Whole-cell biocatalyst with non-natural membrane structure
Project/Area Number |
20360375
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biofunction/Bioprocess
|
Research Institution | Kobe University |
Principal Investigator |
KONDO Akihiko Kobe University, 工学研究科, 教授 (40205547)
|
Co-Investigator(Kenkyū-buntansha) |
TANAKA Tsutomu 神戸大学, 自然科学系・先端融合研究環重点研究部, 助教 (90436551)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2009: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2008: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
|
Keywords | タンパク質 / 酵素 / 非天然分子 / 酵母 / 細胞表層提示 / 菌体触媒 / バイオマス / 有機溶媒耐性 |
Research Abstract |
Introduction of non-natural, functional molecules on the cell surface was developed for establishment of several stress, such as organic medium containing broth. Using biotin-streptavidin interaction, non-natural molecules were successfully incorporated onto yeast cell surface. In addition, novel enzymes, which can conjugate some functional molecules on the cell surfaces, were explored. The evaluation of cell surface modified microorganisms' functions are undergoing such as stress tolerance.
|
Report
(4 results)
Research Products
(10 results)
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[Journal Article] Displaying non-natural, functional molecules on yeast surfaces via biotin-streptavidin interaction.2010
Author(s)
Tanaka, T., Masunari, S., Ishii, J., Wakamura, K., Segawa, M., Fukuda, H., Kondo, A.
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Journal Title
Journal of Biotechnology 145
Pages: 79-83
Related Report
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[Journal Article] Displaying non-natural, functional molecules on yeast surfaces via biotin-streptavidin interaction.2010
Author(s)
Tanaka, T., Masunari, S., Ishii, J., Wakamura, K., Segawa, M., Fukuda, H., Kondo, A.
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Journal Title
Journal of Biotechnology
Volume: 145
Pages: 79-83
Related Report
Peer Reviewed
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