Creation of highly functionalized bone regenerative material based on octacalcium phosphate (OCP) collagen composites

• Project/Area Number: 20300165
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Tohoku University
• Principal Investigator: KAMAKURA Shinji Tohoku University, 大学院・医工学研究科, 教授 (80224640)
• Co-Investigator(Kenkyū-buntansha): ECHIGO Seishi 東北大学, 大学院・歯学研究科, 教授 (70005114) ; SUZUKI Osamu 東北大学, 大学院・歯学研究科, 教授 (60374948) ; MATSUI Keiko 東北大学, 大学院・歯学研究科, 助教 (00302159)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000); Fiscal Year 2010: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2009: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2008: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 再生医工学材料 / 骨再生 / バイオマテリアル / 骨代替材料 / リン酸カルシウムリン酸オクタカルシウム / 燐酸オクタカルシウム

Research Abstract

Bone regenerative properties of various octacalcium phosphate (OCP)?collagen composite (OCP/Col) were investigated. (1) OCP/Col promoted the proliferation and attachment of cells. (2) Bone regeneration by implantation of OCP/Col in small animals was improved by dose-dependent manner of OCP content. The quality of the regenerated bone by implantation of OCP/Col was progressively increased and was compatible to that of normal bone of mechanical properties. (3) In various implantation designs of large animals, sufficient bone regeneration was confirmed by implantation of OCP/Col. These sequential fruitions led to the first clinical trial of OCP/Col implantation in the world.

Research Products

• [Journal Article] Reconstruction of critical-sized bone defect in dog skull by octacalcium phosphate combined with collagen. (2011)
  • Author(s): Kawai T, Matsui K, Iibuchi S, Anada T, Honda Y, Sasaki K, Kamakura S, Suzuki O, Echigo S.
  • Journal Title: Clin Oral Imp Res 13 Pages: 112-123
  • Peer Reviewed
• [Journal Article] Reconstruction of critical-sized bone defect in dog skull by octacalcium phosphate combined with collagen. (2011)
  • Author(s): Kawai T, et al.
  • Journal Title: Clin Oral Imp Res Volume: 13(2) Pages: 112-123
  • Peer Reviewed
• [Journal Article] Bone regeneration by octacalcium phosphate (OCP) collagen composites in a dog alveolar cleft model. (2010)
  • Author(s): Matsui K, Matsui A, Handa T, Kawai T, Suzuki O, Kamakura S, Echigo S.
  • Journal Title: Int J Oral Maxillofac Surg 39 Pages: 1228-1225
  • Peer Reviewed
• [Journal Article] Quality of regenerated bone enhanced by implantation of octacalcium phosphate-collagen composite. (2010)
  • Author(s): Masuda T, Kawai T, Anada T, Kamakura S, Suzuki O.
  • Journal Title: Tissue Eng Part C 16 Pages: 471-478
  • Peer Reviewed
• [Journal Article] Mechanical stress-related calvaria bone augmentation by inlayed octacalcium phosphate-collagen implant. (2010)
  • Author(s): Matsui A, Anada T, Masuda T, Honda Y, Miyatake N, Kawai T, Kamakura S, Echigo S, Suzuki O.
  • Journal Title: Tissue Eng Part A 16 Pages: 139-151
  • Peer Reviewed
• [Journal Article] Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model. (2010)
  • Author(s): Iibuchi S, Matsui K, Kawai T, Sasaki K, Suzuki O, Kamakura S, Echigo S.
  • Journal Title: Int J Oral Maxillofac Surg 39 Pages: 161-168
  • Peer Reviewed
• [Journal Article] Bone regeneration by octacalcium phosphate (OCP) collagen cmmnnsites in a dng alvenlar cleft model. (2010)
  • Author(s): Matsui K, et al.
  • Journal Title: Int J Oral Maxillofac Surg Volume: 39(12) Pages: 1218-1225
  • Peer Reviewed
• [Journal Article] Quality of regenerated bone enhanced by implantation of octacalcium phosphate-collagen composite. (2010)
  • Author(s): Masuda T, et al.
  • Journal Title: Tissue Eng Part C Volume: 16(3) Pages: 471-478
  • Peer Reviewed
• [Journal Article] Octacalcium phosphate(OCP)collagen composites enhance bone healing in a dog tooth extraction socket model. (2010)
  • Author(s): Iibuchi S, et al.
  • Journal Title: Int J Oral Maxillofac Surg 39(2) Pages: 161-168
  • Peer Reviewed
• [Journal Article] Reconstruction of critical-sized bone defect in dog skull by octacalcium phosphate combined with collagen. (2010)
  • Author(s): Kawai T, et al.
  • Journal Title: Clin Oral Imp Res (in press)
  • Peer Reviewed
• [Journal Article] Appositional bone formation by OCP-Collagen composite. (2009)
  • Author(s): Suzuki Y, Kamakura S, Honda Y, Anada T, Hatori K, Sasaki K, Suzuki O.
  • Journal Title: J Dent Res 88 Pages: 1107-1112
  • Peer Reviewed
• [Journal Article] Synthetic octacalcium phosphate augments bone regeneration correlated with its content in collagen scaffold. (2009)
  • Author(s): Kawai T, Anada T, Kamakura S, Matsui K, Sasaki K, Morimoto S, Echigo S, Suzuki O.
  • Journal Title: Tissue Eng Part A 15 Pages: 23-32
• [Journal Article] Appositional bone formation by OCP-Collagen composite. (2009)
  • Author(s): Suzuki Y, et al.
  • Journal Title: J Dent Res 88(12) Pages: 1107-12
  • Peer Reviewed
• [Journal Article] Synthetic octacalcium phosphate augments bone regeneration correlated with its content in collagen scaffold (2009)
  • Author(s): Kawai T
  • Journal Title: Tissue Eng Part A 15(1) Pages: 23-32
  • Peer Reviewed
• [Journal Article] Bone formation in rat calvaria ceases within a limited period regardless of completion of defect repair (2008)
  • Author(s): Honma T
  • Journal Title: Oral Dis 14(4) Pages: 457-464
  • Peer Reviewed
• [Journal Article] Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells (2008)
  • Author(s): Anada T
  • Journal Title: Tissue Eng Part A 14(6) Pages: 965-978
  • Peer Reviewed
• [Presentation] Application of octacalcium (OCP) collagen composites in canine bone defect model. (2010)
  • Author(s): Kamakura S, Matsui K, Iibuchi S, Matsui A, Handa T, Kawai T, Suzuki O, Echigo S.
  • Organizer: 9th Asian Congress on Oral and Maxillofacial Surgery 2010
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Bone regeneration by octacalcium phosphate (OCP) collagen composites in canine alveolar cleft model. (2010)
  • Author(s): Kamakura S, Matsui K, Matsui A, Handa T, Kawai T, Suzuki O, Echigo S.
  • Organizer: Tissue Engineering & Regenerative Medicine International Society (TERMIS) 2010 asia pacific meeting
  • Place of Presentation: Sydney, Australia
• [Presentation] Bone regeneration by octacalcium phosphate (OCP) collagen compo sites in canine alveolar cleft model (2010)
  • Author(s): Kamakura S, et al.
  • Organizer: Tissue Engineering, Regenerative Medicine International Society (TERMIS) 2010 asia paci fic meeting
  • Place of Presentation: Sydney, Australia
• [Presentation] Octacalcium phosphate (OCP) collagen composites enhances bone regeneration in a dog alveolar cleft model. (2009)
  • Author(s): Kamakura S, Matsui K, Matsui A, Handa T, Kawai T, Suzuki O, Echigo S
  • Organizer: International Bone-Tissue-Engineering Congress
  • Place of Presentation: Hannover, Germany
• [Presentation] Octacalcium phosphate (OCP) collagen composites enhance bone healing in a dog tooth extraction socket model. (2009)
  • Author(s): Iibuchi S, Matsui K, Kawai T, Sasaki K, Suzuki O, Kamakura S, Echigo S.
  • Organizer: 19th International Association of Oral and Maxillofacial Surgeons
  • Place of Presentation: Shanghai, China
• [Presentation] Octacalcium phosphate (OCP) collagen composites enhances bone regeneration in a dog alveolar cleft model. (2009)
  • Author(s): Kamakura S, et al.
  • Organizer: 2009 International Bone-Tissue-Engineering Congress
  • Place of Presentation: Hannover, Germany
• [Presentation] 燐酸オクタカルシウム・コラーゲン複合体による骨再生 (2008)
  • Author(s): 鎌倉慎治
  • Organizer: 第30回日本バイオマテリアル学会大会
  • Place of Presentation: 東大本郷キャンパス
  • Year and Date: 2008-11-17
• [Presentation] Long-term results of bone regeneration with OCP-Collagen composites. (2008)
  • Author(s): Kamakura S, Masuda T, Sasaki K, Echigo S, Suzuki O.
  • Organizer: 8th World Biomaterials Congress
  • Place of Presentation: Amsterdam, The Netherlands
• [Book] Bone Regeneration : Growth Factors, Augmentation Procedures and Tissue Engineering Applications.(Nova Science Publishers, Chapter 6: Bone regeneration by octacalcium phosphate (OCP) collagen composites.) (2010)
  • Author(s): Kamakura S, Anada T, Suzuki O.
• [Book] Bone regeneration by octacalcium phosphate (OCP) collagen composites. (2010)
  • Author(s): Legard V, et al.
  • Total Pages: 320
  • Publisher: Nova Science Publishers, Inc.
• [Remarks] ホームページ等
  • URL: http://www.boneregeneration.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.boneregeneration.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.boneregeneration.med.tohoku.ac.jp/
• [Patent(Industrial Property Rights)] 骨形成用キットおよび骨形成治具嵩上げリング (2008)
  • Inventor(s): 鈴木治、越後成志、鎌倉慎治、穴田貴久、本田義知、松井有恒、森元慎二
  • Industrial Property Rights Holder: 東北大学、ニプロ株式会社
  • Filing Date: 2008-08-06
• [Patent(Industrial Property Rights)] 骨形成用キットおよび骨形成治具嵩上げリング (2008)
  • Inventor(s): 鈴木治、越後成志、鎌倉慎治、他
  • Industrial Property Rights Holder: 東北大学ニプロ(株)
  • Filing Date: 2008-08-06