動脈硬化性疾患の発症に直結する新規バイオマーカーの発見と早期診断・治療法の開発
| Project/Area Number |
20300232
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
IKEDA Yasuyuki National Cardiovascular Center Research Institute, 分子薬理部, 客員研究員 (90176107)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAGI Atsuko 独立行政法人国立循環器病研究センター, 分子薬理部, 室長 (90179416)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2010: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2009: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Keywords | リポ蛋白リパーゼ / 高トリグリセリド血症 / 動脈硬化症 / バイオマーカー / メタボリックシンドローム / マクロファージ / 動脈硬化 |
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| Research Abstract |
We newly identified biomarker in serum which may predict the development and progress of arteriosclerosis. It was a glycoprotein of the 20kDa size of the high mannose type secreted by a monocyte-derived macrophage and named this a macrophage-derived -Atherosclerosis Developing Factor (Mφ-ADF).We developed the sandwich ELISA method for the quantification of Mφ-ADF protein and applied this method to clinical samples.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article]2009
Author(s)
高木敦子、池田康行
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Journal Title
広範囲 血液・尿化学検査 免疫学的検査-その数値をどう読むか[第7版]IV.生化学的検査[2]A.脂質関係 日本臨床67巻 増刊号(リポ蛋白質リパーゼ(LPL)・肝性トリグリセリドリパーゼ(HTGL).)
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