Analysis of myocardial molecular motor dynamics and excitation contraction coupling
| Project/Area Number |
20300162
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nara Medical University |
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Principal Investigator |
JUICHIRO Shimizu Nara Medical University, 保健医療学部, 教授 (80294403)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAKI Miyako 奈良県立医科大学, 医学部, 教授 (00033358)
MISAWA Hiromi 奈良県立医科大学, 医学部, 教務職員 (50281275)
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| Co-Investigator(Renkei-kenkyūsha) |
YAGI Naoto 高輝度光科学研究センター, 主席研究員 (80133940)
KATAOKA Noriyuki 川崎医療福祉大学, 医療技術学部, 准教授 (20250681)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
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| Keywords | 生体システム / フィジオーム / SPring-8 / X線回折 / 心臓 / 左心室自由壁 / アクチン / ミオシン / クロスブリッジ / ラット |
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| Research Abstract |
We have studied cardiovascular physiology, especially in myocardial excitation contraction coupling. We have observed and studied the cardiac contractile performance and have made mechanical and energetical analysis. We have reported that load dependent increase in cardiac contractile performance depends on the actin-myosin interaction but not on alteration of the intramyocardial Ca^<2+> dynamics. The X-ray diffraction, provided by the SPring-8 synchrotron radiation facility, is the most useful experimental technique to observe the actin-myosin interaction in the beating whole heart. In this study, we established a method to observe actin-myosin interaction in the rat beating whole heart and analyzed it in the pathophysiological models.
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Altered nano/micro-order elasticity of pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension.2010
Author(s)
Nakamura K, Shimizu J, Kataoka N, Hashimoto K, Ikeda T, Fujio H, Ohta-Ogo K, Ogawa A, Miura A, Mohri S, Nagase S, Morita H, Kusano KF, Date H, Matsubara H, Mochizuki S, Hashimoto K, Kajiya F, Ohe T.
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Journal Title
Int J Cardiol. 140(1)
Pages: 102-7
Related Report
Peer Reviewed
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