Molecular analysis of intestinal stress induction and regulation of the stress by food factors
| Project/Area Number |
20248013
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SHIMIZU Makoto The University of Tokyo, 大学院・農学生命科学研究科, 教授 (30114507)
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| Co-Investigator(Renkei-kenkyūsha) |
TOTSUKA Mamoru 東京大学, 大学院・農学生命科学研究科, 准教授 (70227601)
SATSU Hideo 東京大学, 大学院・農学生命科学研究科, 助教 (80323484)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥47,580,000 (Direct Cost: ¥36,600,000、Indirect Cost: ¥10,980,000)
Fiscal Year 2010: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Fiscal Year 2009: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2008: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
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| Keywords | 腸管上皮細胞 / 炎症モデル / 複合培養 / 抗ストレス作用 |
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| Research Abstract |
Inflammatory reactions induced by various stresses in the intestinal epithelium were investigated from the viewpoint of cell-cell interaction. Interaction between intestinal epithelial cells and immune cells was analyzed using in vitro cell culture model systems newly constructed in this study. Food substances that could suppress inflammatory reactions were also searched using these systems. Activated macrophages and mast cells induced damage to epithelial cells, whereas epithelial cells induced differentiation and functional activation of mast cells. Certain molecules responsible for the cell-cell interactions and food factors with anti-inflammatory functions were successfully found.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Transient up-regulation of immunity-and apoptosis-related genes in Caco-2 cells cocultured with THP-1 cells evaluated by a DNA microarray analysis.2010
Author(s)
Ishimoto, Y, Nakai, Y, Satsu, H, Totsuka, M, Shimizu, M.
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Journal Title
Bioscience, Biotechnology, and Biochemistry 74
Pages: 437-439
NAID
Related Report
Peer Reviewed
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[Journal Article] In vitro analysis of the interaction between human intestinal epithelial cells and macrophage-like cells.
Author(s)
Ishimoto, Y., Satsu, H., Mochizuki, T., Totsuka, M., Shimizu, M.,
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Journal Title
Animal Cell Technology (in press)
Related Report
Peer Reviewed
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