| Project/Area Number |
20249028
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KIYONO Hiroshi The University of Tokyo, 医科学研究所, 教授 (10271032)
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| Co-Investigator(Renkei-kenkyūsha) |
KUNISAWA Jun 東京大学, 医科学研究所, 講師 (80376615)
SATO Shintaro 東京大学, 医科学研究所, 助教 (80447333)
YUKI Yoshikazu 東京大学, 医科学研究所, 助教 (60345030)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥50,830,000 (Direct Cost: ¥39,100,000、Indirect Cost: ¥11,730,000)
Fiscal Year 2010: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
Fiscal Year 2009: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2008: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Keywords | 粘膜免役 / M細胞 / 上皮細胞 / 抗原取り込み / 共生細菌 / 粘膜免疫 / UEA-1 / フコシル化 |
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| Research Abstract |
M (Microfold) cells and related subpopulation cells are known as specialized cells for antigen uptake. To reveal the extracellular regulating factors and the mechanisms for antigen uptake and their differentiation of M cells, we identified several M cell-specific genes, and investigated there functions on M cells. As a result, it was suggested that inducible M-like cells, which have been discovered by our group, were an intermediate cells between Peyer's patch M cells and intestinal epithelial cells. We succeeded in identifying GP2 and MLP as novel M cell-specific molecule. In the case of GP2, our collaborative efforts revealed that GP2 could capture some bacterial groups via FimH protein, and acted as a scaffold to uptake them efficiently. In addition, we established monoclonal anti-GP2 antibody, and verified that this antibody was applicable for effective vaccine antigen delivering to M cells.
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