Activation of endogenous Schwann cells to promote remyelination in injured spinal cord

• Project/Area Number: 20300190
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Research Institute, National Rehabilitation Center for Persons with Disabilities
• Principal Investigator: OGATA Toru Research Institute, National Rehabilitation Center for Persons with Disabilities, 運動機能系障害研究部, 部長 (00392192)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000); Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: シュワン細胞 / 髄鞘形成 / 細胞内シグナル / グリア細胞 / 髄鞘 / 後根神経 / トレーニング / オリゴデンドロサイト / 後根細胞

Research Abstract

To promote remyelination in injured spinal cord, we focused on Schwann cell and its functional modulation. The hypothesis that Schwann cell migration from dorsal roots is enhanced by exercises was not confirmed by rat spinal cord injury model. To develop other methods for functional modulation, we identified the function of Hes gene in downstream of growth factors, and also established in vivo evaluation model for functional modulation. These findings are supposed to contribute for developing therapeutic approaches using Schwann cells.

Research Products

• [Journal Article] Hesl functions downstream of growth factors to maintain oligodendrocyte linage cells in the early progenitor stage (2011)
  • Author(s): Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M
  • Journal Title: Neuroscience 176 Pages: 132-41
  • Peer Reviewed
• [Journal Article] Hes1 functions downstream of growth factors to maintain oligodendrocyte linage cells in the early progenitor stage (2011)
  • Author(s): Ogata T, Ueno T, et al.
  • Journal Title: Neuroscience Volume: 176 Pages: 132-141
  • Peer Reviewed
• [Presentation] Molecular and Electrophysiological approaches for functional recovery in patients with injured spinal cord (2010)
  • Author(s): 緒方徹
  • Organizer: 2nd International Symposium on Rehabilitation Research
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2010-09-09
• [Presentation] Molecular Link between bFGF signals and bHLH transcription factors in regulating proliferation and maturation of oligodendrocyte progenitor cells (2009)
  • Author(s): Toru Ogata, Takaaki Ueno, Kozo Nakamura, Masami Akai
  • Organizer: 第39回北米神経科学学会
  • Place of Presentation: ワシントンDC(米国)
  • Year and Date: 2009-11-15
• [Presentation] 脊髄損傷におけるグリア前駆細胞の活性化と組織修復 (2009)
  • Author(s): 緒方徹、伊藤順一、上野高明、星川慎弥、中村耕三、赤居正美
  • Organizer: 第24回日整会基礎学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] 抗アポトーシス遺伝子導入シュワン細胞のラット脊髄損傷モデルへの移植およびその新しい組織学的評価法の確立 (2009)
  • Author(s): 星川慎弥、伊藤順一、上野高明、田中栄、中村耕三、緒方徹
  • Organizer: 第24回日整会基礎学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-05
• [Presentation] 脊髄損傷治療におけるHesファミリー分子の役割 (2009)
  • Author(s): 緒方徹、上野高明、伊藤順一、中村耕三、田中栄、赤居正美
  • Organizer: 第32回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-09-16
• [Remarks] ホームページ等