Sensor proteins and cellular protection factors for environmental electrophiles

• Project/Area Number: 20241015
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: University of Tsukuba
• Principal Investigator: KUMAGAI Yoshito 筑波大学, 医学医療系, 教授 (00250100)
• Co-Investigator(Kenkyū-buntansha): TAKANO Hirohisa 京都大学, 工学研究科, 教授 (60281698) ; INOUE Kenichiro 北里大学, 薬学部, 教授 (20373219) ; 角 大悟 筑波大学, 大学院・人間総合科学研究科, 准教授 (30400683)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥49,140,000 (Direct Cost: ¥37,800,000、Indirect Cost: ¥11,340,000); Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000); Fiscal Year 2010: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000); Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000); Fiscal Year 2008: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: 親電子化合物 / 共有結合 / 多環芳香族炭化水素キノン体 / ヒ素 / メチル水銀 / S-トランスアリール化 / 環境科学物質 / 親電子物質 / 化学修飾 / センサータンパク質 / リスク軽減因子 / 解毒・排泄

Research Abstract

Exposure of environmental electrophiles to cultured cells and experimental animals caused a covalent or oxidative modification of the reactive thiols of sensor proteins such as PTP1B and Keap1, thereby activating EGFR and Nrf2, respectively. Our findings suggest that environmental electrophiles invade into cells, and then can modulate cellular signal transduction pathways (e.g., initial response, cell proliferation and apoptotic cell death) in a concentration-dependent manner

Research Products

• [Journal Article] Cho AK. The chemical biology of naphthoquinones and its environmentalimpl ications (2012)
  • Author(s): Kumagai Y, Shinkai Y, Miura T
  • Journal Title: Annual Review of Pharmacology and Toxicology Volume: 52 Pages: 221-247
• [Journal Article] The chemical biology of naphthoquinones and its environmental implications (2012)
  • Author(s): Kumagai Y
  • Journal Title: Annual Review of Pharmacology and Toxicology Volume: 52 Issue: 1 Pages: 221-247
  • DOI: 10.1146/annurev-pharmtox-010611-134517
  • Peer Reviewed
• [Journal Article] Peroxiredoxin 6 is a molecular target for 1, 2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells (2011)
  • Author(s): Takayama N, Iwamoto N, Sumi D, Shinkai Y, Tanaka-Kagawa T, Jinno H, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 36 Pages: 817-821
  • NAID: 10030037072
• [Journal Article] Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1, 2-naphthoquinone protein adduct formation (2011)
  • Author(s): Miura T, Shinkai Y, Hirose R, Iwamoto N, Cho AK, Kumagai Y
  • Journal Title: Free Radical Biology & Medicine Volume: 51 Pages: 2082-2089
• [Journal Article] DNA microarray analysis of human neuroblastoma SH-SY5Y cells exposed to methylmercury (2011)
  • Author(s): Toyama T, Yoshida E, Shinkai Y, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 36 Pages: 843-845
  • NAID: 10030037141
• [Journal Article] GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate (2011)
  • Author(s): Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y
  • Journal Title: Chemical Research in Toxicology Volume: 24 Pages: 1836-1844
• [Journal Article] Participation of covalent modification f Keap1 in the activation of Nrf2 by tert-ylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole (2011)
  • Author(s): Abiko Y, Miura T, Bui H Phuc, Shinkai Y, Kumagai Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 255 Pages: 32-39
• [Journal Article] Participation of covalent modification of Keap1 in the activation of Nrf2 by tert-butylbenzoquinone, an electrophilic metabolite of butylated hydroxyanisole (2011)
  • Author(s): Endo A, Sumi D, Iwamoto N, Kumagai Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 255 Pages: 32-39
• [Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury (2011)
  • Author(s): Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y
  • Journal Title: Environmental Health Perspective Volume: 119 Pages: 1117-1122
• [Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1, 2-naphthoquinone (2011)
  • Author(s): Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
  • Journal Title: Chemical Research in Toxicology Volume: 24 Pages: 559-567
• [Journal Article] Two-electron quinone reductase (AKR1C isozyme) augments the oxidative DNA damage induced by quinones in diesel exhaust particles by accelerating redox cycling (2011)
  • Author(s): Yamano S, Shibata M, Kita H, Matsusue K, Narimatsu S, Taguchi K, Kumagai Y
  • Journal Title: Journal of Health Science Volume: 57 Pages: 107-114
• [Journal Article] Peroxiredoxin 6 is a molecular target for 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary epithelial A549 cells (2011)
  • Author(s): Takayama N
  • Journal Title: The Journal of Toxicological Sciences Volume: 36 Issue: 6 Pages: 817-821
  • DOI: 10.2131/jts.36.817
  • NAID: 10030037072
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed
• [Journal Article] Glyceraldehyde-3-phosphate dehydrogenase as a quinone reductase in the suppression of 1,2-naphthoquinone protein adduct formation (2011)
  • Author(s): Miura T
  • Journal Title: Free Radical Biology & Medicine Volume: 51 Issue: 11 Pages: 2082-2089
  • DOI: 10.1016/j.freeradbiomed.2011.09.008
  • Peer Reviewed
• [Journal Article] Inhibition of DNA binding activity of cAMP response element-binding protein by 1,2-naphthoquinone through chemical modification of Cys-286 (2011)
  • Author(s): Endo A
  • Journal Title: Chemico-Biological Interactions Volume: 192 Issue: 3 Pages: 272-277
  • DOI: 10.1016/j.cbi.2011.04.003
  • Peer Reviewed
• [Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. (2011)
  • Author(s): Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y.
  • Journal Title: Envornmental Health Perspective in press
  • Peer Reviewed
• [Journal Article] Initial response and cellular protection through the Keapl/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone. (2011)
  • Author(s): Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y.
  • Journal Title: Chemical Research in Toxicology in press
  • Peer Reviewed
• [Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone. (2011)
  • Author(s): Miura T
  • Journal Title: Chemical Research in Toxicology Volume: 印刷中(掲載確定)
  • Peer Reviewed
• [Journal Article] 1, 2-Naphthoquinone suppresses lipopolysaccharidedependentactivation of IKKss/NF-kB/NO signaling : an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation (2010)
  • Author(s): Sumi D, Akimori M, Inoue K, Takano H, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 891-898
• [Journal Article] Immunochemical method to detect proteins that undergo selective modification by 1, 2-naphthoquinone derived from naphthalene through metabolic activation (2010)
  • Author(s): Miura T, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 843-852
  • NAID: 10026963043
• [Journal Article] Carbon monoxide derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells (2010)
  • Author(s): Toyama T, Shinkai Y, Sumi D, Kumagai Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 249 Pages: 86-90
• [Journal Article] Diesel exhaust particles induce a Th2 phenotype in mouse naive mononuclear cells in vitro (2010)
  • Author(s): Inoue K, Koike E, Endo A, Sumi D, Kumagai Y, Hayakawa K, Kiyono M, Tanaka M, Takano H
  • Journal Title: Experimental and Therapeutic Medicine Volume: 1 Pages: 761-767
• [Journal Article] Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells (2010)
  • Author(s): Sumi D, Shinkai Y, Kumagai Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 244 Pages: 385-392
• [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells (2010)
  • Author(s): Abiko Y, Shinkai Y, Sumi D, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 419-423
  • NAID: 10026469935
• [Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants : diesel exhaust particles (DEP) and 1, 2-naphthoquinone (1, 2-NQ) (2010)
  • Author(s): Teles AM, Kumagai Y, Brain SD, Teixeira SA, Varriano AA, Barreto MA, de Lima WT, Antunes E, Muscara MN, Costa SK
  • Journal Title: Archives of Toxicology Volume: 84 Pages: 109-117
• [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. (2010)
  • Author(s): Abiko Y, Shinkai Y, Sumi D, Kumagai Y.
  • Journal Title: Journal of Toxicological Sciences 35 Pages: 419-423
  • NAID: 10026469935
  • Peer Reviewed
• [Journal Article] 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKb/NF-kB/NO signaling : an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation. (2010)
  • Author(s): Sumi D
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 891-898
  • Peer Reviewed
• [Journal Article] Immunochemical method to detect proteins that undergo selective modification by 1,2-naphthoquinone derived from naphthalene through metabolic activation. (2010)
  • Author(s): Miura T
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 843-852
  • Peer Reviewed
• [Journal Article] Carbon monoxide -derived from heme oxygenase-2 mediates reduction of methylmercury toxicity in SH-SY5Y cells. (2010)
  • Author(s): Toyama T
  • Journal Title: Toxicology and Applied Pharmacology Volume: 249 Pages: 86-90
  • Peer Reviewed
• [Journal Article] 地球規模におけるヒ素汚染の現状 (2010)
  • Author(s): 安孫子ユミ
  • Journal Title: ファルマシア Volume: 46 Pages: 649-653
  • Peer Reviewed
• [Journal Article] Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells. (2010)
  • Author(s): Sumi D
  • Journal Title: Toxicology and Applied Pharmacology Volume: 244 Pages: 385-392
  • Peer Reviewed
• [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells. (2010)
  • Author(s): Abiko Y
  • Journal Title: Journal of Toxicological Sciences Volume: 35 Pages: 419-423
  • Peer Reviewed
• [Journal Article] edox and electrophilic properties of vapor- and particle-phase components of ambient aerosols. (2010)
  • Author(s): Eiguren-Fernandez A
  • Journal Title: Journal of Toxicological Sciences Volume: 110 Pages: 207-212
  • Peer Reviewed
• [Journal Article] Biochemical and cellular effects of electrophiles present in ambient air samples. (2010)
  • Author(s): Iwamoto N
  • Journal Title: Atmospheric Environment Volume: 44 Pages: 1483-1489
  • Peer Reviewed
• [Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ). (2010)
  • Author(s): Teles AM
  • Journal Title: Archives of Toxicolog Volume: 84 Pages: 109-117
  • Peer Reviewed
• [Journal Article] Signal transduction pathways and transcription factors triggered by arsenic trioxide in leukemia cells. (2010)
  • Author(s): Sumi D
  • Journal Title: Toxicology and Applied Pharmacology (印刷中)
  • Peer Reviewed
• [Journal Article] Reduction of arsenic-induced cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells (2010)
  • Author(s): Abiko Y
  • Journal Title: Journal of Toxicological Sciences (印刷中)
  • Peer Reviewed
• [Journal Article] Redox and electrophilic properties of vapor- and particle-phase components of ambient aerosols (2010)
  • Author(s): Eiguren-Fernandez A
  • Journal Title: Environmental Research 110 Pages: 207-212
  • Peer Reviewed
• [Journal Article] Biochemical and cellular effects of electrophiles present in ambient air samples (2010)
  • Author(s): Iwamoto N
  • Journal Title: Atmospheric Environment 44 Pages: 1483-1489
  • Peer Reviewed
• [Journal Article] Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants : diesel exhaust particles(DEP)and 1, 2-naphthoauinone(1, 2-NQ) (2010)
  • Author(s): Teles AM
  • Journal Title: Archives of Toxicology 84 Pages: 109-117
  • Peer Reviewed
• [Journal Article] Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1 (2009)
  • Author(s): Sumi D, Numasawa Y, Endo A, Iwamoto N, Kumagai Y
  • Journal Title: Journal of Toxicological Sciences Volume: 34 Pages: 627-635
  • NAID: 110007485673
• [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere (2009)
  • Author(s): Kumagai Y
  • Journal Title: Journal of Health Sciences Volume: 55 Pages: 887-894
  • NAID: 130000127984
• [Journal Article] 親電子シグナル伝達 (2009)
  • Author(s): 熊谷嘉人
  • Journal Title: 実験医学増刊号 Volume: 27 Pages: 50-55
• [Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes (2009)
  • Author(s): Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y
  • Journal Title: Toxicology and Applied Pharmacology Volume: 237 Pages: 232-236
• [Journal Article] The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range chemical compounds (2009)
  • Author(s): Kobayashi M, Li L, Iwamoto N, Nakajima-Takagi Y, Kaneko H, Nakayama Y, Eguchi M, Wada Y, Kumagai Y, Yamamoto M
  • Journal Title: Molecular and Cellular Biology Volume: 29 Pages: 493-502
  • NAID: 120007138388
• [Journal Article] Catechol estrogens mediated activation of Nrf2 through covalent modification of its quinone metabolite to Keap1 (2009)
  • Author(s): Sumi D
  • Journal Title: The Journal of Toxicological Sciences 34 Pages: 627-635
  • NAID: 110007485673
  • Peer Reviewed
• [Journal Article] Polycyclic aromatic hydrocarbon quinones as redox and electrophilic chemicals contaminated in the atmosphere (2009)
  • Author(s): Kumagai Y
  • Journal Title: Journal of Health Sciences 55 Pages: 887-894
  • NAID: 130000127984
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 熊谷嘉人
  • Journal Title: 実験医学増刊号.親電子シグナル伝達(羊土社) Pages: 50-55
• [Journal Article] Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. (2009)
  • Author(s): Shinkai Y
  • Journal Title: Toxicology and Appled Pharmacology
  • Peer Reviewed
• [Journal Article] The antioxidant defense system Keapl-Nrf2 comprises a multiple sensing mechanism for responding to a wide range chemical compounds. (2009)
  • Author(s): Kobayashi M
  • Journal Title: Molecular and Cellular Biology 29 Pages: 493-502
  • Peer Reviewed
• [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism (2008)
  • Author(s): Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y
  • Journal Title: Archives of Toxicology Volume: 82 Pages: 803-808
• [Journal Article] Redox cycling of 9, 10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells (2008)
  • Author(s): Taguchi K, Shimada M, Fujii S, Sumi D, 24. Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y
  • Journal Title: Free Radical Biology & Medicine Volume: 44 Pages: 1645-1655
• [Journal Article] Xylulose reductase is involved in 9, 10-phenanthrenequinone-induced apoptosis in human T lymphoma cells (2008)
  • Author(s): Matsunaga T, Kamiya T, Sumi D, Kumagai Y, B. Kalyanaraman, Hara A
  • Journal Title: Free Radical Biology & Medicine Volume: 44 Pages: 1191-1202
• [Journal Article] Downregulation of Arginase II and Renal Apoptosis by Inorganic Mercury : Overexpression of Arginase II Reduces Its Apoptosis (2008)
  • Author(s): Kanda H, Kikushima M, Homma-Takeda S, Sumi D, Endo A, Toyama T, Miura N, Naganuma A, Kumagai Y
  • Journal Title: Archives of Toxicology Volume: 82 Pages: 67-73
• [Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells. (2008)
  • Author(s): Taguchi K, Shimada M, Fujii S, Sumi D, Pan XQ, Yamano S, Nishiyama T, Hiratsuka A, Yamamoto M, Cho AK, Froines JR, Kumagai Y.
  • Journal Title: Free Radical Biology & Medicine 44 Pages: 1645-1655
  • Peer Reviewed
• [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury : a possible mechanism. (2008)
  • Author(s): Kanda H, Sumi D, Endo E, Toyama T, Chen CL, Kikushima M, Kumagai Y.
  • Journal Title: Archives of Toxicology. 82 Pages: 803-808
  • Peer Reviewed
• [Journal Article] A food-derived synergist of NGF signaling: Identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. (2008)
  • Author(s): Shibata T
  • Journal Title: Journal of Neurochemistry 107 Pages: 1248-1460
  • Peer Reviewed
• [Journal Article] Reduction of arginase I activity and manganese levels in the liver during exposure of rats to methylmercury: a possible mechanism. (2008)
  • Author(s): Kanda H
  • Journal Title: Archives of Toxicology 82 Pages: 803-808
  • Peer Reviewed
• [Journal Article] Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary apithelial A549 cells. (2008)
  • Author(s): Taguchi K
  • Journal Title: Free Radical Biology & Medicine 44 Pages: 1645-1655
  • Peer Reviewed
• [Journal Article] Xylulose reductase is involved in 9,10-phenanthrenequin one-induced apoptosis in human T lymphoma cells. (2008)
  • Author(s): Matsunaga T
  • Journal Title: Free Radical Biology .& Medicine 44 Pages: 1191-1202
  • Peer Reviewed
• [Journal Article] Downregulation of Arginase II and Renal Apoptosis by In organid Mercury: Overexpression of Arginase II Reduces Its Apoptosis. (2008)
  • Author(s): Kanda H
  • Journal Title: Archives of Toxicology 82 Pages: 67-93
  • Peer Reviewed
• [Journal Article] On the interaction between glyceraldehyde-3-phosphate dehydrogenase and airborne particles: Evidence for elect rophilic species. (2008)
  • Author(s): Shinyashiki M
  • Journal Title: Atmospheric Environment 42 Pages: 517-529
  • Peer Reviewed
• [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 安全性評価研究会セミナー
  • Place of Presentation: 東京都
  • Year and Date: 2011-12-03
• [Presentation] タンパク質と共有結合する薬毒物の生体反応とそれに対する細胞の防御戦略 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 安全性評価研究会セミナー
  • Place of Presentation: 東京都(招待講演)
  • Year and Date: 2011-12-03
• [Presentation] アクアポリン9はマウス初代肝細胞においてヒ素の細胞内蓄積とそれに伴う細胞毒性に関与する (2011)
  • Author(s): 新開泰弘, 角大悟, 外山喬士, 熊谷嘉人
  • Organizer: 第17回ヒ素シンポジウム
  • Place of Presentation: 茨城県
  • Year and Date: 2011-11-19
• [Presentation] メチル水銀によるS-水銀化を介したソルビトール脱水素酵素の機能破綻 (2011)
  • Author(s): 外山喬士, 神田洋紀, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-28
• [Presentation] 大気親電子物質1, 4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発 (2011)
  • Author(s): 広瀬玲子, 三浦高, 新開泰弘, 香川(田中)聡子, 神野透人, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-28
• [Presentation] 大気親電子物質1,4-ナフトキノンによるタンパク質の化学修飾を検出する免疫化学的手法の開発 (2011)
  • Author(s): 広瀬玲子、三浦高、新開泰弘、香川(田中)聡子、神野透人、熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-28
• [Presentation] グルタチオンの新たな機能:大気中親電子物質による細胞内タンパク質の化学修飾制御に係わるS-トランスアリール化 (2011)
  • Author(s): 三浦高, 掛橋秀直, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-27
• [Presentation] ブチルヒトロキシアニソールの親電子代謝物による芳香族炭化水素受容体の活性化 (2011)
  • Author(s): 安孫子ユミ, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-27
• [Presentation] カドミウムによる親電子物質応答配列を介した転写因子Nrf1の活性化 (2011)
  • Author(s): 伊藤友里, 新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 石川県
  • Year and Date: 2011-10-27
• [Presentation] 親電子物質によるタンパク質の化学修飾と心毒性 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 八ヶ岳フォーラム
  • Place of Presentation: 長野県
  • Year and Date: 2011-09-03
• [Presentation] 親電子物質によるタンパク質の化学修飾と心毒性 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 八ヶ岳フォーラム
  • Place of Presentation: 長野県(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 九州大学・生体防御医学研究所共同利用研究集会
  • Place of Presentation: 福岡県
  • Year and Date: 2011-07-22
• [Presentation] 環境中親電子物質によるタンパク質の化学修飾を制御する細胞内システム (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 九州大学・生体防御医学研究所共同利用研究集会
  • Place of Presentation: 福岡県(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] ブチルヒドロキシアニソールで生じるNrf2活性化はその親電子代謝物によるKeap1の化学修飾が関与する (2011)
  • Author(s): 安孫子ユミ, 岩本典子, Bui Hoang Phuc, 新開泰弘, 熊谷嘉人
  • Organizer: 第38回日本トキシコロジー学会学術集会
  • Place of Presentation: 神奈川県
  • Year and Date: 2011-07-11
• [Presentation] 親電子修飾の自己制御を司る解糖系タンパク質 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡県
  • Year and Date: 2011-03-29
• [Presentation] The Keap1-Nrf2 system regulates metallothionein expression and protects vascular endothelial cells from cadmium cytotoxicity (2011)
  • Author(s): Shinkai Y, Kumagai Y, Kimura T, Yamamoto C, Yamamoto M, Jinno H, Tanaka-Kagawa T, Kaji T
  • Organizer: Society of Toxicology 50th Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-08
• [Presentation] Mechanisms by which glyceraldehyde-3-phosphate dehydrogenase protects itself against a chemical modification (2011)
  • Author(s): Miura T, Egara Y, Hirose R, Iwamoto N, Shinkai Y, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
  • Organizer: Society of Toxicology 50th Annual Meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-03-08
• [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略 (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 第4回エコファーマシンポジウム
  • Place of Presentation: 熊本県
  • Year and Date: 2011-02-08
• [Presentation] 環境中親電子物質に対する生体応答およびリスク軽減戦略. (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 第4回エコファーマシンポジウム
  • Place of Presentation: 熊本市(熊本県)
  • Year and Date: 2011-02-08
• [Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 北海道
  • Year and Date: 2011-02-05
• [Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化はヒ素の毒性の軽減に関与する (2011)
  • Author(s): 安孫子ユミ, 新開泰弘, 角大悟, 熊谷嘉人
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 北海道
  • Year and Date: 2011-02-05
• [Presentation] A unique protein mediating cellular protection against methylmercury. (2011)
  • Author(s): Kumagai Y
  • Organizer: NIMD Forum
  • Place of Presentation: 水俣市(熊本県)
  • Year and Date: 2011-01-27
• [Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御 (2011)
  • Author(s): 熊谷嘉人, 外山喬士, 新開泰弘, 角大悟, 山本雅之
  • Organizer: 第10回分子予防環境医学研究会
  • Place of Presentation: 京都府
  • Year and Date: 2011-01-21
• [Presentation] Keap1/Nrf2システムを介したメチル水銀に対する生体応答・毒性防御 (2011)
  • Author(s): 熊谷嘉人、外山喬士、新開泰弘、角大悟、山本雅之
  • Organizer: 分子予防環境医学研究会
  • Place of Presentation: 京都市(京都府)
  • Year and Date: 2011-01-21
• [Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 旭川市(北海道)
  • Year and Date: 2011-01-15
• [Presentation] HepG2細胞においてNrf2/HO-1シグナルの活性化は仁素の毒性の軽減に関与する (2011)
  • Author(s): 安孫子ユミ、新開泰弘、角大悟、熊谷嘉人
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 旭川市(北海道)
  • Year and Date: 2011-01-06
• [Presentation] ヒ素の感知・応答センサーおよびリスク軽減因子としてのKeap1/Nrf2システム. (2011)
  • Author(s): 熊谷嘉人
  • Organizer: 第16回ヒ素シンポジウム
  • Place of Presentation: 旭川市
  • Year and Date: 2011-01-05
• [Presentation] 親電子物質とその制御に係わる細胞内システム (2010)
  • Author(s): 熊谷嘉人
  • Organizer: 第27回臨床フリーラジカル会議
  • Place of Presentation: 京都府
  • Year and Date: 2010-12-04
• [Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化 (2010)
  • Author(s): 安孫子ユミ, Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-10
• [Presentation] S-トランスアルキル化を介した親電子修飾の自己制御タンパク質の同定 (2010)
  • Author(s): 矢澤亜季, 岩本典子, 安孫子ユミ, 浅井聡, 三浦高, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-10
• [Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する (2010)
  • Author(s): 新開泰弘, 山本千夏, 鍜冶利幸, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-10
• [Presentation] ブチルヒドロキシアニソールの親電子代謝物によるKeap1/Nrf2システムの活性化 (2010)
  • Author(s): 安孫子ユミ Bui Hoang Phuc, 岩本典子, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 品川区(東京都)
  • Year and Date: 2010-09-10
• [Presentation] 血管内皮細胞において鉛はJNK-AP-1経路を介して小胞体シャペロンGRP78およびGRP94を誘導する (2010)
  • Author(s): 新開泰弘、山本千夏、鍛冶利幸、熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 品川区(東京都)
  • Year and Date: 2010-09-10
• [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素 (2010)
  • Author(s): 三浦高, 岩本典子, 新開泰弘, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京都
  • Year and Date: 2010-09-09
• [Presentation] 親電子修飾の自己制御能を有する解糖系酵素としてのグリセルアルデヒド3-リン酸脱水素酵素 (2010)
  • Author(s): 三浦高、岩本典子、新開泰弘、熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 品川区(東京都)
  • Year and Date: 2010-09-09
• [Presentation] Nrf2-dependent protection against methylmercury toxicity in vitro and in vivo (2010)
  • Author(s): Kumagai Y, Toyama T, Shinkai Y, Yasutake
  • Organizer: XII International Congress of Toxicology
  • Place of Presentation: Balcelona, Spain
  • Year and Date: 2010-07-22
• [Presentation] Nrf2-dependent protection' against methylmercury toxicity in vitro and in vivo. (2010)
  • Author(s): Kumagai Y, Toyama T, ShinkaiY, Yasutake
  • Organizer: XII International Congress of Toxicology
  • Place of Presentation: バルセロナ(スペイン)
  • Year and Date: 2010-07-22
• [Presentation] 血管内皮細胞においてNrf1はカドミウムに対する防御応答を担う転写因子である (2010)
  • Author(s): 新開泰弘, 山本千夏, 鍛治利幸, 熊谷嘉人
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 沖縄県
  • Year and Date: 2010-06-17
• [Presentation] 血管内皮細胞においてNrflはカドミウムに対する防御応答を担う転写因子である (2010)
  • Author(s): 新開泰弘、山本千夏、鍛治利幸、熊谷嘉人
  • Organizer: 第37回日本トキシコロジー学会学術年会
  • Place of Presentation: 宜野湾市(沖縄県)
  • Year and Date: 2010-06-17
• [Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割 (2010)
  • Author(s): 新開泰弘, 外山喬士, 安武章, 山本雅之, 熊谷嘉人
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 宮城県
  • Year and Date: 2010-05-11
• [Presentation] メチル水銀の解毒排泄における転写因子Nrf2の役割 (2010)
  • Author(s): 新開泰弘、外山喬士、安武章、 山本雅之、熊谷嘉人
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台市(宮城県)
  • Year and Date: 2010-05-11
• [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾 (2010)
  • Author(s): 熊谷嘉人
  • Organizer: 日本衛生学会総会シンポジウム
  • Place of Presentation: 宮城県
  • Year and Date: 2010-05-09
• [Presentation] 環境化学物質によるシステイン残基を介したタンパク質の翻訳後修飾. (2010)
  • Author(s): 熊谷嘉人
  • Organizer: 日本衛生学会総会シンポジウム
  • Place of Presentation: 仙台市
  • Year and Date: 2010-05-09
• [Presentation] 血管内皮細胞における鉛に対する小胞体ストレス応答機構の解析 (2010)
  • Author(s): 新開泰弘
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-27
• [Presentation] メチル水銀によるセンサータンパク質の翻訳後修飾 (2010)
  • Author(s): 外山喬士
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-27
• [Presentation] メチル水銀は脳浮腫形成に関与する脳血管組織のVEGFシステムを活性化する (2010)
  • Author(s): 廣岡孝志
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-27
• [Presentation] Biochemical and Cellular Effects of Ambient Vapor Electrophiles (2010)
  • Author(s): 岩本典子
  • Organizer: AAAR Air Pollution and Health International Specialty Conference
  • Place of Presentation: アメリカ
  • Year and Date: 2010-03-25
• [Presentation] Redox and electrophilic Properties of Vapor- and Particle-phase Components of Ambient Aerosols (2010)
  • Author(s): Eiguren-Fernandez A
  • Organizer: AAAR Air Pollution and Health International Specialty Conference
  • Place of Presentation: アメリカ
  • Year and Date: 2010-03-23
• [Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略 (2010)
  • Author(s): 熊谷嘉人
  • Organizer: 北陸大学学術フロンティア・サテライトミーティング
  • Place of Presentation: 熊本県
  • Year and Date: 2010-02-19
• [Presentation] イオウ原子を利用したメチル水銀に対する生体の防御戦略 (2010)
  • Author(s): 熊谷嘉人
  • Organizer: 北陸大学学術フロンティアー・サテライトミーティング
  • Place of Presentation: 水俣
  • Year and Date: 2010-02-19
• [Presentation] 親電子物質による翻訳後修飾とそれを制御する因子 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 大阪大学蛋白質研究所セミナー「活性酸素のシグナル伝達」
  • Place of Presentation: 大阪府
  • Year and Date: 2009-11-27
• [Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾.フォーラム2009 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジーシンポジウム
  • Place of Presentation: 沖縄県
  • Year and Date: 2009-11-06
• [Presentation] 大気中親電子物質によるレドックスセンサーの翻訳後修飾 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-06
• [Presentation] 大気中揮発相成分はPTP1Bの酸化及び化学修飾を介してEGFR/ERKシグナルを活性化する (2009)
  • Author(s): 岩本典子, 中嶋瞬, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄県
  • Year and Date: 2009-11-05
• [Presentation] 転写因子Nrf2はメチル水銀のリスク軽減因子である (2009)
  • Author(s): 外山喬士, 安武章, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄県
  • Year and Date: 2009-11-05
• [Presentation] 大気中揮発相成分はPTP1Bの酸化及び化学修飾を介してEGFR/ERKシグナルを活性化する (2009)
  • Author(s): 岩本典子
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] Nrf2/HO-1シグナルを介したヒ素の毒性軽減 (2009)
  • Author(s): 安孫子ユミ
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] 転写因子Nrf2はメチル水銀のリスク軽減因子である (2009)
  • Author(s): 外山喬士
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] メチル水銀の毒性軽減における内因性硫化水素の役割 (2009)
  • Author(s): 吉田映子
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] Atmospheric electrophiles causing oxidative stress and protein modification. JSPS Asia and Africa Platform Program International Seminar (2009)
  • Author(s): Kumagai Y
  • Organizer: Environment and Health
  • Place of Presentation: 石川県
  • Year and Date: 2009-10-31
• [Presentation] Atmospheric electrophiles causing oxidative stress and protein modification (2009)
  • Author(s): 熊谷嘉人
  • Organizer: JSPS Asia and Africa Platform Program International Seminar"Environment and Health"
  • Place of Presentation: 金沢
  • Year and Date: 2009-10-31
• [Presentation] Reduction of protein tyrosine phosphatase 1B activity caused by electrophiles is accompanied by a conformational alteration following covalent modification of Cys121 (2009)
  • Author(s): Iwamoto N, Ito S, Kobayashi M, Kumagai Y
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-27
• [Presentation] Initial response and cellular protection against 1, 2-Naphthoquinone through Nrf2/Keap1 system (2009)
  • Author(s): Miura T, Jiang HY, Nishiyama A, Iwamoto N, Sumi D, Yamamoto M, Kumagai Y
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-27
• [Presentation] Protective role of Nrf2 against methylmercury toxicity (2009)
  • Author(s): Toyama T, Yasutake A, Kumagai Y
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-27
• [Presentation] Reduction of arsenic mediated cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells (2009)
  • Author(s): Abiko A, Sumi D, Kumagai Y
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-27
• [Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile (2009)
  • Author(s): Kumagai Y
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-27
• [Presentation] Regulation of ectrophile signaling and cellular protection through Nrf2/Keap1 system during exposure to an environmental electrophile (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Disease
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] Reduction of arsenic mediated cytotoxicity through Nrf2/HO-1 signaling in HepG2 cells (2009)
  • Author(s): 安孫子ユミ
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Diseas
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Protective role of Nrf2 against methylmercury toxicity (2009)
  • Author(s): 外山喬士
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Diseas
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Initial response and cellular protection against 1, 2-Naphthoquinone through Nrf2/Keap1 system (2009)
  • Author(s): Miura T
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Diseas
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Reduction of protein tyrosine phosphatase 1B activity caused by electrophiles is accompanied by a conformational alteration following covalent modification of Cys121 (2009)
  • Author(s): 岩本典子
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Diseas
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Contribution of hydrogen sulfide derived from cystathionine β-synthase to reduction of methylmercury toxicity in SH-SY5Y cells (2009)
  • Author(s): 吉田映子
  • Organizer: 21st Century Advances in the Molecular Toxicology of Environmental Chemicals and Pathogenesis of Diseas
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] 親電子物質による非触媒性Cys121の翻訳後修飾を介したPTP1B/EGFRシグナルの活性化 (2009)
  • Author(s): 岩本典子, 伊藤創平, 小林麻己人, 熊谷嘉人
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2009-10-24
• [Presentation] 親電子物質による非触媒性Cys121の翻訳後修飾を介したPTP1B/EGFRシグナルの活性化 (2009)
  • Author(s): 岩本典子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 兵庫県
  • Year and Date: 2009-10-23
• [Presentation] 親電子物質による翻訳後修飾:親電子シグナルとその制御系. (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-10-22
• [Presentation] 転写因子Nrf2によるメチル水銀の毒性軽減. (2009)
  • Author(s): 外山喬士, 安武章, 熊谷嘉人
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-17
• [Presentation] HepG2細胞における転写因子Nrf2を介したHO-1によるヒ素の毒性軽減 (2009)
  • Author(s): 安孫子ユミ, 角大悟, 熊谷嘉人
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-17
• [Presentation] 転写因子Nrf2によるメチル水銀の毒性軽減 (2009)
  • Author(s): 外山喬士
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-17
• [Presentation] 内因性硫化水素ガスによるメチル水銀毒性の軽減 (2009)
  • Author(s): 吉田映子
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-17
• [Presentation] HepG2細胞における転写因子Nrf2を介したHO-1によるヒ素の毒性軽減 (2009)
  • Author(s): 安孫子ユミ
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-17
• [Presentation] Nrf2/Keap1システムを介したヒ素に対する細胞応答・毒性防御戦略 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: メタロチオネインおよびメタルバイオサイエンス研究会
  • Place of Presentation: 東京都
  • Year and Date: 2009-10-16
• [Presentation] 新電子シグナルの制御機構 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 第62回日本酸化ストレス学会学術集会シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-16
• [Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile (2009)
  • Author(s): Kumagai Y, Iwamoto N
  • Organizer: The 5th International Congress of Asian Society of Toxicology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-09-10
• [Presentation] Activation of EGFR/PTP1B signaling and cellular protection through Nrf2/Keap1 system during exposure to an atmospheric electrophile (2009)
  • Author(s): 熊谷嘉人
  • Organizer: The 5th International Congress of Asian Society of Toxicology
  • Place of Presentation: 台湾
  • Year and Date: 2009-09-10
• [Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquinone (2009)
  • Author(s): Kumagai Y, Iwamoto N
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 熊本県
  • Year and Date: 2009-07-18
• [Presentation] Electrophile-mediated activation of PTP1B/EGFR signaling through post-translational modification of a non-catalytic Cys121 of PTP1B (2009)
  • Author(s): Iwamoto N, Ito S, Kobayashi M, Kumagai Y
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 熊本県
  • Year and Date: 2009-07-18
• [Presentation] Activation of EGFR/MEK/ERK/AP-1 signaling caused by 1, 2-naphthoquin one (2009)
  • Author(s): 熊谷嘉人
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 熊本
  • Year and Date: 2009-07-18
• [Presentation] Electrophile-mediated activation of PTP1B/EGFR signaling through post-translational modification of a non- catalytic Cys121 of PTP1B (2009)
  • Author(s): 岩本典子
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 熊本
  • Year and Date: 2009-07-18
• [Presentation] 新電子シグナルの制御機構 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 第62回日本酸化ストレス学会学術集会シンポジウム
  • Place of Presentation: 福岡県
  • Year and Date: 2009-06-11
• [Presentation] 酸化ストレスを生じる大気中多環芳香族炭化水素 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 日本衛生学会総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2009-04-01
• [Presentation] 一酸化炭素によるメチル水銀の毒性防御機構. (2009)
  • Author(s): 外山喬士
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] 1, 2-NQのCys121修飾によるプロテインチロシンホスファターゼ1B(PTP1B)の構造および活性への影響 (2009)
  • Author(s): 岩本典子, 伊藤創平, 角大悟, 熊谷嘉人
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都府
  • Year and Date: 2009-03-26
• [Presentation] 親電子性環境化学物質1, 2ナフトキノンの毒性発現におけるNrf2/Keap1システムの役割 (2009)
  • Author(s): 三浦高
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都府
  • Year and Date: 2009-03-26
• [Presentation] 1,2-NQのCys121修飾によるプロテインチロシンホスファターゼ1B(PTP1B)の構造および活性への影響. (2009)
  • Author(s): 岩本典子
  • Organizer: 第129年会日本薬学会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合 (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 日本薬学会129年会日本薬学会学術振興賞受賞講演
  • Place of Presentation: 京都府
  • Year and Date: 2009-03-25
• [Presentation] 酸化ストレスおよび化学修飾を生じる環境物質を対象としたフィールドサイエンスと実験科学の融合. (2009)
  • Author(s): 熊谷嘉人
  • Organizer: 日本薬学会129年会日本薬学会学術振興賞受賞講演
  • Place of Presentation: 京都市
  • Year and Date: 2009-03-25
• [Presentation] 1, 2-Naphthoquinone disrupts CREB transcriptional activity through modification of Cys286 (2009)
  • Author(s): Endo A, Sumi D, Kumagai Y
  • Organizer: Society of Toxicology's 48th Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2009-03-16
• [Presentation] メチル水銀によるソルビトール脱水素酵素の阻害機構. (2008)
  • Author(s): 外山喬士
  • Organizer: 第1回メタロミクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2008-11-29
• [Presentation] 1, 2-ナフトキノンによるプロテインチロシンホスファターゼ1Bの活性阻害におけるCys121の役割 (2008)
  • Author(s): 岩本典子, 角大悟, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本県
  • Year and Date: 2008-10-18
• [Presentation] 1, 2-ナフトキノンはCys286を介して転写因子CREBに共有結合しその機能を阻害する (2008)
  • Author(s): 遠藤亜希子, 角大悟, 岩本典子, 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本県
  • Year and Date: 2008-10-18
• [Presentation] 1,2-ナフトキノンによるプロテインチロシンホスファターゼ1Bの活性阻害におけるCys121の役割. (2008)
  • Author(s): 岩本典子
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-18
• [Presentation] 1,2一ナフトキノンはCys286を介して転写因子CREBに共有結合しその機能を阻害する. (2008)
  • Author(s): 遠藤亜希子
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-18
• [Presentation] 大気中に含まれる未知の親電子性物質とそれにに対する生体応答を評価するシステムの構築. (2008)
  • Author(s): 西山彰
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-18
• [Presentation] メチル水銀の分子標的と細胞応答システム. (2008)
  • Author(s): 熊谷嘉人
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本市
  • Year and Date: 2008-10-17
• [Presentation] メチル水銀の分子標的としてのソルビトール脱水素酵素. (2008)
  • Author(s): 外山喬士
  • Organizer: 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-17
• [Presentation] カドミウムの毒性防御の細胞応答システムを担う転写因子Nrf2 (2008)
  • Author(s): 新開泰弘, 山本千夏, 熊谷嘉人, 山本雅之, 鍛冶利幸
  • Organizer: 第35回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京都
  • Year and Date: 2008-06-26
• [Presentation] カドミウムの毒性防御の細胞応答システムを担う転写因事Nrf2. (2008)
  • Author(s): 新開泰弘
  • Organizer: 第35回日本トキシコロジー学会学術年会
  • Place of Presentation: 東京
  • Year and Date: 2008-06-26
• [Presentation] イソチオシアネートによるレドックス制御を介した神経細胞分化促進機構の解析 (2008)
  • Author(s): 柴甲貴広
  • Organizer: 第61回日本酸化ストレス学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2008-06-19
• [Book] 改定版分子予防環境医学 (2010)
  • Author(s): 熊谷嘉人
  • Publisher: 本の泉社.
• [Book] 改定版分子予防環境医学 (2010)
  • Author(s): 熊谷嘉人
  • Publisher: 本の泉社
• [Book] 地球規模におけるヒ素汚染の現状 (2010)
  • Author(s): 安孫子ユミ
  • Publisher: ファルマシア(印刷中)
• [Book] 活性酸素シグナルと酸化ストレス(実験医学増刊号) (2009)
  • Author(s): 熊谷嘉人
  • Publisher: 羊土社.
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/environmental_medicine/index.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/environmentalmedicine/main/toppage.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/environmental_medicine/main/toppage.html
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/community-med/environmental_medicine/main/toppage.html