Analysis of the molecular basis for cold adaptation of psychrotrophic bacteria
| Project/Area Number |
20360372
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ESAKI Nobuyoshi 京都大学, 化学研究所, 教授 (50135597)
MIHARA Hisaaki 京都大学, 化学研究所, 助教 (30324693)
KAWAMOTO Jun 京都大学, 化学研究所, 助教 (90511238)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2010: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2008: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 微生物 / 特殊環境 / 好冷微生物 / 低温適応 / 生体膜 / タンパク質 / 脂質 / 生物・生体工学 / 高度不飽和脂肪酸 / エイコサペンタエン酸 / リン脂質 |
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| Research Abstract |
Cold-adaptation mechanism of Shewanella livingstonensis Ac10 was analyzed. We identified cold-inducible proteins of this bacterium and analyzed their functions. We found that PspA involved in the response to membrane stress and MreB involved in cell division are important for cold adaptation. We also found that phospholipids containing eicosapentaenoyl group interact with various membrane proteins and affect their folding and properties to maintain the function of the cell membrane at low temperatures.
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Report
(4 results)
Research Products
(34 results)
