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Biochemical gas sensors with drug metabolizing system based on body deodorant function

Research Project

Project/Area Number 20300062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Perception information processing/Intelligent robotics
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MITSUBAYASHI Kohji  Tokyo Medical and Dental University, 生体材料工学研究所, 教授 (40307236)

Co-Investigator(Kenkyū-buntansha) HIROYUKI Kudo  東京医科歯科大学, 生体材料工学研究所, 講師 (70329118)
TAKAHIRO Arakawa  東京医科歯科大学, 生体材料工学研究所, 助教 (50409637)
KUMIKO Miyajima  東京医科歯科大学, 生体材料工学研究所, 技術職員 (10516298)
DAISHI Takahashi  東京医科歯科大学, 生体材料工学研究所, 特任助教 (20549943)
HIROKAZU Saito  東京工業高等専門学校, 機械工学科, 准教授 (00205668)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2008: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Keywords代謝酵素 / 揮発性有機化合物 / 光計測 / 人工嗅覚 / 匂いセンサ / 高感度匂いセンサ / 代謝・無臭化機能
Research Abstract

Biochemical gas sensor for formaldehyde (one of volatile organic chemical, human smell detection limit : 400ppb) was developed by incorporating with an enzyme membrane (formaldehyde dehydrogenase) and an NADH fluorometric unit (UV-LED emission and PMT detector). The sensor is possible to monitor the formaldehyde concentration with high gas selectivity. The calibration range of the sensor is from 2.5 ppb to 15.0 ppm formaldehyde.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (40 results)

All 2010 2009 2008

All Journal Article (21 results) (of which Peer Reviewed: 10 results) Presentation (17 results) Book (2 results)

  • [Journal Article] Biochemical gas sensor (bio-sniffer) for ultrahigh-sensitive gaseous formaldehyde monitoring2010

    • Author(s)
      H.Kudo, Y.Suzuki, T.Gessei, D.Takahashi, T.Arakawa, K.Mitsubayashi
    • Journal Title

      Biosensors and Bioelectronics 26

      Pages: 854-858

    • Related Report
      2010 Final Research Report
  • [Journal Article] 2-D spatiotemporal visualization system of expired gaseous ethanol after oral administration for real-time illustrated analysis of alcohol metabolism2010

    • Author(s)
      X.Wang, E.Ando, D.Takahashi, T.Arakawa, H.Kudo, H.Saito, K.Mitsubayashi
    • Journal Title

      Talanta 82

      Pages: 892-898

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fiber optic bio-sniffer (biochemical gas sensor) for high selective monitoring of ethanol vapor using 335nm UV-LED2010

    • Author(s)
      H.Kudo, M.Sawai, Y.Suzuki, X.Wang, T.Gessei, D.Takahashi, T.o Arakawa, K.Mitsubayashi
    • Journal Title

      Sensors and Actuators B : Chemical 147

      Pages: 676-680

    • Related Report
      2010 Final Research Report
  • [Journal Article] Fluorescence biosensing system with a UV-LED excitation for l-leucine detection2010

    • Author(s)
      T.Koshida, T.Arakawa, T.Gessei, D.Takahashi, H.Kudo, H.Saito, K.Yano, K.Mitsubayashi
    • Journal Title

      Sensors and Actuators B : Chemical 146

      Pages: 177-182

    • Related Report
      2010 Final Research Report
  • [Journal Article] Biochemical gas sensor (bio-sniffer) for ultrahigh-sensitive gaseous formaldehyde monitoring2010

    • Author(s)
      Hiroyuki Kudo, et.al.
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 26 Pages: 854-858

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-D spatiotemporal visualization system of expired gaseous ethanol afteroral administration for real-time illustrated analysis of alcohol metabolism2010

    • Author(s)
      Xin WANG, et.al.
    • Journal Title

      Talanta 82 (2010) 892-898

      Volume: 82 Pages: 892-898

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiber optic bio-sniffer (biochemical gas sensor) for high selective monitoring of ethanol vapor using 335nm UV-LED2010

    • Author(s)
      Hiroyuki Kudo, et.al.
    • Journal Title

      Sensors and Actuators B : Chemical

      Volume: 147 Pages: 676-680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence biosensing system with a UV-LED excitation for 1-leucine detection2010

    • Author(s)
      Tomoyuki Koshida, et.al.
    • Journal Title

      Sensors and Actuators B : Chemical

      Volume: 146 Pages: 177-182

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-sniffers for ethanol and acetaldehyde using carbon and Ag/AgCl coated electrodes2009

    • Author(s)
      T.Gessei, H.Sato, E.Kazawa, H.Kudo, H.Saito, K.Mitsubayashi
    • Journal Title

      Microchimica Acta 165

      Pages: 179-186

    • Related Report
      2010 Final Research Report
  • [Journal Article] A NADH-dependent fiber-optic biosensor for ethanol determination with a UV-LED excitation system2009

    • Author(s)
      H.Kudo, M.Sawai, X.Wang, T.Gessei, T.Koshida, K.Miyajima, H.Saito, K.Mitsubayashi
    • Journal Title

      Sensors and Actuators B 141

      Pages: 20-25

    • Related Report
      2010 Final Research Report
  • [Journal Article] Flexible humidity sensor in a sandwich configuration with a hydrophilic porous membrane2009

    • Author(s)
      Y.Miyoshi, K.Miyajima, H.Saito, H.Kudo, T.Takeuchi, I.Karube, K.Mitsubayashi
    • Journal Title

      Sensors and Actuators B 142

      Pages: 28-32

    • Related Report
      2010 Final Research Report
  • [Journal Article] Bio-sniffers for ethanol and acetaldehyde using carbon and Ag/AgCl coated electrodes2009

    • Author(s)
      Tomoko Gessei, et.al.
    • Journal Title

      Microchimica Acta 165

      Pages: 179-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A NADH-dependent fiber-optic biosensor for ethanol determination with a UV-LED excitation system2009

    • Author(s)
      Hiroyuki Kudo, et.al.
    • Journal Title

      Sensors and Actuators B 141

      Pages: 20-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flexible humidity sensor in a sandwich configuration with a hydrophilic porous membrane2009

    • Author(s)
      Yoko Miyoshia, et.al.
    • Journal Title

      Sensors and Actuators B 142

      Pages: 28-32

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A biochemical sniffer-chip for convenient analysis of gaseous formaldehyde from timber materials2008

    • Author(s)
      K.Mitsubayashi, G.Nishio, M.Sawai, E.Kazawa, H.Yoshida, T.Saito, H.Kudo, K.Otsuka, M.Takao, H.Saito
    • Journal Title

      Microchimica Acta 160

      Pages: 427-433

    • Related Report
      2010 Final Research Report
  • [Journal Article] Development of Microconductometric Biosniffer for Detection of Trimethylamine2008

    • Author(s)
      C.Fillit, N.Jaffrezic-Renault, F.Bessueille, D.Leonard, K.Mitsubayashi, J.Tardy
    • Journal Title

      Materials Science and Engineering : C 28

      Pages: 781-786

    • Related Report
      2010 Final Research Report
  • [Journal Article] Electrochemical sensor with flavin-containing monooxygenase for triethylamine solution2008

    • Author(s)
      H.Saito, T.Shirai, H.Kudo, K.Mitsubayashi
    • Journal Title

      Analytical and Bioanalytical Chemistry 391

      Pages: 1263-1268

    • Related Report
      2010 Final Research Report
  • [Journal Article] A biochemical sniffer-chip for convenient analysis of gaseous formaldehyde from timber materials2008

    • Author(s)
      Kohji MITSUBAYASHI, et. al.
    • Journal Title

      Microchimica Acta 160

      Pages: 427-433

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Microconductometric Biosniffer for Detection of Trimethylamine2008

    • Author(s)
      Chrystelle Fillit, et. al.
    • Journal Title

      Materials Science and Engineering : C 28

      Pages: 781-786

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrochemical sensor with flavin-containing monooxygenase for triethylamine solution2008

    • Author(s)
      Hirokazu SAITO, et. al.
    • Journal Title

      Analytical and Bioanalytical Chemistry 391

      Pages: 1263-1268

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odorless digital watermark system with bio-sniffers and an inkjet printer2008

    • Author(s)
      Hirokazu SAITO, et. al.
    • Journal Title

      Proceedings of Eurosensors 2008

      Pages: 1197-1200

    • Related Report
      2008 Annual Research Report
  • [Presentation] Spatiotemporal visualisation system for expired ethanol after drinking2010

    • Author(s)
      Xin WANG, et.al.
    • Organizer
      Pacifichem 2010
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Bioelectronic Gas Sensor (Bio-Sniffer) for Formaldehyde2010

    • Author(s)
      Tomoko GESSEI, et.al.
    • Organizer
      61st Annual Meeting of Intl.Soc.of Electrochem.
    • Place of Presentation
      Nice, France
    • Year and Date
      2010-09-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Fluorometric Bio-Sniffer (Biochemical Gas Sensor) with UV-LED Light for Fomaldehyde Vapor as VOC (Volatile Organic Chemical)2010

    • Author(s)
      Kohji Mitsubayashi
    • Organizer
      Optical MEMS and Nanophotonics 2010
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      2010-08-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] High-sensitive Biochemical Gas sensor (bio-sniffer) for Evaluating Detoxification of Environmental Formaldehyde2010

    • Author(s)
      Tomoko GESSEI, et.al.
    • Organizer
      13th Intl.Meeting on Chemical Sensors
    • Place of Presentation
      Perth, Australia
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Fluorometric bio-sniffer (Opt nose) based on NADH detection with UV-LED for continuous monitoring of residential formaldehyde with sub-ppt sensitivity2010

    • Author(s)
      Yuki Suzuki, et.al.
    • Organizer
      20th Anniv.meeting of World Congress on Biosensors
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2010-05-26
    • Related Report
      2010 Final Research Report
  • [Presentation] Fluorometric bio-sniffer (Opt nose) based on NADH detection with UV-LED for continuous monitoring of residential formaldehyde with sub-ppt sensitivity2010

    • Author(s)
      Yuki Suzuki, et.al.
    • Organizer
      20th Anniv meeting of World Congress on Biosensors
    • Place of Presentation
      Glasgow, UK
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] High sensitive fluorometric bio-sniffer with UV-LED based excitation technique for monitoring formaldehyde vapour2009

    • Author(s)
      Hiroyuki Kudo, et.al.
    • Organizer
      First Bio-Sensing Technology Conference
    • Place of Presentation
      Bristol, UK
    • Year and Date
      2009-11-12
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] A bioelectronic gas sensor (bio-sniffer) for measurement of formaldehyde vapor2009

    • Author(s)
      Tomoko Gessei, et.al.
    • Organizer
      8th Asian Conference on Chemical Sensors
    • Place of Presentation
      Daegu, Korea
    • Year and Date
      2009-11-11
    • Related Report
      2010 Final Research Report
  • [Presentation] A bioelectronic gas sensor(bio-sniffer)for measurement of formaldehyde vapor2009

    • Author(s)
      Tomoko Gessei, et.al.
    • Organizer
      8th Asian Conference on Chemical Sensors
    • Place of Presentation
      Degu, Korea
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bio-transducers for biomedical applications2009

    • Author(s)
      Kohji Mitsubayashi
    • Organizer
      2009 International Conference on Solid State Devices and Materials (SSDM 2009)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2009-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] Bio-transducers for biomedical applications2009

    • Author(s)
      Kohji Mitsubayashi
    • Organizer
      2009 International Conference on Solid State Devices and Materials(SSDM 2009)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2009-10-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Toluene bio-sniffer using enzyme inhibition2008

    • Author(s)
      Yuki SUZUKI, et.al.
    • Organizer
      PRIME 2008
    • Place of Presentation
      Hawaii, USA.
    • Year and Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Bioelectronic gas sensor (bio-sniffer) for formaldehyde vapor2008

    • Author(s)
      Tomoko GESSEI, et.al.
    • Organizer
      PRIME 2008
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] An odorless digital-code system with bio-sniffers and an inkjet printer2008

    • Author(s)
      Ryodai KATO, et.al.
    • Organizer
      PRIME 2008
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-10-15
    • Related Report
      2010 Final Research Report
  • [Presentation] Toluene bio-sniffer using enzyme inhibition2008

    • Author(s)
      Yuki SUZUKI, et. al.
    • Organizer
      PRIME 2008 (Pacific Rim Meeting on Electrochemicaal and Solid-state Science)
    • Place of Presentation
      米国ハワイ・Hilton Hawaiian Village
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bioelectronic gas sensor (bio-sniffer) for formaldehyde vapor2008

    • Author(s)
      Tomoko GESSEI, et. al.
    • Organizer
      PRIME 2008 (Pacific Rim Meeting on Electrochemicaal and Solid-state Science)
    • Place of Presentation
      米国ハワイ・Hilton Hawaiian Village
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] An odorless digital-code system with bio-sniffers and an inkjet printer2008

    • Author(s)
      Ryodai KATO, et. al.
    • Organizer
      PRIME 2008 (Pacific Rim Meeting on Electrochemicaal and Solid-state Science)
    • Place of Presentation
      米国ハワイ・Hilton Hawaiian Village
    • Year and Date
      2008-10-15
    • Related Report
      2008 Annual Research Report
  • [Book] 「第25章生体臭(生体由来の揮発成分)用センサ」、「ヘルスケアとバイオ医療のための先端デバイス機器(監修:三林浩二)」2009

    • Author(s)
      斎藤浩一、三林浩二
    • Publisher
      CMC出版
    • Related Report
      2010 Final Research Report
  • [Book] ヘルスケアとバイオ医療のための先端デバイス機器(監修:三林浩二)2009

    • Author(s)
      斎藤浩一, 他
    • Total Pages
      11
    • Publisher
      【第4編 健康医療センサ・診断機器】第25章 生体臭(生体由来の揮発成分)用センサ
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2018-12-14  

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