Studies on the effects of prenatal exposure to bisphenol A in mouse brain, with special reference to neuronal migration and epigenetic alteratio ns

• Project/Area Number: 20310036
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: FUSHIKI Shinji 京都府立医科大学, 医学研究科, 教授 (80150572)
• Co-Investigator(Kenkyū-buntansha): ITOH Kyoko 京都府立医科大学, 医学研究科, 准教授 (80243301) ; YAOI Takeshi 京都府立医科大学, 医学研究科, 助教 (40311914)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2008: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
• Keywords: 内分泌かく乱物質 / ビスフェノールA / マウス / 神経細胞移動 / エピジェネティックス / DNAメチル化 / 大脳 / 肝 / マウス胎仔

Research Abstract

We demonstrated that prenatal and lactational exposure to bisphenol A(BPA) affected fetal brain development, resulting in disturbed murine behavior accompanied with disrupted neurotransmitter system, including monoamines, in the postnatal development period and in adult mice. We also demonstrated that epigenetic alterations in promoter-associated CpG islands might underlie some of the effects on brain development after exposure to BPA.

Research Products

• [Journal Article] Bisphenol A, an endocrine-disrupting chemical, and brain development (2012)
  • Author(s): Itoh K, Yaoi T, Fushiki S
  • Journal Title: Neuropathology Volume: (オンラインジャーナル) Issue: 4 Pages: 447-457
  • DOI: 10.1111/j.1440-1789.2011.01287.x
  • Peer Reviewed
• [Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior (2012)
  • Author(s): Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S
  • Journal Title: Brain Dev Volume: 34(1) Pages: 57-63
  • NAID: 10031049535
• [Journal Article] Prenatal and lactational exposure to bisphenol A in mice alters expression of genes involved in cortical barrel development without morphological changes (2011)
  • Author(s): Han L, Itoh K, Yaoi T, Moriwaki S, Kato S, Nakamura K, Fushiki S
  • Journal Title: Acta Histochem Cytochem Volume: 44(1) Pages: 25-33
  • NAID: 130000395313
• [Journal Article] Prenatal and lactational exposure to bisphenol A in mice alters expression of genes involved in cortical barrel development without morphological changes. (2011)
  • Author(s): Han L, Itoh K, Yaoi T, Moriwaki S, Kato S, Nakamura K, Fushiki S.
  • Journal Title: Acta Histochem Cytochem Volume: 44 Pages: 25-33
  • NAID: 130000395313
  • Peer Reviewed
• [Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters adult mice behavior. (2011)
  • Author(s): Nakamura K, Itoh K, Dai H, Han L, Wang X, Kato S, Sugimoto T, Fushiki S.
  • Journal Title: Brain Dev Volume: (Epub ahead of print)
  • NAID: 10031049535
  • Peer Reviewed
• [Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice (2010)
  • Author(s): Nakamura K, Itoh K, Yoshimoto K, Sugimoto T, Fushiki S
  • Journal Title: Neurosci Lett Volume: 484(1) Pages: 66-70
• [Journal Article] Prenatal and lactational exposure to low-doses of bisphenol A alters brain monoamine concentration in adult mice. (2010)
  • Author(s): Nakamura K, Itoh K, Yoshimoto K, Sugimoto T, Fushiki S
  • Journal Title: Neurosci Lett Volume: 484 Pages: 66-70
  • Peer Reviewed
• [Journal Article] エピジェネティクスからみた環境化学物質の脳形成・発達への影響 (2009)
  • Author(s): 伏木信次
  • Journal Title: 脳と発達 41 Pages: 219-223
  • NAID: 10024846179
• [Journal Article] エピジェネティクスのオーバービュー (2009)
  • Author(s): 久保田健夫、伏木信次
  • Journal Title: 脳と発達 41 Pages: 203-207
  • NAID: 10024846126
• [Journal Article] 神経疾患のエピジェネティクス (2009)
  • Author(s): 伊東恭子、伏木信次
  • Journal Title: 京都府立医科大学雑誌 118 Pages: 523-531
• [Journal Article] エピジェネティクスの研究方法 (2009)
  • Author(s): 矢追毅
  • Journal Title: 京都府立医科大学雑誌 118 Pages: 533-541
• [Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A (2008)
  • Author(s): Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S
  • Journal Title: Biochem Biophys Res Commun Volume: 376(3) Pages: 563-7
• [Journal Article] Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. 2008 ; 376 : 563-7. (2008)
  • Author(s): Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S.
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 563-567
  • Peer Reviewed
• [Presentation] 環境化学物質の胎生期曝露と脳形成障害.シンポジウム「脳形成障害とオミックス」 (2011)
  • Author(s): 伊東恭子
  • Organizer: 第52回日本神経病理学会総会学術研究会
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-03
• [Presentation] ビスフェノールAがマウス大脳皮質神経細胞遊走に及ぼす影響の解明:タイムラプス蛍光イメージングを用いて (2011)
  • Author(s): 森脇三造、伊東恭子、中村惠子、外崎円、丹藤創、伏木信次
  • Organizer: 第52回日本神経病理学会総会学術研究会
  • Place of Presentation: 京都市
  • Year and Date: 2011-06-03
• [Presentation] ビスフェノールAの脳神経系形成過程に及ぼす影響-皮質遠心性ニューロンのゴルジ法による解析 (2010)
  • Author(s): 中村惠子、伊東恭子、細井創、伏木信次
  • Place of Presentation: 福岡市
  • Year and Date: 2010-05-22
• [Presentation] ビスフェノールAの脳神経形成過程に及ぼす影響:マウス大脳サブプレート神経細胞における網羅的遺伝子発現解析 (2009)
  • Author(s): 荻寛志、伊東恭子、矢追毅、伏木信次
  • Organizer: 第51回日本小児神経学会総会
  • Place of Presentation: 米子コンベンションセンター
  • Year and Date: 2009-05-29
• [Presentation] BPA胎生期曝露がマウス大脳皮質形成過程に及ぼす影響 (2009)
  • Author(s): 伏木信次
  • Organizer: 環境ホルモン学会講演会
  • Place of Presentation: 東京 江戸博物館
  • Year and Date: 2009-02-24