Fabrication of hollow microcapsules and their use as ultrasound contrast agents and drug delivery systems

• Project/Area Number: 20360093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thermal engineering
• Research Institution: The University of Tokyo
• Principal Investigator: DAIGUJI Hirofumi The University of Tokyo, 大学院・新領域創成科学研究科, 准教授 (10302754)
• Research Collaborator: TAKEMURA Fumio 産業技術総合研究所, エネルギー技術研究部門, 主任研究員 (20313041)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2010: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2009: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
• Keywords: 流体 / 化学物理 / 化学工学

Research Abstract

Hollow microcapsules of biodegradable polymers with diameter less than 10 μm are expected to be used as ultrasound contrast agents or carriers for drug delivery systems in medical or pharmaceutical applications. In this study, a simple method was developed that uses microbubbles as templates to fabricate hollow microspheres covered with biodegradable polymers. We elucidated dominant factors affecting size and uniformity of hollow poly-lactic acid microcapsules and hollow polyelectrolytes microcapsules fabricated from microbubble templates.

Research Products

• [Journal Article] Size control of hollow poly-allylamine hydrochloride / poly-sodium styrene sulfonate microcapsules in bubble template method (2011)
  • Author(s): Jay Jesus Molino Cornejo, Eitaro Matsuoka, Hirofumi Daiguji
  • Journal Title: Soft Matter 7 Pages: 1897-1902
  • Peer Reviewed
• [Journal Article] Size control of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules in bubble template method (2011)
  • Author(s): Jay Jesus Molino Cornejo, Eitaro Matsuoka, Hirofumi Daiguji
  • Journal Title: Soft Matter Volume: 7 Pages: 1897-1902
  • Peer Reviewed
• [Journal Article] Fabrication of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules from microbubble templates (2010)
  • Author(s): Hirofumi Daiguji, Eitaro Matsuoka, Satoshi Muto
  • Journal Title: Soft Matter 6 Pages: 1892-1897
  • NAID: 130004648675
  • Peer Reviewed
• [Journal Article] マイクロバブルを用いた中空マイクロカプセルの製造技術 (2010)
  • Author(s): 大宮司啓文、竹村文男
  • Journal Title: 分離技術 40 Pages: 169-174
• [Journal Article] Fabrication of hollow poly-allylamine hydrochloride/poly-sodium styrene sulfonate microcapsules from microbubble templates (2010)
  • Author(s): Hirofumi Daiguji, Eitaro Matsuoka, Satoshi Muto
  • Journal Title: Soft Matter Volume: 6 Pages: 1892-1897
  • NAID: 130004648675
  • Peer Reviewed
• [Journal Article] Fabrication of hollow poly(lactic acid) microcapsules from microbubble templates (2009)
  • Author(s): Hirofumi Daiguji, Shingo Takada, Jay Jesus Molino Cornejo, Fumio Takemura
  • Journal Title: Journal of Chemical Physics B 113 Pages: 15002-15009
  • Peer Reviewed
• [Journal Article] Simple fabrication of hollow polylactic acid microspheres using uniform microbubbles as templates (2009)
  • Author(s): Toshinori Makuta, Shingo Takada, Hirofumi Daiguji, Fumio Takemura
  • Journal Title: Materials Letters 63 Pages: 703-705
  • Peer Reviewed
• [Journal Article] Fabrication of hollow poly(lactic acid) microcapsules from microbubble templates (2009)
  • Author(s): Hirofumi Daiguji, Shingo Takada, Jay J.Molino, Fumio Takemura
  • Journal Title: Journal of Chemical Physics B Volume: 113 Pages: 15002-15009
  • Peer Reviewed
• [Journal Article] Simple fabrication of hollow polylactic acid microspheres using uniform microbubbles as templates (2009)
  • Author(s): Makuta, T.; Takada, S.; Daiguji, H.; Takemura, F.
  • Journal Title: Materials Letters 63 Pages: 704-705
  • Peer Reviewed
• [Journal Article] マイクロバブルから作る中空マイクロカプセル (2008)
  • Author(s): 竹村文男、大宮司啓文
  • Journal Title: コンバーテック 36(9) Pages: 80-83
  • NAID: 40016248021
• [Journal Article] 中空マイクロカプセルの新しい製造技術 (2008)
  • Author(s): 竹村文男、大宮司啓文
  • Journal Title: ケミカルエンジニヤリング 53 Pages: 262-266
• [Presentation] Size control of hollow polylactic acid microcapsules and hollow polyelectrolyte microcapsules in bubble template method (2011)
  • Author(s): Jay J. Molino, Hirofumi Daiguji, Fumio Takemura
  • Organizer: ASME/JSME 8th Thermal Engineering Conference
  • Place of Presentation: Honolulu, USA.
  • Year and Date: 2011-03-17
• [Presentation] Size control of hollow polylactic acid microcapsules and hollow polyelectrolyte microcansules in bubble template method (2011)
  • Author(s): Jay J.Molino, Hirofumi Daiguji, Fumio Takemura
  • Organizer: ASME/JSME 8th Thermal Engineering Conference
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2011-03-17
• [Presentation] Fabrication of hollow polylactic acid microcapsules using microbubble templates (2009)
  • Author(s): Jay J. Molino, Shingo Takada, Hirofumi Daiguji, Fumio Takemura
  • Organizer: ASME 2009 2nd Micro/Nanoscale Heat & Mass Transfer International Conference
  • Place of Presentation: Shanghai, China
  • Year and Date: 2009-12-20
• [Presentation] Fabrication of hollow poly-lactic acid microcapsules from microbubble templates (2009)
  • Author(s): Shingo Takada, Hirofumi Daiguji, Fumio Takemura
  • Organizer: US-Japan Seminar on Nanoscale Transport Phenomena -Science and Engineering
  • Place of Presentation: Boston, USA
  • Year and Date: 2009-07-15
• [Presentation] Fabrication of hollow poly-lactic acid microcapsules from microbubble templates (2008)
  • Author(s): Takada, S.; Daiguji, H.; Takemura, F.
  • Organizer: US-Japan Seminar on Nanoscale Transport Phenomen a-Science and Engineering
  • Place of Presentation: Boston, MA
  • Year and Date: 2008-07-15