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A fusion of super-selective cancer therapy and noninvasive temperature measurement based on magnetic nanoparticles

Research Project

Project/Area Number 20300155
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionNagaoka University of Technology

Principal Investigator

ISHIHARA Yasutoshi  Nagaoka University of Technology, 理工学部, 准教授 (00377219)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords画像診断 / 非侵襲計測 / 低侵襲治療 / 磁性ナノ粒子 / がん / 計測工学 / ナノ / 可視化 / ナノバイオ / 癌
Research Abstract

Fundamental research which aimed at realization of the fused system of heating cancer treatment system and the diagnosis system based on a characteristics of magnetic nanoparticles was performed. As results, the following things were clarified : (1) a heating region can be controlled by applying a electromagnetic wave with a static magnetic field to a magnetic nanoparticles, (2) a heating region can be measured noninvasively by using the phase change information with temperature in a cavity resonator, (3) the image resolution and detection sensitivity on a molecular imaging for the cancer can be improved.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (24 results)

All 2011 2010 2009 2008 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Book (4 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] A fundamental numerical analysis for noninvasive thermometry integrated in a heating applicator based on the reentrant cavity2010

    • Author(s)
      大和田寛, 石原康利
    • Journal Title

      Thermal Med. 26

      Pages: 51-62

    • NAID

      10027082412

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A fundamental numerical analysis for noninvasive thermometory integrated in a heating applicator based on the reentrant cavity2010

    • Author(s)
      H.Ohwada, Y.Ishihara
    • Journal Title

      Thermal Med. 26(2)

      Pages: 43-53

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 磁性ナノ粒子を利用した分子イメージングにおける高分解能画像再構成法2009

    • Author(s)
      草山裕助、石原康利
    • Journal Title

      信学論D J92-D

      Pages: 1653-1662

    • NAID

      110007361135

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] リエントラント型空胴共振器の電磁界分布を利用した非侵襲温度計測2009

    • Author(s)
      大和田寛,石原康利
    • Journal Title

      信学論D J92-D

      Pages: 562-570

    • NAID

      110007386000

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 磁性ナノ粒子を利用した分子イメージングにおける高分解能画像再構成法2009

    • Author(s)
      草山裕助、石原康利
    • Journal Title

      信学論.D J92-D(9)

      Pages: 1653-1662

    • NAID

      110007361135

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リエントラント型空胴共振器の電磁界分布を利用した非侵襲温度計測2009

    • Author(s)
      大和田寛, 石原康利
    • Journal Title

      信学論D J92-D

      Pages: 562-570

    • NAID

      110007386000

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん温熱療法における非侵襲温度計測法に関する研究2008

    • Author(s)
      大和田寛, 石原康利
    • Journal Title

      BIOMEDICAL THERMOLOGY 27

      Pages: 56-63

    • NAID

      10021283204

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles2011

    • Author(s)
      石原康利, 桑原剛志, 和田森直
    • Organizer
      SPIE Medical Imaging 2011(7965, pp.79652J.1-79652J.8 査読有)
    • Place of Presentation
      Florida
    • Year and Date
      2011-02-13
    • Related Report
      2010 Final Research Report
  • [Presentation] Sensitivity improvement of a molecular imaging technique based on magnetic nanoparticles2011

    • Author(s)
      Y.Ishihara, T.Kuwabara, N.Wadamori
    • Organizer
      SPIE Medical Imaging 2011
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-02-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性ナノ粒子を用いた分子イメージングにおける高分解能画像化手法の検討2010

    • Author(s)
      桑原剛志、和田森直、坪根正、石原康利
    • Organizer
      平成22年度電子情報通信学会信越支部大会(p.118 査読無)
    • Place of Presentation
      長岡市
    • Year and Date
      2010-10-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 磁性ナノ粒子を用いた分子イメージングにおける高分解能画像化手法の検討2010

    • Author(s)
      桑原剛志, 和田森直, 坪根正、石原康利
    • Organizer
      電子情報通信学会平成22年度信越支部大会
    • Place of Presentation
      長岡技術科学大学
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 磁性ナノ粒子を用いた分子イメージング手法の検討2009

    • Author(s)
      桑原剛志、和田森直、石原康利
    • Organizer
      平成21年度電子情報通信学会信越支部大会(p.131 査読無)
    • Place of Presentation
      長野市
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] 磁性ナノ粒子を用いた分子イメージング手法の検討2009

    • Author(s)
      桑原剛志、和田森直、石原康利
    • Organizer
      電子情報通信学会信越支部大会
    • Place of Presentation
      信州大学工学部
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Resolution improvement of the molecular imaging technique based on magnetic nanoparticles2009

    • Author(s)
      Y.Ishihara, Y.Kusayama
    • Organizer
      SPIE Medical Imaging 2009(7258, pp.72584I.1-72584I.8 査読有)
    • Place of Presentation
      Florida
    • Year and Date
      2009-02-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Resolution improvement of the molecular imaging technique based on magnetic nanoparticles2009

    • Author(s)
      Y. Ishihara, Y. Kusayama
    • Organizer
      SPIE Medical Imaging 2009
    • Place of Presentation
      Florida
    • Related Report
      2008 Annual Research Report
  • [Presentation] 磁性ナノ粒子を利用した分子イメージングの高分解能化に関する検討2008

    • Author(s)
      草山裕助、石原康利
    • Organizer
      電子情報通信学会信越支部大会(p.100 査読無)
    • Place of Presentation
      長岡市
    • Year and Date
      2008-09-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 磁性ナノ粒子を利用した分子イメージングにおける高分解能画像再構成法2008

    • Author(s)
      草山裕介,石原康利
    • Organizer
      生体医工学シンポジウム(p.2-03-03 査読無)
    • Place of Presentation
      豊中市
    • Year and Date
      2008-09-20
    • Related Report
      2010 Final Research Report
  • [Book] Electromagnetic waves(by V.Zhurbenko)(Image resolution and sensitivity improvements of a molecular imaging technique based on magnetic nanoparticles ISBN 978-953-307-568-6)2011

    • Author(s)
      Y.Ishihara, T.Kuwabara, N.Wadamori
    • Publisher
      In-Tech(掲載決定)
    • Related Report
      2010 Final Research Report
  • [Book] Electromagnetic wave (ISBN 978-953-307-568-6)2011

    • Author(s)
      Y.Ishihara, T.Kuwabara, N.Wadamori
    • Total Pages
      714
    • Publisher
      In-Tech
    • Related Report
      2010 Annual Research Report
  • [Book] New Developments in Biomedical Engineering(by D.Cmpolo)(Noninvasive localized heating and temperature monitoring based on a cavity applicator for hyperthermia ISBN 978-953-7619-57-2)2010

    • Author(s)
      Y.Ishihara, N.Wadamori, H.Ohwada
    • Publisher
      In-Tech
    • Related Report
      2010 Final Research Report
  • [Book] New developments in biomedical engineering (ISBN 978-953-7619-57-2)2010

    • Author(s)
      Y.Ishihara, N.Wadamori, H.Ohwada
    • Total Pages
      714
    • Publisher
      In-Tech
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.isc.meiji.ac.jp/~insteng

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 磁性ナノ粒子の磁化応答信号を利用した画像再構成装置及び画像再構成方法2009

    • Inventor(s)
      石原康利、草山裕助
    • Industrial Property Rights Holder
      明治大学
    • Patent Publication Number
      2010-172410
    • Filing Date
      2009-01-28
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] 磁性ナノ粒子の磁化応答信号を利用した画像再構成装置及び画像再構成方法2009

    • Inventor(s)
      石原康利, 草山裕助
    • Industrial Property Rights Holder
      国立大学法人長岡技術科学大学
    • Industrial Property Number
      2009-016562
    • Filing Date
      2009-01-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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