Activation of endogenous Schwann cells to promote remyelination in injured spinal cord
Project/Area Number |
20300190
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Research Institute, National Rehabilitation Center for Persons with Disabilities |
Principal Investigator |
OGATA Toru Research Institute, National Rehabilitation Center for Persons with Disabilities, 運動機能系障害研究部, 部長 (00392192)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2010: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
Keywords | シュワン細胞 / 髄鞘形成 / 細胞内シグナル / グリア細胞 / 髄鞘 / 後根神経 / トレーニング / オリゴデンドロサイト / 後根細胞 |
Research Abstract |
To promote remyelination in injured spinal cord, we focused on Schwann cell and its functional modulation. The hypothesis that Schwann cell migration from dorsal roots is enhanced by exercises was not confirmed by rat spinal cord injury model. To develop other methods for functional modulation, we identified the function of Hes gene in downstream of growth factors, and also established in vivo evaluation model for functional modulation. These findings are supposed to contribute for developing therapeutic approaches using Schwann cells.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Hesl functions downstream of growth factors to maintain oligodendrocyte linage cells in the early progenitor stage2011
Author(s)
Ogata T, Ueno T, Hoshikawa S, Ito J, Okazaki R, Hayakawa K, Morioka K, Yamamoto S, Nakamura K, Tanaka S, Akai M
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Journal Title
Neuroscience 176
Pages: 132-41
Related Report
Peer Reviewed
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