentration-dependent manner
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