Creation of highly functionalized bone regenerative material based on octacalcium phosphate (OCP) collagen composites
| Project/Area Number |
20300165
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
KAMAKURA Shinji Tohoku University, 大学院・医工学研究科, 教授 (80224640)
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| Co-Investigator(Kenkyū-buntansha) |
ECHIGO Seishi 東北大学, 大学院・歯学研究科, 教授 (70005114)
SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948)
MATSUI Keiko 東北大学, 大学院・歯学研究科, 助教 (00302159)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 再生医工学材料 / 骨再生 / バイオマテリアル / 骨代替材料 / リン酸カルシウムリン酸オクタカルシウム / 燐酸オクタカルシウム |
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| Research Abstract |
Bone regenerative properties of various octacalcium phosphate (OCP)?collagen composite (OCP/Col) were investigated. (1) OCP/Col promoted the proliferation and attachment of cells. (2) Bone regeneration by implantation of OCP/Col in small animals was improved by dose-dependent manner of OCP content. The quality of the regenerated bone by implantation of OCP/Col was progressively increased and was compatible to that of normal bone of mechanical properties. (3) In various implantation designs of large animals, sufficient bone regeneration was confirmed by implantation of OCP/Col. These sequential fruitions led to the first clinical trial of OCP/Col implantation in the world.
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Report
(4 results)
Research Products
(31 results)
