Development of DNA-binding ligands detecting trinucleotide repeats
| Project/Area Number |
20350032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
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| Keywords | 核酸 / トリヌクレオチドリピート / ミスマッチ塩基対 / リガンド / 相互作用 / 蛍光検出 / 繰り返し塩基配列 / 検出 / 蛍光 |
|---|
| Research Abstract |
Recent molecular genetic studies have shown that expansion of DNA trinucleotide repeats cause human neurological diseases, which are called trinucleotide repeat disorder. Unfortunately, there are no effective therapeutic approaches for the treatment of these diseases. In this work, we have successfully developed fluorescent ligands for C-C mismatch detection in CCG trinucleotide repeats that are associated with fragile site XE-linked mental retardation. It is expected that the discovery of such small molecules that bind trinucleotide repeats would provide a method for the smart diagnosis of the repeated length and a rational basis for the development of effective therapeutic agents.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article]2009
Author(s)
北森武彦 編, 寺前紀夫、西澤精一
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Journal Title
化学フロンティア20 新しい地平をひらく分析手法の最前線脱塩基DNAの微小空間での反応を利用した遺伝子分析法(12章)(化学同人)
Pages: 1-195
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