A large-scale cohort study for preventing lifestyle-related diseases and clarifying gene-environment interactions on the development of such diseases

• Project/Area Number: 20249038
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Saga University
• Principal Investigator: TANAKA Keitaro 佐賀大学, 医学部, 教授 (50217022)
• Co-Investigator(Kenkyū-buntansha): SHINCHI Koichi 佐賀大学, 医学部, 教授 (30404164) ; HIGAKI Yasuki 福岡大学, スポーツ科学部, 教授 (10228702) ; HARA Megumi 佐賀大学, 医学部, 教授 (90336115) ; NISHIDA Yuichiro 佐賀大学, 医学部, 助教 (50530185)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000); Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000); Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000); Fiscal Year 2010: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000); Fiscal Year 2009: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000); Fiscal Year 2008: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
• Keywords: 生活習慣病 / がん / 危険因子 / 遺伝子環境交互作用 / コーホート研究 / 防御因子 / 遺伝子

Research Abstract

This study aimed to clarify environmental and genetic factors and their interactions on the development of lifestyle-related diseases such as cancer, based on a 20-year follow-up of about 12000 residents in Saga city. We conducted a follow-up survey (183 deaths and 267 cancer cases identified), a reproducibility study of a lifestyle questionnaire (434 subjects included), cross-sectional studies (e.g., diet, physical activity, stress, and genetic polymorphisms in association with inflammation and blood sugar), and a secondary survey 5 years after the baseline survey (8454 subjects included). We will continue a follow-up and perform longitudinal studies in the future.

Research Products

• [Journal Article] Effect of the <i>PPARG2</i> Pro12Ala Polymorphism and Clinical Risk Factors for Diabetes Mellitus on HbA1c in the Japanese General Population (2012)
  • Author(s): Hara, M., et al.
  • Journal Title: Journal of Epidemiology Volume: 22 Issue: 6 Pages: 523-531
  • DOI: 10.2188/jea.JE20120078
  • NAID: 10031126935
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Obesity and liver cancer risk : an evaluation based on a systematic review of epidemiologic evidence among the Japanese population (2012)
  • Author(s): Tanaka, K., et al
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 42 Pages: 212-221
  • Peer Reviewed
• [Journal Article] Profile of Participants and Genotype Distributions of 108 Polymorphisms in a Cross-Sectional Study of Associations of Genotypes With Lifestyle and Clinical Factors: A Project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study (2011)
  • Author(s): K. Wakai, N. Hamajima, R. Okada, M. Naito, E. Morita, A. Hishida, S. Kawai, K. Nishio, G. Yin, Y. Asai, K. Matsuo, S. Hosono, H. Ito, M. Watanabe, T. Kawase, T. Suzuki, K. Tajima, K. Tanaka, Y. Higaki, M. Hara, T. Imaizumi, N. Taguchi, K. Nakamura, H. Nanri, T. Sakamoto, M. Horita, K. Shinchi, et al(49 others)
  • Journal Title: Journal of Epidemiology Volume: 21 Issue: 3 Pages: 223-235
  • DOI: 10.2188/jea.JE20100139
  • NAID: 10030212853
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Association Between Dietary Pattern and Serum C-Reactive Protein in Japanese Men and Women (2011)
  • Author(s): H. Nanri, K. Nakamura, M. Hara, Y. Higaki,T. Imaizumi, N. Taguchi, T. Sakamoto, M. Horita, K. Shinchi, K. Tanaka
  • Journal Title: Journal of Epidemiology Volume: 21 Issue: 2 Pages: 122-131
  • DOI: 10.2188/jea.JE20100110
  • NAID: 10029680825
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Optimal cutoff values of waist circumference and the discriminatory performance of other anthropometric indices to detect the clustering of cardiovascular risk factors for metabolic syndrome in Japanese men and women (2011)
  • Author(s): Nakamura, K., Nanri, H., Hara, M., Higaki, Y., Imaizumi, T., Taguchi, N., Sakamoto, T., Horita, M., Shinchi, K., Tanaka, K.
  • Journal Title: Environ. Health Prev. Med. Volume: 16 Issue: 1 Pages: 52-60
  • DOI: 10.1007/s12199-010-0165-y
  • NAID: 10029519901
  • Peer Reviewed
• [Journal Article] Influence of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration in people with obesity (2011)
  • Author(s): Nishida, Y., et al
  • Journal Title: Internal Medicine Volume: 50 Pages: 2121-2128
  • NAID: 130001087892
  • Peer Reviewed
• [Journal Article] Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors : a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) study (2011)
  • Author(s): Wakai, K., et al
  • Journal Title: Journal of Epidemiology Volume: 21 Pages: 223-235
  • Peer Reviewed
• [Journal Article] Association between dietary pattern and serum C-reactive protein in Japanese men and women. (2011)
  • Author(s): Nanri, H., Nakamura, K., Hara, M., Higaki, Y., Imaizumi, T., Taguchi, N., Sakamoto, T., Horita, M., Shinchi, K., Tanaka, K.
  • Journal Title: J. Epidemiol 21 Pages: 122-131
  • NAID: 10029680825
  • Peer Reviewed
• [Journal Article] Optimal cutoff values of waist circumference and the discriminatory performance of other anthropometric indices to detect the clustering of cardiovascular risk factors for metabolic syndrome in Japanese men and women. (2011)
  • Author(s): Nakamura, K., Nanri, H., Hara, M., Higaki, Y., Imaizumi, T., Taguchi, N., Sakamoto, T., Horita, M., Shinchi, K., Tanaka, K.
  • Journal Title: Environ. Health Prev, Med 16 Pages: 52-60
  • NAID: 10029519901
  • Peer Reviewed
• [Journal Article] Optimal cutoff values of waist circumference and the discriminatory performance of other anthropometric indices to detect the clustering of cardiovascular risk factors for metabolic syndrome in Japanese men and women (2011)
  • Author(s): Nakamura, K., et al.
  • Journal Title: Environmental Health and Preventive Medicine Volume: 16 Pages: 52-60
  • Peer Reviewed
• [Journal Article] Association between dietary pattern and serum C-reactive protein in Japanese men and women (2011)
  • Author(s): Nanri, H., et al.
  • Journal Title: Journal of Epidemiology Volume: 21 Pages: 122-131
  • Peer Reviewed
• [Journal Article] Factors Influencing Participation Rate in a Baseline Survey of a Genetic Cohort in Japan (2010)
  • Author(s): M. Hara, Y. Higaki, T. Imaizumi, N. Taguchi, K. Nakamura, H. Nanri, T. Sakamoto, M. Horita, K. Shinchi, K. Tanaka
  • Journal Title: Journal of Epidemiology Volume: 20 Issue: 1 Pages: 40-45
  • DOI: 10.2188/jea.JE20090062
  • NAID: 10026251340
  • ISSN: 0917-5040, 1349-9092
  • Peer Reviewed
• [Journal Article] Factors influencing participation rate in a baseline survey of a genetic cohort in Japan. (2010)
  • Author(s): Hara, M., Higaki, Y., Imaizumi, T., Taguchi, N., Nakamura, K., Nanri, H., Sakamoto, T., Horita, M., Shinchi, K., Tanaka, K.
  • Journal Title: J. Epidemiol 20 Pages: 40-45
  • NAID: 10026251340
  • Peer Reviewed
• [Journal Article] Factors influencing participation rate in a baseline survey of a genetic cohort in Japan (2010)
  • Author(s): Hara, M., et al.
  • Journal Title: Journal of Epidemiology 20 Pages: 40-45
  • NAID: 10026251340
  • Peer Reviewed
• [Journal Article] Interaction between cytochrome P450 1A2 genetic polymorphism and cigarette smoking on the risk of hepatocellular carcinoma in a Japanese population (2009)
  • Author(s): Imaizumi, T., et al.
  • Journal Title: Carcinogenesis 30 Pages: 1729-1734
  • Peer Reviewed
• [Journal Article] Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors : a project in the Japan Multi-institutional Collaborative Cohort (J-MICC) Study.
  • Author(s): Wakai, K., Hamajima, N., Okada, R., Naito, M., Morita, E., Hishida, A., Kawai, S., Nishio, K., Yin, G., Asai, Y., Matsuo, K., Hosono, S., Ito, H., Watanabe, M., Kawase, T., Suzuki, T., Tajima, K., Tanaka, K., Higaki, Y., Hara, M., Imaizumi, T., Taguchi, N., Nakamura, K., Nanri, H., Sakamoto, T., Horita, M., Shinchi, K., et al (49others)
  • Journal Title: J. Epidemiol in press
  • NAID: 10030212853
  • Peer Reviewed
• [Presentation] 炎症性サイトカインの遺伝子多型とHbA1cとの関連 (2013)
  • Author(s): 西田裕一郎、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] hOGG1 遺伝子のSer326Cys多型と空腹時血糖の関連 (2013)
  • Author(s): 原めぐみ、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 日本人中高年者の食事パターンと高血圧症との関連 (2013)
  • Author(s): 南里妃名子、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 睡眠時間とHbA1cの関連:J-MICC Study(佐賀地区) (2013)
  • Author(s): 大塚康子、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] ストレス対処行動とBMIとの関連:J-MICC Study(佐賀地区) (2013)
  • Author(s): 島ノ江千里、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] hOGG1遺伝子のSer326Cys多型と空腹時血糖の関連 (2013)
  • Author(s): 原めぐみ、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] 睡眠時間とHbA1cの関連：J-MICC Study（佐賀地区） (2013)
  • Author(s): 大塚康子、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] ストレス対処行動とBMIとの関連：J-MICC Study（佐賀地区） (2013)
  • Author(s): 島ノ江千里、他
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪
• [Presentation] ストレス対処行動とhs-CRP値との関連－J-MICC Study（佐賀地区）－ (2013)
  • Author(s): 島ノ江千里、他
  • Organizer: 第19回日本行動医学会学術総会
  • Place of Presentation: 東京
• [Presentation] 身体活動が血中IL-6, IL-8, IL-15, TNF-αに及ぼす影響 (2012)
  • Author(s): 西田裕一郎、他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
• [Presentation] 自覚ストレスとhs-CRP値との関連-J-MICC Study (佐賀地区)- (2012)
  • Author(s): 島ノ江千里、他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
• [Presentation] 食事パターンとADRβ2およびADRβ3遺伝子多型が血中トリグリセリドに与える影響 (2012)
  • Author(s): 島ノ江千里、他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
• [Presentation] 身体活動が血中IL-6,IL-8,IL-15,TNF-aに及ぼす影響 (2012)
  • Author(s): 西田裕一郎, 他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
• [Presentation] 自覚ストレスとhs-CRP値との関連-J-MICC Study(佐賀地区)- (2012)
  • Author(s): 島ノ江千里, 他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京
• [Presentation] Association between the PPARG2 Pro12Ala gene variant and HbA1c in a middle-aged Japanese population (2011)
  • Author(s): M. Hara, et al
  • Organizer: 19th IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, England
• [Presentation] Association between dietary pattern and serum C-reactive protein in Japanese men and women (2011)
  • Author(s): H. Nanri, et al
  • Organizer: 19th IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, England
• [Presentation] 喫煙状況および受動喫煙状況と高感度CRPの関連:J-MICC Study-佐賀地区- (2011)
  • Author(s): 中村和代、他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] 食事パターンとADRβ2およびADRβ3遺伝子多型がHbA1cに与える影響 (2011)
  • Author(s): 南里妃名子、他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] PPARG 遺伝子のPro12Ala多型とHbA1cとの関連 (2011)
  • Author(s): 原めぐみ、他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] Association between the PPARG2 Pro 12 Ala gene variant and HbA1c in a middle-aged Japanese population (2011)
  • Author(s): Hara, M., et al
  • Organizer: 19th IEA World Congress of Epidemiology
  • Place of Presentation: Edinburgh, England
• [Presentation] 喫煙状況および受動喫煙状況と高感度CRP の関連:J-MICC Study-佐賀地区-. (2011)
  • Author(s): 中村和代, 他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] 食事パターンとADRss2およびADRss3 遺伝子多型がHbA1c に与える影響 (2011)
  • Author(s): 南里妃名子, 他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] PPARG 遺伝子のPro12Ala 多型とHbA1c との関連 (2011)
  • Author(s): 原めぐみ, 他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] PPARG遺伝子のPro12Ala多型とHbA1cとの関連 (2011)
  • Author(s): 原めぐみ, 他
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] Association between physical activity and high-sensitivity C-reactive protein in a healthy Japanese population (2010)
  • Author(s): Higaki, Y., et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼金県越谷市
  • Year and Date: 2010-01-10
• [Presentation] Coffee drinking and decreased serum liver enzyme levels in a middl-eaged Japanese population (2010)
  • Author(s): Hara, M., et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼金県越谷市
  • Year and Date: 2010-01-10
• [Presentation] Reproducibility of a lifestyle questionnaire used for the J-MICC Study in Saga region (2010)
  • Author(s): Nakamura, K., et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼金県越谷市
  • Year and Date: 2010-01-09
• [Presentation] Dietary patterns and serum liver enzyme levels in Japanese men and women : the J-MICC Study in Saga region (2010)
  • Author(s): Nanri, H., et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼金県越谷市
  • Year and Date: 2010-01-09
• [Presentation] Greater light-intensity physical activity is associated with higher levels of total and high-molecular-weight adiponectin (2010)
  • Author(s): Nishida, Y, et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼金県越谷市
  • Year and Date: 2010-01-09
• [Presentation] Association between physical activity and high-sensitivity C-reactive protein in a healthy Japanese population (2010)
  • Author(s): Y. Higaki, et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Reproducibility of a lifestyle questionnaire used for the J-MICC Study in Saga region (2010)
  • Author(s): K. Nakamura, et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Dietary patterns and serum liver enzyme levels in Japanese men and women: the J-MICC Study in Saga region (2010)
  • Author(s): H. Nanri, et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Greater light-intensity physical activity is associated with higher levels of total and high-molecular-weight adiponectin (2010)
  • Author(s): Y. Nishida, et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Coffee drinking and decreased serum liver enzyme levels in a middle-aged Japanese population (2010)
  • Author(s): M. Hara, et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Association between physical activity and high-sensitivity C-reactive protein in a healthy Japanese population. (2010)
  • Author(s): Higaki, Y., et al
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] Greater light-intensity physical activity is associated with higher levels of total and high-molecular-weight adiponectin. (2010)
  • Author(s): Nishida, Y., et al.
  • Organizer: 第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県越谷市
• [Presentation] メタボリックシンドロームの腹囲診断基準の検討:J-MICC Study-佐賀地区- (2009)
  • Author(s): 中村和代、他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2009-01-23
• [Presentation] 日本人中高年者の食事パターンと高感度CRPとの関連 (2009)
  • Author(s): 南里妃名子、他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2009-01-23
• [Presentation] メタボリックシンドロームの腹囲診断基準の検討 : J-MICC Study-佐賀地区- (2009)
  • Author(s): 中村和代, 他
  • Organizer: 第19回日本疫学会学術総会
  • Place of Presentation: 金沢
  • Year and Date: 2009-01-23
• [Remarks]
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html
• [Remarks] J-MICC Study（ジェイミックスタディ）佐賀フィールドとは
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html
• [Remarks]
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html
• [Remarks] ホームページ
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html
• [Remarks]
  • URL: http://www.prevent.med.saga-u.ac.jp/jmiccsaga.html